Sequenced genomes contain thousands of "unknown" genes

 
The total number of genes in the human genome has dropped from the initial estimates of 30-35,000 to about 25,000. Of these, more than 4,000 encode functional RNAs, leaving about 20,500 protein-encoding genes in the human genome [Humans Have Only 20,500 Protein-Encoding Genes].

Up to 40% of these protein-encoding genes are "unknown" in the sense that no function has been assigned to their protein products. In the jargon of genomics, the genes are "unannotated," meaning that nobody has assigned a function to the gene in the human genome database (Reichardt, 2007).

That means 8,000 unknown genes. About 1000 of these genes are "orphan" genes—genes that have no homologues in other species, including chimpanzees (Clamp, 2007).

Humans aren't unique. All sequenced eukaryotic genomes have a high percentage (~30-40%) of "unknown" protein-encoding genes.

A new paper in PLoS One looks at the "unknown" genes in the filamentous fungus Neurospora crassa (pink bread mold) (Kasuga et al. 2009). The Neurospora genome has about 9,000 protein-encoding genes and more than half of them have not been annotated. They are the "unkown" genes.

The genomes of about 40 different species of fungus have been sequenced and many of these are filamentous fungi related to Neuropsora. What this means is that it's possible to compare the Neurospora genes to those in many different genomes from closely related species; those that are part of the same family (less closelyrelated); part of the same phylum; and distantly related. You can't do such an extensive study with human genomes because there aren't very many mammalian genomes that have been sequenced and carefullyannotated. A draft sequence of the chimpanzee genome, for example, has been published but it is neither complete nor reliable enough for genomic comparisons. The only other primate genome is from macaque (Rhesus monkey) and that's far from finished. (The human and mouse genomes are the only ones listed as "complete" on the NCBI/Entrez website.)

The question is: are the unknown genes confined to Neurospora and its close relatives? If so, it would suggest that new genes have evolved within the past several million years and that's why we don't know their function.

Kasuga et al. created six sets of genes ...

1. Genes with homologs in distantly related eukaryotes and possibly prokaryotes. These are ancient genes.
2. Genes that are only found in fungi and not in plants or animals or protists (Dikarya).
3. Genes found only in Ascomycetes.
4. Genes confined to the Pezizomycotina clade to which Neurospora belongs.
5. Genes found only in Neurospora.
6. Others: genes that are found in some of the first groupings but not in all the smaller grouping.

The classification depends on the similarity cutoff. If the lowest cutoff is 25% sequence identity, then there will be more homologs in the eukarote or prokaryote class than if the cutoff is raised to 35%. The distibution of the various classes at each of three minimum sequence identify cutoffs is shown in their second figure.


Taking the 30% threshold numbers (middle group), it looks like there are 2,358 highly conserved genes with homologs in distantly related eukaryotes and prokaryotes. In contrast, there are 2,219 genes that don't have homologs in any other species. These are the orphan genes in Neurospora.

You might expect that most of the unknown/unannotated genes would be confined to Neurospora and closely related species. You might expect that highly conserved genes would be more likely to have been identified. That's partly true. Here are the numbers.


Only 16.5% of the highly conserved genes are mystery genes of unknown function. While this is much lower that the total (56%), it's still surprising that so many of the core genes remain unidentified. Presumably they are doing something very important. There are dozens of thesis projects available for talented graduate students who want to make a valuable contribution to biology.

It's not a surprise that 94% of the orphans are unannotated. These genes are likely to be new genes that have evolved recently in Neurospora and they would be expected to carry out unusual reactions that aren't found in other species. These "genes" are also the ones most likely to be artifacts (false positives) of the gene searching software. They may not be genes at all.

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[Image Credit: Neurospora-National Institute of General Medical Sciences]

Clamp, M., Fry, B., Kamal, M., Xie, X., Cuff, J., Lin, M.F., Kellis, M., Lindblad-Toh, K. and Lander, E.S. (2007) Distinguishing protein-coding and noncoding genes in the human genome. Proc. Natl. Acad. Sci. (USA) 104:19428-19433. [DOI 10.1073/pnas.0709013104]

Kasuga, T., Mannhaupt, G., and Glass, N.L. (2009) Relationship between Phylogenetic Distribution and Genomic Features in Neurospora crassa. PLoS ONE 4(4):e5286. [DOI:10.1371/journal.pone.0005286]

Reichardt, J.K.V. (2007) Quo vadis, genoma? A call to pipettes for biochemists. Trends in Biochemical Sciences (TIBS) 32:529-530. [DOI:10.1016/j.tibs.2007.10.001]

Conservative Spin

 

Canadian Cynic has built a career out of keeping an eye on The Blogging Tories. Every now and then CC comes up with something that makes you scratch your head and ask, "Can The Blogging Tories really be that stupid?"

Here's a posting from ErwinGerrits.com that will answer the question.

Funny how the current deficit budget is now universally referred to as “The Conservative Deficit”, even after this current budget was forced upon us by the Liberals, NDPers and the bloc-heads after a mid-winter stand-off on the Governour General’s front stoop. As I recall, the Conservative’s Economic Update, brought forward in December, did not make us go into a deficit at all. It was after the three stooges reared their ugly heads and blackmailed the country, that the current deficit budget was tabled.

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International team cracks mammalian gene control code

International team cracks mammalian gene control code

Stop the presses! Revise the textbooks! John Mattick and his collaborators have discovered how genes are controlled in mammals.

Anyone who knows Mattick's past history will know what's coming—Mattick overthrew the Central Dogma of Molecular Biology over six years ago (Mattick, 2003; Mattick, 2004).^1,2

An international consortium of scientists, including researchers from The University of Queensland (UQ), have probed further into the human genome than ever before.

They have discovered how genes are controlled in mammals, as well as the tiniest genetic element ever found.

Their discoveries will be published in three milestone papers in leading journal Nature Genetics.

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1. See Basic Concepts: The Central Dogma of Molecular Biology for the truth about the Central Dogma.

2. See Greg Laden Gets Suckered by John Mattick for an example of how easy it is to get fooled by John Mattick.

Mattick, J.S. (2003) Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms. BioEssays 25:930-939.

Mattick, J.S. (2004) The hidden genetic program of complex organisms. Sci. Am. 291:60-67.

Idiot America?

 
Oh dear, my accommodationist friends aren't gonna like this.

From the amazon.com site ....

The Culture Wars Are Over and the Idiots Have Won

A veteran journalist's acidically funny, righteously angry lament about the glorification of ignorance in the United States.

In the midst of a career-long quest to separate the smart from the pap, Charles Pierce had a defining moment at the Creation Museum in Kentucky, where he observed a dinosaur. Wearing a saddle.... But worse than this was when the proprietor exclaimed to a cheering crowd, “We are taking the dinosaurs back from the evolutionists!” He knew then and there it was time to try and salvage the Land of the Enlightened, buried somewhere in this new Home of the Uninformed.

With his razor-sharp wit and erudite reasoning, Pierce delivers a gut-wrenching, side-splitting lament about the glorification of ignorance in the United States, and how a country founded on intellectual curiosity has somehow deteriorated into a nation of simpletons more apt to vote for an American Idol contestant than a presidential candidate.

With Idiot America, Pierce's thunderous denunciation is also a secret call to action, as he hopes that somehow, being intelligent will stop being a stigma, and that pinheads will once again be pitied, not celebrated.

I can't wait for the sequel—Idiot Canada.

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[Hat Tip: Canadian Cynic]

Bob McDonald Explains why Canadian Scientists Are Upset

 
Bob McDonald is the host of Quirks & Quarks on CBC radio. He has a blog and here's part of what he posted on Friday [Another Earth Day, Canadian scientists concerned].

While people around the globe celebrate the beauty of our planet on Earth Day, April 22nd, scientists in Canada are concerned that government funding is heading in the wrong direction to provide sensible solutions to environmental problems. More than 2000 scientists from across the country have signed an open letter to Prime Minister Harper and the Leader of the Opposition, expressing concerns over cuts to basic science research. It’s basic science that takes the pulse of the planet.

The scientists are concerned that government money is overlooking vital areas. For example, the current Conservative budget allocates $2 billion for university infrastructure - in other words, renovations to aging buildings. But those funds come with a catch. They must be matched with private funding, something everyone is having trouble finding during these tough economic times. Keeping roofs on buildings is important, but if there are no scientists to work in them, what’s the point?

The Canada Foundation for Innovation, a major source of science funding, did receive $740 million, but it also comes with that match-funding hook. The other funding agencies, the Natural Sciences and Engineering Research Council and the Canadian Institutes of Health Research, have had their budgets cut back, while Genome Canada was essentially ignored.

The rest of the government’s support for science is going towards the automotive industry, carbon sequestration, biofuels and scholarships for business students. In other words, applied science is taking precedent over basic science.

While we do need both, when it comes to the environment, the two types of science are often at loggerheads.

Politicians like to support applied science because it leads to jobs and products, such as more efficient cars or new wireless devices. Basic science, on the other hand, can’t promise an immediate economic return because it simply looks at nature to understand how things work - and more importantly these days, how things are changing. As we’ve seen with climate change, basic scientists have been out in the field watching ice caps disappear before their eyes, carbon dioxide levels rise and climate patterns shift. At the same time, those dealing with the technology at the heart of the problem resist the basic science to keep the current systems in place.

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[Hat Tip: T. Ryan Gregory]

Monday's Molecule #118

 
This is a very famous protein but most of you won't be able to identify it from the structure alone. You'll need a hint of some sort.

Letting you know that the ligands are Mg²⁺ and adenosine-5′-triphosphate might not be enough so I'll also tell you that one of the authors on the structure paper was M.E. Noble.

There is one Nobel Laureate who is most closely identified with the function of this particular molecule, although that scientist was NOT the first to identify it. You have to identify the Nobel Laureate who got the prize for working out the function of the protein.

The first person to identify the molecule and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are six ineligible candidates for this week's reward: Bill Chaney of the University of Nebraska, Elvis Cela from the University of Toronto, Peter Horwich from Dalhousie University, Devin Trudeau from the University of Toronto, Shumona De of Dalhousie University, and Maria Altshuler of the University of Toronto.

I note that Canadians are trouncing the rest of the world. That's as it should be.

I still have one extra free lunch donated by a previous winner to a deserving undergraduate so I'm going to continue to award an additional free lunch to the first undergraduate student who can accept it. Please indicate in your email message whether you are an undergraduate and whether you can make it for lunch.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Prizes so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow.

Comments will be blocked for 24 hours.

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Agnotology

 
A reader (David) posted a comment about my recent Denyse O'Leary quotation. He alerted me to a new word: agnotology [Comments].

The Wikipedia entry is informative [agnolology agnatology] but there's lots more to learn about this word. Everyone is agreed that the word was invented by Robert Proctor a Standford University Professor who studies the history of science. Everyone is agreed that it refers to the study of ignorance, or why we don't know certain things. But there's more to it than that ....


Here's an excerpt from an article by Clive Thompson in WIRED magazine [Clive Thompson on How More Info Leads to Less Knowledge].

Normally, we expect society to progress, amassing deeper scientific understanding and basic facts every year. Knowledge only increases, right?

Robert Proctor doesn't think so. A historian of science at Stanford, Proctor points out that when it comes to many contentious subjects, our usual relationship to information is reversed: Ignorance increases.

He has developed a word inspired by this trend: agnotology. Derived from the Greek root agnosis, it is "the study of culturally constructed ignorance."

As Proctor argues, when society doesn't know something, it's often because special interests work hard to create confusion. Anti-Obama groups likely spent millions insisting he's a Muslim; church groups have shelled out even more pushing creationism. The oil and auto industries carefully seed doubt about the causes of global warming. And when the dust settles, society knows less than it did before.

"People always assume that if someone doesn't know something, it's because they haven't paid attention or haven't yet figured it out," Proctor says. "But ignorance also comes from people literally suppressing truth—or drowning it out—or trying to make it so confusing that people stop caring about what's true and what's not."

This is an important insight. It's not something that we didn't know already but it's good to emphasize the concept and give it a name.

Creationism is an excellent example. It's not just that creationists fail to understand science, it's also that they are being actively lied to in an attempt to spread ignorance. In other words, there are people who deliberately spread misinformation in order to oppose knowledge.

If we are going to fight creationism we have to do more than just teach evolution in the schools. If we do that then we are just barely holding our own against the people who spread ignorance. At best, students will be aware of a conflict between what they learn in school and what they learn everywhere else.

In order to fight the spread of ignorance we have to take on the liars directly and show why they are lying. They need to be discredited and exposed. Unfortunately, many of the enemy are "Christians" and Christians get special protection in our society. You can criticize astrology and quackary but not religion.

That has to change. Perhaps we can lump them all under the term "agnotology" and treat them all the same?

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And Now for a Little Comic Relief

 
It's been a few weeks since my last humorous posting so at the start of a new week I thought I'd give you something to laugh about.

Here's a few words from Denyse O'Leary.

The reason so many of us have risen up against Darwinism is not that we think natural selection never occurs but that we have never accepted - without evidence - the idea that it produces a high level of information (and that was Darwin's argument) And - as Mike Behe shows in Edge of Evolution, it doesn't.

It is amazing what people who get tenure at prestigious universities are willing to support without evidence. Including "chance" as a key explanation of high levels of information, which we must all know is completely untrue.

If you doubt that, try throwing the bag of Scrabble letters around the room and reassembling them randomly, and see what happens.

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Modified Bases in DNA

 
Adenine: from the Greek adenas "gland": first isolated from pancreatic glands (1885)

Cytosine: derived from cyto- from the Greek word for "receptacle," refering to cells (1894)

Guanine: originally isolated from "guano" or bird excrement (1850)

Thymine: first isolated from thymus glands (1894)

(source Horton et al. 2006)Bacterial genomes contain a number of unusual bases in addition to the classic adenine (A), cytosine (C), guanine (G), and thymine (T). The most common of the unusual bases are 5-methylcytosine, N⁴-methylcytosine, and N⁶-methyladenine (Erlich et al. 1987).

Bacteriophage DNA, especially the DNA of bacteriophage T4 and its close relatives, can contain 5-hydroxymethylcytosine. The base is usually glycoslylated in normal phage. (A sugar group is attached to the hydroxymethyl group.)

Many of these modified bases serve to protect DNA from restriction endonucleases—enzymes that cleave foreign DNA at specific sites. The restriction endonucleases act on bacteriophage (virus) DNA preventing it from replicating inside the bacterial cell [see Restriction, Modification, and Epigenetics].

If bacteriophage modify their nucleotides at the site of cleavage, they will escape the defenses of the bacterial cell. Of course, bacteria that make restriction endonucleases have to protect their own DNA or else they will be committing suicide. That's why their genomes have modified nucleotides.

Many other modified bases have been found in DNA but they are quite rare. Examples are uracil, α-putrescinylthymine, and 5-dihydroxypentyluracil.


Eukaryotic DNA doesn't have as many modified bases. In fact, 5-methylcytosine is the only one that's common in all eukaryotes. N⁶-methyladenine is known to exist in protist and plant DNA and it is thought to exist at low levels in mammalian DNA as well (Ratel et al. 2006). The presence of hydroxymethycytosine has been reported in various animals as far back as 1972 (Penn et al. 1972).


Now Kriaucionis and Heintz (2009) have re-discovered hydroxymethylcytosine in mammalian DNA. Their paper appears in the latest issue of Science. Apparently the modified nucleotide is found in certain brain cells. Their result confirms the work done by Penn et al. (1972), a result that had not been confirmed in several other studies. This makes hydroxymethylcytosine the seventh modified base in eukaryotic DNA—unless there are some that I don't know about.

The problem with the press release is that it doesn't put the discovery in the proper context.

ScienceDaily (Apr. 17, 2009) — Anyone who studied a little genetics in high school has heard of adenine, thymine, guanine and cytosine – the A, T, G and C that make up the DNA code. But those are not the whole story. The rise of epigenetics in the past decade has drawn attention to a fifth nucleotide, 5-methylcytosine (5-mC), that sometimes replaces cytosine in the famous DNA double helix to regulate which genes are expressed. And now there's a sixth: 5-hydroxymethylcytosine.

In experiments to be published online April 16 by Science, researchers reveal an additional character in the mammalian DNA code, opening an entirely new front in epigenetic research.

We aren't told that the sixth nucleotide is actually N⁶-methhyladenine. We aren't told that many other modified bases have been discovered in bacteria, including hydroxylmethylcytosine. And we aren't told that the authors actually cite earlier work showing the presence of hydroxymethylcytosine in mammalian DNA.

That's a shame. The authors are quoted in the press release. They should have made more of an effort to ensure that it was scientifically accurate.

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Ehrlich, M., Wilson, G.G., Kuo, K.C., and Gehrke. C.W. (1987) N4-methylcytosine as a minor base in bacterial DNA. J Bacteriol. 169:939-943. [Journal of Bacteriology]

Kriaucionis, S. and Heintz, N. (2009) The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain. Science Published Online April 16, 2009 [DOI: 10.1126/science.1169786]

Penn, N.W., Suwalski, R., O'Riley, C., Bojanowski, K. and Yura, R. (1972) The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J. :781–790. [Biochem. J.]

Ratel, D., Ravanat, J.L., Berger, F., and Wion, D. (2006) N6-methyladenine: the other methylated base of DNA. Bioessays :309-15. [PubMed

Dancing in Antwerp's Train Station

 
I have a confession to make. Ms. Sandwalk and I, along with four other couples we've known for many years, are learning how to do ballroom line dances. It's so much fun.

Perhaps that's why this video makes me smile. It's a promotion by a Belgian TV show that's looking for a "Maria" to play the lead in "The Sound of Music." I hope my daughter—who lives in Belgium— never hears about it 'cause she already knows all the words to every song in the musical.



UPDATE: Some people may not know about the T-Mobile add in the Liverpool Street Station in London [T-Mobile Dance].

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P.S. My dancing group is almost as good as these guys. Maybe we should do a performance in Union Station in downtown Toronto?

[Hat Tip: GrrlScientist]

Jerry Coyne's View of Evolutionary Psychology

 
You'll have to read Evolutionary psychology: the adaptive significance of semen flavor to find out what Coyne thinks of evolutionary psychology. I think he's captured the essence of the movement.

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P.S. I was looking for an appropriate illustration of the behavior that Coyne describes. Turns out that if you enter the appropriate term in your Google search box, you'll find quite a few photographs out there on the internet. I decided not to use any of them but the search was interesting.

Do You Want to Know the Sequence of Your Genome?

 
It's very likely that each one of us carries several recessive lethal alleles and many alleles that make us more susceptible to various diseases. You can count on it.

Do you want to know which of the many known deleterious alleles you have in your genome? That's one of the questions asked in an article published in The Economist: Getting Personal.

Though he has the world’s most advanced gene-sequencing technology at his fingertips, Dr Altshuler refuses to get his own genome sequenced: “If someone gave it to me on a CD, I’d refuse to look at the disc. The information is meaningless.” Bill Gates agrees. He has not had his genome sequenced either, nor does he plan to, though after a moment’s reflection he adds, “unless I find out I have cancer.”

Keep in mind that there's nothing much you can do if you find out that you have a predisposition for cancer or some other disease, like Alzheimer's. You can change your lifestyle but it's not clear whether that will change the probabilities significantly. Furthermore, there are so many claims out there about how to prevent disease that you'll never be sure you're doing the right thing.

And what do you do if you want to have children with someone who also knows their genome sequence? Figure out the probabilities that your children will not inherit any of your bad alleles. Is that a responsibility that you want? Why?

I'm with David Altshuler on this one and so was John Hawks until recently. Now John is changing his mind—Turning ACGT into poetry. Part of my problem is that I don't feel very comfortable seeking advice from a for-profit company when it comes to interpreting my genome sequence. But we won't have much choice; there's absolutely no way that the average person is going to be able to do the interpretation, so they will have to pay for it. And they'll have to get an update every few years as we learn more about human genes. (Whole genome interpretation is not a service that will be covered by socialized medicine.)

Do you want to know the sequence of your genome? Assuming that you can afford the sequencing cost, how do you intend to use the information and how will you interpret it?

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Sign the Open Letter

 
Are you a Canadian scientist who is upset about cuts to research funding by the current government? Read the Open letter to the Prime Minister and Leader of the opposition and add your name to the list of over 2000 scientists.

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Proportional Representation Is about to Pass in British Columbia

 
The Single-Transferable Vote (STV) is a system where each voting district (riding/constituency) has multiple members. You vote for several candidates by ranking them from most preferred to least preferred. If a candidate gets more than the minimum number of votes needed for election then the "surplus" votes are transferred to the second choice candidates.

If, after transferring "surplus" votes, there are still candidates to be elected, then the candidate with the lowest number of votes is eliminated and the votes are transferred to the voter's next choice. This process of elimination and transfer continues until the required number of candidates are elected [BC-STV].

The system was chosen by a non-partisan citizens' assembly.



A majority of voters in British Columbia voted in favor of this form of proportional representation in the last referendum but they failed to get the 60% majority required to change the voting system. It looks like they will succeed on May 12th, making British Columbia the first province to abolish the old first-past-the-post system and adopt a form of proportional representation.

I'm certain that Ontario won't be far behind. We lost the vote for proportional representation last time but that was probably because the general public didn't understand it. That, plus the fact that many prominent newspaper columnists and editors lied made untrue statements about the dangers of proportional representation. They didn't understand it either.

April 15, 2009
FOR IMMEDIATE RELEASE
Poll: 65 per cent of British Columbians support BC-STV
Younger voters overwhelming in their support

Vancouver, B.C. – The numbers are in and British Columbia voters are giving a big thumbs up to electoral reform with 65 per cent saying they will vote for BC-STV in the upcoming referendum on May 12. That is the top line result of a major survey conducted by Angus Reid Strategies. Support for a new way of electing our MLAs is particularly strong among younger voters – those 18 to 34 – at 74 per cent.

“The survey results indicate that British Columbians and particularly younger voters are ready to embrace a new electoral system in British Columbia,” said Catherine Rogers, vice president, Angus Reid Strategies. “A large majority are looking for electoral change and want an electoral system that is fair and that elects MLAs who are more accountable to them.”

When presented with the question that will appear on the ballot, 65 per cent said yes to BC-STV while only 35 per cent chose to keep the current first-past-the post system. Angus Reid Strategies conducted the online survey March 9 to 12 and polled 702 British Columbians across the province. While support for BC-STV continues to grow, awareness of the upcoming referendum is at 44 per cent.

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The 50 Most Brilliant Atheists of All Time

 
The 50 Most Brilliant Atheists of All Time

Congratulations to Jodie Foster (#46) who's a lot more attractive than atheist #45 who, in turn, is a heck of a lot prettier than #37.

1. Democritus
2. Diagoras of Melos
3. Epicurus
4. Theodorus the Atheist
5. Andrew Carnegie
6. Ivan Pavlov
7. Sigmund Freud
8. Clarence Darrow
9. Richard Strauss
10. Bertrand Russell
11. Jawaharlal Nehru
12. Linus Pauling
13. Paul Dirac
14. Ayn Rand
15. Katherine Hepburn
16. Jacques Monod
17. Subrahmanyan Chandresekhar
18. Alan Turing
19. Francis Crick
20. Claude Shannon
21. Richard Feynman
22. Noam Chomsky
23. James D. Watson
24. Peter Higgs
25. Warren Buffet
26. John Searle
27. Steven Weinberg
28. Carl Sagan
29. David Suzuki
30. George Carlin
31. Bruce Lee
32. Leonard Susskind
33. Stephen Jay Gould
34. Richard Dawkins
35. Daniel Dennett
36. Stephen Hawking
37. Mick Jagger
38. Richard Leakey
39. David Gilmour
40. Brian Eno
41. David Sloan Wilson
42. Steve Wozniak
43. Douglas Adams
44. Steven Pinker
45. PZ Myers
46. Jodie Foster
47. Russell T Davies
48. David Chalmers
49. Sean Carroll
50. Mark Zuckerberg

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G T C A

 
Just when I've (almost) mastered Y M C A, along comes a new challenge.

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Summer Course on Intelligent Design Creationism

 
You can sign up for a full week course on Intelligent Design Creationism at the Discovery Institute in Seattle, Washington (USA) [Deadline Nears for Summer Seminars on Intelligent Design]. It runs from July 10 - 18, 2009 and it's free.

The course is open to any student ... almost. There are a few small hurdles that have to be jumped in order to qualify.

1. A copy of your resume;
2. A letter of recommendation from an ID-friendly source;
3. A copy of your academic transcript;
4. A short (one page) statement of your interest in ID within your field of study.

If anyone wants to attend I'd be happy to write a letter of recommendation.

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Christine Hurley - The Flamboyant Psychic

 
Back in October 2007, I posted a short message about a psychic who was arrested for fraud. I linked to Mike's Weekly Skeptic Rant because he had an interesting multiple choice question [see Psychic Arrested in Calgary].

A Calgary psychic named Christine Hurley posted a comment where she claimed to be as interested as the rest of us in weeding out psychic frauds. (Yes, I do see the irony.)

Since then, she has posted several more comments designed to promote her "skills" in psychic reading. You can benefit from her psychic powers by charging $120 to your credit card for a 30 minute phone reading [Christine Hurley: Prices]. An even better bargain is one hour on the phone for $150!

I'm not exactly sure how this works. Presumably Ms. Hurley will tell you all the important things you need to know in the first 30 minutes. Maybe there are some interesting details that require another half hour.

Read the comments and testimonials that are accumulating at Psychic Arrested in Calgary. It's really amazing to see how some people can be completely duped by Christine Hurley into believing that she has psychic powers.

I wonder why she spends so much time collecting $120 (CDN) from her suckers clients when she could "easily" pocket $1,000,000 (US) in James Randi's One Million Dollar Paranormal Challenge? Does anyone know why she hasn't collected the prize? As a true psychic she must know how Randi's test is going to turn out.

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[Photo Credit: Bryan Schlosser, The Leader-Post]

The Evolution Conspiracy

 
The Evolution Conspiracy is a book by Lisa Shiel. I'd never heard of her until a few days ago but some of you might know her because she's a fan of bigfoot. She has a masters degree in library science.

You can't buy the book until next September but you can read all the rave reviews of this unpublished book on Lisa's website: The Evolution Conspiracy. You can also get an inkling of what the book is about by reading her promotional material. Here's an excerpt ...

Evolution.

One word, deceptive in its simplicity, has transformed the way we look at ourselves and everything around us. Once thought of as unique, man has become one of the animals with no special claim on the planet. As children, few of us question what we learn in biology class about the origins of life and the position man holds in the hierarchy. Science textbooks present evolution as fact—indisputable, inevitable, and incomprehensible to everyone outside the exalted few with PhDs in the appropriate fields.

That’s why this book promotes one key premise—anyone can understand evolution.

That's refreshing. Anyone can understand evolution. Anyone, that is, except Lisa Shiel. Her stupidity and ignorance are on display in the comments she's making on science blogs and on her own website. By her own admission she is dropping comments on all the evolution blogs in order to promote her book [Banned by Evolutionists! Can You Handle It?].

The purpose of this posting is to help give her as much publicity as possible in order to expose her as just another kook who has no idea what evolution is all about.

Here's an example from a posting she made on April 7th: You Can’t Tell a Species by Its Cover.

The theory of evolution involves numerous complicated and confounding strands—almost as many strands, I dare say, as DNA itself. Charles Darwin posited that natural selection drives the evolution of species, and this idea has become the cornerstone of evolutionary theory. In natural selection, traits that seem beneficial are preserved in a species while undesirable traits gradually disappear. Because natural selection cannot account for all adaptations, scientists devised the theory of genetic drift, in which changes occur at random.

Yet no one has ever reproduced the creation of a species via either natural selection or genetic drift; in fact, no one has ever demonstrated scientifically that one species evolves into another. If a theory must adhere to the scientific method to remain a scientific theory, then evolution has failed the test. The scientific method requires repeated testing, and the ability to reproduce results.

Now toss into this mess the recent discovery that some species “evolve” genetically while remaining unchanged anatomically. Scientists at Massey University in New Zealand have found that a reptile called the tuatara differs genetically from its 8,000-year-old ancestors, while retaining the same anatomical makeup and outward appearance. The tuatara’s DNA changes make it the Speedy Gonzales of genetic evolution. According to Axel Meyer of Germany’s University of Konstanz, the discovery suggests “a real disconnect” can exist between genetic and anatomical evolution.

Finally, consider the recent discovery that cryptic species can fool us too—two creatures look identical, but their DNA identifies them as different species. Perhaps the fossilized tuatara aren’t really tuatara after all…

Evolution: The unscientific scientific theory.

Makes you wonder if Lisa Shiel has even read her own book—a book that presumably explains evolution correctly. There are so many factual and conceptual errors in this short posting that it catapults Lisa into contention for the most ignorant IDiot award. And that's saying a lot 'cause the competition is fierce.

Anyway, the bottom line is that there's nothing to see here folks. You can move along to other books and other blogs. Lisa even makes Denyse O'Leary look good.

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Nobel Laureate: Max Theiler

 

The Nobel Prize in Physiology or Medicine 1951

"for his discoveries concerning yellow fever and how to combat it"

Max Theiler (1899 - 1972) won the Noble Prize in 1951 for his work on combating yellow fever.

Theiler's most important contribution was the discovery of a variant of the yellow fever virus that did not cause the disease in humans. When injected into healthy patients, this variant produced immunity to the normal disease-producing virus.

This discovery was not immediately useful since attenuated virus from mice was more effective in producing immunity—a result also discovered by Theiler. The Nobel Committee felt that Theiler had made a significant contribution to understanding viral diseases.

One gets the impression from reading the presentation speech that Theiler was also being recognized as a representative of work done by the Rockefeller Foundation.

THEME:
Nobel Laureates

The significance of Max Theiler's discovery must be considered to be very great from the practical point of view, as effective protection against yellow fever is one condition for the development of the tropical regions - an important problem in an overpopulated world. Dr. Theiler's discovery does not imply anything fundamentally new, for the idea of inoculation against a disease by the use of a variant of the etiologic agent which, though harmless, produces immunity, is more than 150 years old. Jenner used a natural virus variant, cowpox virus, against smallpox, and Pasteur produced a similar variant of the rabies virus by repeated passage through animals. So far there have been only a few successful attempts to master a disease by such measures, but Dr. Theiler's discovery gives new hope that in this manner we shall succeed in mastering other virus diseases, many of which have a devastating, effect and against which we are still entirely powerless. Max Theiler, therefore, has rendered mankind such a service as Nobel made a condition for the awarding of this prize.

Dr. Theiler. For a period of almost forty years the International Health Division of the Rockefeller Foundation has carried on very comprehensive and fruitful work in combating yellow fever and extending our knowledge of it. Among the many who have made their contributions, you take an especially prominent place, because you have made their contributions profitable and because you have opened the way to greater understanding of the epidemiology of the disease and to an effective prophylaxis against it. The Caroline Institute esteems your research work so highly, not the least for its practical value, that it has found it proper to award this year's Nobel Prize in Physiology or Medicine to you.

I ask you, Dr. Theiler, to receive the prize from the hands of His Majesty, our gracious King.

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[Photo Credit: ©Bettmann/CORBIS, Rights Managed, Corbis]

The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.

Gary Goodyear's Letter to Nature

 
Canadian government reaffirms support for science and discovery

Sir

You report researchers' concerns about the Canadian government's support for science in two recent News stories (Nature 457, 646; 2009 and Nature 458, 393; 2009). As Minister of State for Science and Technology, I can say that, despite the global economic situation, the government of Canada remains committed to innovation and discovery. We have increased funding to researchers, both in universities and in the private sector.

In the past three years, for example, we have significantly increased the budgets of federal granting councils, increased scholarships through the Canada Graduate Scholarships Program, and increased the Industrial Research Assistance Program for small and medium-sized businesses. The Budget 2009 announcements include Can$750 million (US$590 million) for the Canada Foundation for Innovation to attract and retain world-leading researchers, and a Can$2-billion infrastructure programme. The government has also put in place two five-year funding agreements with Genome Canada that are worth Can$240 million, to support large-scale, world-class research.

Your readers should therefore rest assured that the government of Canada will continue to fund research for the benefit of all scientists and Canadians.

Isn't it strange that basic science researchers are upset about the fact that funding to the major granting councils has been cut for the next three years?

Either the researchers are correct, and Canadian basic research is in trouble, or Gary Goodyear is correct and the Conservatives are doing a fine job.

I know who is telling the truth.

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Do Science and Religion Conflict in Louisiana?

 
The National Center for Science Education reports on the results from a recent poll in Louisiana [Polling Evolution in Louisiana]. Respondents were asked the following question.

Do you think the scientific theory of evolution is well supported by evidence and widely accepted within the scientific community, or that it is not well supported by evidence and many scientists have serious doubts about it?

39% answered "yes" and 21% didn't know. 40% said that evolution is not well supported by evidence and/or is not accepted by the scientific community.

Let's dismiss the 21% who didn't know the answer. That leaves almost 80% of the population who see no conflict between science and religion. Half of them probably believe in a God who accepts evolution and the other half of them think that the scientists reject evolution, which maked science compatible with creationism.

That's pretty amazing, and scary, when you think about it.

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Teabagging

 
Today is April 15th. It's a significant day in America because income taxes are due. It's also the day when some people are protesting taxes by having "teabagging" parties. If you don't live in the USA, or watch American television, you've probably never heard of "teabagging." Here's a quick summary from a show that I watched on MSNBC.


Listen for Lawrence O'Donnell, who explains the importance of socialism in America. According to O'Donnell, America is like all other Western industrialized nations. It has a mixed economy (capitalism and socialism).

I agree with that. I don't agree with his claim that, compared to all other nations, American probably has the best mix of socialism and capitalism.

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Monday's Molecule #117: Winners

 
UPDATE: The molecule is yellow fever virus.

The Nobel Laureate is Max Theiler.

This week's winner is Maria Altshuler of the University of Toronto.

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Today's "molecule" is fairly complex for a "molecule" but not quite as complex as a living cell. You have to identify the particular type of "molecule" that's shown here but it will be too hard to do that without some clues. One of the clues is the connection to a Nobel Laureate. The other one is cleverly hidden in the bottom part of this posting.

The first person to identify the "molecule" and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are seven ineligible candidates for this week's reward: Dima Klenchin from the university of Wisconsin, Alex Ling from the University of Toronto, Bill Chaney of the University of Nebraska, Elvis Cela from the University of Toronto, Peter Horwich from Dalhousie University, Devin Trudeau from the University of Toronto, and Shumona De of Dalhousie University

Dima and Bill have donated their free lunch to a deserving undergraduate so I'm going to continue to award an additional free lunch to the first undergraduate student who can accept it. Please indicate in your email message whether you are an undergraduate and whether you can make it for lunch.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Prizes so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow.

Comments will be blocked for 24 hours. Comments are now open.

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Child Abuse and the Anti-Vaccination Movement

 
I was attending the Center for Inquiry 12th World Congress in Washington last weekend and I happened to catch a re-broadcast of a Larry King show on the "dangers" of vaccinating children. It was an appropriate reminder of the lack of rationalism in our society.



Normally I'm fairly tolerant of people who reject standard medicine. In fact, society might actually benefit when these stupid people are eliminated by succumbing to various diseases. That's what the Darwin awards are for.

But this case is different. These adults are not putting themselves at risk—they are endangering their children.

If you stop vaccinating your children you are putting them at risk for many deadly diseases. Some of your children will die. If everyone stops vaccinating children then millions of children will die. How can anyone in their right mind think that vaccinations are so dangerous that the risk is worth it?

I'm not surprised that movie actors and average citizens are kooks. I am surprised that normally responsible TV networks like CNN contribute to potential child abuse. But I'm absolutely shocked that there are physicians who go along with the kooks.

One of those physicians is Dr. Bernadine Healy who appears in this CNN clip. I was astonished to hear her advocate more studies, lending credibility to the claims that vaccinations cause autism and other diseases. Bernadine Healy is a Republican who was the head of the National Institutes of Health under George H.W. Bush. She was removed when Clinton took over the Presidency in 1993.

Healy's defense of the anti-vaccination movement did not ring true. Her "statistics" didn't sound reasonable to me but I was in no position to refute them directly. Fortunately Orac has taken up the task at Bernadine Healy: Flirting with the anti-vaccine movement. Thanks Orac.

You know we're in trouble when the media and former NIH directors can't tell the difference between science and superstition.

This reminds me of the debate over the fluoridation of water back in the 1950's. There were kooks who warned us that fluoridation was dangerous and that it was a communist plot.

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Dying for Love in Afghanistan

 
It's been eight years since coalition forces "liberated" Afghanistan. Here's the result: Taleban 'kill love affair couple'.

Mr Azad said: "An unmarried young boy and an unmarried girl who loved each other and wanted to get married had eloped because their families would not approve the marriage."

Officials said the couple were traced by militants after they tried to go to Iran. They were made to return to their village in Khash Rod district. [Nimroz province, south-west Afghanistan - see map]

"Three Taleban mullahs brought them to the local mosque and they passed a fatwa (religious decree) that they must be killed. They were shot and killed in front of the mosque in public," the governor said. ...

Extrajudicial "honour killings" have been widely carried out in Afghanistan since then by conservative families angered by a relative who has brought them shame - usually by refusing to marry a chosen partner.

The Taleban have widened their influence over the past three years and now control many remote districts where there are not enough coalition forces to establish a permanent presence.

The people of Afghanistan should make up their own minds about whether this sort of behavior is tolerable. We cannot do it for them. As long as the country is semi-united in repulsing foreign invaders it will put off the social reforms that could bring it into the 21st century.

It's time to leave and let them face up to, and solve, their own internal problems. No people in the world would tolerate a foreign army from a different culture coming in and telling them how to behave—even if they suspected that their behavior was immoral.

Imagine that the USA was invaded and conquered by a European army who insisted that gays be allowed to marry, socialized medicine is begun, the metric system is imposed, proportional representation becomes the law, and capital punishment is abolished. Would those changes be welcomed by Americans who all of a sudden recognize that the foreigners are correct? Or would the changes be resisted even more fiercely because advocating change means siding with the enemy?

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[Hat Tip: Pharyngula]

Wild chimpanzees exchange meat for sex

 
I don't know if it's true that Wild chimpanzees exchange meat for sex but I know some vegetarians who may find it interesting.

Wild female chimpanzees copulate more frequently with males who share meat with them over long periods of time, according to a study led by researchers from the Max Planck Institute for Evolutionary Anthropology in Germany, published in the open-access, peer-reviewed journal PLoS ONE April 8.

It probably works for humans as well.

I'm going out to buy some steaks for dinner.

The original paper is Gomes and Boesch (2009)

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Gomes, C.M. and Boesch, C. (2009) Wild Chimpanzees Exchange Meat for Sex on a Long-Term Basis. PLoS ONE 4(4): e5116. DOI:10.1371/journal.pone.0005116

Which Gas Is Cheapest?

 
Here's three photographs of gas station signs. The one on the left was taken in Mississauga, Ontario, Canada and the two on the right were taken in Bethesda, Maryland, USA. The Bethesda gas stations are one block apart.

Assuming that the photos were taken on the same day (Wednesday, April 8, 2009), which station has the cheapest gas if you pay by credit card?

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A Breakthrough in Gene Expression?

When we teach protein synthesis in undergraduate molecule biology classes we cover the main mechanisms regulating the rate of translation.

One of them is the influence of codon bias among synonymous codons. We've known for 35 years that rare codons are translated more slowly that the common codons. Highly expressed genes have a pronounced codon bias in favor of the most common codons. As a result of this phenomenon, it is not true that every codon for leucine, for example, is equal. Some are better than others in some genes. Synonymous codons are not always neutral in their effect. (For a complete description of this phenomenon see: Silent Mutations and Neutral Theory.)

We also teach about the influence of messenger RNA secondary stucture. The classic examples in the E. coli ribosomal protein genes are in all the textbooks, as are the examples of attentuation—especially in the Trp operon. Again, this stuff was standard fair in textbooks and courses beginning in the 1970's.

A press release caught my eye: Penn biologists discover how 'silent' mutations influence protein production. "Cool," I thought, "maybe this is something that I'll have to put into the next edition of my textbook."

Here's the breakthrough.

For biologists, these results fundamentally change the understanding of the role of synonymous mutations, which were previously considered evolutionarily neutral. ....

The silent mutations changed the amount of fluorescent protein by as much as 250-fold, without changing the properties of the protein. Codon bias, the probability that one codon of three adjacent nucleotides will code for one amino acid over another, was previously thought to be the cause for protein expression variance, but it did not correlate with gene expression in these experiments.

"At first we were stumped," Plotkin said. "How were the silent mutations influencing protein levels? Eventually, we looked at mRNA structure and discovered that this was the underlying mechanism."

Imagine that. They've rediscovered what most of my students have been taught for 35 years!

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[Image Credit: The figure is from page 706 of my textbook. Similar figures are in all biochemistry and molecular biology textbooks. The figure shows the secondary mRNA structure around the initiation codon of the S7 ribosomal protein gene in E. coli. The secondary structure inhibits translation initiation. Although in this case the actual codons are not involved in the formation of double-stranded regions, in other cases they are.]

Monday's Molecule #117

 
Today's "molecule" is fairly complex for a "molecule" but not quite as complex as a living cell. You have to identify the particular type of "molecule" that's shown here but it will be too hard to do that without some clues. One of the clues is the connection to a Nobel Laureate. The other one is cleverly hidden in the bottom part of this posting.

The first person to identify the "molecle" and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are seven ineligible candidates for this week's reward: Dima Klenchin from the university of Wisconsin, Alex Ling from the University of Toronto, Bill Chaney of the University of Nebraska, Elvis Cela from the University of Toronto, Peter Horwich from Dalhousie University, Devin Trudeau from the University of Toronto, and Shumona De of Dalhousie University

Dima and Bill have donated their free lunch to a deserving undergraduate so I'm going to continue to award an additional free lunch to the first undergraduate student who can accept it. Please indicate in your email message whether you are an undergraduate and whether you can make it for lunch.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Prizes so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow.

Comments will be blocked for 24 hours.

---

Down with Darwinism!

 
I've been fuming ever since hearing Michael Ruse speak on Friday night. It's a crying shame that the skeptics at the 12th World Congress had to get their information about evolution from him.

One of the things I detest about Michael Ruse is his insistence on using the word "Darwinism" to describe evolutionary biology. As most of you know I am not a Darwinist.

Adam M. Goldstein at Evolution:Education and Outreach reminds us that we should all stop using the word "Darwinism" when we are trying to educate people about evolutionary biology [Give the old man a break, and let’s stop it with “Darwinism”].

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[Hat Tip: Stranger Fruit]

The New Skeptics

 
The next generation of skeptics/atheists is well represented at the CFI World Congress in Washington.

Meet Derek Rodgers (left), a computer science student at Dalhousie University in Halifax, Nova Scotia (Canada) and Jason Ball (right), a political science/history and philosophy of science student at Melborne University (Australia). Jason might be taking a course from John Wilkins next term. I expressed my sympathy. :-)

Visit the Dalhousie Atheists and Young Australian Skeptics to see what these leaders of the future are doing today.

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A Night at the Newseum

 
Okay, so technically it wasn't a "night" at the Newseum—it was most of a day. Ms. Sandwalk and I had a wonderful time at the Newseum. It's on Pensylvania, just one block from the Mall and right next door to the Canadian embassy.

If you're in Washington you must go to the Newseum.

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Michael Ruse: 90% 0f Scientists Are Selectionists

 
I'm at the Center for Inquiry 12th World Congress in Washington D.C.

Last night I attended a session on "The Influence of Darwin." The four panelists were: Michael Ruse, a philosopher, Barbara Forrest, a philosopher, David Contosta, a historian, and Edward Tabash, a lawyer.

Ruse presented his usual distorted view of evolutionary biology only this time he added a comment in his defense. He said, "90% of scientists are selectionists, and the other 10% are selectionists 90% of the time." This was obviously a response to people who have criticized Ruse for being too much of an adaptationist.

Incidentally, Ruse made it clear that he is an atheist, even though he is strongly opposed to the idea that science/evolution leads to a loss of faith. I mention this because I've seen numerous references to Ruse implying that he is religious.

I asked the panel why there was no scientist on the panel and whether they thought that they could represent science accurately. I added, provocatively, that in my opinion three of the four panelists did not do a good job of describing science

The panel didn't think this was problem. I assume Darwin had a great influence on law, philosophy, and history but not much of an influence on science.

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Twisted Tree of Life Award #3

 
Jonathan Eisen at The Tree of Life has just awarded his third Twisted Tree of Life Award. And well-deserved it is.

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New Breakthrough in Evolution Theory

 
Imagine a culture of yeast cells growing in a medium where sucrose is the only carbon source. Sucrose isn't the preferred carbon source for yeast but yeast can handle it if need be. Cells secrete an enzyme called invertase that breaks down sucrose to glucose and fructose


The products of the reaction, glucose and fructose, can be taken up by the cell or they may diffuse away before being taken up. Molecules produced by the invertase from one cell can be absorbed by a neighboring cell.

As the concentration of free glucose and fructose rises in the medium, cells that lack the ability to synthesize and secrete invertase may survive. Thus invertase negative mutants may accumulate because they don't need to make their own invertase in order to have a source of carbon. In game theory, such mutants are called "cheaters."

Hands up, all you people who think that the existence of a stable equilibrium of cheaters and cooperators is a new discovery in evolutionary theory.

Right, it's not.

The editors of Nature think it is, so they published the paper from the Dept. of Physics at MIT (Gore et al., 2009).

The MIT PR department thought it was revolutionary enough to warrant a press release that was picked up by ScienceDaily [Cooperative Behavior Meshes With Evolutionary Theory].

One of the perplexing questions raised by evolutionary theory is how cooperative behavior, which benefits other members of a species at a cost to the individual, came to exist.

Cooperative behavior has puzzled biologists because if only the fittest survive, genes for a behavior that benefits everybody in a population should not last and cooperative behavior should die out, says Jeff Gore, a Pappalardo postdoctoral fellow in MIT's Department of Physics.

Gore is part of a team of MIT researchers that has used game theory to understand one solution yeast use to get around this problem. The team's findings, published in the April 6 online edition of Nature, indicate that if an individual can benefit even slightly by cooperating, it can survive even when surrounded by individuals that don't cooperate.

In short, the study offers a concrete example of how cooperative behaviors can be compatible with evolutionary theory.

I agree that this is an interesting example but I don't think the public is well served by presenting it as a new contribution to evolutionary theory. The public is entitled to think that evolutionary biologists must be really stupid if they've never thought of this before.

They (the public) would be really confused if they happened to read the Wikipedia entry on John Maynard Smith (1920 - 2004).

There are no references to Maynard Smith's work in the citations at the end of the Nature paper, although there is a reference to "Smith, J.M." who wrote the book Evolution and the Theory of Games.

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Gore, J., Youk, H., and van Oudenaarden A. (2009) Snowdrift game dynamics and facultative cheating in yeast. Nature advance online publication 6 April 2009. [DOI: doi:10.1038/nature07921]

What Stephen Harper Said in 1997

 
I don't know where Canadian Cynic gets all this stuff but he has just posted a link to a speech by Stephen Harper in 1997 [CTV.ca].

It's worth reading the entire speech if you can stomach it. If you can't, then try this little excerpt.

OTTAWA -- The text from a speech made by Stephen Harper, then vice-president of the National Citizens Coalition, to a June 1997 Montreal meeting of the Council for National Policy, a right-wing U.S. think tank, and taken from the council's website:

Ladies and gentlemen, let me begin by giving you a big welcome to Canada. Let's start up with a compliment. You're here from the second greatest nation on earth. But seriously, your country, and particularly your conservative movement, is a light and an inspiration to people in this country and across the world.

Now, having given you a compliment, let me also give you an insult. I was asked to speak about Canadian politics. It may not be true, but it's legendary that if you're like all Americans, you know almost nothing except for your own country. Which makes you probably knowledgeable about one more country than most Canadians.

But in any case, my speech will make that assumption. I'll talk fairly basic stuff. If it seems pedestrian to some of you who do know a lot about Canada, I apologize.

I'm going to look at three things. First of all, just some basic facts about Canada that are relevant to my talk, facts about the country and its political system, its civics. Second, I want to take a look at the party system that's developed in Canada from a conventional left/right, or liberal/conservative perspective. The third thing I'm going to do is look at the political system again, because it can't be looked at in this country simply from the conventional perspective.

First, facts about Canada. Canada is a Northern European welfare state in the worst sense of the term, and very proud of it. Canadians make no connection between the fact that they are a Northern European welfare state and the fact that we have very low economic growth, a standard of living substantially lower than yours, a massive brain drain of young professionals to your country, and double the unemployment rate of the United States.

In terms of the unemployed, of which we have over a million-and-a-half, don't feel particularly bad for many of these people. They don't feel bad about it themselves, as long as they're receiving generous social assistance and unemployment insurance.

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