Why it's necessary to be intelligent in order to explain function in the human genome

I follow the posts of Intelligent Design Creationists in order to see whether they have finally begun to understand science. Imagine my excitement when this post appeared on the Science and Culture website!

Why Intelligence Is Necessary to Explain Nature’s Functional Information

Alas, my excitement was short-lived. The post is actually about a podcast interview with William Dembski and not somebody intelligent.

• On the Meaning of the Word "Function"
• The Function Wars: Part I
• The Function Wars: Part II
• The Function Wars: Part III
• The Function Wars: Part IV
• Restarting the function wars (The Function Wars Part V)
• The Function Wars Part VI: The problem with selected effect function
• The Function Wars Part VII: Function monism vs function pluralism
• The Function Wars Part VIII: Selected effect function and de novo genes
• The Function Wars Part IX: Stefan Linquist on Causal Role vs Selected Effect
• The Function Wars Part X: "Spam DNA"?
• The Function Wars Part XI: Stefan Linquist responds to my critique
• The Function Wars Part XII: Revising history and defending ENCODE
• The Function Wars Part XIII: Ford Doolittle writes about transposons and levels of selection
• The function wars are over

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These AI predictions are becoming ridiculous!

The first issue of Nature in 2026 has an article by science writer David Adam.

The Science of 2050
Nature explores the future breakthroughs that could shape our world.

The online version has a different title and subtitle but the text is the same. It begins with a quote from "futurologist" Nick Bostrum.

“There’s a good likelihood that by 2050, all scientific research will be done by superintelligent AI rather than human researchers. Some humans might do science as a hobby, but they wouldn’t be making any useful contributions.”

There's no attempt in the article to apply critical thinking to such a ridiculous prediction and the author doesn't consider the implications. If Bostrum (whoever that is) is right then that's the end of graduate studies and after 2050 nobody will be getting a Ph.D. in physics, biology, geology, or chemistry.

I hope I live long enough to see AI collecting and analyzing fossils in Greenland or studying volcanoes in Hawaii. Maybe I'll still be around when AI figures out how memories are stored or which transcription factor binding sites are functional in the human genome. And if I'm very, very lucky I'll see live to see all of my colleagues in the Department of Biochemistry abandon their labs and take up some scientific hobby like alchemy or intelligent design.

David Adam and the editors of Nature should be ashamed of themselves for publishing such nonsense.

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Teaching the nature of science vs the scientific method

There's been a lot of talk about how to teach science literacy. The discussion in the USA centers around STEM (science, engineering, technology, mathematics) and this acronym has also spread to other countries. It's an unfortunate development since there's a big difference between teaching science and teaching those other three topics.

Most studies suggest that we focus on teaching The Nature of Science (NOS). There's no definition of this topic that everyone agrees to but the essence is that students need to understand how our society generates knowledge. In the context of the natural sciences, this means understanding the process of discovery. There's general agreement that what this means is critical thinking that's evidence-based. It's another way of saying that we need to teach critical thinking and the importance of using evidence to back up and test your claims of knowledge. "Appreciating the scientific process can be even more important than knowing scientific facts. People often encounter claims that something is scientifically known. If they understand how science generates and assesses evidence bearing on these claims, they possess analytical methods and critical thinking skills that are relevant to a wide variety of facts and concepts and can be used in a wide variety of contexts.”

National Science Foundation, Science and Technology Indicators, 2008

The reasoning behind this emphasis is based on two pedagogical facts. The first is that it's impossible to teach all the facts and theories of a typical scientific discipline like astronomy or geology. It's pointless to make students memorize information that they will forget as soon as the class is over, Instead, as the argument goes, we need to teach students to understand how evidence is gathered and how it becomes fact. Teach students how to appreciate science and its power to create knowledge. That's something that will stick with them all their lives.

What are American primaries?

I'm a Canadian who's always been puzzled about American primaries. It seems to me that the purpose of these primaries is to help a political party choose its candidates for the next election. It seems like two of the parties, the Republican party and the Democratic Party, have managed to get state governments to fund their primary elections for reasons that are not very clear to those of us who live in other countries.

Today I was watching Michael Smerconish on CNN. He always has a poll question that provides a deep (and troubling) insight into his way of thinking. Today he announced that he is part of a class action lawsuit demanding that independent voters be allowed to vote in primary elections. That sounds weird to me because I'm used to a system where only members of a party get to choose who their candidates will be.

I was aware of the fact that many Americans see this differently and I knew that some states allow non-party members to pick the party candidate. Nevertheless, I was curious to see how CNN listeners would respond to his poll question.

Here are the results.

I find that result astonishing. 86% of respondents think they should be able to choose the candidate of the Republican or Democrat party even if they don't belong to one of those parties. What do they (you?) think is the purpose of primaries in the United States?

Here's a list of states and who they allow to vote in one of the primaries. It seems like the states actually have laws governing how political parties are able to choose their candidates.

I don't know of any other democracy that has such a bizarre system. I'm a member of one of the political parties in Canada and I participated in selecting our party leader. I would be outraged if my government passed a law allowing members of another party (or nonmembers) to help select my party leader or candidate. Why are such laws acceptable in the United States?

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Answers in Genesis uses the latest DNA research to destroy evolutionary proof (not!)

There's been so much bad news this week that I though you might enjoy a little humor to lighten your day. Here are some devout Young Earth Creationists making fun of some stupid comments they've found on the internet and calling on some professor to "destroy" evolutionists who believe in junk DNA [Latest in DNA Research Destroys Evolutionary “Proof”].

Even more regulatory elements?

The expression of genes is regulated at many levels but one of the most important is regulation at the level of transcription. Transcription initiation is controlled by transcription factors that bind to sequences near the promoter and either activate or repress transcription.

A lot of work has been done on transcription regulation in mammals over the past 40 years. The general impression from these detailed studies of individual genes is that regulation usually involves a relatively small number of transcription factors that bind to sequences within 1000 bp or so of the transcription start site.

This model was challenged by the ENCODE studies in 2012. ENCODE researchers claimed to have discovered hundreds of thousands of cis-regulatory elements (CRE's) covering a substantial percentage of the genome. If they are correct, then this means that there are dozens of transcription factors controlling the expression of every gene.

Will AlphaGenome from Google DeepMind help us understand the human genome?

I recently reported that Google's AI program does a horrible job of summarizing the junk DNA controversy. [The scary future of AI is revealed by how it deals with junk DNA] That led to a discussion about the "intelligence" in artificial intelligence and whether AI was capable of distinguishing between accurate and inaccurate data.

Google DeepMind is an artificial intelligence research laboratory headquartered in London, UK. Two of its programmers, Demis Hassabis and John Jumper, were awarded the 2024 Nobel Prize in Chemistry for developing AlphaFold, a program that predicts the tertiary structure of proteins.

Intelligent Design Creationists post their #1 story of 2025

Here's the post on Science & Culture (sic) by Casey Luskin: Happy New Year! No. 1 Story for 2025: Bombshell Overturns Myth of 1 Percent Difference.

How many times have you heard it said that the human and chimpanzee genomes are so similar that they are only “1 percent different” at the level of their DNA? This shows, we were told, not only that humans and chimps share common ancestry, but that humans aren’t all that special, which is a common talking point in science journalism and other public discussions. After all, we’re just slightly modified chimps! This “fact” has been discussed so much that it has become what the late biologist Jonathan Wells famously called an “icon of evolution.”

But now, new data reported in a recently published Nature paper by Yoo et al. has overturned this previous claim. The new findings reveal that human DNA is far more different from chimp DNA than previously thought.

That should be major news in the science world, yet those involved don’t seem interested in highlighting their discovery.