Monday, April 28, 2008

Monday's Molecule #69

 
This colorful molecule plays an important role in regulating carbohydrate metabolism, among other things. Your task for today is to identify the molecule. Be as specific as possible (what species?).

Identify the Nobel Laureate(s) who was/were awarded a Nobel Prize for discovering fundamental properties of this molecule without knowing the sequence or the structure. [Hint: The award was very controversial in the home country of the Nobel Laureate(s).]

Here's part of the PDB file to help you.

SEQRES 1 A 191 PHE PRO THR ILE PRO LEU SER ARG LEU PHE GLN ASN ALA
SEQRES 2 A 191 MET LEU ARG ALA HIS ARG LEU HIS GLN LEU ALA PHE ASP
SEQRES 3 A 191 THR TYR GLU GLU PHE GLU GLU ALA TYR ILE PRO LYS GLU
SEQRES 4 A 191 GLN LYS TYR SER PHE LEU GLN ALA PRO GLN ALA SER LEU
SEQRES 5 A 191 CYS PHE SER GLU SER ILE PRO THR PRO SER ASN ARG GLU
SEQRES 6 A 191 GLN ALA GLN GLN LYS SER ASN LEU GLN LEU LEU ARG ILE
SEQRES 7 A 191 SER LEU LEU LEU ILE GLN SER TRP LEU GLU PRO VAL GLY
SEQRES 8 A 191 PHE LEU ARG SER VAL PHE ALA ASN SER LEU VAL TYR GLY
SEQRES 9 A 191 ALA SER ASP SER ASP VAL TYR ASP LEU LEU LYS ASP LEU
SEQRES 10 A 191 GLU GLU GLY ILE GLN THR LEU MET GLY ARG LEU GLU ASP
SEQRES 11 A 191 GLY SER PRO ARG THR GLY GLN ALA PHE LYS GLN THR TYR
SEQRES 12 A 191 ALA LYS PHE ASP ALA ASN SER HIS ASN ASP ASP ALA LEU
SEQRES 13 A 191 LEU LYS ASN TYR GLY LEU LEU TYR CYS PHE ARG LYS ASP
SEQRES 14 A 191 MET ASP LYS VAL GLU THR PHE LEU ARG ILE VAL GLN CYS
SEQRES 15 A 191 ARG SER VAL GLU GLY SER CYS GLY PHE
The first person to correctly identify the specific molecule and name the Nobel Laureate(s) wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first collected the prize. There is only one ineligible candidates for this week's reward.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureates so you might want to check the list of previous Sandwalk postings.

Correct responses will be posted tomorrow along with the time that the message was received on my server. I may select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.

UPDATE: This week's winner is David Schuller of Cornell University (again). He correctly identified the molecule as human growth hormone and the Nobel Laureate is Bernardo Houssay (1947). Thanks to all the others who sent in their guesses.


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