Here's Buzz Aldrin reacting to being called a coward and a liar. This is one of those times when I can't blame someone for throwing a punch.
[Hat Tip: Canadain Cynic]
[Hat Tip: Canadain Cynic]
Neutral pH is the pH at which the concentrations of H+ and OH- are equal in aqueous solvent. This pH is 7.0 for pure water at 25°C.Post your answers in the comments. You can post anonymously if you want but all the best biochemists will be signing their names.
What is the neutral pH in your blood? What is the neutral pH in extremeophiles growing at 0°C or 100°C? (You may have to look up the values of some parameters in the Handbook of Chemistry & Physics).
The figure is from Williams et al. (1997).
Williams, J.C., Weijland, A., Gonfloni, S., Thompson, A., Courtneidge, S.A., Superti-Furga, G., Wierenga, R.K. (1997) The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions. J. Mol. Biol. 274:757-75. [PubMed] [doi:10.1006/jmbi.1997.1426]
The public's willingness to reject science for religious reasons is certainly lamentable. But by arguing that science contradicts religion and makes it untenable, many atheists reinforce the very concerns that are keeping people from accepting science to begin with. Someone like Collins, by contrast, can convince those who think science conflicts with their beliefs that this needn't be the case.This is the same old story we've heard before. Yes, it's true that someone like Francis Collins, who claims that science and religion are compatible, can be a great comfort to people who long to hear this. But that's not the point. The point is whether science and religion really are compatible. That's the question that certain atheists are asking and it won't be settled by pointing to Francis Collins. That's about as absurd as claiming that incompatibility is proven by pointing to Neil deGrasse Tyson or Jerry Coyne.
And Collins's approach isn't just good as a strategy to get the public to better appreciate science. The idea that science and religion can be compatible is strong on the intellectual merits as well. Granted, it depends how you define your terms: if your religion holds that Genesis must be read literally, then you are in direct conflict with scientific findings about the age of the Earth, the diversity of life on the planet, and so on. Yet if we consider religion more broadly—in its own considerable diversity—we find many sophisticated believers who've made a peace between their belief and the findings of modern science. It's not just Collins; consider the words of the Dalai Lama: "If science proves some belief of Buddhism wrong, then Buddhism will have to change."Oh dear. Close but no cigar. They're still relying on the argument from authority—in this case the Dalai Lama—and their "evidence" still depends on the fallacy of The Doctrine of Joint Belief. And there's those mysterious "sophisticated believers" that we hear so much about but never actually encounter. Where are they hidden?
[Hat Tip: RichardDawkins.net]
An intense national search ensued to find a new director. No one was more surprised than I to find the selection process converging on me. Being quite happy at the time leading a genome Center at the University of Michigan, and never having imagined myself as a federal employee, I initially indicated no interest. But the decision haunted me. There was only one Human Genome Project. This was going to be done only once in human history. If it succeeded, the consequences for medicine would be unprecedented. As a believer in God, was this one of those moments where I was somehow being called to take on a larger role in a project that would have profound consequences for our understanding of ourselves? Here was a chance to read the language of God, to determine the intimate details of how humans have come to be. Could I walk away? I have always been suspicious of those who claim to perceive God's will in moments such as this, but the awesome significance of this adventure, and the potential consequences for humankind's relationship with the Creator, could hardly be ignored.
Visiting my daughter in North Carolina in November 1992, I spent a long afternoon praying in a little chapel, seeking guidance about this decision. I did not "hear" God speak—in fact, I have never had that experience. But during those hours, ending in an evensong service that I had not expected, a peace settled over me. A few days later, I accepted the offer.
The three reviewers appointed by the moderate and liberal board members are all professors of history or education at Texas universities, including Mr. de la Teja, a former state historian. The reviewers appointed by conservatives include two who run conservative Christian organizations: David Barton, founder of WallBuilders, a group that promotes America's Christian heritage; and Rev. Marshall, who preaches that Watergate, the Vietnam War and Hurricane Katrina were God's judgments on the nation's sexual immorality. The third is Daniel Dreisbach, a professor of public affairs at American University.Let's imagine for a moment that the conservative reviewers on the panel are theistic evolutionists. (This is a thought experiment, take it as a given.) How would my accommodationist friends deal with their recommendations? Is it okay to teach Christianity in history classes as long as it's kept out of science classes?
The conservative reviewers say they believe that children must learn that America's founding principles are biblical. For instance, they say the separation of powers set forth in the Constitution stems from a scriptural understanding of man's fall and inherent sinfulness, or "radical depravity," which means he can be governed only by an intricate system of checks and balances.
The curriculum, they say, should clearly present Christianity as an overall force for good -- and a key reason for American exceptionalism, the notion that the country stands above and apart.
"America is a special place and we need to be sure we communicate that to our children," said Don McLeroy, a leading conservative on the board. "The foundational principles of our country are very biblical.... That needs to come out in the textbooks."
But the emphasis on Christianity as a driving force is disputed by some historians, who focus on the economic motivation of many colonists and the fractured views of religion among the Founding Fathers. "There appears to me too much politics in some of this," said Lybeth Hodges, a professor of history at Texas Woman's University and another of the curriculum reviewers.
1. No Canadian political party seems to have them.
[Hat Tip: Canadian Cynic]
Check out Uncertain Principles for another version of La Marseillaise—this is the famous scene in Casablanca.
The figure is from Williams et al. (1997).
Williams, J.C., Weijland, A., Gonfloni, S., Thompson, A., Courtneidge, S.A., Superti-Furga, G., Wierenga, R.K. (1997) The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions. J. Mol. Biol. 274:757-75. [PubMed] [doi:10.1006/jmbi.1997.1426]
1. Also known as socialized medicine.
Ahn, S.M., Kim, T.H., Lee, S., Kim, D., Ghang, H., Kim, D.S., Kim, B.C., Kim, S.Y., Kim, W.Y., Kim, C., Park, D., Lee, Y.S., Kim, S., Reja, R., Jho, S., Kim, C.G., Cha, J.Y., Kim, K.H., Lee, B., Bhak, J., Kim, S.J. (2009) The first Korean genome sequence and analysis: Full genome sequencing for a socio-ethnic group. Genome Res. 2009 Jun 24. [Epub ahead of print] [PubMed] [doi: 10.1101/gr.092197.109],Pay attention to the dates ... it's going to be important.
Kim, J.I., Ju, Y.S., Park, H., Kim, S., Leek S., Yi, J.H., Mudge, J., Miller, N.A., Hong, D., Bell, C.J., Kim, H.S., Chung, I.S., Lee, W.C., Lee, J.S., Seo, S.H., Yun, J.Y., Woo, H.N., Lee, H., Suh, D., Lee, S., Kim, H.J., Yavartanoo, M., Kwak, M., Zheng, Y., Lee, M.K., Park, H., Kim, J.Y., Gokcumen, O., Mills, R.E., Zaranek, A.W., Thakuria, J., Wu, X., Kim, R.W., Huntley, J.J., Luo, S., Schroth, G.P., Wu, T.D., Kim, H., Yang, K.S., Park, W.Y., Kim, H., Church, G.M., Lee, C., Kingsmore, S.F., Seo, J.S. (2009) A highly annotated whole-genome sequence of a Korean individual. Nature July 8 [epub ahead of print] [PubMed] [doi: 10.1038/nature08211]This paper was received by the journal on March 6, 2009. It was accepted on June 18, 2009 and published online on July 8, 2009.
The announcement, however, is likely to fuel a dispute over who was the first to have completed a genome map in Korea. Professor Kim Seong-jin, director of the Lee Gil-ya Cancer and Diabetes Research Institute at Gachon University of Medicine and Science in Incheon, completed a genome map in December last year and published it in the international journal Genome Research.It's going to be very difficult for the authors of the second paper to defend their actions. It looks like they behaved unethically by completely ignoring their competitors in their publication and then making a feeble excuse in the press release.
Seo said, “Since the accuracy is inadequate, (Kim’s) map cannot be considered Korea’s first.”
Gachon professor Ahn Seong-min refuted Seo’s claim, however, saying, “Professor Kim’s genomes were analyzed 29 times and the map is no less accurate than Professor Seo’s.”
1. Published sequences don't include centromeric regions and other regions with large blocks of repetitive DNA.
[Hat Tip: Canadian Cynic]
As recently as twelve years ago, very little was known about the nature of the sex hormones. As regards the oestrogenic, or follicle, hormone it was established that extracts from certain organs, e.g. the ovaries and placenta, bring about the characteristic oestrus phenomena in castrated female rats. Only a few observations were available concerning the stability and solubility of their active principles. Further development in the chemistry of the oestrogenic hormones could not take place until the purely biological discoveries by Allen and Doisy in 1923 and by Aschheim and Zondek in 1927 had been made.
Butenandt made the first big step forward in clarifying the chemistry of the follicle hormone in 1929 in Göttingen, simultaneously with Doisy in the United States. Both workers succeeded in isolating from the urine of pregnant women a substance in crystalline form having oestrogenic effects. Butenandt named this substance folliculine, a designation which was later changed to oestrone. He established that its empirical formula was C18H22O2, and that it was an oxyketone.
Shortly after the discovery of oestrone, Marrian in London (1930) isolated from the urine of pregnant women a new hormone which he called oestriol. Butenandt confirmed Marrian's discovery and explained the relationship between the new substance and oestrone. The relation between sterols and oestrogenic substances which had been assumed on crystallographical grounds became probable from the chemical point of view only after Butenandt and Marrian had shown, independently of one another, that only three benzoide double bonds enter into the ring system of these substances.
In 1932, Butenandt was able, from observations made in spectral analysis, and especially on the basis of the then established correct formula of cholesterol to draw up the formulae of the chemical structure of oestrone and oestriol. But there remained the important task of proving the chemical structure of the ring system as assumed by Butenandt. By breaking down the oestriol molecule stage by stage Butenandt proved that both œstrogenic hormones contained a phenanthrene core. At the same time he was able to obtain the same dimethyl phenanthrene from etiobilianic acid, a transformation product of cholic acid. He had thus confirmed the close relationship existing between the follicle hormones on the one hand and the bile acids and sterols on the other.
[Photo Credit: ULLSTEIN BILD from Nature]
The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.
Americans like science. Overwhelming majorities say that science has had a positive effect on society and that science has made life easier for most people. Most also say that government investments in science, as well as engineering and technology, pay off in the long run.Matt Nisbet believes every word. He points out that the "experts" (e.g. he and his buddies) have been saying this for years. As he puts it in his most recent posting [On the Pew Science Survey, Beware the Fall from Grace Narrative].
And scientists are very highly rated compared with members of other professions: Only members of the military and teachers are more likely to be viewed as contributing a lot to society's well-being.
I shared a similar observation in a post yesterday, detailing the Pew results that indicate an almost unrivaled amount of cultural respect, admiration, authority, and deference to science and scientists.Matt can't understand why some of us are a bit skeptical. He doesn't seem to be the least bit concerned about a public who have "an almost unrivaled amount of cultural respect, admiration, authority, and deference to science and scientists" and yet reject evolution, the role of humans in global warming, and the importance of vaccinating your children. Matt never bothers to ask why a public that admires science so much would flock to homeopaths, buy Q-ray bracelets, and read the astrology column in the daily newspaper.
The implication is that relative to authority, deference, and respect, scientists have earned a rich bounty of perceptual capital. When controversies occur, the challenge is to understand how to use this capital to sponsor dialogue, invite differing perspectives, facilitate public participation, reach consensus when appropriate, learn from disagreement, and avoid common communication mistakes that undermine these goals.I disagree with the premise. I think that real public respect for science is much lower than the Pew summary indicates. To me the survey results suggests a general public that doesn't understand science very well and doesn't trust scientists.
[Hat Tip: Pharyngula]
1. In the U.S., scientists and their organizations enjoy almost unrivaled respect, admiration, and cultural authority. Americans overwhelmingly trust scientists, support scientific funding, and believe in the promise of research and technology. Among institutions, only the military enjoys greater admiration and deference.It's a strange kind of "authority" that we scientists enjoy when only 32% of the general public believe that humans evolved due to natural processes. Among scientists, 87% hold this view. If that's what you call "trust" then I'd hate to see what "distrust" looks like!
More than half of the public (55%) says that science and religion are “often in conflict.” Close to four-in-ten (38%) take the opposite view that science and religion are “mostly compatible.” Yet the balance is reversed when people are asked about science’s compatibility with their own religious beliefs. Only 36% say science sometimes conflicts with their own religious beliefs and six-in-ten (61%) say it does not.
Highly observant Americans are among the most likely to see conflicts between science and their own religious beliefs. But less religiously observant people are more likely to see broader conflicts between science and religion in general. Among those who attend religious services at least weekly, 46% say they see a conflict between science and their religious beliefs (52% do not). Among those who seldom or never attend services, just 21% see a conflict. Yet 60% of those who seldom or never attend services believe science and religion are “often in conflict,” compared with 48% of Americans who attend religious services weekly or more often.
Religious belief among scientists varies somewhat by sex, age and scientific specialty. Younger scientists are substantially more likely than their older counterparts to say they believe in God. In addition, more chemists than those in other specialties say they believe in God. More men (44%) than women (36%) say they believe neither in God nor a higher power; belief in God is comparable for men and women scientists, but more women than men profess belief in a different supreme being or higher power.This result confirms some other studies showing that younger scientists are more religious than older scientists. Some people see this as the beginning of a trend leading to scientists becoming more religious.
When asked about the importance of various factors that motivated them to pursue careers in science, an overwhelming share of scientists (86%) say an interest in solving intellectually challenging problems was very important. This view is widely shared across scientific specialties.
Substantially smaller percentages of scientists say the desire to work for the public good (41%) and the desire to make an important discovery (30%) were very important reasons for choosing science as a career. However, large majorities do cite these factors as at least somewhat important (81% work for public good, 74% make important discovery).
....
Few scientists say that the desire for a financially rewarding career was a very important part of their decision to become a scientist (4%). However, a third (33%) say this was at least somewhat important in their choice of career.
As might be expected, far more scientists working in industry than those working in other sectors view a desire for a financially rewarding career as very or somewhat important. About half of industry scientists (51%) say this, compared with only about three-in-ten of those working for government (31%), academia (29%) and for non-profits (29%).
More generally, a far larger share of those in the applied sciences (43%) attribute their career choice at least in part to a desire for a financially rewarding career, compared with 25% of those in basic sciences. Among scientific specialties, those in chemistry (40%) are more likely than those in other fields to say financial rewards were a consideration in their career choice.
In an age of uncertainty, society globally needs a new compass to set it on a path of real progress. The Happy Planet Index (HPI) provides that compass by measuring what truly matters to us - our well-being in terms of long, happy and meaningful lives - and what matters to the planet - our rate of resource consumption. The HPI brings them together in a unique form which captures the ecological efficiency with which we are achieving good lives.That sounds like something right out of the 60s. Those of us who were there have to recognize that we didn't succeed in changing society for the better in spite of our idealism. Are today's students going to do any better when they've even lost the idealism?
This report presents results from the second global HPI. It shows that we are still far from achieving sustainable well-being, and puts forward a vision of what we need to do to get there.
The current economic and ecological crises have discredited the dogmas of the last 30 years. The unwavering pursuit of economic growth - embodied in the overwhelming focus on Gross Domestic Product (GDP) - has left over a billion people in poverty, and has not notably improved the well-being of those who were already rich, nor even provided us with economic stability. Instead it has brought us straight to the cliff edge of rapidly diminishing natural resources and unpredictable climate change. We need to see this current crisis as an opportunity. Now is the time for societies around the world to speak out for a happier planet, to identify a new vision of progress, and to demand new tools to help us work towards it. The HPI is one of these tools. We also hope that it will inspire people to act.
- David Suzuki
- The Queen, Elizabeth II
- Gen. Rick Hillier (Ret'd)
- Stephen Lewis
- Michael J. Fox
- Lloyd Robertson
- Peter Mansbridge
- Stehpen Harper
- Sheila Fraser
- Rick Mercer
President Obama Announces Intent to Nominate Francis Collins as NIH Director
WASHINGTON – Today, President Barack Obama announced his intent to nominate Francis S. Collins as Director of the National Institutes of Health at the Department of Health and Human Services.
President Obama said, "The National Institutes of Health stands as a model when it comes to science and research. My administration is committed to promoting scientific integrity and pioneering scientific research and I am confident that Dr. Francis Collins will lead the NIH to achieve these goals. Dr. Collins is one of the top scientists in the world, and his groundbreaking work has changed the very ways we consider our health and examine disease. I look forward to working with him in the months and years ahead."
Francis S. Collins, Nominee for Director, National Institutes of Health, Health and Human Services
Francis S. Collins, M.D., Ph.D., a physician-geneticist noted for his landmark discoveries of disease genes and his leadership of the Human Genome Project, served as Director of the National Human Genome Research Institute (NHGRI) at the National Institutes of Health from 1993-2008. With Dr. Collins at the helm, the Human Genome Project consistently met projected milestones ahead of schedule and under budget. This remarkable international project culminated in April 2003 with the completion of a finished sequence of the human DNA instruction book. In addition to his achievements as the NHGRI Director, Dr. Collins’ own research laboratory has discovered a number of important genes, including those responsible for cystic fibrosis, neurofibromatosis, Huntington's disease, a familial endocrine cancer syndrome, and most recently, genes for adult onset (type 2) diabetes and the gene that causes Hutchinson-Gilford progeria syndrome. Dr. Collins has a longstanding interest in the interface between science and faith, and has written about this in The Language of God: A Scientist Presents Evidence for Belief (Free Press, 2006), which spent many weeks on the New York Times bestseller list. He has just completed a new book on personalized medicine, The Language of Life: DNA and the Revolution in Personalized Medicine (HarperCollins, to be published in early 2010). Collins received a B.S. in Chemistry from the University of Virginia, a Ph.D. in Physical Chemistry from Yale University, and an M.D. with Honors from the University of North Carolina. Prior to coming to NIH in 1993, he spent nine years on the faculty of the University of Michigan, where he was an investigator of the Howard Hughes Medical Institute. He has been elected to the Institute of Medicine and the National Academy of Sciences, and was awarded the Presidential Medal of Freedom in November 2007.
A senior New Brunswick Roman Catholic priest is demanding the Prime Minister's Office explain what happened to the sacramental communion wafer Stephen Harper was given at Roméo LeBlanc's funeral mass.
During communion at the solemn and dignified service held last Friday in Memramcook for the former governor general, the prime minister slipped the thin wafer that Catholics call "the host" into his jacket pocket.
In Catholic understanding, the host - once consecrated by a priest for the Eucharist - becomes the body and blood of Jesus Christ. It is crucial that the small wafer be consumed when it is received.
Monsignor Brian Henneberry, vicar general and chancellor in the Diocese of Saint John, wants to know whether the prime minister consumed the host and, if not, what happened to it.
If Harper accepted the host but did not consume it, "it's worse than a faux pas, it's a scandal from the Catholic point of view," he said.
So why are Larry and many others still clinging to the myth of "junk DNA"? Do they not read the literature?Of course we read the literature, Charlie, but unlike you we read all of the literature. You can't just pick out the papers that support your position and assume that the question has been settled.
The figure is from Mattick (2007), an excellent example of what I'm talking about. This is a paper attacking the current consensus on junk DNA but in doing so it uses a figure that reveals an astonishing lack of understanding of genomes. This makes everything else in paper suspect. The figure was chosen by Ryan Gregory to be the classic example of a Dog's Ass Plot.
Mattick, J.S. (2004) The hidden genetic program of complex organisms. Sci Am. 291:60-67.
Why do so many of Darwinists spout so much filth, hostility, and aimless detraction?Realizing that she might get the wrong answers she adds another rule to the contest.
Note: Entries that merely claim it isn’t happening will not be judged. Too many people here know otherwise.On a completely urelated topic, here are some interesting quotations from Conservapedia ...
Dr. Josef Mengele's evolutionary thinking was in accordance with social Darwinist theories that Adolph Hitler and a number of German academics found appealing.[15] Dr. Joseph Mengele studied under the leading proponents the "unworthy life" branch of evolutionary thought.[16] Dr. Mengele was one of the most notorious individuals associated with Nazi death camps and the Holocaust.[17] Mengele obtained a infamous reputation due to his experiments on twins while at Auschwitz-Birkenau.[18]And here's an interesting posting from Denyse O'Leary herself: If you accept the argument in Descent of Man, you accept a racist argument . Now don't get me wrong, I'm not saying that the creationists are being mean and hostile by accusing evolutionists of racism and genocide. No siree, not me. I'm sure they wouldn't do that.
Prominent evolutionist and atheist Richard Dawkins stated the following regarding Adolf Hitler in an interview: “What’s to prevent us from saying Hitler wasn’t right? I mean, that is a genuinely difficult question."[19] The interviewer of Richard Dawkins wrote the following regarding the Richard Dawkins comment about Hitler: "I was stupefied. He had readily conceded that his own philosophical position did not offer a rational basis for moral judgments. His intellectual honesty was refreshing, if somewhat disturbing on this point."[20]
In addition to greatly influencing Hitler's Nazism, evolutionary ideas influenced the thinking of the Communists, including Marx, Engels, Vladimir Lenin, and Joseph Stalin.[21] Marx wrote, "Darwin's book is very important and serves me as a basis in natural science for the class struggle in history."
...
As noted earlier, evolutionary ideas contributed to the scourge of racism. [25][26] Charles Darwin and Thomas Huxley contributed greatly to the theory of evolution broadly being accepted in the 1900s. [27] Darwin, Huxley, and the 19th century evolutionists were racist in sentiment and believed the white race was superior.
[Hat Tip: Pharyngula]
When studying the natural odorants occurring in musk and civet, muscone and civetone, little known until then, Ruzicka obtained fundamentally new and surprising results during the years 1924-1926. He discovered that the molecule of muscone as well as that of civetone contains one single ring of carbon atoms, the number of which was considerably larger than that in all hitherto known cyclic molecules, larger even than had been considered possible. During his investigations of these odora he synthesized many kindred macrocyclic compounds, and drew attention to the plant-physiologically remarkable fact that these could be prepared from natural fatty acids.
Many interesting relationships exist between the polyterpenes studied by Ruzicka and a series of physiologically and medicinally important groups of compounds, viz. the bile acids, the sterols and the sex hormones. Among the many interesting results obtained by Ruzicka and his collaborators with sex hormones, the preparation of compounds with the same action as male sex hormones is of signal importance. It is his merit that by establishing preparative methods for androsterone and testosterone the technical synthesis of these two hormones has been made possible.
Moreover, the numerous new related compounds prepared by Ruzicka have contributed fundamentally to our knowledge of the physiologically so very important sex hormones, thus creating a sound basis for future investigations.
[Photo Credit (bottom): ETH-Bibliothek Zürich, Bildarchiv: Creative Commons License]
The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.