Ben Stein Is an IDiot

 
I know, I know, ... I'm not telling you something you don't already know. Ben Stein's role in Expelled: No Intelligence Allowed is more than sufficient to demonstrate that, indeed, intelligence is not permitted in that movie.

In case you didn't know how stupid Stein really is, there's even more proof in his various interviews. John Derbyshire has just posted an excerpt from an interview with Paul Crouch Jr. on the Trinity Broadcasting Network [see Science Equals Murder]. Stein's views need to be widely known. Here's what he said ...

Stein: When we just saw that man, I think it was Mr. Myers [i.e. biologist P.Z. Myers], talking about how great scientists were, I was thinking to myself the last time any of my relatives saw scientists telling them what to do they were telling them to go to the showers to get gassed … that was horrifying beyond words, and that’s where science — in my opinion, this is just an opinion — that’s where science leads you.

Crouch: That’s right.

Stein: …Love of God and compassion and empathy leads you to a very glorious place, and science leads you to killing people.

Crouch: Good word, good word.

Like the man says, when you're an IDiot, there's no intelligence allowed.

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Nobel Laureate: Bernardo Houssay

 

The Nobel Prize in Physiology or Medicine 1947.

"for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar"

Bernardo Alberto Houssay (1887 - 1971) received the Nobel Prize in Physiology or Medicine for his work on pituitary gland hormones that affect carbohydrate metabolism. He shared the prize with Carl and Gerty Cori.

Houssay was mainly responsible for recognizing that the anterior lobe of the pituitary gland secreted a peptide hormone that antagonized insulin. We now know that this hormone is growth hormone [Monday's Molecule #69]. It has general effects on growth and development as well as regulating carbohydrate metabolism in adults.

Bernardo Houssay was a citizen of Argentina. He was known as an outspoken liberal and an advocate of democracy. Houssay was fired from his academic position when Juan Perón took over as dictator in 1945 but he remained in Argentina working in a private laboratory. The Nobel Prize award in 1947 was seen, quite rightly, as a repudiation of Juan Perón and his policies. This was very controversial in Argentina [see Bernardo Alberto Houssay for one of many biographies].

THEME:

Nobel Laureates
The presentation speech was given by Professor H. Theorell, Head of the Biochemical Nobel Department of the Royal Caroline Institute.

Your Majesty, Your Royal Highnesses, Ladies and Gentlemen.

The teaching body of the Caroline Institute has decided to award one half of the 1947 Nobel Prize for Physiology or Medicine to Professor Carl Cori and Dr. Gerty Cori «for their discovery of the course of the catalytic conversion of glycogen», and the other half to Professor Bernardo Houssay «for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar».

The work of these prize-winners is within the same centrally important sphere, namely the metabolism of sugar in the body. They have elucidated the enzymatic reactions between glucose and glycogen, and have shown how these reactions are controlled by physiological factors. Faulty sugar metabolism may lead to diabetes, with its universally known symptoms. Everyone now knows, too, that in the majority of cases it has been possible to keep this disease in check by insulin since its discovery by Banting and MacLeod, to whom the Nobel Prize was awarded in 1923. It would be a grave mistake, however, to believe that this brilliant discovery unravelled the immense complex of problems concerning sugar metabolism. Certainly it is long known that insulin decreases the blood sugar level, but until recently the mechanism of this effect was veiled in mystery.

The task of sugar metabolism is to supply energy for the activities of life. One cannot make the slightest muscular movement without the combustion of an appropriate amount of sugar. It is readily understandable that one of our most urgent tasks is to elucidate this branch of metabolism. A clear light has been thrown on previously obscure points in our knowledge, by the discoveries for which the prizes are awarded this year.

Ninety years ago the great French physiologist, Claude Bernard, discovered that the liver and muscles contain a starch-like substance, which he called glycogen, the «sugar former». Every molecule of glycogen consists of a large number of grape sugar molecules, which are united together to be stored up in that form until they are needed. When needed, the glycogen disintegrates again into grape sugar, or glucose, to use a more scientific name. In this way the glucose content of the blood can be kept fairly constant in spite of an uneven supply. The credit for having revealed how the interplay between the glucose and the glycogen takes place falls to Professor and Doctor Cori. From the works of Robison and Embden in the 1920's it was known that the sugar in living cells and tissues, e.g. in yeast and in muscle, appears under certain circumstances bound to phosphoric acid. Closer analysis showed that in these combinations the phosphoric acid was bound to the sixth in the chain of the six carbon atoms of the sugar molecule.

...

This latest work of the Cori's is directly connected with the discovery of the effect of the hypophysis on the utilization of sugar by Professor Bernardo A. Houssay, who has also been awarded a prize. The hypophysis, or the pituitary gland, is a small secreting gland at the base of the brain, where it lies sunk in a bony hollow in the most sheltered spot in the whole body. Its importance justifies its sheltered position, but its size is far from impressive: that of a bean in man, a pea in the dog, and a radish seed in the toad Bufo marinus.

People sometimes cite, more or less jokingly, the statement by Cartesius, the famous philosopher, that the soul lies in the pineal gland. Now it does so no more than in any other individual organ, but if Cartesius had chanced, instead, to guess at the hypophysis, which looks much the same and is situated immediately in front of the pineal gland, he would have been nearer the truth, for in spite of its diminutive size the hypophysis exercises a number of vital functions and occupies a commanding position in relation to the other endocrinous glands. By means of its hormones the hypophysis controls the thyroid, the sex glands and the cortex of the suprarenal glands; it regulates the formation of milk and the growth of the whole body. By means of extremely beautiful experiments Houssay has shown that it also plays a prominent role in the conversion of sugar.

It was the discovery of insulin which aroused Houssay's interest in the hypophysis. As early as in the 1880's the great French research worker, Pierre Marie, had found that the excretion of sugar in the urine was a regular symptom in acromegalia, which is due to a disturbance in the function of the hypophysis, and therefore a connection between the function of the hypophysis and the metabolism of sugar might be suspected.

Houssay has worked chiefly with dogs and a large kind of toad, Bufo marinus, which is plentiful in the Argentine. In many series of experiments the hypophysis, or sometimes only its anterior lobe, was removed by operation. In the case of dogs, especially, the operation calls for highly developed technical skill if the result is not to be «the operation was successful, but the patient died». Houssay then found that the animals which had been operated on were abnormally sensitive to insulin and died with symptoms of bloodsugar deficiency from doses which were quite harmless for normal animals. In conformity with this, the glycogen content in the liver was abnormally low. A corresponding pathological picture is met with in the case of Simmond's disease in man. Dogs and toads exhibited the same kind of reaction, as have all the rest of the vertebrates hitherto investigated. This proves that Houssay had discovered a universal biological mechanism.

The discovery that a daily implantation of anterior lobe of hypophysis from toads on the operated animals protected the latter from the dangerous effect of insulin, was also of immense importance.

Thus the hormone of the anterior lobe of the hypophysis was clearly antagonistic to the hormone of the pancreas, insulin. This was confirmed and illustrated by a further series of ingenious experiments. Davidoff and Cushing had observed already in 1927 that if diabetes was provoked in dogs by the removal of a part of the pancreas, the symptoms were moderated if part of the hypophysis was also taken away. However, these experiments were not entirely conclusive, since as a rule the diabetes provoked in this way may disappear spontaneously. Houssay and Biasotti obtained definite elucidation by means of a more radical procedure. The whole hypophysis was first removed and subsequently the pancreas. For three whole days after the latter operation no sugar appeared in the urine, which is always the case if the pancreas is removed from an animal which still has its hypophysis.

In 1931, in the course of their work on the growth hormone of the hypophysis, H. M. Evans and his co-workers in U.S.A. found that the extract which naturally was still impure - provoked diabetes if injected into animals. At the same time and independently of Evans, Houssay and his co-workers arrived at similar results. After injections of extract from the anterior lobe of the hypophysis, the diabetes persisted, in many cases for months, and this was found to be due to injury to the insulin-producing cells in the pancreas.

The active factor in the hypophysis is so extremely sensitive that all the preparations must be made at a low temperature, if they are not to be spoiled. Therefore a number of research workers, who were less careful than Houssay on this point, did not at first succeed in confirming his results. It may be added that the Cori's had to grapple with the same difficulties in the preparation of their extract of hypophysis, which to some extent confirms that both groups of workers were dealing with the same active substances.

A short description of the most important results of many years of scientific work can never give a complete idea of the days and nights of labour which is most frequently fruitless. Diligence and patience are indispensable components in the mental equipment of the research worker. These alone seldom or never lead to pioneer discoveries, however, because it is impossible to deal thoroughly and systematically with all the conceivable alternatives, at least in the case of biological problems. The possibilities are all too many. Intuition is the indispensable lode-star, promising new goals to be reached by a labyrinth of paths, the majority of which are blind alleys.

In work characterized by unremitting diligence, brilliant skill, and masterly acumen, today's prize-winners in physiology or medicine have shown themselves to possess all the qualities of the great research worker in natural sciences. They have thrown light on previously undreamt of connections between the inaccessible world of the enzymes and the hormones. The task of the doctor to prevent, heal or alleviate disease demands a knowledge of the functions of the body; this year's prize-winners have opened new fields in which Ernest Starling's happy expression «The physiology of today is the medicine of tomorrow» will prove its truth.

Professor Carl Cori and Doctor Gerty Cori. During the past decade the scientific world has followed your work on glycogen and glucose metabolism with an interest that has gradually increased to admiration. Since the discovery of glycogen by Claude Bernard ninety years ago, we have been almost totally ignorant of how this important constituent of the body is formed and broken down. Your magnificent work has now elucidated in great detail the extremely complicated enzymatic mechanism involved in the reversible reactions between glucose and glycogen. Your synthesis of glycogen in the test tube is beyond doubt one of the most brilliant achievements in modern biochemistry. Your discovery of the hormonal regulation of the hexokinase reaction would seem to lead to a new conception of how hormones and enzymes cooperate.

In the name of the Caroline Institute I extend to you hearty congratulations on your outstanding contribution to biochemistry and physiology.

Professor Houssay. That great philanthropist, Alfred Nobel, had a great personal interest in physiology. Few things gave him so great a pleasure as being able to witness the brilliant development of this science in the nineteenth century. In the development of physiology, Professor Houssay, you have played a very active part, particularly regarding the work which you have brought into prominence and which is now to be honoured by the Nobel Prize.

The hypophysis is a small gland, but its importance is not related to its size, since it regulates many of our most important functions. Amongst these functions, which you have studied and analysed in a clear and striking manner, is the dominant role the gland plays in our metabolic processes.

On behalf of the Caroline Institute I congratulate you on receiving the Nobel Prize which is presented to you today, and which is a sure sign that your name will ever remain engraved in the annals of physiology.

Professor Carl Cori and Doctor Gerty Cori; Professor Houssay. I now have the honour of asking you to accept the prize from the hands of His Majesty our gracious King.

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Richard Dawkins—polite and gracious to a fault

 
Some of you might remember Peter McKnight. He's a columnist for the Vancouver Sun (Canada) and he wrote a piece last year defending Marcu Ross and his Ph.D. degree [Peter McKnight on the Marcus Ross Issue].

My interactions with Peter McKnight have been quite enjoyable so it is with considerable satisfaction that I point you to his latest article on Richard Dawkins [How to reconcile Richard Dawkins?]. Peter puts his finger squarely on the discrepancy between what Dawkins says in public about religion and what he says in private.

I like the private Richard Dawkins when it comes to a position on religion as the root of all evil, and atheists as being free of violence.

Unlike the public Dawkins, I don't oppose superstitious beliefs because they lead to evil—I oppose them because there's no evidence that those beliefs are correct.

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[Hat Tip: RichardDawkins.net]

Should Undergraduate Programs Be Easier?

 
We have a biochemistry program for undergraduates. It would be called a major at most universities but at the University of Toronto we call it a Biochemistry Specialist Program. Here's an outline with the number of credits, where (1) is a standard two-semester course ...

1st year
Calculus (1), Biology (1), Physics (1), Chemistry (1)

2nd year
Biochemistry (1), Organic Chemistry (0.5), Physical Chemistry (0.5), Cell & Molecular Biology (1)

3rd year
Biochemistry Laboratory (0.5), Proteins (0.5), Nucleic Acids (0.5), Molecular Biology (1), 1.5 extra credits from a list of science courses

4th year
Advanced Biochemistry Laboratory (1), four (0.5) credit courses from a list of biochemistry and molecular biology courses

Here's the problem. Enrolment in this program is dropping because the students perceive it as being too hard. A number of easier, less rigorous, programs have recently become available in other departments. These other programs are being promoted as excellent choices for an undergraduate degree. Students are being told that these easy program will be just as acceptable as the more difficult ones when they apply to graduate school. (That won't be true in our department.)

Students believe that they will get higher grades in these other programs and that will make it easier to get into medical school or graduate school.

What should we do? There's a possibility that our program will disappear if we do nothing. On the other hand, making it a lot easier by dumbing down the material and giving higher grades goes against the principles that many of us believe in.

Have any other schools faced this situation? What did you do? What do the students think?

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Who Do You Know?

 
The Friendly Atheist asks ...

Who is the most famous person you know (who would admit to knowing you back)?

You can see my answer over there. Sandwalk readers might like to jump in and drop a few names.

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Monday's Molecule #69

 
This colorful molecule plays an important role in regulating carbohydrate metabolism, among other things. Your task for today is to identify the molecule. Be as specific as possible (what species?).

Identify the Nobel Laureate(s) who was/were awarded a Nobel Prize for discovering fundamental properties of this molecule without knowing the sequence or the structure. [Hint: The award was very controversial in the home country of the Nobel Laureate(s).]

Here's part of the PDB file to help you.

SEQRES 1 A 191 PHE PRO THR ILE PRO LEU SER ARG LEU PHE GLN ASN ALA
SEQRES 2 A 191 MET LEU ARG ALA HIS ARG LEU HIS GLN LEU ALA PHE ASP
SEQRES 3 A 191 THR TYR GLU GLU PHE GLU GLU ALA TYR ILE PRO LYS GLU
SEQRES 4 A 191 GLN LYS TYR SER PHE LEU GLN ALA PRO GLN ALA SER LEU
SEQRES 5 A 191 CYS PHE SER GLU SER ILE PRO THR PRO SER ASN ARG GLU
SEQRES 6 A 191 GLN ALA GLN GLN LYS SER ASN LEU GLN LEU LEU ARG ILE
SEQRES 7 A 191 SER LEU LEU LEU ILE GLN SER TRP LEU GLU PRO VAL GLY
SEQRES 8 A 191 PHE LEU ARG SER VAL PHE ALA ASN SER LEU VAL TYR GLY
SEQRES 9 A 191 ALA SER ASP SER ASP VAL TYR ASP LEU LEU LYS ASP LEU
SEQRES 10 A 191 GLU GLU GLY ILE GLN THR LEU MET GLY ARG LEU GLU ASP
SEQRES 11 A 191 GLY SER PRO ARG THR GLY GLN ALA PHE LYS GLN THR TYR
SEQRES 12 A 191 ALA LYS PHE ASP ALA ASN SER HIS ASN ASP ASP ALA LEU
SEQRES 13 A 191 LEU LYS ASN TYR GLY LEU LEU TYR CYS PHE ARG LYS ASP
SEQRES 14 A 191 MET ASP LYS VAL GLU THR PHE LEU ARG ILE VAL GLN CYS
SEQRES 15 A 191 ARG SER VAL GLU GLY SER CYS GLY PHE

The first person to correctly identify the specific molecule and name the Nobel Laureate(s) wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first collected the prize. There is only one ineligible candidates for this week's reward.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureates so you might want to check the list of previous Sandwalk postings.

Correct responses will be posted tomorrow along with the time that the message was received on my server. I may select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.

UPDATE: This week's winner is David Schuller of Cornell University (again). He correctly identified the molecule as human growth hormone and the Nobel Laureate is Bernardo Houssay (1947). Thanks to all the others who sent in their guesses.

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Gene Genie #30

 

The 30th edition of Gene Genie has been posted at Gene Expression [Gene Genie #30].

Welcome to the 30th Gene Genie!

The beautiful logo was created by Ricardo at My Biotech Life.

The purpose of this carnival is to highlight the genetics of one particular species, Homo sapiens.

Here are all the previous editions .....

1. Scienceroll
2. Sciencesque
3. Genetics and Health
4. Sandwalk
5. Neurophilosophy
6. Scienceroll
7. Gene Sherpa
8. Eye on DNA
9. DNA Direct Talk
10. Genomicron
11. Med Journal Watch
12. My Biotech Life
13. The Genetic Genealogist
14. MicrobiologyBytes
15. Cancer Genetics
16. Neurophilosophy
17. The Gene Sherpa
18. Eye on DNA
19. Scienceroll
20. Bitesize Bio
21. BabyLab
22. Sandwalk
23. Scienceroll
24. biomarker-driven mental health 2.0
25. The Gene Sherpa
26. Sciencebase
27. DNA Direct Talk
28. Greg Laden’s Blog
29. My Biotech Life
30. Gene Expression

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Does science make belief in God obsolete?

 
The John Templeton Foundation has a website where "leading scientists and scholars" discuss the question "Does science make belief in God obsolete?" [A Templeton Conversation] One of these prominent intellectuals is Ken Miller and his answer is "Of course not."

One of our regular readers (Oldcola) left a comment on this site where he criticized the views of Ken Miller. His comment was initially posted intact but within a few days a heavily edited version replaced the original comment. The man responsible for editing the comment is Gary Rosen.

Apparently, the Templeton Foundation objected to the claim that they were soft on creationism, according to Oldcola. Oldcola requested that his edited comment be removed, and it was.

You can read an extended critique of Ken Miller's position on Oldcola's blog Coffee and Sci(ence) [Does science make belief in God obsolete?]. It's an excellent essay.

Incidentally, although it's not directly relevant to Miller's position, and it's not something that he clearly states, I find that theists of all sorts make the same false assumption when discussing the conflict between science and religion. They almost always assume that their atheist friends started life as theists and then lost their faith. Thus, they assume that there is something about science that disproves the default assumption; namely, that God exists.

While this might be true of many atheists, especially in the USA, it's not true of many others in Europe and elsewhere. Many atheists never bought into a belief in supernatural beings in the first place. This will be more and more likely as time goes on and the children of atheists have children of their own. When scientists like Ken Miller have to explain why science makes them go from being an atheist to a beleiver, it becomes much more difficult. Just look at the contortions that Francis Collins had to come up with.

Here's the point. It's up to theists to start making the case for the existence of God instead of just whining about those who have lost their faith. Let's say you've been raised in a home where superstitious beliefs are not valued. Then you start studying science seriously when you get to university. Is there anything about science that points to the existence of supernatural beings given that you haven't been brainwashed to believe in them as a child? I don't think so.

As Oldcola points out, many theists are simply afraid to abandon their comforting delusions. They believe science teaches us that the universe has no purpose—they are correct—and for them this depressing thought is sufficient to prove that science must be wrong. What they fail to understand is that the thought is only "depressing" if you've been brainwashed to to believe that there is a purpose in the first place.

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Is Anyone Stupid Enough to Fall for This?

 
I received this message today ...

Dear UTORONTO.CA Email Account Owner,

This message is from UTORONTO.CA messaging center¹ to all UTORONTO.CA email account owners. We are currently upgrading our data base and e-mail account center. We are deleting all unused UTORONTO.CA email account to create more space for new accounts.

To prevent your account from closing you will have to update it below so that we will know that it's a present used account.

CONFIRM YOUR EMAIL IDENTITY BELOW

Email Username :

EMAIL Password :

Address :

Department :

Attention!!! Account owner that refuses to update his or her account within ten days of receiving this Notification will lose his or her account permanently.

Thank you for using UTORONTO.CA!

Notification Code:VX2G99AAJ

Sandra Jacobson
ONLINE SERVICES

My question is serious. Is there any data out there to suggest that scams² like this actually succeed? Are there people who respond to these notices by sending off their email passwords?

Also, what's the purpose behind this attempt to get email passwords? What do they plan to do with them? Are they hoping that the email passwords will give them access to the user accounts or do they just like to read email messages?

---

1. The sender is "Online Services (onlineservices@utoronto.edu)." A domain that does not exist. The reply-to address is "dataguards@instructor.net." I've often wondered how these scams work. How do the perps get the replies if the return address is bogus?

2. It's easier to recognize that this is a bogus message because of the language—obviously not written by someone whose native language is English—but even if it was grammatically correct most people would know that it's a scam, right?

Darwin's Garden

 
In order to walk on the sandwalk you have to pass through Darwin's garden behind Down House. Most visitors take advantage of the opportunity to pass through the greenhouses and the potting shed as well. Darwin was a passionate gardener and he did many experiments with plants. Some of his original varieties are still growing in the garden.

The New York Botanical Garden has mounted an exhibit of Darwin's experiments on plants [What Darwin Saw Out Back]. I'll have to see if Mrs. Sandwalk wants to take a trip to New York to see it with me.

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[Hat Tip: Don Henry]

Ben Stein Meets Charles Darwin

 
Do you remember this image from the Expelled trailer? [Expelled: The Movie] It's a picture of Ben Stein looking at the statue of Charles Darwin in the cafeteria of the Natural History Museum in London (UK).

The group over at the The Beagle Project ran a contest to come up with a funny caption for the photo and the result has just been announced [Caption (absolutely no) contest!]. It's excellent—very close to what I would have said if I had the wit and talent to enter the contest.

A fortnight ago we launched a caption contest for the provocative image below, originally taken from Time's negative review of Expelled. We received twenty-six highly humorous entries, but there was one that towered, marble head and shoulders, above the rest, both for its comic value and also for the amount of work involved in realising it.

I'm not going to give away the answer because you all need to scoot on over to The Beagle Project log and donate some money while you're there.

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Fibrin and Blood Clots

 
The formation of blood clots in mammals is an example of a complex pathway that does not seem to be very well "designed." This hasn't stopped the intelligent design creationists who often use it as an example of irreducible complexity. They conclude that the clotting pathway cannot possibly have evolved.

Last year I posted a bunch of articles on blood clotting because I needed to learn about it myself. Since then I've kept an eye on the literature but I've been too lazy to write up all the new information that comes out on a regular basis. Fortunately, André Brown has come to the rescue. He published a paper on the elastic properties of fibrinogen last year (Brown et al. 2007) and now he reviews a recent paper by his collaborator, John Weisel, that has just come out in Science. André's blog is Biocurious, a blog about biology written by two physics graduate students. The post url is New Perspective on Blood Clot Mechanics.

Theme

Blood Clotting
The image above shows blue strands of fibrin trapping red blood cells (red) and platelets (pink) to form a clot. It is from Yuri Veklich and John W. Weisel, University of Pennsylvania School of Medicine [Building better clots]. The structure of fibrinogen (below) hints at the complexity. Follow the link in the "Theme Box" to learn more.

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Brown, A.E.X., Litvinov, R.I. Discher, D.E. and Weisel, J.W. (2007) Forced Unfolding of Coiled-Coils in Fibrinogen by Single-Molecule AFM. Biophys J. 92: L39–L41. [doi: 10.1529/biophysj.106.101261]

Fun with Polls

 
The Expelled website has a poll asking "Do you think the theory of Intelligent Design should be taught in our education system?"

When PZ Myers discovered it, the "yes" voters were ahead three to one. Now that the Pharyngula readers have voted [Crash this poll], the results are very different. Eat your heat out Ben Stein!!

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Do We Need Genetic Counselors?

 
The blogs promoting genetic testing usually think that we don't need genetic counselors to interpret the results and advise on what to do. For the most part, they seem happy to leave it up to the individual to decide on a course of action if they discover they have a particular genetic trait. I don't agree. I think this is much more complicated and I'm pretty skeptical about the motives of the private, personal genetics, for-profit, companies.

The Sciphu Weblog has an interesting posting on this issue [Now this is why we need genetic counselors]. It's worth reading.

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Top 100 Public Intellectuals

 
The Foreign Policy website has a list of the top 100 public intellectuals from around the world [The Top 100 Public Intellectuals: Bios].

The Canadians are: Malcolm Gladwell, Michael Ignatieff, Steven Pinker, and Charles Taylor. I would have included Irshad Manji, Bob Rae, and Don Cherry.

I included Don Cherry because he would fit right in with David Petraeus who is listed as a top 100 public intellectual.

There are several scientists and people who write about science and religion: Pope Benedict XVI, Noam Chomsky, Richard Dawkins, Daniel Dennett, Jared Diamond, Christopher Hitchens, James Lovelock, Lee Smolin, Harold Varmus, J. Craig Venter, E.O. Wilson. It's interesting that Francis Collins and Ken Miller aren't on the list since the main criterion for inclusion seems to be that the person has written a book and they have Miller & Collins have both written books.

I would have included Richard Lewontin, Bruce Alberts, and David Suzuki. Are there any others who should be on the list? Who should be deleted to make room?

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[Hat Tip: Sean at Cosmic Variance]