Saturday, February 28, 2009

United Kingdom Protects Science Budget

 
From NatureNews: Brown pledges to protect science during downturn.

British Prime Minister Gordon Brown said he would not let science "become a victim of the recession" in a speech today at the University of Oxford.

Speaking to an invited audience, Brown said he would defend investment in science by maintaining the ring fence around the science budget, so that it cannot be raided to prop up other areas competing for public funds such as the health service and industry.

He signalled his aim for Britain to move away from an economy "heavily centred" on financial services and towards one focused on science.

....

Responding to Brown's speech, Nick Dusic, director of the Campaign for Science & Engineering in the UK (CaSE), a London-based lobby group says, "The prime minister is absolutely right that now is the time to show the world the UK is the place to do science. Unfortunately he needed to go further today in his commitments because other countries are raising the bar by making science and engineering central to their economic recovery."

Dusic added that just maintaining current spending commitments will mean that Britain loses ground against countries, like the United States, that are giving science a huge boost within their stimulus packages.
Meanwhile, Stephen Harper and the Conservative Party are cutting the budgets of the major granting agencies in Canada.

How stupid is that?


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Have You Been Scammed by Nigerians? Get Compensation!!!

 

Jim Lippard alerts us to the Best Nigerian 419 scam ever.

I think he might be right, but the competition isn't that tough.


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Friday, February 27, 2009

Crime and Punishment

 
True to their ideology, Stephen Harper and the Conservatives have introduced another "get tough on crime" bill. This one increases the jail sentences for gang-related killings.

There's only one problem. It won't work. Everyone with an IQ over 100 knows that you can't stop gang violence by just increasing prison terms for the ones who get caught.

Today's Toronto Star has two articles on the topic. The first one, Tory gang approach too little too late: critics, explains the consensus opinion of leading criminologists.

The punitive response may play well to citizens who fear gun battles erupting on city streets. But that get-tough approach lards the Criminal Code with redundant laws that haven't worked in other countries, says criminologist Irvin Waller.

"This is yet again a debate about penalties when it's very clear from looking south of the border that these penalties do not make a lot of difference to the number of people killed," he said.

"It's not a debate about what will actually stop them from happening."

Waller, a professor at the University of Ottawa, wrote the book Less Law, More Order to educate politicians on prevention and smart policing practices that have worked in other countries.
The second article, Critics say more jail time won't help curb violence, goes into more detail about what the experts are saying.
Criminologists predict tough sentences won't be effective in preventing gun and gang violence

Proposals to slap first-degree murder charges and tougher sentences on gangsters and police assailants will have little practical effect on curbing gang crime and gun violence, criminologists and other critics say.

More front-line officers, more intrusive investigative police powers and more resources for crime prevention are needed, they say.

Ross Hastings, director of the Institute for the Prevention of Crime at the University of Ottawa, joins other criminologists in arguing there is no evidence tougher sentences deter criminals, but the "certainty of being caught" is more likely to do so.

Nonetheless, amid an alarming rise in Vancouver's gang violence, politicians of all stripes rushed yesterday to endorse federal proposals to label gang killings first-degree murder offences, and to stiffen jail terms for drive-by or reckless gang-motivated shootings and assaults on police.

All three federal opposition parties promised to fast-track the measures proposed by the Tories.
I'm disappointed in all four political parties. Most of our MP's have IQ's above 100 and they know the rational response to gang violence. They know that this bill will be completely ineffective.

The only reason for supporting it is to pander to voters who don't understand the problem. There are far too many voters whose knee-jerk reaction in the face of any crime is to call for "justice" by increasing jail time. A majority of those voters probably support the Conservatives so there's nothing to be gained by the opposition parties' lack of fortitude.

Shame on Stephen Harper for his (probable) hypocrisy. Shame on Michael Ingatieff, Jack Layton, and Gilles Duceppe for being even more hypocritical. They should know better.


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Darwin Stamps

 
A few days ago I got a letter from the Royal Mail. It was a complete set of Darwin stamps issued by the Royal Mail in the UK to honour Charles Darwin. You can see some of them on the right. They are stunning. Thank-you Ms. Sandwalk for arranging to have them sent.

I also got a postcard from Kate. She mailed it from London on Darwin's birthday. It was addressed to someone called "The Nutty Professor" but for some strange reason it ended up in my mailbox anyway. Thank-you Kate & Mick.

Great Britain, especially London, was the intellectual capital of the world back in Queen Victoria's time. Most of the world's top scientists were there and the number of scientific advances that came out of that environment was truly amazing.

Much of it was due to the wealth of the British Empire (science loves money) but also to the intellectual freedom, individualism, and entrepreneurship that was characteristic of that society. It was the same society that created the industrial revolution and sustained it for one hundred years.1

What's amazing is that not only did Victorian England nurture and support men like Charles Darwin but that today, 150 years later, Great Britain is still proud to celebrate the scientist whose name is most closely associated with evolution.


1. Eat your heart out, Ken Miller (Only a Theory). :-)

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Matt Nisbet Chooses Sides

 
Carl Zimmer has posted another article on the Geroge Will affair [Unchecked Ice: A Saga in Five Chapters]. Recall that George Will made a number of scientifically inaccurate comments in his Washington Post article last week. He defends himself in another column today.

Carl dissects the issue in order to set the record, straight. Any decent science journalist should be concerned about accuracy and I'm pleased that Carl has made an effort to stand up for the truth. The Washington Post takes the brunt of the blame.

What has kept me hooked on this saga is not George Will’s errors. Errors are as common as grass. Some are made out of ignorance, some carefully constructed to give a misleading impression. What has kept me agog is the way the editors at the Washington Post have actually given their stamp of approval on Will’s columns, even claiming to have fact-checked them and seeing no need for a single correction.
Chris Mooney has also attacked the newspaper for it's lack of integrity [George Will Lies; His Editor Does Nothing].
Many of the column's incorrect factual assertions were challenged, and as Will is revisiting the column due to the response it has garnered, it's inconceivable that he doesn't know that. For God's sake, Will claimed that "according to the U.N. World Meteorological Organization, there has been no recorded global warming for more than a decade." That's false. And Will doesn't even address the issue at all in his latest column.

Meanwhile, the Post's editorial page editor Fred Hiatt has made himself look terrible over all this. He should have held Will to the truth and thereby upheld his paper's standards. Instead he tells CJR this:
"It may well be that he is drawing inferences from data that most scientists reject -- so, you know, fine, I welcome anyone to make that point. But don't make it by suggesting that George Will shouldn't be allowed to make the contrary point. Debate him."
All of this is good. It is highly appropriate that science journalists reestablish their credibility by criticizing amateurs who don't know what they're talking about.

Where is Matt Nisbet in all of this? Here's what Nisbet says in In the Clamor Over George Will, Pundits Win But Public Loses.
The same observation currently applies to the clamor over George Will's recent syndicated column on global warming. As I detail in a cover article at the March/April issue of the journal Environment, Will's column is part of a decade-old message playbook on climate change, effectively (and falsely) framing the problem in terms of lingering scientific uncertainty.

The irony of this latest netroots clamor is that dozens of bloggers are just feeding the George Will beast, sustaining and amplifying attention to his false claims about climate science while providing easy cues to the public that the issue can be readily interpreted through the lens of partisanship and ideology. (Sound familiar? As I wrote at Skeptical Inquirer, the same thing happened in the initial response to Ben Stein's anti-evolution doc Expelled.)

The conflict and heat generated not only focuses more attention on Will's preferred uncertainty interpretations, but it also distracts from the narratives and frames that are actually likely to build broad-based support for action. As I note in the Environment article, these frames include an emphasis on the moral and religious imperative to action along with a focus on the public health and energy innovation dimensions of climate change.
Over the past two years, many of us have been pointing out the conflict between "framing" and scientific accuracy. Now Nisbet makes it perfectly clear. If you criticize the scientific accuracy of an article in the main stream media then you might be hurting the cause.

The implication is that you should let scientific errors go unchallenged because challenging them give them credence. The more insidious implication is that scientific inaccuracy may be okay as long as it advances the cause.

It seems to me that Nisbet's view and Chris Mooney's recent claims are not compatible. I look forward to seeing how Mooney replies to Nisbet. Chris has already tried to distance himself from Nisbet last Spring over the Ben Stein affair [see For Once, Chris Mooney Talks Sense].

Internecine framing wars, what could be more fun than that?


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The Atheist Ad Campaign on The Agenda

 
TV Ontario (TVO) has a daily program called The Agenda with Steve Paikin. It's usually very good.

Last week they had a show on the atheist bus campaign featuring Justin Trottier of the Center for Inquiry and Robert Buckman, a well-known Toronto atheist. Here's the entire show. I don't think any one of the participants is particularly proud of their performance. But see below ....


At one point in the show, the Christian woman, Kathy Shaidle, brings up the "Stalin, the atheist, killed 30 million people (therefore God exists)" argument and Robert Buckman tries to answer in a reasonable manner. He doesn't do a bad job (excerpt below) but Canadian Cynic has a suggestion: What Robert Buckman should have said.

I caution Sandwalk readers that CC's language can be a bit crude ... but it sure is funny.





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Thursday, February 26, 2009

Nobel Laureate: Kary Mullis

 

The Nobel Prize in Chemistry 1993.

"for contributions to the developments of methods within DNA-based chemistry: for his invention of the polymerase chain reaction (PCR) method"


Kary B. Mullis (1944 - ) won the Nobel Prize in Chemistry for the polymerase chain reaction technique. This technique is used to amplify a given stretch of DNA by repeatedly copying it several dozen times. The technique has been honed and modified and it's now a standard tool in every biochemistry and molecular biology laboratory.

Mullis shared the prize with last week's Nobel Laureate, Michael Smith, who developed the technique of in vitro mutagenesis. I'm not a big fan of awarding Nobel Prizes to those who develop a new technique. I'm much more comfortable with awards to scientists who directly advance our understanding of how life works. That's why my personal favorites are Nobel Laureates like Jacques Monod, François Jacob, Ed Lewis, Otto Warburg, Linus Pauling, AndrĂ© Lwoff, Barbara McClintock, and Peter Mitchell (plus many others).

Fortunately, it usually turns out that the winners of "technology" prizes are very good scientists who have also made a significant contribution to advancing our knowledge of fundamental concepts. That's certainly true of Michael Smith, Walter Gilbert, and Fred Sanger, to name just a few.

Kary Mullis was an unusual recipient in many ways. You can get a flavor for his personality by reading his Autobiography and, especially, his Nobel Lecture. There has never been a speech like that in the history of the Nobel Prize and, chances are, there will never be another.

Read about Kary Mullis on Wikipedia to see what he's been up to since he stopped being an active scientist in 1988. By the time he was awarded the Nobel Prize he was concentrating on being a writer. (This might explain the speech!)

Here's the Press Release describing Kary Mullis' contribution.

THEME:
Nobel Laureates

The "Polymerase Chain Reaction" (PCR)

The PCR technique was first presented as recently as 1985 but is nevertheless already one of the most widespread methods of analysing DNA. With PCR it is possible to replicate several million times, in a test tube, an individual DNA segment of a complicated genetic material. Mullis has described how he got the idea for the PCR during a night drive in the Californian mountains. Two short oligonucleotides are synthesized so that they are bound correctly to opposite strands of the DNA segment it is wished to replicate. At the points of contact an added enzyme (DNA polymerase) can start to read off the genetic code and link code words through which two new double strands of DNA are formed. The sample is then heated, which makes the strands separate so that they can be read off again. The procedure is then repeated time after time, doubling at each step the number of copies of the desired DNA segment. Through such repetitive cycles it is possible to obtain millions of copies of the desired DNA segment within a few hours. The procedure is very simple, requiring in theory only a test tube and some heat sources, even though there are now commercial PCR apparatuses that manage the whole procedure automatically and with great precision.


The PCR method can be used for reduplicating a segment of a DNA molecule, e.g. from a blood sample. The procedure is repeated 20-60 times, which can give millions of DNA copies in a few hours.

As has site-directed mutagenesis, the PCR method has decisively improved the outlook for basic research. The sequencing and cloning of genes has been appreciably simplified. PCR has also made Smith's method of site-directed mutagenesis more efficient. Since it is possible with PCR to perform analyses on extremely small amounts of material, it is easy to determine genetic and evolutionary connections between different species. It is very probable that PCR combined with DNA sequencing is going to represent a revolutionary new instrument for studies of the systematics of plant and animal species.

The biomedical applications of the PCR method are already legion. Now that it is possible to discover very small amounts of foreign DNA in an organism, viral and bacterial infections can be diagnosed without the time-consuming culture of microorganisms from patient samples. PCR is now being used, for example, to discover HIV infections. The method can also be exploited to localise the genetic alterations underlying hereditary diseases. Thus PCR, like site-directed mutagenesis, has a great potential within gene therapy. Without the PCR method, the HUGO project, with its objective of determining every single DNA code in, among other things, the human genetic material, would hardly be realistic. In police investigations PCR can give decisive information since it is now possible to analyse the DNA in a single drop of blood or in a hair found at the scene of a crime.

Another fantastic application is that it is possible to mass-produce DNA from fossil remains. Researchers have, for example, succeeded in producing genetic material from insects that have been extinct for more than 20 million years by using the PCR method on DNA extracted from amber. This possibility has already inspired authors of science fiction. The very popular film "Jurassic Park" is about the fear that arises when researchers using PCR recreate extinct giant reptiles.


The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.

[Photo Credit: Geschichte der PCR]

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Congratulations Carl Zimmer

 
It's often said that "real" science journalists are passionate about presenting accurate science [see Chris Mooney].

Strangely, in spite of this passion, they've tended to remain very silent when a major newspaper publishes inaccurate scientific information—at least in the fields I'm interested in.

That changed a little bit with the George Will affair in the past week. George Will is a Pulitzer Roze winning journalist (not a science journalist). He wrote about global climate change in The Washington Post. Apparently there's another piece in the press.

Carl Zimmer takes him on: George Will: Locked In Ice!. Congratulations Carl! This is why you are one of the best science journalists.


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Teaching the Controversy: Astrology & Genesis

 
Here's how Neil deGrasse Tyson teaches us about astrology. The idea is to get people to realize that astrology is bunk.



My daughter's teacher (with an M.Sc. in chemistry) used this technique on her Grade 5 class. I dare say it did some good in promoting critical thinking.

Why can't we do the same with some other pseudoscience topics, like Young Earth Creationism? Why can't we teach critical thinking by getting young students to think about the consequences of a deluge that wiped out all of humanity in 2600 BC?1 They could discuss why the Egyptian records failed to notice that every single Egyptian lost their life sometime during the third dynasty when the pyramids were being built. They could do a simple calculation to see how you get from Noah and his family to 45 million people in the Roman Empire. (And possibly 300 million people in the world at about the time when Julius Caesar was born.)

Why can't we do that? Because religion has special protection from this kind of critical analysis. You can attack astrology but you can't attack anything religious no matter how silly it might be.

We should try and change that. Let's have more classroom discussion about the conflict between science and some religious beliefs. The well known seminar by Ricky Gervais (below) shows how you could do it. It should be required viewing in all Grade 5 classrooms!




1. They could also think about the kind of God who would do this.

[Hat Tip: Friendly Atheist: The Quick Astrology Test]

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It's Good to Blog


 
Today's editorial in Nature declares, It's good to blog.

Indeed, researchers would do well to blog more than they do. The experience of journals such as Cell and PLoS ONE, which allow people to comment on papers online, suggests that researchers are very reluctant to engage in such forums. But the blogosphere tends to be less inhibited, and technical discussions there seem likely to increase.

Moreover, there are societal debates that have much to gain from the uncensored voices of researchers. A good blogging website consumes much of the spare time of the one or several fully committed scientists that write and moderate it. But it can make a difference to the quality and integrity of public discussion.


[Hat Tip: Chance and Necessity]

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Is the bus ad campaign working?

 
The atheist bus campaign is being run and organized by a small group of individuals who have put a lot or work into it. Most of them are members of Freethought Association of Canada whose President is Justin Trottier.

I support the campaign to put atheist ads on city buses for the following reasons.

  1. It supports other atheists and encourages them to "come out of the closet" and discuss their atheism openly.
  2. It stimulates debate and discussion within our society, often raising questions that many have never seriously considered.
  3. For those who get it, it injects a welcome note of humor into a subject that really needs it.
The campaign will be a success if it attracts attention and gets people talking about rationalism and superstition. That discussion has already been kick-started by several best-selling books in the past few years and this ad campaign will keep the discussion going.

Up until recently, atheism was rarely mentioned in the main stream media and atheists were never interviewed on television. All that has changed in recent years and now you can hardly do a story on religion without getting the "other side." That's remarkable progress in a very short period of time. Today, it looks like more that 20% of Canadians are atheists and that number is growing rapidly in spite of what religious leaders might tell you.

Here's an example of what I'm talking about. The atheist bus campaign is worried because Global TV calls Atheists ‘Fanatics’?, but that's missing the point. The point is that a show like this would have been unheard of ten years ago. Look at how Christian, Muslim, and Jewish leaders are now obliged to defend their belief in God.

There's a remarkable segment in this video beginning at 4:30. The head of Toronto's Transit Commission is asked whether the TTC would approve some religious ads written up by the host of the TV show. The TTC head says, "These, would be more than welcome." That's the correct answer. Game on.




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Atheist bus ads are up and running in Toronto

 
I'm told that buses with the atheist ads are on the streets of Toronto, although I haven't seen one yet. If you spot one, you are asked to take a photo and post it on the official website of the Canadian Atheist Bus Campaign [Photos of the Atheist Bus ads in Toronto].

I'm pleased to report that so far there haven't been any reports of people fainting in the street and crime levels have remained steady in spite of the threat to Toronto's morals.

Meanwhile, the ads have been turned down in Ottawa and Halifax. We're waiting to hear from Calgary. Check atheistbus.ca for the latest updates. While you're there, donate some money to the cause. I gave them $100 and that's just a beginning. The campaign has raised $45,500 so far.

Click on the image below to see the fine print. It says "www.atheistbus.ca This advert was paid for by public donations." I'm really proud of the fact that the Canadian campaign doesn't shy away from using the word "atheist." After all, that's what it's all about.



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Wednesday, February 25, 2009

Monday's Molecule #109: Winners!

 
UPDATE: The molecule is the Klenow fragment of E. coli DNA polymerase I. It's the part of the enzyme that's missing the 5′→3′ exonulcease activity. The Nobel Laureate is Kary Mullis, one of the most eccentric scientists ever to win a Nobel Prize—and that's saying a lot because Nobel Laureates are a very unusual group.

The winner is Guy Plunket III from the University of Wisconsin. There was no undergraduate winner this week so I awarded the second prize to Deb McKay, who is currently teaching in a Toronto high school. Her answer wasn't perfect but she offered me a bribe I couldn't refuse.1




Today's molecule is actually two molecules but we only care about the protein. You need to identify this protein, being as specific as possible. A general description of the type of protein won't do because the image clearly show a particular version.

There's are several possible Noble Laureates associated with this molecule. One of them was Michael Smith—last week's Nobel Laureate. The person I'm looking for was never a Professor. That's not necessarily a bad thing, it just helps you narrow down the field of possible prize winners.

The first person to identify the molecule and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are seven ineligible candidates for this week's reward: John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), Wesley Butt of the University of Toronto, David Schuller of Cornell University, Nova Syed of the University of Toronto, Dima Klenchin of the University of Wisconsin and undergraduate Alex Ling of the University of Toronto, and James Fraser of the University of California, Berkeley.

John, David, and Dima have offered to donate their free lunch to a deserving undergraduate so I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.


1. A sneak peek at the new science curriculum for Ontario schools. Were you thinking of something else, perhaps?

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Tuesday, February 24, 2009

Short Term Gains at NIH (USA)

 
Alex Palazzo highlights the shortsightedness of the stimulus package when it comes to NIH funded projects [NIH & the Stimulus in the NY Times].

I agree with him 100%. Science doesn't work that way. We once had that problem in Canada. A temporary increase in funding of the granting agencies lead to compounding the pain of the inevitable budget cut a few years later.

At least Alex won't have to deal with that problem when he arrives in Canada this summer. This time our government avoided the problem by starting with the budget cuts! What a relief not to have to worry about how to spent all those extra dollars....

Thank-you Stephen Harper. And thanks also to our Minister of State (Science and Technology), Gary Goodyear. Dr. (sic) Goodyear (above) is a chiropractor. It's nice to know our science policy is in such good hands.


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Why We Immunize

 
Normally I don't write about the people who oppose immunizing children. I leave that to Orac and others. There are so many crazy people out there that the average skeptic simply doesn't have time to fight them all.

Here's an article by Jim Macdonald that Orac linked to: Why We Immunize. Everyone should read it.


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Do You Have Biblical Morals?

 
Oops. I thought for sure I'd do better than PZ Myers.

Your morality is 0% in line with that of the bible.
 

Damn you heathen! Your book learnin' has done warped your mind. You shall not be invited next time I sacrifice a goat.

Do You Have Biblical Morals?
Take More Quizzes



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Monday, February 23, 2009

The Future of Science Journalism

 
Chris Mooney warns us that science journalism is in trouble. He notes that many newspapers are firing their science writers and he warns of the dangers [The Death and Strangulation of Science Journalism].

What's disturbing, though, is to see a meta-discussion of the "trouble" with the practitioners of science journalism without any discussion of the real "trouble": the economic realities that are killing them off, one by one.

Memo to scientists: If you don't like science journalists, you're going to like even less what you get once they're gone.
I responded by saying ....
Not to worry. We'll figure out some way to frame it so that it sounds like a good thing!

:-)

Seriously, most of what passes for science journalism is so bad we will be better of without it.

Maybe the general public would have been more interested in science if science journalists hadn't been writing so much hype about "breakthroughs" for the past twenty years. Maybe the public would have been more interested in science if so-called "science" journalists hadn't been confused about the difference between science and technology.

Science isn't about what the latest discoveries can do to make your life better. It's about learning how the natural world actually works. It's all about knowledge and not application or politics.

Science journalists have let us down. I say good riddance.
Now Chris has started a separate thread in order to disucuss this point [Science Journalism: When Things Get Rough, You Find Out Who Your Real Friends Are].
My post last week about the death knell of science journalism prompted some incredible responses. Here's Larry Moran, putting it more bluntly than I expected, and enunciating an opinion we'd better hope does not prevail:

...

Breathtaking, huh? I seriously hope opinions like this are not very widespread in the scientific community.
Well Chris, I hate to tell you this but there are plenty of scientists who share my opinion, even though they may not have put it so bluntly.

And you know what, Chris? You and Matt are partly to blame for this sad state of affairs. I know you don't want to talk about framing because you have "moved on," but your criticism of scientists didn't do a lot to inspire our confidence in science journalism.

But let's move on and look at what you have to say today.
Honestly, based upon the foregoing, I have to question whether Larry Moran knows what a science journalist is--or at least, whether we're talking about the same thing. For it seems to me that virtually everything he's complaining about, a real science journalist would complain about as well.

Take the media slights against science described above--the hyping of "breakthrough" findings, the confusion of science and technology, and the swapping of serious science coverage for "feel good" or "news you can use" infotainment fare. Although you will certainly find exceptions, in general these aren't the fault of dyed-in-the-wool science journalists, of the sort that proudly claim membership in the National Association of Science Writers (as I do). In fact, you can bet that within their respective media organizations--when they still were working within them; most of NASW today is freelance--science journalists have fought against many such calls over the years.

And you can also bet that they frequently lost out in those internal battles.
I don't believe you.

But, for the sake of argument, let's assume that you are correct. Let's assume that most science journalists know full well that science doesn't produce weekly breakthroughs (all evidence to the contrary). Let's assume that most science journalists know the difference between science and technology. Let's assume that what they really want to do is write about how science leads to advances in understanding of the natural world instead of sensationalizing the subject by writing about, .... oh, let's say, "hurricanes, politics, and the battle over global warming."

Even if everything you say is true, the bottom line is that science journalists failed to make their case and were "forced" to do the bidding of senior editors—or whoever it is you blame.

If that's case, why should we support the status quo and stand up for the people who have (according to you) failed to deliver the goods?
The point is that nobody loves science more than science journalists--and nobody more devoutly wishes to see it covered accurately and widely, so that the "general public" thereby benefits, and comes to appreciate science more thoroughly. So how is it that now, a scientist like Larry Moran won't stand up for these science evangelists in the media, and blames them for a host of failings that, in truth, they themselves most assuredly abhor?
I gave you my answer. It's because I don't believe you. Is George Johnson one of your examples? How about Graham Lawton?

Now don't get me wrong. I'm not saying that every science journalist is doing a bad job. I've tried hard to pick out the good ones and give them the credit they deserve. What I'm saying is that, from my perspective, the majority of science journalists do not behave in the way you describe. It's all too easy to find articles that get the science wrong and articles that are more hype than reality.

Face the facts Chris, science journalists have not been very successful at finding allies among scientists. There's a very good reason for that. Try reading about the kerfluffle over the New Scientist cover to get a feeling for the problem.

Here's another exercise for anyone who cares about the quality of science journalism, as I do. Read the press releases on ScienceDaily. You won't find very many scientists who are impressed with that kind of science journalism.


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Monday's Molecule #109

 
Today's molecule is actually two molecules but we only care about the protein. You need to identify this protein, being as specific as possible. A general description of the type of protein won't do because the image clearly show a particular version.

There's are several possible Noble Laureates associated with this molecule. One of them was Michael Smith—last week's Nobel Laureate. The person I'm looking for was never a Professor. That's not necessarily a bad thing, it just helps you narrow down the field of possible prize winners.

The first person to identify the molecule and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are seven ineligible candidates for this week's reward: John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), Wesley Butt of the University of Toronto, David Schuller of Cornell University, Nova Syed of the University of Toronto, Dima Klenchin of the University of Wisconsin and undergraduate Alex Ling of the University of Toronto, and James Fraser of the University of California, Berkeley.

John, David, and Dima have offered to donate their free lunch to a deserving undergraduate so I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours.


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Saturday, February 21, 2009

Evolution in The Hamilton Spectator

 
Rama Singh is a Professor in the Department of Biology at McMaster University in Hamilton, Ontario (Canada). He happens to be the supervisor of Carlo Artieri, who writes Musings of the Mad Biologist.

Carlo noted on his blog (Evolution is a fact, not just theory...) that his boss has just published an article on evolution in the local newspaper. Read it at: Evolution is a fact, not just theory.

I'll quote the subheading and a couple of paragraphs and leave it up to my readers to discuss. Is this a good example of how scientists should explain evolutionary biology to the general public?

The only unproven area is Darwin's natural selection

...

Living organisms, on the other hand, evolve by variational evolution that depends on the survival and reproduction of the "fittest" individuals in the population, which is composed of many genotypes.

Unlike evolution, which is taken as a fact, the theory of natural selection, Darwin's mechanism for evolution, has come under criticism as to whether it is sufficient to explain evolution. In particular, early developmental biologists questioned if natural selection was adequate to explain the diversity and complexity of life.

Yet after 150 years of vigorous research (and many Nobel prizes!), no one has come up with a better theory. In fact, the more scientists have explored biology, the more they have become convinced of the facts of evolution.

Natural selection is a fact of everyday life. Resources are limited, individuals differ in their survival and reproduction, and evolution is a common sense conclusion deduced from facts and reasons. The problem with evolutionary change is that it takes place on such a slow place that we do not see it. However, we can imagine how evolution occurs by looking at the spectacular variety of food plants, flowers and domestic animals that we have produced by using the same principles of genetics and selection that nature uses. We may not witness the origin of species, but we have witnessed species becoming extinct in our own life time.
I'll get the conversation going by pointing out that well before the 150 years Professor Singh mentions in his article, random genetic drift was proposed as a pretty good theory about how evolution can occur. It may not be "better" than natural selection but I think it's good enough to have deserved a mention.


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"A" for effort

 
Anyone involved in teaching has heard the sob story. One student works really, really hard in the course but only gets 65% on the final exam. Another student gets 95% without breaking a sweat.

The "C" student thinks this is very unfair. They should get a much higher mark because they put so much effort into the course.

The issue is addressed in the New York Times a few days ago [Student Expectations Seen as Causing Grade Disputes].

In line with Dean Hogge’s observation are Professor Greenberger’s test results. Nearly two-thirds of the students surveyed said that if they explained to a professor that they were trying hard, that should be taken into account in their grade.

Jason Greenwood, a senior kinesiology major at the University of Maryland echoed that view.

“I think putting in a lot of effort should merit a high grade,” Mr. Greenwood said. “What else is there really than the effort that you put in?”

“If you put in all the effort you have and get a C, what is the point?” he added. “If someone goes to every class and reads every chapter in the book and does everything the teacher asks of them and more, then they should be getting an A like their effort deserves. If your maximum effort can only be average in a teacher’s mind, then something is wrong.”
Michelle Cottle has a comment in The New Republic [An A for Effort? Talk About a Lousy Idea]. Now, this isn't a publication that I routinely look to for views that are similar to my own1 but her comment below pretty much hits the nail on the head as far as I'm concerned.
No, Jason. What would be wrong is if a university trained its students to believe that they were excellent simply for getting up off their futons and doing what was expected of them. Did the reading? Attended class? Stayed up late working on a paper? Good for you, puppy! Sure, you did a craptastic job on that paper--not to mention the final--suggesting that you have no more than a fourth-grader's grasp of the material. But what the hell!? You worked hard. You showed up--even when you had that reallllly bad hangover. You may not have learned much, but you sure did try. Have a nice fat A. And here's hoping it comes in handy when your first employer fires you for not being able to tell your ass from your elbow when it comes to doing your job.

Sweet Jesus, where did such dizzying nonsense come from? Sure, it's easy to blame today's youth for being whiny, spoiled, and entitled. But the kids had to get these delusional ideas from somewhere. I suspect at least part of the blame lies with all those well-intentioned self-esteem-boosting messages that anxious parents, educators, and coaches feel compelled to spout in this era of making every child feel like a winner all the time. You know, the cheery, you-can-do-it mantras along the lines of, "All that matters is that you tried," "The only way to fail is not to try at all."

Um. No. While I understand the self-defeating doubt that we're trying to short-circuit here, there are, practically speaking, lots of ways to fail--much less fail to get an A. One of those is by not having much of an aptitude for a particular area of study. Not all of us are equipped to be rocket scientists, economists, or playwrights, just as not all of us are equipped to be actors or professional basketball players. If anything, a student who tries really, really, really hard at something and still repeatedly falls short might benefit from realizing that his talents lie elsewhere. (As could the rest of us: Not to state the obvious, but I don't want a brain surgeon who graduated at the top of his class because he had perfect attendance. I want one who is an artist with a scalpel.) Go ahead: Aim for the stars. Don't let anyone tell you you can't do something. But if you actually try that thing and it turns out that you're not so hot at it, don't whine about unfair grading. Acknowledge that you have major room for improvement and decide where to go from there. The sooner kids learn how to deal with failure and move on, the less likely we are to have a bunch of whiny, fragile, self-entitled, poorly qualified adults wandering around wondering why their oh-so-stellar efforts aren't properly appreciated in the real world.

Alternatively, now might be a good time to revisit my dream of becoming a concert pianist. I've never had much of an ear for music, but I bet if I quit my day job and worked at it really, really hard--or at least showed up at all my lessons and did the homework--someone would eventually reward my "excellence."
Hopeful Monster has something to say over on Chance and Necessity [Student effort ≠ high grades].

I want students to recognize that part of what we're testing is innate ability, or intelligence. There's no getting around it. If you are smart and you work hard you are going to get a higher grade than a student who works hard but isn't very smart. It's unfortunate that there are very smart students who don't have to work hard to get an "A," but that's life. What should count in university is how well you understand the material, not how much effort you put in while trying to understand.

By the way, I think that university Professors have to shoulder a great deal of the blame for the current sad state of "higher" education. It's not just the students. We Professors have always had the power to fix the problems but for the most part we have done nothing about it. Many of us have actually contributed to the problems by giving out marks for attendance and allowing "extra" assignments to raise your grade.


1. By this, I don't mean to imply that The New York Times is any better.

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Shopping for Darwin

 
What's a celebration without shopping? Now you can enjoy the Darwin year celebrations by buying hundreds of Darwinian items at the Darwin Year Store. Half of the proceeds go to supporting biodiversity conservation-related charities.



I don't look good in T-shirts but there's plenty of other gifts for me on that site. All those shoppers who might be looking to buy me something for St. Patrick's day should check out the large mugs.

Some of them have even seen the very Darwin notebook where this drawing comes from, do you remember, Ms. Sandwalk? I told you it would be important to see this notebook. Now you know why.


[Hat Tip: Ryan Gregory]

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Friday, February 20, 2009

Nobel Laureate: Michael Smith

 

The Nobel Prize in Chemistry 1993.

"for contributions to the developments of methods within DNA-based chemistry: for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies"


Michael Smith (1932 - 2000) won the Nobel Prize in Chemistry for developing the technique of site-directed mutagenesis. Today this is a common technique in biochemistry labs. It enables researchers to specifically alter a nucleotide in a gene in order to study its effect. It is frequently used in structural biology labs to explore the roles of varous amino acid residues in the function of a protein.

Smith's work was based on the development of DNA sequencing technology in the 1970s and on extensive work on the formation of DNA:DNA double-standed hybrids with oligonucleotides containing mismatches.

Here's the Press Release describing Michael Smith's contribution (there was a co-recipient but we don't mention him unless we have to).

THEME:
Nobel Laureates

Background

Chemically, the genetic material of living organisms consists of DNA (deoxyribonucleic acid). DNA molecules consist of two very long strands twisted around each other to form a double helix. Each strand is formed of smaller molecules, nucleotides, that represent the letters of the genetic material. There are only four different letters, designated A, T, C and G. The two DNA strands are complementary, being held together by A - T and G - C bonds. It is only when the genetic code is to be read off e.g. for protein building in the cell that the two strands are separated. The genetic information in DNA exists as a long sentence of code words, each of which consists of 3 letters which can be combined in many different ways (e.g. CAG, ACT, GCC). Each three-letter code word can be translated by special components within the cell into one of the twenty amino acids that build up proteins. It is the proteins that are responsible for the functions of living cells, including their ability to function, among other things, as enzymes maintaining all the chemical reactions required for supporting life. The proteins' three-dimensional structure and hence their function is determined by the order in which the various amino acids are linked together during protein synthesis.

Site-directed mutagenesis

The flow of genetic information goes from DNA via the translator molecule RNA to the proteins. By re-programming the code of a DNA molecule, e.g. changing the word CAC to GAC, it would be possible to obtain a protein in which the amino acid histidine is replaced by the amino acid aspartic acid. In nature, such mix-programming of the genetic material (mutation) occurs randomly, and is nearly always fatal to the organism. However, a dream of biochemical researchers has been to alter a given code word in a DNA molecule so as to be able to study how the properties of the mutated protein differ from the natural. It was through Smith's oligonucleotide-based site-directed mutagenesis that this dream became reality. As early as the 1970s Smith learned to synthesize oligonucleotides, short, single-strand DNA fragments, chemically. He also studied how these synthetic fragments could bind a virus to DNA. Smith then discovered that even if one of the letters of the synthetic DNA fragment was incorrect it could still bind at the correct position in the virus DNA and be used when new DNA was being synthesized. At the beginning of the 1970s Smith was a visiting researcher at Cambridge and the story goes that it was during a coffee-break discussion that the idea arose of getting a reprogrammed synthetic oligonucleotide to bind to a DNA molecule and then having it replicate in a suitable host organism. This would give a mutation which in turn would be able to produce a modified protein. In 1978 Smith and his co-workers made this idea work in practice. They succeeded both in inducing a mutation in a bacteriophagic virus and "curing" a natural mutant of this virus so that it regained its natural properties. Four years later Smith and his colleagues were able for the first time to produce and isolate large quantities of a mutated enzyme in which a pre-determined amino acid had been exchanged for another one.

A protein with a changed (mutated) amino acid can be
produced with site directed mutagenesis. A chemically
synthesized DNA fragment with a changed code word is bound
to a virus DNA which is multiplied in a bacterium. The DNA
molecule with the changed code word is reduplicated and can
be used for producing the changed protein.

Smith's method has created entirely new means of studying in detail how proteins function, what determines their three-dimensional structure and how they interact with other molecules inside the cell. Site-directed mutagenesis has without doubt revolutionised basic research and entirely changed researchers' ways of performing their experiments. The method is also important in biotechnology, where the concept protein design has been introduced, meaning the construction of proteins with desirable properties. It is already possible, for example, to improve the stability of an enzyme which is an active component in detergents so that it can better resist the chemicals and high temperatures of washing water. Attempts are being made to produce biotechnically a mutated haemoglobin which may give us a new means of replacing blood. By mutating proteins in the immune system, researchers have come a long way towards constructing antibodies that can neutralise cancer cells. The future also holds possibilities of gene therapy, curing hereditary diseases by specifically correcting mutated code words in the genetic material. Site-directed mutagenesis of plant proteins is opening up the possibility of producing crops that can make more efficient use of atmospheric carbon dioxide during photosynthesis


The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.

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Darwin on Gradualism

 
The image on the right was created by Mike Rosulek. You can view the complete set at More Darwin. He's planning to sell T-shirts and poster with all proceeds going to support the National Center for Science Education.

The idea of slow gradual change is an essential component of most people's thinking about evolution.1 The debate over gradualism began in earnest with the publication of Punctuated Equilibria: an Alternative to Phyletic Gradualism by Eldredge and Gould (1972).

They defined phyletic gradualism as ...

Paleontology's view of speciation has been dominated by the picture of "phyletic gradualism." It holds that new species arise from the slow and steady transformation of the entire population.
They illustrate this point with two "classic" views of gradualism.

In the first view (left) we see speciation by gradual transformation of a single population. This form of speciation is called anagenesis.

This kind of thinking still dominates today. It's the way most people picture the result of natural selection working on a species over time. The species gradually adapts to a changing environment until its descendants come to look very different from its ancestors. This is the way most people think when they're talking about human evolution over the past several million years. It's the model you probably have in mind when you envisage arms races.

The other form of speciation is called cladogenesis. It's when an ancestral species splits into two parts—often due to geographical separation—and each separate population evolves gradually into distinct species. This is the way most people think about adaptive radiations. The key point, according to Eldredge and Gould, is the slow and steady change in each lineage as they diverge from one another.

Eldredge and Gould (1972) proposed a different way of thinking about evolution and speciation based on their observations of numerous fossil lineages. They suggested that speciation normally takes place via geographic separation of a subset of individuals in a species (allopatric speciation). This isolated group can evolve fairly rapidly so that within a relatively short time (tens of thousand of years) it comes to look very different from its ancestors.

If this geographically isolated population becomes reproductively isolated as well, then it forms a new species, distinct from its parents. The new species may then flow back into the same geographical location as the parent and there won't be any mixing of the gene pools. Meanwhile, the parent species has not changed much, so the effect on the fossil record is the rapid appearance of a new species while the old one continues to exist.2

At that point, both species will persist unchanged for millions of years (stasis) until the process of rapid speciation by cladogenesis repeats in one of both lineages. The pattern observed in the fossil record is called punctuated equilibria. It's a pattern that's very different from classic gradualism.

Here's how they illustrate it in their paper.



The important initial claims of the punctuated equilibria model are: (1) most change takes place rapidly during speciation by cladogenesis, and (2) for most of their existence species do not change very much. Later on, the implications of these two observations became more obvious. If the number of species is constantly increasing by splitting then why aren't we overwhelmed by species? The answer is that not only are species "born", they also "die" (become extinct). The overall pattern of evolution is characterized by the differential birth and death of species and this leads to species sorting as an important mode of evolution.

Lot's of people don't like punctuated equilibria and there are legitimate debates over interpretations of the fossil record. Some people say that the pattern is rarely seen, even when you have a complete record over millions of years. Others say that PE occurs in some lineages but it's not common.

Those who oppose punctuated equilibria are often upset about the claims concerning gradualism. The dispute often boils down to denying that anyone was ever a gradualist. The implication is that there's nothing new about punctuated equilibria so why all the fuss?

Much of the dispute hinges on whether Charles Darwin was a gradualist. It's often based on a misunderstanding of the word "gradualism" as it is used by Eldredge and Gould. Some people interpret it to mean "constant speedism" and they comb Darwin's works to find examples where he wrote about different rates of evolution in a lineage. "Aha!", they say, "see, Darwin wasn't a gradualist at all."

Gould addresses these critics in The Structure of Evolutionary Theory. He points out that there are some trivial examples of gradualism in Darwin's writings but the important definition is ...
Slowness and Smoothness (but not Constancy) of Rate
Darwin also championed the most stringent version of gradualism—not mere continuity of information, and not just insensibility of innumerate transitional steps; but also the additional claim that change must be insensibly gradual even at the broadest temporal scale of geological durations, and that continuous flux (at variable rates to be sure) represents the usual state of nature.
Gould goes on to support his claim based, in part, on Darwin's commitment to Lyell's uniformitarianism. Gould also points out that Huxley was vexed with Darwin for adopting such a gradualist approach to evolution.

You can tell from reading The Structure of Evolutionary Theory that Gould was annoyed at some of his critics. Bear in mind that Gould was a student of the history of biology and a collector of old books on the subject. He wrote numerous essays on the misinterpretation of historical figures (e.g. Goldschmidt). When he makes a claim about what Darwin thought, it shouldn't be dismissed as the deranged delusions of an uniformed scientist.

The same might not be true of other scientists, or philosophers, who write about history ....
Since Darwin prevails as the patron saint of our profession, and since everyone wants such a preeminent authority on his side, a lamentable tradition has arisen for appropriating single Darwinian statements as defenses for particular views that either bear no relation to Darwin's own concern, or that even confute the general tenor of his work....

I raise this point here because abuse of selective quotation has been particularly notable in discussions of Darwin's views on gradualism. Of course Darwin acknowledged great variation in rates of change, and even episodes of rapidity that might be labelled catastrophic (at least on a local scale); for how could such an excellent naturalist deny nature's multifariousness on such a key issue as the character of change itself? But these occasional statements do not make Darwin the godfather of punctuated equilibrium, or a cryptic supporter of saltation....
For more on this debate, see John Wilkins on Myth 4: Darwin was a gradualist.


1. The words on the poster are a take-off on one of the campaign slogans of Barack Obama.

2. There are other models that can account for the observations. In other works, Eldredge and Gould have explained how punctuated equilibria is also compatible with sympatric speciation.

Eldredge, N. and Gould, S.J. (1972) Punctuated Equilibria: an Alternative to Phyletic Gradualism. in "Models in Paleobiology" T.J.M. Schopf ed., Freemna, Cooper & Co., San Francisco pp. 82-115. [PDF]

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Thursday, February 19, 2009

Subway ads and dead stars

 
Today I saw this "advertisement" in the subway on my way to work. I think it's an excellent example of science education and I congratulate the people at the Dunlap Institute for Astronomy and Astrophysics, University of Toronto and CoolCosmos for making the effort. (Click on the ad below to enbiggen and read the fine print. Refresh the page on CoolCosmos to see all five ads.)


Phil Plait will be jealous.


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We Need this Course at the University of Toronto

 
Carl Zimmer ran a Science Writing Workshop at Yale University a few weeks ago.

I want him to give the same workshop here but I don't know if we can afford him.

Carl told us on his blog (The Island of Science Writing) about a short course in science writing that he is teaching this summer at the Shoals Marine Laboratory in Maine (USA). That sounded pretty neat so I thought I'd check it out by following the link [SCIENCE WRITING: BIOSM 3110]. I entertained the hope that I could take this course from Carl ... until I saw the price. The total cost for the week ($2,286) includes room and board but it's still a little steep for me, even considering the quality of the lecturer.

Hey Carl, do you have a discount for senior citizens?


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Blunt Talk from Four Evolutionists

 
Do you remember this cover? It caused a minor uproar a few weeks ago [see Explaining the New Scientist Cover].

Today's issue of New Scientist has a letter signed by four people who criticize the journal for its choice of cover design. It may be just about the only important thing those four have in common. There are; Daniel Dennett, Jerry Coyne, Richard Dawkins, and PZ Myers. What a motley crew! [Darwin Was Right].

What on earth were you thinking when you produced a garish cover proclaiming that "Darwin was wrong" (24 January)?

First, it's false, and second, it's inflammatory. And, as you surely know, many readers will interpret the cover not as being about Darwin, the historical figure, but about evolution.

Nothing in the article showed that the concept of the tree of life is unsound; only that it is more complicated than was realised before the advent of molecular genetics. It is still true that all of life arose from "a few forms or... one", as Darwin concluded in The Origin of Species. It is still true that it diversified by descent with modification via natural selection and other factors.

Of course there's a tree; it's just more of a banyan than an oak at its single-celled-organism base. The problem of horizontal gene-transfer in most non-bacterial species is not serious enough to obscure the branches we find by sequencing their DNA.
Darwin was wrong about a lot of things but the tree of life wasn't one of them. It's still an accurate metaphor for most of the history of life—certainly the parts Darwin wrote about.

That's not to deny the fundamentally accurate part of the inside story. At its base the tree of life looks an awful lot like a web. That's correct. It's just that it has nothing to do with Darwin. The magazine's attempt to connect modern molecular evolution with Charles Darwin was just cheap opportunism.

I can't resist noting an irony in the letter. The authors say that, "It is still true that [life] diversified by descent with modification via natural selection and other factors." The irony is that the article inside the magazine discusses molecular evolution ("molecular genetics" in their terminology). The trees derived from those studies are based almost exclusively on neutral mutations that have become fixed in species by random genetic drift. What these studies show is that life diversified by descent with modification via random genetic drift.

Even when they are writing about changes at the molecular level, some adaptationists just can't bring themselves to utter the words "random genetic drift" in public.


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Welcome to Canada, President Obama

 
President Obama (USA) just arrived in Canada. Here he is being greeted by Governor General Michaelle Jean. You can see the complete video on YAHOO! News.

Gosh, there hasn't been this much excitement over a visit to Canada since the Pope came here in 2002! Obama's visit may even be more exciting that the Queen's last trip in 2005.


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Wednesday, February 18, 2009

Stephen Jay Gould Challenged the Modern Synthesis

 
As most of you know, Gould (1941 - 2002) was a critic of the hardened version of the Modern Synthesis. He thought that evolutionary theory needed to be updated to include some things that the originators of the Modern Synthesis were unaware of—or rejected prematurely.

His paper in Science in 1982 reached a wide audience and most biologists first became aware of his challenge by reading this paper (Gould, 1982) [read it here—if you have a subscription to Science].

But two years earlier, Gould published a more scholarly critique in the journal Paleobiology (Gould 1980). The opening sentence of the abstract throws down the gauntlet.

The modern synthesis, as an exclusive proposition, has broken down on both of its fundamental claims: extrapolationism (gradual allelic substitution as a model for all evolutionary change) and nearly exclusive reliance on selection leading to adaptation.
Ryan Gregory discusses this paper in detail on Genomicron [Gould (1980)]. If you want to be informed in this debate you absolutely must read what he has to say about this key paper in evolutionary theory.

Ryan discusses three important myths about Gould. The false myths are: (1) he rejected natural selection, (2) he wanted to overthrow the Modern Synthesis, (3) saltation and punctuated equilibria are somehow connected.

The last myth is so widespread that people as diverse as Jarry Coyne, Greg Laden, and Daniel Dennett have gotten themselves hopelessly confused about punctuated equilibria by not reading carefully [see Macromutations and Punctuated Equilibria]. They should know better.

They will know better (I hope) once they have read Ryan Gregory's posting.

Today, there are many people who want to change the Modern Synthesis. Advocating some new addition to evolutionary theory has become a minor industry—aided and abetted by science journalist who are more interested in controversy than accuracy. But those failings should not blind us to the very legitimate challenges to the Modern Synthesis raised by Gould over twenty-five years ago.

It's disappointing that most of those challenges are still not understood by biologists. Read Ryan's summary of Gould (1980), and learn.


[Image Credit: Photograph of Stephen Jay Gould by Kathy Chapman from Lara Shirvinski at the Art Science Research Laboratory, New York (Wikipedia)]

Gould, S.J. (1980) Is a new and general theory of evolution emerging? Paleobiology 6:119-130.

Gould, S.J. (1982) Darwinism and the expansion of evolutionary theory. Science 216:380-387.

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World of Warcraft in France

 
Dear WOW Spammer,

You are spamming my blog with all kinds of links to your websites in France. I don't know what you are trying to achieve because I remove every single one of your comments within a few hours. Please confirm this fact. There's isn't a single link left on Sandwalk.

This is a waste of your time and mine. Please stop.


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Tuesday, February 17, 2009

The Modern Synthesis

 
Most people do not understand current ideas about evolution. The following is a brief summary of the Modern Synthesis of Genetics and Evolution as put forth by evolutionary biologists in the late 1940s.

The idea that life on Earth has evolved was widely discussed in Europe in the late 1700s and the early part of the 1800s. In 1859 Charles Darwin supplied a mechanism—namely natural selection—that could explain how evolution occurred. Darwin's theory of natural selection helped to convince most people that life has evolved and this point has not been seriously challenged in the past one hundred and fifty years.

It is important to note that Darwin's book The Origin of Species by Means of Natural Selection did two things. It summarized all of the evidence in favor of the idea that organisms have descended with modification from a common ancestor. Darwin built a strong case for evolution. In addition, Darwin advocated natural selection as a mechanism of evolution.

Biologists no longer question whether evolution has occurred or is occurring. That part of Darwin's book is now considered to be so overwhelmingly demonstrated that is is often referred to as the FACT of evolution. However, the MECHANISM of evolution is still debated [Evolution Is a Fact and a Theory].

During the first part of this century the incorporation of genetics and population genetics into studies of evolution led to a Neo-Darwinian theory of evolution that recognized the importance of mutation and variation within a population. Natural selection then became a process that altered the frequency of genes in a population and this came to be the minimal definition evolution [What Is Evolution?].

The earliest version of this essay appears on the TalkOrigins Archive.

A later version is at Evolution by Accident.
This point of view held sway for many decades but by the 1940s the classic Neo-Darwinian view was replaced by a new concept that brought together field biology, paleontology, and population genetics. The new version took pains to exclude all mechanisms except natural selection and random genetic drift. This new version was called The Modern Synthesis after the title of a 1942 book by Julian Huxley.

We have learned much since Darwin's time and it is no longer appropriate to claim that natural selection is the only mechanism of evolution. I can understand why this point may not be appreciated by the average non-scientist because natural selection is easy to understand at a superficial level. It has been widely promoted in the popular press and the image of "survival of the fittest" is too powerful and too convenient.

One of the goals of the Modern Synthesis was to reach consensus on the importance of macroevolution. The founders of the Modern Synthesis insisted that macroevolution could be explained by microevolution and no additional mechanisms—such as the bogeyman of saltation—were required.

Ernst Mayr, one of the original founders of the Modern Synthesis, sums it up this way ...

The term "evolutionary synthesis" was introduced by Julian Huxley in Evolution: The Modern Synthesis (1942) to designate the general acceptance of two conclusions: gradual evolution can be explained in terms of small genetic changes ("mutations") and recombination, and the ordering of the genetic variation by natural selection; and the observed evolutionary phenomena, particularly macroevolutonary processes and speciation, can be explained in a manner that is consistent with the known genetic mechanisms.

Ernst Mayr (1980) "Some Thoughts on the History
of the Evolutionary Synthesis" in The Evolutionary Synthesis,
E. Mayr & W.B. Provine eds. Harvard University Press.
The original version of the Modern Synthesis included mechanisms other than natural selection, especially random genetic drift. Later on, there was a hardening of the synthesis so that natural selection became the predominant mechanism and drift was relegated to a bit part (see Mayr quotation, above). The original version is described by Douglas Futuyma as ....
The major tenets of the evolutionary synthesis, then, were that populations contain genetic variation that arises by random (ie. not adaptively directed) mutation and recombination; that populations evolve by changes in gene frequency brought about by random genetic drift, gene flow, and especially natural selection; that most adaptive genetic variants have individually slight phenotypic effects so that phenotypic changes are gradual (although some alleles with discrete effects may be advantageous, as in certain color polymorphisms); that diversification comes about by speciation, which normally entails the gradual evolution of reproductive isolation among populations; and that these processes, continued for sufficiently long, give rise to changes of such great magnitude as to warrant the designation of higher taxonomic levels (genera, families, and so forth).

Futuyma, D.J. in Evolutionary Biology,
Sinauer Associates, 1986; p.12
This description would be incomprehensible to Darwin since he was unaware of genes and genetic drift. The Modern Synthesis differed from Darwinism in four important ways:
  1. It defined evolution as a change in the frequency of alleles in a population; an idea based on population genetics.

  2. In addition to natural selection, it recognized random genetic drift as an important mechanism of evolution.

  3. It recognized that characteristics are inherited as discrete entities called genes. Variation within a population is due to the presence of multiple alleles of a gene. Variation is caused by mutation.

  4. It postulated that speciation is (usually) due to the gradual accumulation of small genetic changes. This is equivalent to saying that macroevolution is simply a lot of microevolution.
The Modern Synthesis was a theory about how evolution worked at the level of genes, phenotypes, and populations whereas Darwinism was concerned mainly with organisms, speciation and individuals. This was a major shift in emphasis and those who fail to appreciate it find themselves out of step with the thinking of evolutionary biologists.

The major controversies among evolutionary biologists today concern the validity of points #2 and #4 (above).

Following the centennial celebrations of the publication of Origin in 1959, there was a gradual hardening of the Modern Synthesis. The 1960s version concentrated almost exclusively on natural selection as a mechanism and random genetic drift was pretty much ignored. Today, there is debate about the relative importance of these two mechanisms and some are calling for an updating of the "hardened" Modern Synthesis.

This update would restore random genetic drift as an important mechanism, recognize neutral theory, and incorporate molecular phylogeny (and the molecular clock).

There are many who believe that the fossil record does not show gradual change but instead long periods of stasis followed by rapid speciation. This model is referred to as Punctuated Equilibrium and it is widely accepted as true, at least in some cases. The debate is over the relative contributions of gradual versus punctuated change, the average size of the punctuations, and the mechanism.

The Modern Synthesis is challenged over the emphasis on gradualism and over the claim that microevolution is sufficient to explain macroevolution. Some evolutionary biologists suggest that evolutionary theory be modified to incorporate mechanisms that occur at levels higher than the population (e.g. species sorting). These scientists advocate an extension called hierarchical theory.

There are other challenges to the Modern Synthesis. Some of them are valid and some of them are silly. But I think it's fair to say that the 50-year old version needs some serious updating to incorporate some of the new concepts.

Some scientists continue to refer to modern evolutionary theory as Neo-Darwinian. In some cases these scientists do not understand that the field has changed but in other cases they are referring to what I have called the Modern Synthesis, only they have retained an old name from the early 1900s.


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Monday's Molecule #108: Winner

 
UPDATE: This week's molecule is the genome of ΦX174, a small bacterial virus. It was the first complete genome to be sequenced (Smith et al., 1977, Sanger et al., 1978, Sanger et al., 1978). The sequencing was done in Fred Sanger's lab and Sanger was awarded the Noble Prize a few year later for developing the dideoxy sequencing technology [The Sanger Method of DNA Sequencing].

ΦX174 is interesting because it has overlapping genes—a feature that we now know to be uncommon.

One of the authors on the papers was Michael Smith. He spent a year in Sanger's lab on sabbatical. In 1978 Smith used the ΦX174 sequence in his experiments to develop site-directed mutagenesis (Hutchison et al. 1978). Smith got the Nobel Prize in 1993. He is this week's Nobel Laureate.

This week's winner is James Fraser of the University of California, Berkeley. We will be meeting for lunch in a few months.


Hutchison, C.A. 3rd, Phillips, S., Edgell, M.H., Gillam, S., Jahnke, P., and Smith, M. (1978) Mutagenesis at a specific position in a DNA sequence. J. Biol. Chem. 253:6551-6560.

Sanger, F., Air, G.M., Barrell, B.G., Brown, N.L., Coulson, A.R., Fiddes, C.A., Hutchison, C.A., Slocombe, P.M., and Smith, M. (1977) The nucleotide sequence of bacteriophage phiX174. Nature 265:687-695.

Sanger, F., Coulson, A.R., Friedmann, T., Air, G.M., Barrell, B.G., Brown, N.L., Fiddes, J.C., Hutchison, C.A. 3rd, Slocombe, P.M., and Smith, M. (1978) The nucleotide sequence of bacteriophage phiX174. J. Mol. Biol. 125:225-246.

Smith, M., Brown, N.L., Air, G.M., Barrell, B.G., Coulson, A.R., Hutchison, C.A. 3rd, and Sanger, F. (1977) DNA sequence at the C termini of the overlapping genes A and B in bacteriophage phi X174. Nature 265:702-705.





Today's Monday's Molecule really is a molecule. Your task is to identify the molecule from the cartoon shown here. It won't be sufficient to just find the name of the molecule, you will also have to identify the significance behind determining its chemical structure.

There's one scientist who was involved in that determination who also did some important work based, in part, on knowing the sequence. This scientist was awarded a Nobel Prize for his work but the prize didn't come until 15 years later. Name this Nobel Laureate.

The first person to identify the molecule and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are eight ineligible candidates for this week's reward: Ramon, address unknown, Jason Oakley of the University of Toronto, John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), Wesley Butt of the University of Toronto, David Schuller of Cornell University, Nova Syed of the University of Toronto, Dima Klenchin of the University of Wisconsin and undergraduate Alex Ling of the University of Toronto

John, David, and Dima have offered to donate their free lunch to a deserving undergraduate so I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.


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USA Is Ahead of the World in Science Education

 
This falls into the category of, "Wow, I didn't know that!"1. According to a press release from Michigan State University: College Science Requirements Keep US Ahead Of World, Researcher Argues ...

Despite frequent warnings of the inadequacy of education in the United States, citizens here are still among the world's most scientifically literate, a Michigan State University researcher said.

You can thank those general education requirements that force English majors to sit through biology classes and budding engineers to read Hemingway, Jon Miller said.

...

Fifty years after English novelist and physicist C.P. Snow warned of a disturbing lack of scientific literacy among the cultural elite and a parallel literary void among Britain's scientists and technologists, little has changed in most of the world, Miller argued. And that's part of what keeps the U.S. at the forefront of scientific endeavor and technological innovation.

"What makes the American market and society different," he said, "is that we have more science- and technology-receptive citizens and consumers, and as a society we're willing to spend money for basic science and have been doing that for years."

Americans as a group tend to be more open-minded about innovations such as genetically modified food, he said. Scientific reasoning also works its way into such disciplines as law, he noted, where facts are routinely marshaled to support or disprove theories.
Who would 'av thunk it? American are better at critical scientific reasoning because there are more science-receptive citizens. And it even extends to the law.

I guess that's why American courts spend so much time trying to keep superstition out of the science classroom.


1. Personally, I don't think there's all that much difference between science literacy in the USA and other Westeren industrialized nations. However, the idea that the USA is actually superior to other nations does strain belief, somewhat.

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Why Are Women Religious?

 
At my talk last Friday I was asked about the field of evolutionary psychology. This seems to be a popular topic among educated non-scientists. I suppose I shouldn't be surprised that most people are only interested in human evolution—that doesn't mean I can't be disappointed.

The person who asked the question wondered why opponents of evolutionary psychology don't get more ink. The implication was clearly that the opponents are in the minority or don't have a very strong case. I should have directed him the the Wikipedia website: Evolutionary psychology controversy. It summarizes the main problems with evolutionary psychology.

Let's look at a recent article by Elisabeth Cornwell, an Assistant Professor of Research at the University of Colorado at Colorado Springs. Her article attempts to explain why women tend to be more religious than men [Why Women Are Bound to Religion: An Evolutionary Perspective]. We may be able to use her article to illustrate some of the problems with explaining human behavior using evolution.

It is because of hormones that male and female brains differ. While there is no evidence for differences in intelligence (as was believed in the nineteenth century and on into the twentieth - women were not even allowed to vote until 1920!), to deny that differences exist is simply wishful thinking. Evolution cares nothing for either misogyny or feminism; it cares not for what is moral or immoral, just or unjust: without caring at all, it builds survival machines to carry genes into the next generation.

But what has this to do with religious beliefs among women? Quite a bit actually. When we look at some of the behavioral and psychological differences between women and men, we can glimpse some of the adaptations necessary for our ancestors' survival.
Emphasizing differences between men and women is a common theme these days. Some of these differences are due to genetic differences between men and women (e.g. hormones) and some are just cultural differences that have no genetic component. The trick is to distinguish between those differences.

When it comes to specific behaviors, such as religious belief, we need to be very careful. Is there a gene for "religious belief" or is this an epiphenomenon, or a cultural thing? If there's no gene controlling "religious belief" then we're not talking about evolution or biological adaptation.
With this in mind, we can begin to understand why it is so essential for women to fit into their social group. Exclusion would have meant extinction since those women who could not live in accord with the other members of their group would have had fewer or no descendants. Thus, the evolutionary pressures that shaped the need to live in harmony with the group pressed more strongly on women than on men. This is not to suggest that there were not strong evolutionary pressure for males, too, to conform, indeed there were. However, males who risked upsetting the status quo and did so successfully would have gained an advantage in their own reproductive success. Females who tried the same would not.
Like most people who advocate the evolution of specific behaviors, Elisabeth Cornwell is not spelling out the details of her proposal. Let's try and fill in the blanks.

The idea that women might feel the need to belong to a group isn't wrong. There may even be some biological differences between men and women (hormones?) that underlie this preference for belonging. But that's not all that Elisabeth Cornwell is proposing.

What she is suggesting is that there may have been a time in the ancient past when women didn't care about fitting into a social group. Then a new mutation arose that changed this behavior so that women with the mutation wanted to be part of a group. The mutation didn't have the same effect in men even though they must have carried it. Because of "evolutionary pressure" this socialization allele increased in the population until almost everyone had it—but it only worked in women.

Alternatively, women may have elected to form strong social groups because it was a smart thing to do. Over time, women risked being ostracized if they didn't conform to the social norm. (That seems to be a common behavior among women, even today. )

So, we have two competing explanations. One is that there's a gene (allele) for socialization that is responsible for this behavior in women, and that this allele arose during the course of human evolution and became fixed because it conferred selective advantage on women who carried it.

The other possible explanation is that women's biology did not change. The evolution of intelligence in primates, millions of years ago, led to formation of social groups in apes because these groups of women made life easier. It was a deliberate decision, made by intelligent apes. This is not biological evolution.
Religion is a human invention, the gods and goddesses that have come and gone during our short history have all displayed the best and (more often) worst human traits. They fell in love, jealousy was common, revenge, anger and trickery prevailed, the struggle for power was universal, and all could be brought to folly and woe due to excessive hubris, greed, and lust. Soap operas pale in comparison! What concerns me, though, is that religion reflected the culture of the times - and, for better or worse, the religions most prominent today are all rather ancient beasts that grew out of a time when women were subservient to men, and often considered as property to be bartered, battered, and controlled.
One of the main criticisms of evolutionary psychology is that its proponents are often guilty of cultural bias. They tend to extrapolate from the culture they know to all of human behavior. This is an important criticism since the stories are not about biological evolution within a small society but about the evolution of human behavior—all humans.

In this case, Elisabeth Cornwell is talking about cultures that date back only 3,000 or 4,000 years. They are the cultures that produced Judaism, Christianity, and Islam. They are not relevant when it comes to discussions about human evolution.

Another criticism of evolutionary psychology is related to the previous one. It's the premise that evolutionary psychologists know enough about pre-historic societies to be able to make reliable statements about evolutionary pressures. As a matter of fact, we simply don't know how our hunter-gatherer ancestors behaved. We don't know if women formed tight-knit social groups that excluded men, or if women living 50,000 years ago tended to be more "religious." Maybe women were smarter than men and they didn't believe the crap that male shamans1 were spouting!
So we are back to our original question: Why do women today continue to fall victim to an archaic system of beliefs that foster misogynistic behavior? Why are women even more likely to be religious than men? The simple answer is that it is safe. Please don't take this as a slight against women -- it isn't. Male/female differences exist, but I'm certainly not suggesting that risk taking is a better option than playing it safe. After all, women are less likely than men to die doing incredibly stupid things (check out the Darwin Awards it is nearly exclusively male 'winners'). But the fact that women are less likely to push the status quo for fear of social exclusion and even retribution makes a lot of evolutionary sense.
Actually it doesn't make a lot of sense from an evolutionary perspective except as an epiphenomon. Female ape brains may be biologically different from male ape brains and those differences may make it easier for females to form groups. The fact that, today, women in Western industrialized nations tend to be more religious than men could be entirely due to culture.

In other cultures, and other times, it might be men who are more devoted to religion. I don't believe that a woman's brain is hard-wired to be more susceptible to superstition than a man's. Nor do I believe that humans evolved a propensity to be superstitious over being rational.


1. shamans is the correct plural of shaman.

[Hat Tip: RichardDawkins.net]

For more, see Pop Evolutionary Psychology, Modern women are excellent gatherers, Changing Your Mind About Evolutionary Psychology, Please Tell Me This Is a Joke, and Changing Your Mind: Are Humans Evolving?.

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Junk DNA Is "Dead as a doornail"?

 
I just received an email message from AndrĂ¡s Pellionisz informing me that in America the concept of junk DNA is "dead as a doornail." He "proves" his case in an article on his website [HoloGenomics].

A Eureka Moment concerning the fractal character of neurons led in turn to a novel picture of genomics where protein structures act back recursively upon their DNA code -- in outright contradiction to prevailing orthodoxy. A household name in neuroscience for his tensor network theory, Dr. AndrĂ¡s Pellionisz has recently had another far-reaching discovery borne out. This insight has now received striking confirmation in stunning results from the new field of epigenetics -- promising a whole raft of novel medical diagnoses and therapies.

Sunnyvale, Calif. (PRWEB) July 16, 2008 -- A landmark article on "The Principle of Recursive Genome Function" (received December 7, accepted December 18, 2007) by AndrĂ¡s J. Pellionisz appears online in Springer's e-Journal Cerebellum.

The paper marks the first anniversary of an historic event--the release of pilot results for ENCODE, the Encyclopedia of DNA Elements project. Building on the results of the Human Genome Project, the ENCODE effort revealed a far more complex DNA coding sequence than was ever previously imagined. "There's a lot more going on than we thought," said Collins, who was director of the National Human Genome Research Institute (NHGRI). Dr. Collins issued a mandate a year ago "the scientific community will need to rethink some long-held views".

A happy few did not need to rethink either the "central dogma of molecular biology" (Crick, 1956) or the misnomer of "junk" DNA (Ohno 1972), since they never believed them in the first place. The dictum claiming that a flow of information from proteins back to DNA "never happens" or the idea that 98.7% of the human genome should be disregarded as junk was never very believable.
THEME

Genomes & Junk DNA
There are some interesting scientific debates about the role of noncoding DNA in large genomes. Much of it is junk but there's lot of other functions that we've known about for decades. Many respectable scientists dispute the notion that most of our genome is junk.

Unfortunately, very little of that interesting scientific debate can be seen on AndrĂ¡s Pellionisz's website. Instead, I direct you to the site in order to see a classic example of a modern kook in action. The site has all of the characteristics of kookdom (see crank) and serves as a self-evident answer to the question Is AndrĂ¡s Pellionisz a Kook?.


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Monday, February 16, 2009

I Wish My Country's Leader Could Say This!

 
I don't think Prime Minister Stephen Harper believes any of the things that Barack Obama says in this video. My country is cutting back on science at the very time when science needs all the support it can get.




[Hat Tip: Pharyngula]

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Monday's Molecule #108

 
Today's Monday's Molecule really is a molecule. Your task is to identify the molecule from the cartoon shown here. It won't be sufficient to just find the name of the molecule, you will also have to identify the significance behind determining its chemical structure.

There's one scientist who was involved in that determination who also did some important work based, in part, on knowing the sequence. This scientist was awarded a Nobel Prize for his work but the prize didn't come until 15 years later. Name this Nobel Laureate.

The first person to identify the molecule and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are eight ineligible candidates for this week's reward: Ramon, address unknown, Jason Oakley of the University of Toronto, John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), Wesley Butt of the University of Toronto, David Schuller of Cornell University, Nova Syed of the University of Toronto, Dima Klenchin of the University of Wisconsin and undergraduate Alex Ling of the University of Toronto

John, David, and Dima have offered to donate their free lunch to a deserving undergraduate so I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours.


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IDiots and the Genetic Fallacy.

 
The term Genetic Fallacy is used to describe fallacious arguments that attack an idea based on its origins (genesis) and not its current validity.

The most common (but not the only) examples are attempts to discredit someone's idea by impugning the character of the person who originated the idea. For example, you could try to cast doubt on Thomas Jefferson's views about freedom by attacking his morality. Same with Benjamin Franklin, who, we all know, wasn't a very nice person. That has no bearing on the truth of his ideas or his work on electricity.

In the battle between rationalism and superstition, we can always count on the Intelligent Design Creationists to give us examples of every single logical fallacy. They are very good at irrational thinking.

Here's the latest from Denyse O'Leary: If you accept the argument in Descent of Man, you accept a racist argument. Some of her arguments against science are so classic I wouldn't be surprised if they enter the philosophy textbooks as examples of the important logical fallacies.

Quite honestly, I find current Darwinist efforts to get the old Brit toff off the hook for racism embarrassing. Far from differing from his generation's racist beliefs, Darwin wanted to provide solid scientific support for them. And to the extent that anyone accepts the argument in Descent of Man, they accept a racist argument.

Has anyone noticed how Darwinists carefully protect themselves from having the issue framed bluntly in those terms?


[Image Credit: ThadGuy.com]

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Chuck Lorre on How to Become an Atheist

 
Chuck Lorre is a TV producer. One of his shows is Two and a half men, another is The Big Bang Theory. Chuck Lorre has a blog but it's a strange kind of blog—no comments allowed and the titles of each posting are just numbers. Many (all?) of them appear in the credits at the end of his shows.

Here's #240, posted on Feburary 2, 2009.

A wise man once told me that we are all God in drag. I like that. Sometimes when I'm in a public place or sitting at a stop light, I'll watch people walking by and I'll silently say to myself, "He's God. She's God. He's God. She's God." Before long I always find myself feeling a warm sense of affinity for these strangers. The experience is even more powerful when I do this while observing a person who is clearly suffering. On occasion I'll test my little spiritual practice by turning on Fox News. Within minutes I become an atheist.


[Photo Credit: Could Chuck Lorre Be the Smartest Person in Television?]

[Hat Tip: Carmi's Art Life World: Chuck Lorre Makes Me Laugh]

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In Praise of Jodrell Bank

 
Jodrell Bank was one of the instruments that excited my imagination back when I was a junior member of the astronomical society. Ms. Sandwalk and I are thinking of visiting the Lake District in England. She would be delighted to take a side trip to see Jodrell Bank.

The photos of the main telescope almost convinced me to be an astronomer—but then I found out that biology was much more challenging!

Mark has posted an article In Praise of Jodrell Bank on Cosmic Variance.




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Variation and Natural Selection

 
Here's a photograph of many varieties of hybrid radish. It's from the Botany Photo of the Day posted on Darwin's birthday by Nhu Nguyen to illustrate speciation in action.



Please visit the UBC website to see the entire posting. I'd like to comment on one particular statement. Nhu Nguyen writes,

This is a weedy species that grows in coastal (and some central) areas of California. According to research by Norman Ellstrand's group at UC Riverside, this species is evolving in a quantifiable manner. It is a hybrid between Raphanus sativus, the common radish, and Raphanus raphanistrum.

Curiously, the same hybrid occurs elsewhere in similar climates such as that of South Africa, but something special about ecosytems in California allowed it to proliferate. It is now different enough from either of its parents that Ellstrand's group is considering describing this as a new species. This has occurred within the timespan that the two parents were brought together by humans in California."

There are many color variations of this evolving species. It is exactly through this variation that the process of natural selection works. If allowed to go its own way, some of these color morphs may persist, others may perish, all depending on the selective forces present where they occur. Eventually, each of these via time and selection could become a species of its own. California thus would be the center of diversity for a new group of Raphanus species.
What is the evidence that natural selection is acting one these variants? I doubt that there's any evidence at all.

While it's true that evolution may result in many of these variants becoming separate species, there's no reason to suppose that there are "selective forces" working on different colored flowers. It could just as easily happen that one or more colored variations could become fixed in a new species by random genetic drift.

I'm not sure what the problem is here. Is it just sloppy language on the part of some botanists? Do they use the words "natural selection" as a synonym for "evolution" without thinking about it? Or, are they confirmed adaptationists who actually believe that all visible phenotypes must be subject to selection?

There seem to be a large number of scientists who think that all speciation events are driven by natural selection. This was (mostly) what Darwin thought but I was previously under the impression that this had changed in the 20th century to recognize that random genetic drift plays an important role in speciation.


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Does This Look Designed?

 
Check out today's Botany Photo of the Day from the University of British Columbia Botanical Garden and Centre for Plant Research. The species is Euphorbia caput-medusae L. from South Africa.

It's an example of a strange-looking species that most of us are not familiar with. We need to keep in mind that life is complicated and weird.


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Sunday, February 15, 2009

Literary Darwinism

 
A reader tells me that Trent University (Peterborough, Ontario, Canada) celebrated Darwin's birthday with a talk by Joseph Carroll on The Historical Position of Literary Darwinism. She asked me what I thought of Literary Darwinism.

I had never heard of it so I asked my good friend "Google" and he (she?) didn't disappoint. There's a Wikipedia entry on Darwinian Literary Studies (aka Literary Darwinism).

As Leda Cosmides and John Tooby indicate in their essay "The Psychological Foundations of Culture," scientific models and theories allow us to sense abstract objects and relationships just as our eyes and ears allow us to sense concrete ones. In Darwinian literary studies, as in evolutionary psychology, "[t]he tools of evolutionary functional analysis function as an organ of perception, bringing the blurry world of human psychological and behavioral phenotypes into sharp focus and allowing one to discern the formerly obscured level of our richly organized species-typical functional architecture."[2] In other words, since the human mind is embodied in evolving organic structures such as the brain, researchers should be able to explain aspects--not only of cognitive systems such as language ability, but of cultural systems such as art and literature--in terms of the environmental factors, or selection pressure, that give rise to them. A chief goal of Darwinian literary studies is to show how the reading and writing of literature contributes to the inclusive fitness of the human organism. In this sense the discipline relates closely to adaptationism, and it shares with the adaptationist social sciences the ultimate goal of understanding human nature.
So it's closely related to adaptationism and evolutionary psychology, eh? I don't think I'm going to like literary Darwinism. Sounds like just another misinterpretation of evolution by a bunch of non-scientists.

Let's look at an example.
A good example of applied Darwinian criticism is Joseph Carroll's reading of Pride and Prejudice, which shows how the fundamental biological problem of mate choice informs the plot of Austen's novel[3]. In this view, the novel narrates a social order in which males compete on the basis of socioeconomic attributes such as money and rank, whereas females compete according to 'personal' attributes such as youth and beauty. The story of Darcy and Elizabeth's courtship establishes a model for partial subversion of this social order, since the couple manage to abide by it even though the proximate causes of their mutual attraction have more to do with the conventionally undervalued attributes of dignity, honesty, kindness, and intelligence. A Darwinian critic might argue that the whole book functions as a tool for humans to perceive, order, and make sense of the conflicting impulses that characterize romantic relationships.
I don't know whether I count as a "Darwinian critic" or not but it seems to me that Austen is pointing out that women can be either smart or stupid when it comes to choosing a mate and so can men. Jane Austin is describing the breakdown of an English social order that existed prior to the nineteenth century. That social order is very different than those in other societies at the same time (e.g. India, China, North American natives), which, in turn, is probably nothing like the society of our ancestors 50,000 years ago. I don't see what this has to do with human evolution—or whatever these English scholars mean by "Darwinism."


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Dan Falk Gets It Right!

 
Dan Falk is a Toronto-based science writer and winner of 2002 Canadian Science Writers’ Association Science in Society Journalism Award. He writes for major Canadian newspapers and is a frequent contributer to the CBC television program Quirks and Quarks. He is the author of In Search of Time: Journeys Along a Curious Dimension, which I have not read—an oversight I plan to correct as soon as possible.

I'm critical of many science writers for misrepresenting science in their articles appearing in newspapers or magazines. It's even worse when ordinary journalists attempt to write about science [The Ottawa Citizen Should Be Ashamed of David Warren].

Today I'm deligheted to bring to your attention an excellent article by Dan Falk in today's Toronto Star "[You are here: Your microspot in the universe: What Galileo and Darwin should really be remembered for: making us feel smaller"].

You really should follow the link and read the whole article. Here's the conclusion—I hope it will tempt you.

As physicist Steven Weinberg famously said, "The more the universe seems comprehensible, the more it also seems pointless."

Both Galileo and Darwin showed us that our place in the cosmos is less central – perhaps less special – than we had imagined. For some it has been a bitter pill to swallow. But there is also every reason to rejoice in their discoveries. We are indeed animals, but we are animals that can comprehend the structure of DNA and the unity of life.

And yes, we live in one remote corner of the galaxy, itself one of billions of galaxies, but from this outpost we have probed the fabric of the universe, from the smallest quark to the most distant quasars.

Galileo and Darwin broadened our horizons, perhaps to a greater degree than any other two thinkers in history. As a result of their vision, we live in a larger, richer and more wonderful universe.
Thank-you Dan Falk. It's refreshing to see that kind of writing in a major newspaper. I'm looking forward to the letters to the editor, especially from those who haven't yet swallowed the bitter pill.


[Photo Credit: The photograph of Dan Falk on the University of Toronto campus is from his article, TIME TRAVEL AND THE DOWNING STREET DILEMMA, on the pagebooks.ca website.]

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Congratulations Steve Darwin!

 
Steve Darwin is Steve #1000. Find out who he is (no relation to Charles) and why he is #1000 by visiting the website of the National Center for Science Education [Steve Darwin is Steve #1000].


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Saturday, February 14, 2009

You Can Lead an Atheist to Evidence, But You Can't Make Him Think

 
Here's a video of Pat Robertson and Ray Comfort—two of the best secret weapons on the atheism side. Just watch this video to see why.




[Hat Tip: Friendly Atheist]

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Jerry Coyne Meets Ken Miller

 
Read about it on Coyne's blog [Darwin Day, Philadelphia. 1. I meet Ken Miller].

At any rate, after dinner I met Ken and we chatted about things. The first thing he said to me was that one of his friends advised him to break a beer bottle over my head, which was more than a little intimidating when imparted to me by a guy well over six feet tall looking down on my puny five-foot-eight self! But we discussed our differences, tried to iron out misunderstandings on both of our parts, and amiably shook hands. We will never agree on the science-versus-faith thing, but on most issues we are on the same side, and I admire him in many ways. I was glad that we met.
I'd love to have been there.


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Can You Guess Who Wrote This?

 

Yet how the former led to the latter, how it was that complexity emerged and is sustained even in that near-miracle of a chemical factory we call the cell is still largely enigmatic. Self-organisation is certainly involved, but one of the puzzles of evolution is the sheer versatility of many molecules, being employed in a myriad of different capacities. Indeed it is now legitimate to talk of a logic to biology, not a term you will hear on the lips of many neo-Darwinians. Nevertheless, evolution is evidently following more fundamental rules. Scientific certainly, but ones that transcend Darwinism. What! Darwinism not a total explanation? Why should it be? It is after all only a mechanism, but if evolution is predictive, indeed possesses a logic, then evidently it is being governed by deeper principles. Come to think about it so are all sciences; why should Darwinism be any exception?

But there is more. How to explain mind? Darwin fumbled it. Could he trust his thoughts any more than those of a dog? Or worse, perhaps here was one point (along, as it happens, with the origin of life) that his apparently all-embracing theory ran into the buffers? In some ways the former possibility, the woof-woof hypothesis, is the more entertaining. After all, being a product of evolution gives no warrant at all that what we perceive as rationality, and indeed one that science and mathematics employ with almost dizzying success, has as its basis anything more than sheer whimsy. If, however, the universe is actually the product of a rational Mind and evolution is simply the search engine that in leading to sentience and consciousness allows us to discover the fundamental architecture of the universe – a point many mathematicians intuitively sense when they speak of the unreasonable effectiveness of mathematics – then things not only start to make much better sense, but they are also much more interesting. Farewell bleak nihilism; the cold assurances that all is meaningless. Of course, Darwin told us how to get there and by what mechanism, but neither why it is in the first place, nor how on earth we actually understand it.

To reiterate: when physicists speak of not only a strange universe, but one even stranger than we can possibly imagine, they articulate a sense of unfinished business that most neo-Darwinians don't even want to think about. Of course our brains are a product of evolution, but does anybody seriously believe consciousness itself is material? Well, yes, some argue just as much, but their explanations seem to have made no headway. We are indeed dealing with unfinished business. God's funeral? I don't think so. Please join me beside the coffin marked Atheism. I fear, however, there will be very few mourners.
The answer is at ... Darwin was right. Up to a point.


[Hat Tip: RichardDawkins.net]

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Friday, February 13, 2009

Moving Darwin

 
A statue of Charles Darwin was sculpted by Sir Joseph Boehm in 1885. It cost £2200. The money was raised by soliciting individual contributions from individuals around the world and so much money flowed in that there was enough left over to fund research in evolution.

The statue was unveiled on June 9, 1885. Charles Darwin was hugely popular, as you can see by the crowd of people outside the Natural History Museum. The statue was placed in a prominent position at the top of the main staircase in the Central Hall.

In 1927, Darwin wasn't as popular and his statue was moved to make way for an elephant display. The place of honor was soon taken up by a statue of Robert Owen, founder of the museum, and not a huge fan of Darwin [The North Hall Statues].

Darwin, and his friend Huxley, sat in the North Hall, under the main stairs in what became the museum cafeteria. This is not a place of honor and when I saw it there in 2006 I thought it looked very much like the museum was trying to hide Darwin from its visitors.



The Natural History Museum decided that they had better take steps to rehabilitate Darwin in preparation for the 2009 celebrations. So last Spring they moved Darwin back to the original position at the top of the stairs in the Central Hall.

You can watch a video of the statue on the move on the Natural History Museum website [Darwin's statue on the move].

I'm glad they decided to move the statue. While there's a danger of reading too much into the traveling statue, I think it reflects a time in the early 2oth century when Darwin's reputation was somewhat eclipsed. At that time, there were many scientists who didn't think that natural selection could explain evolution.



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Quotable Quotes

 
From PZ Myers [I get email].

One frequent motif recurs in creationist email: they may believe in god, but they don't believe in paragraphs.


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On Re-reading the Origin of Species

 
It's been a great pleasure to read the Origin of Species in preparation for my talk tonight and for our book club meeting last Monday. I had forgotten how clever Darwin was and how he carefully weighs his arguments for evolution.

I had also fallen prey to several myths about the book. For example, I didn't realize that Origin of Species is all about speciation and the difference between species and varieties.

The editors of Current Biology asked several scientists to re-read Origin of Species in honor of Darwin's 200th birthday. The results are published on the journal's website [(Re)Reading The Origin].

I've already mentioned Jerry Coyne's defense of the term "Darwinism" [Jerry Coyne on Darwinism. The contribution from Christiane NĂ¼sslein-Volhard is excellent—she points out one of Dawin's most important arguments and reminds us that it has been largely forgotten because it now seems so obvious.

Many of the scientists comment on the wonderful prose in Origin and on Darwin's delightful style of writing. I agree with them. Mark Ptashne doesn't. He couldn't read the book when he was younger and even today he had to read a condensed version because the original is too difficult! ("Who has the patience to dig through the convoluted sentences, extracting the buried nuggets?")1

At my book club meeting, and in many discussions with non-scientific friends, the dominant impression is that Darwin is a very humble man who almost apologizes for having a good idea. That's not the Darwin I see. Simon Conway Morris isn't fooled either ....

But what suddenly became clear is that this is a book haunted by the ghost of William Paley the grandfather of creationist thinking and exponent of seemingly irrefutable arguments for organic design. The Origin is Darwin's riposte. Its metaphorical power depends on suspense and a scattering of clues, but significantly Paley himself is mentioned only once. And cleverly not in the context of his ideas on organic design but in an oblique dig at the question of natural evil. First and foremost, The Origin is an exorcism of the doctrine of special creation, and conducted by one of the most skilled exorcists science has ever seen. The brief crescendo in the last chapter is preceded by repeated and sudden flashes of disdain, a quick insertion of the knife before the narrative calmly continues in its ostensibly more objective purpose of piling up the evidence. Darwin knew his enemy intimately, but was far too astute to engage in a head-on clash.

Darwin was right, and he knew it. His expressions of doubt are largely rhetorical and how seamless—at least from a distance—is the edifice upon which he constructs his theory. Yet, it is equally intriguing how he conceals his intellect: the carefully marshalled facts are allowed to speak for themselves and the implications introduced with restraint and circumspection—a sotto voce naturalist. Darwin never doubted his abilities.
Why are so many people not able to see this? I think it's because they aren't familiar with the typical English style of understatement and well-disguised sarcasm.

Darwin's contemporaries weren't fooled. You should read Brian Switek's posting on Darwin's Heartache to see how Darwin's friends responded to the book in November 1859. His old Cambridge mentor, Adam Sedgwick, was not happy.

Andrew Berry and Hopi Hoekstra didn't comment on their own reading of Origin of Species; instead they listed the comments of their students in the course evaluations! The good news is that some students actually liked the book.

My favorite review is by Peter Lawrence who, I must confess, is one of my favorite scientists. Peter noticed something that I also noticed; namely, that Darwin's style of argument is very much a lost art. Here's how Peter puts it ...
I had only dipped into this wonderful book in my student days. But what a revelation for a somewhat jaded scientist to read it now! It is not only the brilliance, farsighted and original nature of the ideas, there is the sheer diversity of knowledge, the pervading presence of thought, of simple direct experiments, of debate, of argument, the consideration of other views and the style. In writing and reading scientific articles nowadays, we become imprisoned, constrained in what is considered appropriate and our vocabulary is reduced. Also our sentences are stifled by fashion and by journals that kill invention and independence with their strict word limits and their 'house style.' Just one example: punctuation. Darwin used everything, even the long dash and the exclamation mark. In my scientific writing I have been frequently told that these are not allowed—OK for great literature, but banned from scientific usage. I don't know why, but dulling down our scientific writing is not in our best interest. By contrast, in Darwin's time, Victorian fashion encouraged a flowery style as well as intellectual freedom; he took full advantage of both. He could write explorative and educative prose. He could spend many pages explaining narrow but important distinctions between different viewpoints and, time and again, one can see the outcome of careful reading and deep reflection. Our data-dominated publications, pared down to fit them into limited space, would be much more comprehensible if there were more argument, more explanation and more justification; indeed, if we reflected more, I think we could make big reductions in our published pages by making sure they carry and convey at least one message of note.


1. I suspect he hasn't read The Structure of Evolutionary Theory , either.

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Thursday, February 12, 2009

YouTube Birthday Card

 




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Happy Birthday Charles Darwin

 
Charles Darwin was born on this day in 1809.

Here are the opening paragraphs of Janet Browne's wonderful biography of Charles Darwin.

He was born into Jane Austen's England. Indeed, the Darwins could have stepped straight out of the pages of Emma, the four girls sharply intelligent about the foibles of others, their father as perceptive as Mr. Knightly. The boys had several equally distinctive qualities. Charles Darwin and his older brother, Erasmus, were obliging and sympathetic young men full of the gentle humour, domestic attachments, and modest traits that made Austin's characters stand out in the drawing rooms of local notables, with a good range of idiosyncratic failings to match. These natural attributes were enhanced by a substantial family fortune. Like sensible Mr Weston with his warm heart and easy financial circumstances, the two were general favourites: "always acceptable," as Emma Woodhouse said of Weston. Behind the scenes presided Mrs. Darwin, a clever, well-educated woman, at one time a friend of the novelist Maria Edgeworth, who now led a retired life, the female counter part to Mr. Woodhouse, "never quite well & never quite ill," according to her sister Kitty.

The Darwins like Austen's fictional families, lived in a sleepy market town in the countryside, in their case in Shrewsbury, the county capital of Shropshire, standing on the River Severn halfway between the manufacturing Midlands and Wales. Further downstream in the Severn Gorge smouldered William Hazledine's ironworks, the driving force of the Industrial Revolution. North-east sat the smoking chimneys of the Potteries. But Shrewsbury itself was untouched by any signs of industrial change.




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Dawkins on Chance

 
I know I'm going to be accused of beating a dead horse but as Emile Zucherkandl and Linus Pauling said in 1965 ...

Some beating of dead horses may be ethical, when here and there they display unexpected twitches that look like life.
It is absolutely safe to say that if you meet somebody who claims not to believe in evolution, that person is ignorant, stupid or insane (or wicked, but I’d rather not consider that).

Richard Dawkins
Richard Dawkins has reviewed Jerry Coyne's new book Why Evolution is True in The Times Literary Supplement. The text of the review is posted on RichardDawkins.net [Heat the Hornet].

As you might have guessed, when an adaptationist reviews a book by a fellow adapationist you can expect heaps of praise. Dawkins does not disappoint.

One particular claim caught my eye since Dawkins has made it in the past. I know for a fact that others have pointed out to Dawkins the flaws in this claim. Here's what he says,
Coyne is right to identify the most widespread misunderstanding about Darwinism as the idea that, in evolution, “everything happens by chance”. This common claim is flat wrong – obviously wrong, transparently wrong, even to the meanest intelligence (a phrase that has me actively restraining myself). If evolution worked by chance, it obviously couldn’t work at all.
It's true that to say everything happens by chance is wrong. However, it is not true to say that, "If evolution worked by chance, it obviously couldn’t work at all."

Here's a quotation from the most popular textbook on evolution, Evolution by Douglas J. Futuyma. It's in Chapter 10—a chapter titled Random Genetic Drift: Evolution at Random.

Almost all factors are affected simultaneously by both chance (unpredictable) and nonrandom, or deterministic (predictable), factors.... So it is with evolution. As we will see in the next chapter, natural selection is a deterministic, nonrandom process. But at the same time, there are important random processes in evolution, including mutation and random fluctuations in the frequencies of alleles or haplotypes: the process of random genetic drift.

Genetic drift and natural selection are the two most important causes of allele substitution—that is of evolutionary change—in populations
Futuyma closes the chapter with a summary of the important points. The first two are ...
  1. The frequencies of alleles that differ little or not at all in their effect on organisms' fitness (neutral alleles) fluctuate at random. This process, called random genetic drift, reduces genetic variation and leads eventually to the random fixation of one allele and the loss of the other., unless it is countered by other processes, such as gene flow or mutation.
  2. Different alleles are fixed by chance in different populations.
Thus, according to the textbook, evolution by chance occurs in spite of the fact that Dawkins says, "If evolution worked by chance, it obviously couldn’t work at all."

Now, the only way to reconcile his statement is to assume that either Dawkins doesn't know about random genetic drift, or he uses a non-standard definition of "evolution" (or he is wicked, but I’d rather not consider that ).

I know that Dawkins has written about random genetic drift so I have to assume that he uses a definition of the word "evolution" that excludes it. Since he is using a non-standard definition of evolution, I think it would be wise of him to make this clear in his writing. He should have written something like ...
In my opinion, the only valid mechanism of evolution is evolution by natural selection and that is definitely not a chance process. If natural selection worked by chance it obviously couldn't work at all.


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Wednesday, February 11, 2009

Nobel Laureate: Christian de Duve

 

The Nobel Prize in Physiology or Medicine 1974


"for their discoveries concerning the structural and functional organization of the cell"

Christian de Duve (1917 - ) won the Noble Prize in 1974 for discovering lysosomes and peroxisomes. He shared the prize with two other cell biologists; Albert Claude and George Palade.

Here's the Press Release.

THEME:
Nobel Laureates
Whereas Palade is in the first hand the morphologist searching the chemical correlate of the structures he has observed Christian de Duve is the biochemist who through his work can make predictions about new structural entities. Also the work of de Duve was a direct consequence of Claude's contributions in the area of chemical fractionation of cell components. de Duve started his work using differential centrifugation and he looked for the distribution of different enzymes among the four fractions resulting from Claude's procedure. These were nuclei, mitochondria (energy producers of the cell), microsomes (fragmented endoplasmic reticulum) and cell sap. He then found that certain enzymes sedimented such that they could not belong to any of the known morphological components. He discovered that they would sediment with a special class of particles, a fifth fraction. Interestingly all the enzymes were of a kind attacking protoplasmic components and de Duve therefore postulated that they had to be confined to membrane limited particles in order not to damage the cell. In accordance with this he found that agents dissolving membranes liberated the enzymes. It was soon possible for de Duve in collaboration with electron microscopists to make a morphological identification of the isolated components which were named lysosomes.

Lysosomes have now been shown, by de Duve and others, to be engaged in a series of cellular activities during which biological material must be degraded. The lysosomes are used in defense mechanisms, against bacteria, during resorption and secretion. They can also be used for a controlled degradation of the cell in which they are contained, e.g. to remove worn out components. Normally the cell is protected from the aggressive enzymes by protecting membranes but during certain conditions the lysosomal membranes may break down and the lysosomes are then real suicide pills for the cell. In medicine the lysosomes are of interest in many areas. There are a number of hereditary diseases with lysosomal enzyme deficiencies. This leads to accumulation of undigestible material in the lysosomes which swell and engorge the cell so as to prevent its proper functioning.

de Duve has not only a highly dominating role in lysosome research, he is also the discoverer of another cell component, the peroxisome, the function of which is still enigmatic but which may very well offer a story as fascinating as that of the lysosomes in the future.


The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.

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The Ottawa Citizen Should Be Ashamed of David Warren

 
David Warren writes for the Ottawa Citizen—an otherwise respectable newspaper. Denyse O'Leary is one of Warren's biggest fans. Today's column in the Citizen is about The doctrine of Darwin.

Here are some things that David Warren has to say. Trust me, I'm not making them up; you can check for yourself by following the link to the newspaper.

Darwin's contribution was the mechanism of natural (and later, sexual) selection. This mechanism was simultaneously proposed by Alfred Russel Wallace, a true genius who made many other signal observations and discoveries; but Darwin alone became obsessed with this one, and insisted that it could carry us beyond adaptation within a species, across natural barriers to the creation of entirely new forms, over eons of time. Wallace was not so sure, and to this day, Darwin's notion exists merely as a surmise. It has never been proven.

Which is its great strength. For what cannot be proven can never be disproven, either. The Darwinian account is merely belied by the fossil record, which has provided none of the inter-species "missing links" that Darwin anticipated, and which instead yields only sudden radical changes.
You have to wonder about the intelligence of someone who can write as an authority on Darwin while remaining completely ignorant of the entire field of paleontology. Does Warren go out of his way to avoid reading anything by any science writers, who have been documenting all kinds of transitional fossils, even in the past year?
The man himself was very much a product of his age: a bourgeois Victorian adapted to an intellectual environment in which such fatuities as Utilitarianism and Malthusianism were in the air. In retrospect, he is a redundant character, for Wallace already had the theory, and many others could have drudged out Darwin’s specific points.
You don't have to read a biography of Darwin to recognize the stupidity of this assertion—although reading a book or two is probably a good idea before shooting off your mouth. No, you don't have to read a whole book to learn that Darwin developed the essence of his theory of natural selection more than 15 years before Wallace ever thought of such a thing. Furthermore, Darwin was far, far, ahead of Wallace in his thinking about evolution. Darwin's genius lay in presenting the case for evolution in a way that Wallace—and no one else that we know of—ever could.

All you have to do to find this out is read some rather short articles, or Wikipedia. Is that too much to ask?

As if that's not bad enough, Denyse O'Leary quotes a birthday greeting from David Warren on her blog [Darwinism: Well then, no birthday cake for you, David!].
I oppose Darwinism because it is an intellectual & scientific fraud. I have opposed it all my adult life on that account alone; as I've told you before, I opposed it as crap science when I was an atheist. But I oppose it today with greater & greater passion, because I see that it provides the cosmological groundwork for real evil.
Is that the sort of person who should be writing 200th birthday greetings for the Ottawa Citizen?


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Not Saint Darwin

 
John Wilkins has posted a link to his essay in Resonance. Go to his blog (Evolving Thoughts), click on the link, read, and enjoy.

I can't think of an essay/article that better captures the essential reason why Darwin made such an important contribution to science. It takes a philosopher to make the case.1

Here's a teaser ... there's much more were this comes from ....

What we remember Darwin for is a synthesis and the empirical support he brought in its defense. He brought together many ideas that were `in the air', so to speak, reading more widely than almost anyone else as well as doing his experimental and anatomical work, and more importantly, managed to filter out most of the bad ideas.

Darwin's achievement was to identify crucial questions and offer a coherent theoretical account that answered them . For instance, in the first half of the nineteenth century, the reasons for the systematic arrangements of plants and animals, why they were arranged 'group with in group' as he put it, was being explored by idealists like William Swainson [12] and William Macleay [13], who offered Pythagorean accounts based on similarities and magic numbers. Darwin offered a general account—which we call common descent—that explained why this was a fact, but also why it was not regular (for example, extinction is not evenly distributed across all groups).

The broader point I want to make here is about the nature of science. Often as not, it is the synthesizers who reorganize how we view things, and as David Hull [14] and others (e.g., Ellegard [15]) have shown, within ten years of the publication of the Origin, nearly all specialists in the sciences concerned had adopted common descent and transmutation (descent with modification). It was the closest any science has ever come to an actual Kuhnian paradigm shift.


1. Perhaps I should say a "good" philosopher since there are others (Dennett, Ruse) who seem to have missed the point.

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Evolution is not "survival of the fittest"

 
By the 6th edition of Origin of Species Darwin had begun to adopt the term "survival of the fittest" and a synonym for "natural selection." His decision was prompted by several colleagues, notably Alfred Russel Wallace. The term "survival of the fittest had recently been coined by Herbert Spencer.

Unfortunately, modern society interprets "survival of the fittest" to mean that only the strong survive. They think of evolution in terms of a winner take all competition between the weak and the strong.

I was reminded of this misconception a few nights ago at our book club meeting. We were discussing Origin of Species and every single member of the group viewed evolution in these terms. Much of the discussion was about the future of human evolution and the book club members were fixated on what kind of mutations would make us stronger and better. What would happen to the poor individuals who couldn't compete?

Michael Shermer has written a nice article in the latest issue of Scientific American: A Skeptic's Take on the Public Misunderstanding of Darwin. His main point deserves to be widely publicized.

Natural selection simply means that those individuals with variations better suited to their environment leave behind more offspring than individuals that are less well adapted. This outcome is known as “differential reproductive success.” It may be, as the second myth holds, that organisms that are bigger, stronger, faster and brutishly competitive will reproduce more successfully, but it is just as likely that organisms that are smaller, weaker, slower and socially cooperative will do so as well.

This second notion in particular makes evolution unpalatable for many people, because it covers the theory with a darkened patina reminiscent of Alfred, Lord Tennyson’s “nature, red in tooth and claw.” Thomas Henry Huxley, Darwin’s “bulldog” defender, promoted this “gladiatorial” view of life in a series of popular essays on nature “whereby the strongest, the swiftest, and the cunningest live to fight another day.” The myth persists. In his recent documentary film Expelled: No Intelligence Allowed, Ben Stein linked Darwinism to Communism, Fascism and the Holocaust.


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Jerry Coyne on Darwinism

 
Jerry Coyne is an adaptationist. Thus, it comes as no great surprise that he is comfortable with equating evolutionary biology and Darwinism. Here's what he writes in defense of Carl Safina's New York Times article [Darwinism must die????].

Well, how much confusion has really been caused by using the term “Darwinism”? How many people have been made to think that we biologists adhere to an ideology rather than a strongly supported theory?
That's a tough question. I'd estimate it at about 3 billion but I could be off by a factor of two.
Would creationism and its country cousin, intelligent design, suddenly vanish if we started using the terms “modern evolutionary theory” (ugh!) or the insidious-sounding “neoDarwinism”? I don’t think so.
Nope. The problem isn't so much how the IDiots interpret the term "Darwinism," it's how the average evolution supporter interprets it. The average person seems to be completely unaware of the fact that natural selection doesn't explain everything about common descent. They are surprised to learn that many modern scientist are not adaptationists or confirmed traditional Darwinists.
“Darwinism” is a compact, four-syllable term for “modern evolutionary theory,” which is ten syllables long.
No it is not. Nobody in their right mind would claim that random genetic drift—the dominant mechanism of evolution—is Darwinian. Nobody in their right mind would suggest that it is just a slight modification of natural selection.

Today we know that new beneficial mutations have only a slight chance of becoming fixed in a population. We know that deleterious mutations can become fixed. And we know that a large percentage of mutations are completely invisible to natural selection but they can, nevertheless, become fixed.

Ryan Gregory made the same point in his posting: Jerry Coyne on Darwinism. So did Eugenie C. Scott and Glenn Branch in Don't Call it "Darwinism".

Jerry Coyne is not stupid. He's well aware of the fact that Darwin didn't know everything. But according to Coyne, the expansion of evolutionary theory hasn't amounted to anything more than simple "refinement" and the term "Darwinism" still encompasses the essence of modern evolutionary theory.

Apparently Coyne has an article about to appear in Current Biology where he says ....
Still, these advances amount to refinements of Darwinism rather than its Kuhnian overthrow. Evolutionary biology hasn’t suffered the equivalent of quantum mechanics. But some biologists, chafing in their Darwinian straitjacket, periodically announce new worldviews that, they claim, will overturn our view of evolution, or at least force its drastic revision. During my career I have heard this said about punctuated equilibrium, molecular drive, the idea of symbiosis as an evolutionary force, evo-devo, and the notion that evolution is driven by the self-organization of molecules. Some of these ideas are worthwhile, others simply silly; but none do more than add a room or two to the Darwinian manse. Often declared dead, Darwinism still refuses to lie down. So by all means let’s retain the term. It is less of a jawbreaker than “modern evolutionary biology,” and has not, as was feared, misled people into thinking that our field has remained static since 1859. What better honorific than “Darwinism” to fĂªte the greatest biologist in history?
This is a remarkable bit of writing. Every modern textbook on evolution has a large section devoted to random genetic drift as a fundamental mechanism of evolution and yet Coyne doesn't even mention it. He also doesn't mention population genetics. Isn't that strange?


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Kill all the science writers?

 
Several bloggers are upset enough at Carl Safina that they have posted detailed critiques of his article in the New York Times: Darwinism Must Die So That Evolution May Live.

I not so upset. In fact I mostly agree with the opening paragraphs of Safina's article ...

Equating evolution with Charles Darwin ignores 150 years of discoveries, including most of what scientists understand about evolution. Such as: Gregor Mendel’s patterns of heredity (which gave Darwin’s idea of natural selection a mechanism — genetics — by which it could work); the discovery of DNA (which gave genetics a mechanism and lets us see evolutionary lineages); developmental biology (which gives DNA a mechanism); studies documenting evolution in nature (which converted the hypothetical to observable fact); evolution’s role in medicine and disease (bringing immediate relevance to the topic); and more.

By propounding “Darwinism,” even scientists and science writers perpetuate an impression that evolution is about one man, one book, one “theory.” The ninth-century Buddhist master Lin Chi said, “If you meet the Buddha on the road, kill him.” The point is that making a master teacher into a sacred fetish misses the essence of his teaching. So let us now kill Darwin.
However, it gets worse from then on and this opens the door for serious criticism. Read P.Z. Myers (Darwin is already dead, and we know it) and John Pieret (Charles Darwin Superstar).

I especially like one of the paragraphs from John's posting1 ...
Science writers are a different matter altogether, however. But why should Darwin suffer for their sins? Wouldn't the more efficacious solution be to kill all the science writers? It would at least make a refreshing change from lawyers.


1. John is a lawyer.

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Tuesday, February 10, 2009

Fire the Professors!

 
Colleges and universities in Georgia (USA) have faculty members who are experts on human sexual behavior. Horrors!

Here's what one state legislator thinks they should do about it. Wait 'till Ben Stein hears about this!




[Hat Tip: Reed Cartwright on De Rerum Natura]

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Darwin: Difficulties on Theory

 
Darwin devoted an entire chapter (Chapter VI) to Difficulties on Theory. This is a remarkable chapter since it addresses head-on the most serious objections to his theory of natural selection.

We'd like to think that this behavior—bringing up objections to your ideas—is standard operating procedure for most scientists but, alas, it is a lost art. You would be hard pressed to find a modern science book where an author makes an effort to address criticisms in a fair and rational manner.

Long before having arrived at this part of my work, a crowd of difficulties will have occurred to the reader. Some of them are so grave that to this day I can never reflect on them without being staggered; but, to the best of my judgment, the greater number are only apparent, and those that are real are not, I think, fatal to my theory.

These difficulties and objections may be classed under the following heads:-Firstly, why, if species have descended from other species by insensibly fine gradations, do we not everywhere see innumerable transitional forms? Why is not all nature in confusion instead of the species being, as we see them, well defined?

Secondly, is it possible that an animal having, for instance, the structure and habits of a bat, could have been formed by the modification of some animal with wholly different habits? Can we believe that natural selection could produce, on the one hand, organs of trifling importance, such as the tail of a giraffe, which serves as a fly-flapper, and, on the other hand, organs of such wonderful structure, as the eye, of which we hardly as yet fully understand the inimitable perfection?

Thirdly, can instincts be acquired and modified through natural selection? What shall we say to so marvellous an instinct as that which leads the bee to make cells, which have practically anticipated the discoveries of profound mathematicians?

Fourthly, how can we account for species, when crossed, being sterile and producing sterile offspring, whereas, when varieties are crossed, their fertility is unimpaired?
The rest of the chapter is a discussion of possible explanations to account for the first two difficulties. The two others are addressed in separate chapters (Chaper VII: Instinct and Chapter VIII: Hybridism).


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Monday's Molecule #107: Winners

 
The red arrow points to a lysosome and the blue arrows identify peroxisomes. The man who discovered and characterized these organelles is Christian de Duve (1974)

This week's winners are regulars: Dima Klenchin of the University of Wisconsin and undergraduate Alex Ling of the University of Toronto.



This Monday's "molecule" looks a lot like an electron micrograph of a cell instead of a molecule. That's because it's hard to connect a specific molecule with some Nobel Laureates. Your task today is to identify the two things identified by the red and blue arrows.

There's one Nobel Laureate who is closely identified with the discovery of these two things. Name this Nobel Laurete.

The first person to identify the images and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are eight ineligible candidates for this week's reward: Bill Chaney of the University of Nebraska, Maria Altshuler of the University of Toronto, Ramon, address unknown, Jason Oakley of the University of Toronto, John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), Wesley Butt of the University of Toronto, David Schuller of Cornell University, and Nova Syed of the University of Toronto.

Bill, John, and David have offered to donate their free lunch to a deserving undergraduate so the next two undergraduates to win and collect a free lunch can also invite a friend. Since undergraduates from the Toronto region are doing better in this contest, I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.


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Westminster Abbey: Darwin vs Newton

 
Charles Darwin died on April 19, 1882. His friends arranged for him to be buried in Westminster Abbey, an honor befitting the greatest scientist who ever lived.

Here's a excerpt from the Westminster Abbey website [Charles Darwin].

The Dean of Westminster, George Granville Bradley, was away in France when he received a telegram forwarded from the President of the Royal Society in London saying “…it would be acceptable to a very large number of our fellow-countrymen of all classes and opinions that our illustrious countryman, Mr Darwin, should be buried in Westminster Abbey”. The Dean recalled “ I did not hesitate as to my answer and telegraphed direct…that my assent would be cheerfully given”. The body lay overnight in the Abbey, in the small chapel of St Faith, and on the morning of 26 April the coffin was escorted by the family and eminent mourners into the Abbey. The pall-bearers included Sir Joseph Hooker, Alfred Russel Wallace, James Russell Lowell (U.S. Ambassador), and William Spottiswoode (President of the Royal Society).

The burial service was held in the Lantern, conducted by Canon Prothero, with anthems sung by the choir. The chief mourners then followed the coffin into the north aisle of the Nave where Darwin was buried next to the eminent scientist Sir John Herschel, and a few feet away from Sir Isaac Newton. The simple inscription on his grave reads “CHARLES ROBERT DARWIN BORN 12 FEBRUARY 1809. DIED 19 APRIL 1882”. Although an agnostic, Darwin was greatly respected by his contemporaries and the Bishop of Carlisle, Harvey Goodwin, in a memorial sermon preached in the Abbey on the Sunday following the funeral, said “I think that the interment of the remains of Mr Darwin in Westminster Abbey is in accordance with the judgment of the wisest of his countrymen…It would have been unfortunate if anything had occurred to give weight and currency to the foolish notion which some have diligently propagated, but for which Mr Darwin was not responsible, that there is a necessary conflict between a knowledge of Nature and a belief in God…”.
Darwin's grave is simple and very much in keeping with typical British understatement. Everyone knows who Charles Darwin is. It occupies a prime location near many other scientists. Unfortunately, it is not as close to the grave of Charles Lyell as Emma Darwin would have liked.

Isaac Newton is buried nearby. His tomb is a little more gaudy and glittery than Darwin's as if his supporters needed to prove something that wasn't obvious.

Here's another image of Newton's tomb. You can't image anyone writing a book about how Charles Darwin was part of a conspiracy to protect the descendants of Jesus, can you? Somehow this seems perfectly believable for Newton.



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Books by Charles Darwin

 
Most people don't seem to appreciate the depth and breadth of Darwin's work. Someone posted a comment on a recent Sandwalk thread arguing that Darwin was a "one trick pony" compared to Isaac Newton. This is hard to justify when you scan the variety of scientific articles that Darwin published in his lifetime and you consider the record of his scientific correspondance—much of which has been preserved.

But setting all that aside, the list of books that he published gives us a fair impression of the range of subjects that Darwin covered. I'm not even sure that this list is complete.

This list of Darwin's books is not meant to belittle the contributions of Isaac Newton, that other contender for world's best scientist. After all, we all know that in addition to Principia, Newton also wrote numerous works on the interpretation of the Bible (e.g. Observations on Daniel and The Apocalypse of St. John (1733)) and he spent a lot of time studying alchemy. Newton predicted that the world would end in 2060 and Newton followers will no doubt become very anxious as we approach that date.

Books by Charles Darwin

  • The structure and distribution of coral reefs. Being the first part of the geology of the voyage of the Beagle, under the command of Capt. Fitzroy, R.N. during the years 1832 to 1836. (1842)

  • Geological observations on the volcanic islands visited during the voyage of H.M.S. Beagle, together with some brief notices of the geology of Australia and the Cape of Good Hope. Being the second part of the geology of the voyage of the Beagle, under the command of Capt. Fitzroy, R.N. during the years 1832 to 1836. (1844)

  • Geological observations on South America. Being the third part of the geology of the voyage of the Beagle, under the command of Capt. Fitzroy, R.N. during the years 1832 to 1836. (1846)

  • Narrative of the surveying voyages of His Majesty's Ships Adventure and Beagle between the years 1826 and 1836, describing their examination of the southern shores of South America, and the Beagle's circumnavigation of the globe. (1839)

  • A monograph of the sub-class Cirripedia, with figures of all the species. The Lepadidae; or, pedunculated cirripedes. [Vol. 1] (1851)

  • A monograph of the sub-class Cirripedia, with figures of all the species. The Balanidae, (or sessile cirripedes); the Verrucidae. [Vol. 2] (1854)

  • A monograph on the fossil Lepadidae, or, pedunculated cirripedes of Great Britain. [Vol. 1] (1851)

  • A monograph on the fossil Balanidae and Verrucidae of Great Britain. [Vol. 2] (1855)

  • On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life (1st ed.) (1859), 2nd ed (1860). 3rd ed. (1861) , 4th ed. (1866), 5th ed. (1869), 6th ed. (1872)

  • On the various contrivances by which British and foreign orchids are fertilised by insects. (1862), 2nd ed. (1877)

  • The expression of the emotions in man and animals. (1872)

  • Insectivorous plants. (1875), 2nd. ed. (1888)

  • The movements and habits of climbing plants. (1875)

  • The effects of cross and self fertilisation in the vegetable kingdom. (1876), 2nd ed. (1878)

  • The variation of animals and plants under domestication. (1868), 2nd ed. (1875)

  • The Descent of Man, and Selection in Relation to Sex (1st ed.) (1871), 2nd ed. (1882)

  • The Expression of the Emotions in Man and Animals. (1872)

  • The structure and distribution of coral reefs. 2d ed. (1872)

  • Geological observations on the volcanic islands and parts of South America visited during the voyage of H.M.S. 'Beagle'. 2d ed. (1876)

  • The power of movement in plants. (1880)

  • The formation of vegetable mould, through the action of worms. (1881)

  • The Autobiography of Charles Darwin 1809–1882. (unpublished until 1958)


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Monday, February 09, 2009

Who is this man, and why is he smiling?

 
Find out in today's Toronto Star [Darwin still spurs tributes, debates].



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Evolution of Pine Genomes

 
There are about 120 species of pine trees (genus Pinus). Their genome sizes range from 18,000 Mbp to 40,000 Mbp, which is about 6x - 13x the size of mammalian genomes.

In some species the increase in genome size among closely related species is due to polyploidization but that's not the case with pine species. All of them have 24 chromosomes and the differences in DNA content are due to increases in the lenghts of the chromosomes.

It's possible that different species of pine could have larger or smaller gene families. This would mean that the species with larger genomes have many more copies of some genes than species with smaller genomes. However, this is unlikely to account for much of the difference since simultaneous duplication events in all parts of the genome.

The most logical explanation is an increase in the amount of junk DNA, specifically the number of retrotransposons. Flowering plants have retrotrapsposons with long terminal repeats (LTRs) just like those found in animal genomes [Junk in your Genome: LINEs].

Morse et al. (2009) have studied the retrotransposons in Pinus taeda and related species. The discovered a new retrotransposon family called Gymny that appears to be confined to Pinus taeda and very closely related members of the same subgenus. Each Gymny element is 6.2 kb in length and the genome contains about 22,000 copies. The total amount of Gymny DNA is equivalent to the size of the Arabidopsis genome (157 Mbp).

In addition to the full length copies there are many fragments of Gymny retrotransposons and probably many degenerated copies that can no longer be readily detected. The copies are spread out over all chromosomes as shown in the photograph. (Gymny sequences are stained red.)

In addition to Gymny, the authors also found other abundant retrotransposons in the Pinus taeda genome (e.g. Gyspy and Copia) but the Gymny elements appear to be confined to a subset of species in the Pinus genus. They are not found in other flowering plants.

The evolutionary history of these Pinus species suggests that there was a huge expansion of Gymny elements about 50 Myr ago and the expansion of retrotransposons accounts for much of the increase in genome size among these species.

There are now several examples of genome size increase due to expansion in the number of retrotransposons. The authors discuss several of these previously known cases.

It is difficult to imagine how a huge increase in the amount of retrotransposon DNA could be a selective advantage in some species. The most reasonable explanation is that these sequences play no significant role in the life of the organism. It's just junk DNA that's not harmful.


[Photo Credit: Pinus taeda, loblolly pine]

Morse, A.M., Peterson, D.G., Islam-Faridi ,M.N., Smith, K.E., Magbanua, Z., et al. (2009) Evolution of Genome Size and Complexity in Pinus. PLoS ONE 4(2): e4332. [doi:10.1371/journal.pone.0004332]

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The Bishop Is Offended

 
Donate to The Canadian Atheist Bus Campaign and get those atheist signs on Canada's buses and subways.

It's going to happen in Toronto, and Calgary is probably the next city according to the Freethought Association. An article in last week's Calgary Herald highlights some of the opposition to the atheist campaign [Calgary next for atheist bus ads, activist group says].

Calgary Catholic Bishop Fred Henry said the ideal date to launch such a campaign would be April Fool's Day.

"I don't know what the norms Calgary Transit uses to accept advertising, but if the benchmark is that it should be non-offensive, I'm offended," said Henry.

"This is insulting to us. The interfaith dialogue that goes on in this city is characterized by deep respect for all the individual players."

Henry characterized the ad's message as aggressive, inward-looking, self-indulgent and narcissistic.
"Aggressive, inward-looking, self-indulgent and narcissistic," now that's offensive. Is this what Bishop Henry means by "deep respect for all the individual players"?


[Hat Tip: Jeffrey Shallit at Recursivity.]

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Tour Darwin's House

 
Down House, home of Charles Darwin, has been closed for renovations but it reopens this week in time to celebrate Darwin's birthday. You can take a video tour on the BBC website [At home with Darwin... 200 years on].

Of course there's nothing like being there yourself and walking on the Sandwalk. I went with a friend1 in 2006 and I'd love to go back.


1. I've been there!.

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Monday's Molecule #107

 
This Monday's "molecule" looks a lot like an electron micrograph of a cell instead of a molecule. That's because it's hard to connect a specific molecule with some Nobel Laureates. Your task today is to identify the two things identified by the red and blue arrows.

There's one Nobel Laureate who is closely identified with the discovery of these two things. Name this Nobel Laurete.

The first person to identify the images and the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first won the prize.

There are eight ineligible candidates for this week's reward: Bill Chaney of the University of Nebraska, Maria Altshuler of the University of Toronto, Ramon, address unknown, Jason Oakley of the University of Toronto, John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), Wesley Butt of the University of Toronto, David Schuller of Cornell University, and Nova Syed of the University of Toronto.

Bill, John, and David have offered to donate their free lunch to a deserving undergraduate so the next two undergraduates to win and collect a free lunch can also invite a friend. Since undergraduates from the Toronto region are doing better in this contest, I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours.


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Darwin on Uniformitarianism

 
Charles Darwin was a fan of Charles Lyell (1797 - 1875). Lyell's three volume work Principles of Geology did much to convince Darwin that the Earth was very old and that geological change took place slowly over the course of millions of years. This principle of slow, gradual change is called uniformitarianism and it was meant to refute the idea that major geological structures are the result of sudden catastrophic events. Lyell's geology is inconsistent with a great deluge.

Darwin saw his efforts to explain evolution and refute special creation as a way to incorporate uniformitarianism into biology. In Chapter IV: Natural Selection he writes,

I am well aware that this doctrine of natural selection, exemplified in the above imaginary instances, is open to the same objections which were at first urged against Sir Charles Lyell's noble views on 'the modern changes of the earth, as illustrative of geology;' but we now very seldom hear the action, for instance, of the coast-waves, called a trifling and insignificant cause, when applied to the excavation of gigantic valleys or to the formation of the longest lines of inland cliffs. Natural selection can act only by the preservation and accumulation of infinitesimally small inherited modifications, each profitable to the preserved being; and as modern geology has almost banished such views as the excavation of a great valley by a single diluvial wave, so will natural selection, if it be a true principle, banish the belief of the continued creation of new organic beings, or of any great and sudden modification in their structure.


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Sunday, February 08, 2009

Don't Call It "Darwinism"

 
Eugenie C. Scott and Glenn Branch have written an article for the latest issue of Evolution: Education and Outreach in which they urge everyone to talk about evolutionary biology but Don’t Call it “Darwinism”.

Using “Darwinism” as synonymous with “evolutionary biology” is thus a touch unfair to the men and women who have contributed to the scientific edifice to which Darwin provided the cornerstone, including (to name a few) Wallace, Huxley, Weisman, De Vries, Romanes, Morgan, Weidenreich, Teilhard, von Frisch, Vavilov, Wright, Fisher, Muller, Haldane, Dobzhansky, Rensch, Ford, McClintock, Simpson, Hutchinson, Lorenz, Mayr, DelbrĂ¼ck, Jukes, Stebbins, Tinbergen, Luria, Maynard Smith, Price, Kimura, Ostrom, Wilson, Hamilton, and Gould, to say nothing of even more who are still contributing to evolutionary biology. As Olivia Judson (2008) recently commented, terms like “Darwinism” “suggest a false narrowness to the field of modern evolutionary biology, as though it was the brainchild of a single person 150 years ago, rather than a vast, complex and evolving subject to which many other great figures have contributed.”


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Darwin: "I am fully convinced that species are not immutable ..."

 
One of the most famous passages in Origin of Species can be found at the end of the introduction where Darwin makes it very clear that his ideas are meant to challenge special creation.

Although much remains obscure, and will long remain obscure, I can entertain no doubt, after the most deliberate study and dispassionate judgement of which I am capable, that the view which most naturalists entertain, and which I formerly entertained — namely, that each species has been independently created — is erroneous. I am fully convinced that species are not immutable; but that those belonging to what are called the same genera are lineal descendants of some other and generally extinct species, in the same manner as the acknowledged varieties of any one species are the descendants of that species. Furthermore, I am convinced that Natural Selection has been the main but not exclusive means of modification.


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Darwin on Variation

 
Variation, or what we might call mutation, is the raw material on which natural selection acts. Charles Darwin demonstrated that variation was common in many species but he did not know the cause. It wasn't until fifty years after the publication of Origin of Species that geneticists began to understand that mutations were random and spontaneous.

Today we know that most mutations result from errors in replicating DNA and that they arise independently of any effect they might have on the organism.

Here's how Darwin thought of variation in Chapter V: Laws of Variation. He believed that variations arose as a result of the conditions of life and that some variations were due to the use or disuse of organs.

I HAVE hitherto sometimes spoken as if the variations so common and multiform in organic beings under domestication, and in a lesser degree in those in a state of nature had been due to chance. This, of course, is a wholly incorrect expression, but it serves to acknowledge plainly our ignorance of the cause of each particular variation. Some authors believe it to be as much the function of the reproductive system to produce individual differences, or very slight deviations of structure, as to make the child like its parents. But the much greater variability, as well as the greater frequency of monstrosities, under domestication or cultivation, than under nature, leads me to believe that deviations of structure are in some way due to the nature of the conditions of life, to which the parents and their more remote ancestors have been exposed during several generations.


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Dawkins on Darwin

 
Here's a series of videos from the National Geographic Channel. Richard Dawkins explains ...

  1. The Importance of Charles Darwin
  2. Fossils and Darwin
  3. Why Darwin Was Right
  4. On Creationism
  5. On God and the Universe
Each one is only about 2 minutes long. They are all excellent. Everyone should watch them and learn.


[Hat Tip: RichardDawkins.net]

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Saturday, February 07, 2009

National Geographic: What Darwin Didn't Know

 
The main article in the February issue of National Geographic is by science writer Matt Ridley and it's title is Modern Darwins. Here's a quick summary of the article.

Charles Darwin didn't know about DNA so he wasn't aware of the power of molecular evolution and he didn't know that we could trace ancestry by comparing sequences.

Darwin didn't know that we would be able to identify and isolate the genes responsible for natural selection.

Darwin's greatest idea was that natural selection is largely responsible for the variety of traits one sees among related species. Now, in the beak of the finch and the fur of the mouse, we can actually see the hand of natural selection at work, molding and modifying the DNA of genes and their expression to adapt the organism to its particular circumstances.
So Darwin was right about the idea that natural selection is the mechanism that generates most traits among related species.

Darwin thought that evolution was slow but we now know that it can occur very quickly.

Darwin didn't know about the FOXP2 gene.

Darwin was right about sexual selection.

Darwin didn't know that his blue eyes were due to a mutation in the OCA2 gene but he would be happy to know that the trait probably spread by sexual selection.

Darwin didn't know about genetic switches and he didn't know that changes in gene expression could explain the "humiliating surprise" that we have the same number of genes as a mouse.

Darwin didn't know about Tiktaalik, a transitional fossil that show how fish evolved into amphibians.

Darwin's biggest mistake was his messy ideas about genetics. He didn't know about Mendel and particulate inheritance.

That's about it. Apparently Darwin knew about everything else.


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Darwin's Tree of Life

 
On reading Origin of Species one can't help but be struck by Darwin's insight and intellect. His description of the tree of life from the summary of Chapter 4: Natural Selection is just one example.

As you read the passage, note how Darwin emphasizes competition between species. This was an important theme in Origin of Species. Modern evolutionary theory tends to describe natural selection as a competition between individuals within a species.

The affinities of all the beings of the same class have sometimes been represented by a great tree. I believe this simile largely speaks the truth. The green and budding twigs may represent existing species; and those produced during each former year may represent the long succession of extinct species. At each period of growth all the growing twigs have tried to branch out on all sides, and to overtop and kill the surrounding twigs and branches, in the same manner as species and groups of species have tried to overmaster other species in the great battle for life. The limbs divided into great branches, and these into lesser and lesser branches, were themselves once, when the tree was small, budding twigs; and this connexion of the former and present buds by ramifying branches may well represent the classification of all extinct and living species in groups subordinate to groups. Of the many twigs which flourished when the tree was a mere bush, only two or three, now grown into great branches, yet survive and bear all the other branches; so with the species which lived during long-past geological periods, very few now have living and modified descendants. From the first growth of the tree, many a limb and branch has decayed and dropped off; and these lost branches of various sizes may represent those whole orders, families, and genera which have now no living representatives, and which are known to us only from having been found in a fossil state. As we here and there see a thin straggling branch springing from a fork low down in a tree, and which by some chance has been favoured and is still alive on its summit, so we occasionally see an animal like the Ornithorhynchus or Lepidosiren, which in some small degree connects by its affinities two large branches of life, and which has apparently been saved from fatal competition by having inhabited a protected station. As buds give rise by growth to fresh buds, and these, if vigorous, branch out and overtop on all sides many a feebler branch, so by generation I believe it has been with the great Tree of Life, which fills with its dead and broken branches the crust of the earth, and covers the surface with its ever branching and beautiful ramifications.


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Friday, February 06, 2009

What Causes Speciation?

 
The latest issue or Science magazine contains a number of articles on speciation.

The one that most interests me is Schluter (2009), a paper that discusses mechanisms of speciation. Schulter begins with ...

It took evolutionary biologists nearly 150 years, but at last we can agree with Darwin that the origin of species, "that mystery of mysteries" (1), really does occur by means of natural selection (2–5). Not all species appear to evolve by selection, but the evidence suggests that most of them do. The effort leading up to this conclusion involved many experimental and conceptual advances, including a revision of the notion of speciation itself, 80 years after publication of On the Origin of the Species, to a definition based on reproductive isolation instead of morphological differences (6, 7).
I've heard this a lot recently but it doesn't make sense to me. How could the evolution of reproductive isolation be selected?
The main question today is how does selection lead to speciation? What are the mechanisms of natural selection, what genes are affected, and how do changes at these genes yield the habitat, behavioral, mechanical, chemical, physiological, and other incompatibilities that are the reproductive barriers between new species? As a start, the many ways by which new species might arise by selection can be grouped into two broad categories: ecological speciation and mutation-order speciation. Ecological speciation refers to the evolution of reproductive isolation between populations or subsets of a single population by adaptation to different environments or ecological niches (2, 8, 9). Natural selection is divergent, acting in contrasting directions between environments, which drives the fixation of different alleles, each advantageous in one environment but not in the other. Following G. S. Mani and B. C. Clarke (10), I define mutation-order speciation as the evolution of reproductive isolation by the chance occurrence and fixation of different alleles between populations adapting to similar selection pressures. Reproductive isolation evolves because populations fix distinct mutations that would nevertheless be advantageous in both of their environments. The relative importance of these two categories of mechanism for the origin of species in nature is unknown.
Is there an expert on speciation out there who can explain this? I understand how two incipient species can adapt to different environments and become morphologically distinct but I don't understand how this kind of adaptation leads to selection for reproductive isolation. This is a problem that we discussed earlier [Testing Natural Selection: Part 2].

The second mechanism is even more difficult for me. I understand how chance mutations can arise and become fixed but to my mind this isn't natural selection. It's speciation by random genetic drift. It's just an accident that the mutations being fixed in the separated populations happen to lead to reproductive isolation.

Schluter tells us that mutation-order speciation is "distinct from genetic drift." He seems to refer to it as "selection" of some sort without explaining why. ("The unidentified component of speciation, if built by selection and not genetic drift, could be the result of either ecological or mutation-order mechanisms.") He says that the mutations that give rise to reproductive isolation are "advantageous" in both populations but they just happened to occur in one of them and not the other. Again, the question is what sort of mutations favoring reproductive isolation would be "advantageous," and therefore selected?

If the mutation arises later on in the other species will it sweep to fixation and remove the reproductive isolation barrier?

It's not clear to me that we have identified the mechanisms of reproductive isolation in a large number of examples. Schluter seems to agree,
The most obvious shortcoming of our current understanding of speciation is that the threads connecting genes and selection are still few. We have many cases of ecological selection generating reproductive isolation with little knowledge of the genetic changes that allow it. We have strong signatures of positive selection at genes for reproductive isolation without enough knowledge of the mechanisms of selection behind them. But we hardly have time to complain. So many new model systems for speciation are being developed that the filling of major gaps is imminent. By the time we reach the bicentennial of the greatest book ever written, I expect that we will have that much more to celebrate.
Given our lack of knowledge how can biologists be so confident that Darwin was right? How do they know that most speciations are due to natural selection and not random genetic drift—especially since drift and accident seem to be intuitively more likely?

Is this an example of adaptationist bias or is there really lots of evidence to support speciation by natural selection?


Schluter, D. (2009) Evidence for Ecological Speciation and Its Alternative. Science 323: 737 - 741 [DOI: 10.1126/science.1160006]

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Evolution Explains Taxonomy

 
Charles Darwin advanced many different arguments in support of his claim that life has evolved. One of the most potent arguments is that evolution explains the classification scheme proposed by Linnaeus and used by all naturalists in the early part of the nineteenth century.

The following passage is from the summary of Chapter 4: Natural Selection in Origin of Species.

It is a truly wonderful fact the wonder of which we are apt to overlook from familiarity that all animals and all plants throughout all time and space should be related to each other in group subordinate to group, in the manner which we everywhere behold namely, varieties of the same species most closely related together, species of the same genus less closely and unequally related together, forming sections and sub-genera, species of distinct genera much less closely related, and genera related in different degrees, forming sub-families, families, orders, sub-classes, and classes. The several subordinate groups in any class cannot be ranked in a single file, but seem rather to be clustered round points, and these round other points, and so on in almost endless cycles. On the view that each species has been independently created, I can see no explanation of this great fact in the classification of all organic beings; but, to the best of my judgment, it is explained through inheritance and the complex action of natural selection, entailing extinction and divergence of character, as we have seen illustrated in the diagram.


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Nature tells the world scientific community about Canada's lack of support for science

 
The latest issue of Nature reports on Prime Minister Stephen Harper's plan to slash the budgets of the major granting agencies [Cash concerns for Canadian scientists].

Billions of dollars in science infrastructure investments have been overshadowed by cuts to major grant-funding programmes in Canada's federal budget....

Although the budget does contain Can$87.5 million for graduate-student scholarships, the research community is perplexed by the government's decision to cut funding to Canada's three federal granting councils. Over three years, the budgets of the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council and the Social Sciences and Humanities Research Council will be reduced by almost Can$148 million. "It's an unfortunate consequence of getting poor advice or not listening to good advice," says Aled Edwards, a structural biologist at the University of Toronto, Ontario, and director and chief executive of the international Structural Genomics Consortium. He argues that the most efficient way to invest in research is through the funding councils, where peer review determines where the dollars are spent....

But the long-term effect of cutting funds for research may be that Canadian scientists will take their research south of the border, says Edwards. Canada's research funding pales in comparison with that in the United States, and the latest budget threatens to widen the gap between the two countries, he adds. "We're at serious risk of a brain drain."


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Thursday, February 05, 2009

Nobel Laureates: John B. Fenn and Koichi Tanaka

 

The Nobel Prize in Chemistry 2002.

"for their development of soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules"

John B. Fenn (1917 - ) and Koichi Tanaka (1959 - ) were awarded the Nobel Prize for developing techniques using mass spectrometry to determine the molecular mass of proteins and peptides. Here's the Press Release describing their achievements.

THEME:
Nobel Laureates

Mass spectrometry is a very important analytical method used in practically all chemistry laboratories the world over. Previously only fairly small molecules could be identified, but John B. Fenn and Koichi Tanaka have developed methods that make it possible to analyse biological macromolecules as well.

In the method that John B. Fenn published in 1988, electrospray ionisation (ESI), charged droplets of protein solution are produced which shrink as the water evaporates. Eventually freely hovering protein ions remain. Their masses may be determined by setting them in motion and measuring their time of flight over a known distance. At the same time Koichi Tanaka introduced a different technique for causing the proteins to hover freely, soft laser desorption. A laserpulse hits the sample, which is “blasted” into small bits so that the molecules are released.


The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.

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Darwin Birthday Party in Toronto

 

Darwin Birthday Party

Starts: Friday, February 13th 2009 at 5:30 pm
Ends: Friday, February 13th 2009 at 7:00 pm
Location: Centre for Inquiry Ontario, 216 Beverley St, Toronto ON (1 minute south of College St at St. George St)

Come celebrate Darwin's Birthday! There will be cake, games and a toast to one of the greatest men in science who ever lived. Stick around for the Pre and Post Darwin Science talks that follow.

A CFI Members Exclusive Activity!

Pre- and Post-Darwinian Science

Starts: Friday, February 13th 2009 at 7:00 pm
Ends: Friday, February 13th 2009 at 9:30 pm
Location: Centre for Inquiry Ontario, 216 Beverley St, Toronto ON (1 minute south of College St at St. George St)

What was science like before Darwin, and how did it change after Darwin?

Larry Moran will be discussion our modern scientific world in light of the impact Darwin and his theory of evolution due to natural selection has had on it.

Larry Moran is a Professor in the Department of Biochemistry at the University of Toronto.

$5, $3 for students and FREE for Friends of the Centre


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Wednesday, February 04, 2009

Genomics, Proteomics and Mass Spectrometry

 
The explosion in sequence information as a result of various genome projects has resulted in many unexpected payoffs. One of them has to do with the identification of tiny amounts of unknown protein.

Many experiments in biochemistry and molecular biology lead to the recognition of a novel protein that hasn't been identified. For example, one could go fishing for proteins that bound to other proteins or look at the protein composition of various complexes.

Often the only thing one knows about the protein is its molecular weight on an SDS gel. You can cut out the band containing your protein of interest and extract the protein but that only gives you a tiny amount of denatured protein.

With the development of protein mass spectrometry it becomes possible to determine an accurate molecular weight of the protein [Biochemistry and Mass Spectrometry]. In theory, one could then compare this molecular weight to all the calculated molecular weights of all the proteins encoded in the genome. These calculated molecular weights can be determined from the genome sequence—if you're lucky enough to be working with an organism whose genome has been completely sequenced.

Unfortunately, there are many proteins with similar molecular weights so this straightforward technique doesn't work. However, if you digest the protein with enzymes that cut it several times at specific sites, you create group of peptide fragments. The molecular weights of the peptides can be determined by mass spec and the "fingerprint" of your unknown protein can be compared to calculated fingerprints of every protein in the proteome.

Here's an example of a tryptic digest of an unknown human protein of Mr = 90,000. The sizes of the various fragments can be measured accurately and compared to the predicted fragment sizes based on the known DNA sequence of the gene. If you're lucky, there is only one protein that will give rise to the observed peptides. Thus, the unknown protein can be unambiguously identified from the mass of its peptides.

In this case, the protein is Hsp90. As you might have guessed, the success of this techniques owes almost as much to the development of efficient software and databases as it does to the advances in mass spectroscopy.

The technique is powerful but the equipment is expensive and requires well-trained technicians.

There are many different kinds of mass specs and every lab will have its own customized setup. The one shown here belongs to Joseph Loo of Chemistry & Biochemistry, UCLA (Los Angeles, CA, USA). I "borrowed" it from his website [Joseph Loo].

Modern research facilities will have access to special labs where protein fingerprinting is routinely performed. In some cases, a major facility will serve as a regional center for analyses and charge a fee ($50-150) for each sample.

The image of the tryptic peptides of Hsp90, above, are from the website of such a facility in the Department of Biochemistry at the University of Buffalo (Buffalo, NY, USA) [Proteomic Capabilities]. Now that you know how the technique works, the description on their website will look much less intimidating.

The MALDI-TOF facility housed in the Department of Biochemistry provides access to mass spectrometric fingerprinting of unknown proteins. MALDI-TOF (Matrix-assisted, Laser-Desorption-Ionization/Time of flight) mass spectrometry is presently the method of choice for identification of unknown proteins via mass analysis of proteolytic peptides, and for characterization of post-translational modifications. This technique is rapid, highly sensitive, and applicable to a wide variety of research problems. Applications include direct characterization of mutated proteins, estimating the extent of protein derivatization (e.g., biotinylation), and identification of unknown proteins isolated from polyacrylamide gels. Depending on the specific application and complexity of the system, reliable data can be obtained in the fmol-pmol range.
In practice, the identification of a protein from its predicted fingerprint doesn't always work. The determined molecular weights aren't precise enough to unambiguously identify the protein and some peptides don't "fly." In addition, post-translational modifications of the protein will interfere with the molecular weights calculated from the gene sequence.

In most cases when you send out your sample you get back a list of possibilities that has to be narrowed down by other means (e.g., another protease digest).

This limitation has led to the development of coupled mass specs where the peptides from one are fragmented and fed into another. What this gives you is the sequence of each peptide by a technique called MS/MS. With sequence information you can search all the databases for sequence similarity and identify proteins even if the gene for that particular species hasn't been cloned and sequenced.


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Biochemistry and Mass Spectrometry

 
The following description is from Horton et al.,Principles of Biochemistry 4/e. It explains the use of mass spectrometry in a biochemical context.

Mass spectrometry, as the name implies, is a technique that determines the mass of a molecule. The most basic type of mass spectrometer measures the time that it takes for a charged gas phase molecule to travel from the point of injection to a sensitive detector. This time depends on the charge of a molecule and its mass and the result is reported as the mass/charge ratio. The technique has been used in chemistry for almost one hundred years but its application to proteins was limited because, until recently, it was not possible to disperse charged protein molecules into a gaseous stream of particles.

This problem was solved in the late 1980s with the development of two new types of mass spectromety. In electrospray mass spectrometry the protein solution is pumped through a metal needle at high voltage to create tiny droplets. The liquid rapidly evaporates in a vacuum and the charged proteins are focused on a detector by a magnetic field. The second new technique is called matrix-assisted desorption ionization (MALDI). In this method the protein is mixed with a chemical matrix and the mixture is precipitated on a metal substrate. The matrix is a small organic molecule that absorbs light at a particular wavelength. A laser pulse at the absorption wavelength imparts energy to the protein molecules via the matrix. The proteins are instantly released from the substrate (desorbed) and directed to the detector (see Figure). When time-of-flight (TOF) is measured, the technique is called MALDI–TOF.

The raw data from a mass spectrometry experiment can be quite simple, as shown in the Figure (right). There, a single species with one positive charge is detected so the mass/charge ratio gives the mass directly. In other cases, the spectra can be more complicated, especially in electrospray mass spectrometry. Often there are several different charged species and the correct mass has to be calculated by analyzing a collection of molecules with charges of +1, +2, +3 etc. The spectrum can be daunting when the source is a mixture of different proteins. Fortunately, there are sophisticated computer programs that can analyze the data and calculate the correct masses. The current popularity of mass spectrometry owes as much to the development of this software as it does to the new hardware and new methods of sample preparation.

Mass spectrometry is very sensitive and highly accurate. Often the mass of a protein can be obtained from picomole quantities that are isolated from an SDS–PAGE gel. The correct mass can be determined with an accuracy of less than the mass of a single proton.


©Laurence A. Moran and Pearson/Prentice Hall

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Monday's Molecule #106: Winners

 
UPDATE: The machine is a mass spectrometer and the technique illustrated is matrix-assisted desorption ionization (MALDI) coupled to time-of-flight (TOF) measurement (MADLI-TOF).

The first person to get it right was David Schuller of Cornell University. The first undergraduate from the Toronto area was Nova Syed of the University of Toronto.



This is the second week in a row that Monday's molecule has been on a Tuesday. Sorry for the delay. I promise to get back on schedule next week.

The observant among you might have noticed that this "Monday's" molecule is not a molecule. It's my version of a machine. You have to identify what kind of a machine this is and what it does.

There are two Nobel Laureates who get credit for developing the technique shown here. One of them is responsible for the specific technique and the other for a similar variant. Name the two Nobel Lauretes.

The first person to identify the machine/technique and the Nobel Laureates wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first collected the prize.

There are six ineligible candidates for this week's reward: Bill Chaney of the University of Nebraska, Maria Altshuler of the university of Toronto, Ramon, address unknown, Jason Oakley of the University of Toronto, John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), and Wesley Butt of the University of Toronto

Bill and John have offered to donate their free lunch to a deserving undergraduate so the next two undergraduates to win and collect a free lunch can also invite a friend. Since undergraduates from the Toronto region are doing better in this contest, I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.


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Mendel's Garden #28

 
The 28th edition of Mendel's Garden has just been posted on Quintessence of Dust [Mendel’s Garden 28th Edition].

Hello and welcome to the 28th edition of the genetics blog carnival known as Mendel's Garden, where we celebrate blogging on topics related to anything touching on what Mendel discovered (or thought he discovered). While reading these interesting and informative pieces, please think about work that should be featured in a future edition and/or blogs (like yours) that would serve well as future hosts.

So do tomato seeds get you excited? No? Oh. Well, they should, if you're at all interested in evolutionary genetics.


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This is what we're up against.

 
PZ posted the first video on Pharyngula. I think it's important to watch both of them to see what goes on in church basements. How can we deal with this level of ignorance about science? It's especially frustrating because these young women are obviously intelligent enough that they should know better.






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Tuesday, February 03, 2009

Monday's Molecule #106

 
This is the second week in a row that Monday's molecule has been on a Tuesday. Sorry for the delay. I promise to get back on schedule next week.

The observant among you might have noticed that this "Monday's" molecule is not a molecule. It's my version of a machine. You have to identify what kind of a machine this is and what it does.

There are two Nobel Laureates who get credit for developing the technique shown here. One of them is responsible for the specific technique and the other for a similar variant. Name the two Nobel Lauretes.

The first person to identify the machine/technique and the Nobel Laureates wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first collected the prize.

There are six ineligible candidates for this week's reward: Bill Chaney of the University of Nebraska, Maria Altshuler of the university of Toronto, Ramon, address unknown, Jason Oakley of the University of Toronto, John Bothwell from the Marine Biological Association of the UK, in Plymouth (UK), and Wesley Butt of the University of Toronto

Bill and John have offered to donate their free lunch to a deserving undergraduate so the next two undergraduates to win and collect a free lunch can also invite a friend. Since undergraduates from the Toronto region are doing better in this contest, I'm going to continue to award an additional free lunch to the first undergraduate student who can accept a free lunch. Please indicate in your email message whether you are an undergraduate and whether you came make it for your free lunch (with a friend).

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureate(s) so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow. I reserve the right to select multiple winners if several people get it right.

Comments will be blocked for 24 hours.


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What Timothy Sandefur says ....

 
I very much admire Jerry Coyne's article on science vs religion in The New Republic [see: Jerry Coyne on Science vs. Religion]. There's been some discussion on The Edge where participants are asked to address the question Does the empirical nature of science contradict the revelatory nature of faith?.

Timothy Sandefur discusses Coyne's article and the various commnents on his blog Freespace [The future of science teetering on the Edge]. He does such a good job that you should all hop over there as soon as possible and read what he has to say.

Timothy points out that the debate is really about ways of knowing. Can we obtain valid information using the scientific way of knowing? Yes we can. This is rationalism, in my terminology.

Can we obtain valid information using faith as a way of knowing? No we can't. This is superstition and it is the opposite of rationalism.

Is it possible to simultaneously practice both ways of knowing? Here's part of the response by Timothy Sandefur.

Keep the issue in mind: the question is not whether it is possible for someone simultaneously to hold unproven, baseless beliefs about a supernatural dimension and scientific, reasoned conclusions with regard to observed phenomena. It is possible for all sorts of people to believe all sorts of things—just as Humpty Dumpty practiced every day believing six impossible things before breakfast. But it is not possible to do these things and still have intellectual integrity. It requires instead intellectual dis-integration: the skill (if it can be called a skill) of not thinking about the possible connections between the phenomena of the universe. That is, it requires precisely the opposite effort that science requires. It requires one not to think. Alas, as Coyne observes, this effort is officially endorsed by many organizations motivated by political expediency:
It is in [scientists’] personal and professional interest to proclaim that science and religion are perfectly harmonious. After all, we want our grants funded by the government, and our schoolchildren exposed to real science instead of creationism. Liberal religious people have been important allies in our struggle against creationism, and it is not pleasant to alienate them by declaring how we feel. This is why, as a tactical matter, groups such as the National Academy of Sciences claim that religion and science do not conflict. But their main evidence—the existence of religious scientists—is wearing thin as scientists grow ever more vociferous about their lack of faith.
But it’s not just that there aren’t as many religious scientists as some claim. It’s the fact that these two ways of knowing are and always have been, incompatible by their nature, and that those who pledge allegiance to both are either dishonest or simply wrong.
It's nice to see a lawyer making sense.


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Gene Genie #43

 
The 43rd edition of Gene Genie has been posted at Pharmamotion: pharmacology animations and resources [Gene Genie #43: Personal genomics, health and evolution].

Once again, PharmaMotion is hosting a blog carnival. This time is the turn of Gene Genie, a carnival dedicated to cover the buzz around the web about genetics (with some orientation to personalized genetics). I hope that PharmaMotion readers find it interesting.
The beautiful logo was created by Ricardo at My Biotech Life.

The purpose of this carnival is to highlight the genetics of one particular species, Homo sapiens.

Here are all the previous editions .....
  1. Scienceroll
  2. Sciencesque
  3. Genetics and Health
  4. Sandwalk
  5. Neurophilosophy
  6. Scienceroll
  7. Gene Sherpa
  8. Eye on DNA
  9. DNA Direct Talk
  10. Genomicron
  11. Med Journal Watch
  12. My Biotech Life
  13. The Genetic Genealogist
  14. MicrobiologyBytes
  15. Cancer Genetics
  16. Neurophilosophy
  17. The Gene Sherpa
  18. Eye on DNA
  19. Scienceroll
  20. Bitesize Bio
  21. BabyLab
  22. Sandwalk
  23. Scienceroll
  24. biomarker-driven mental health 2.0
  25. The Gene Sherpa
  26. Sciencebase
  27. DNA Direct Talk
  28. Greg Laden’s Blog
  29. My Biotech Life
  30. Gene Expression
  31. Adaptive Complexity
  32. Highlight Health
  33. Neurophilosophy
  34. ScienceRoll
  35. Microbiology Bytes
  36. Human Genetic Disordrs
  37. The Genetic Genealogist
  38. ScienceRoll
  39. Genetics & Health
  40. Human Genetics Disorders
  41. ScienceRoll
  42. Genetic Future
  43. Pharmamotion



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Should senior scientists be bloggers?

 
Eva asks the questions on her Nature Network blog [Bloggers]. I was going to leave a comment there but I can never remember my login name and password.

I hate sites like that.

The answer seems pretty obvious to me. Some small percentage of senior scientists will enjoy blogging but most won't. It's not a big deal. There's no reason to encourage more senior scientists to blog. They'll do it naturally if they feel the need.


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Monday, February 02, 2009

The University of Vermont Does the Right Thing

 
My impression of the University of Vermont has just gone way up. According to WCAX News in Vermont, the University has decided that Ben Stein is not an appropriate commencement speaker [Stein Withdraws as UVM Speaker].

Burlington, Vermont - February 2, 2009

Ben Stein won't be bidding UVM graduates goodbye after all.

Just last week, the university announced that Stein, who is highly acclaimed as an actor, author, and economist, would be delivering this year's commencement address. But Monday, the school announced that he has now withdrawn as speaker.

Stein has made headlines recently for his views regarding Darwin's theory of evolution, intelligent design and the role of science in the Holocaust. Several people from the academic community-- both locally and beyond the UVM campus-- quickly expressed concern over his selection and once notified of that, Stein withdrew from the ceremony.

"This is not, to my mind, an issue about academic freedom or the openness of the campus to all points of view. Ben Stein spoke here last spring to great acclaim," UVM President Dan Fogel said. "It's an issue about the appropriateness of awarding an honorary degree to someone whose views in many ways ignore or affront the fundamental values of scientific inquiry and I greatly regret that I was not attuned to those issues."

Fogel said the school's honorary degree committee has a list of potential candidates and he will consult others before extending an invitation to another potential commencement speaker.
Good for President Fogel. He's right. It is not appropriate to award an honorary degree to "someone whose views in many ways ignore or affront the fundamental values of scientific inquiry."

I wonder if Dan Fogel realizes that he has just earned himself a prominent place in "Expelled II"?


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A Message from Genome Canada

 
Genome Canada did not get the funding it requested in the latest budget. In fact, it got nothing at all. Here's a message from the Board of Directors of Genome Canada [Federal Budget 2009].

  • Genome Canada is pleased with the federal government’s 2009 budget in which millions will be invested in research infrastructure over the next two years. This is good news for the scientific community across the country that needs to be at the cutting-edge of research infrastructure and new technologies in order to maintain Canada’s competitiveness at the national and international level.
  • Although Genome Canada did not receive funding in the 2009 federal budget to fund new genomics research projects, this will not impact Genome Canada’s current projects that received a full commitment of funding from previous federal government investments in 2007 and 2008.
  • Genome Canada has in place two five-year funding agreements with the Government of Canada for a total of $240M: $100 M (2008-2012) $140 M (2009- 2013)
  • These investments flow to Genome Canada on a cash requirement basis. Thus, a total of $107M has been invested in 2008-09; and a total of $106.5M will be invested in 2009-10, creating and maintaining over 2,350 HQP positions per year.
  • Over the same period of time, Genome Canada has raised over $225M from other strategic partners in the private, public and philanthropic sectors to support genomics research in Canada.
  • Since its inception in 2000, Genome Canada has provided operating funds to Canadian genomics researchers, while complementing other sources of funds for infrastructure coming from such agencies as Canada Foundation for Innovation, to allow them to be among world leaders in their respective fields such as human health, agriculture, environment, forestry, fisheries, new technology, and GE3LS (ethical, environmental, economic, legal and social issues).
  • Genome Canada is confident that the Government of Canada and its other financial strategic partners will do everything possible over the coming years to secure additional funding to support new initiatives in genomics research in Canada while increasing Canada’s productivity, wealth and well-being of all Canadians.
What a bunch of wimps. Here's the list of the Board of Directors.

It's one thing to praise the government for not giving you the money you requested but it's quite another to heap praise on a government that is cutting funding to the major granting councils. Yes, it's true that the budget contains money for infrastructure support but that money will be useless without operating grants. Operating grants are the bread and butter of scientific research. They are what pays for the day-to-day expenses of operating a research lab. It doesn't matter how nice your building is if you can't buy enzymes and chemicals. Modern science is expensive.

Operating grants also pay the salaries of research assistants, graduate students, summer students, and post-docs.

Myopic governments don't like to fund operating grants because that's a long-term commitment. One-time-only (OTO) money is much better 'cause you can get a big bang for your buck (publicity and votes) and you don't have to make any promises.

Genome Canada's directors should know this. They should not be sending out a press release that looks like they are backing the government decision to destroy basic research. Unless, of course, they agree with that strategy.

This brings up another point about Genome Canada. Many scientists, including me, don't think that the Genome Canada model is the way to fund research. In that sense, I'm not all that upset that it wasn't funded. If you want to learn more about the problems of co-funding and market-drive science then read the latest posting from Chris Hogue [Market Driven Science in Crisis?]. He knows what he's talking about.


Hat Tip: iBiome: Genome Canada cut good for science?, And now, the walkback

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