What Does the Bladderwort Genome Tell Us about Junk DNA?

The so-called "C-Value Paradox" was described over thirty years ago. Here's how Benjamin Lewin explained it in Genes II (1983).

The C value paradox takes its name from our inability to account for the content of the genome in terms of known function. One puzzling feature is the existence of huge variations in C values between species whose apparent complexity does not vary correspondingly. An extraordinary range of C values is found in amphibians where the smallest genomes are just below 10⁹bp while the largest are almost 10¹¹. It is hard to believe that this could reflect a 100-fold variation in the number of genes needed to specify different amphibians.

Since then we have dozens and dozens of examples of very similar looking species with vastly different genome sizes. These observations require an explanation and the best explanation by far is that most of the genomes of multicellular species is junk. In fact, it's the data on genome sizes that provide the best evidence for junk DNA.

How Do IDiots Define Evolution?

It's not difficult to find a proper definition of evolution. All you have to do is check your basic introductory textbooks on evolution. Google is not your friend in this case 'cause there's a lot of misinformation out there. If you're really interested in a scientific definition of evolution why not go right to the primary source?

Most textbooks use some version of the following for the minimal DEFINITION of evolution [see What IS Evolution?].

Evolution is a process that results in heritable changes in a population spread over many generations.

Now, we all know that Intelligent Design Creationists are keen on real science. They certainly don't want to mislead their flock. Let's see how they define evolution in the latest book they are promoting [From Discovering Intelligent Design: Define Your Terms].

A Concept-Driven Graduate Education

Like most graduate departments, we are constantly evaluating and modifying our graduate program but rarely do we step back and look at the big picture. What are we trying to accomplish?

Graduate education, like undergraduate education, has been subjected to serious study over the past few decades. Guttlerner and Van Vactor (2013) have just published a brief review in Cell that summarizes the goals and how they are trying to achieve them at Havard.

The authors begin by pointing out the importance of a concept-driven curriculum.

The modernization of science education requires a shift from a content-driven curriculum to an interdisciplinary, concept-driven curriculum (Association of American Medical Colleges and Howard Hughes Medical Institute, 2009; American Association for the Advancement of Science, 2009; National Research Council, 2003, 2009). Such a curriculum organizes information around unifying concepts and frees educators from the insurmountable task of presenting the complete breadth of an ever-expanding scientific knowledge base (D’Avanzo, 2008). Concept-driven education is increasingly seen as fundamental for contemporary research scientists and physicians (Association of American Medical Colleges and Howard Hughes Medical Institute, 2009).

Inside Higher Ed Weighs in on the Ball State Academic Freedom Controversy

This is getting more and more interesting. Now there's an article in Inside Higher Ed discussing the controversy over whether Eric Hedin of Ball State University should be teaching a science course that emphasizes Intelligent Design Creationism. [see Science or Religion?]

The article discusses the difference of opinion between Jerry Coyne, on the one hand, and PZ Myers and me, on the other. It's very interesting to read the comments. Jerry Coyne has posted on the Inside Higher Ed article at: Ball State agrees to investigate science course infected with Christianity. His readers have lots to say on the issue of academic freedom.

Let's be clear about one thing. I'm not an American so I'm not terribly concerned about the American Constitution. If Eric Hedin were teaching in Canada, the legal issue would never come up. The part of this that I don't like is outsiders threatening departmental chairs to get them to take action against one of their faculty members. Four Creationists have tried to get the administration of my university to shut down Sandwalk and in all cases my university simply filed the letters in the waste basket.¹ I ban people from Sandwalk if I ever hear of them trying to intimidate someone by complaining to their employer. That's unacceptable behavior in my book.

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1. After sending me a copy.

Earthquake!

Epicentre near Ottawa. Two quakes: 5.2 magnitude at 9:43 am and a 4.1 magnitude aftershock 10 minutes later. I didn't feel either of them. Earthquakes like this happen about 30,000 time a year. We feel one of them every few years in this part of Canada. They are mostly harmless, but exciting.

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[Photo credit: CBC News]

On Teaching Genetics Using Students' and Parents' ABO Blood Types

There are some schools that think it's cool to show examples of simple Mendelian inheritance by collecting and analyzing the blood types of their students and their parents. What could possibly go wrong?

Let me tell you why this is a bad idea. It's true that 99% of the time the blood type of a student is going to be consistent with that of their presumed biological parents. But what if it's not? That could mean that a child is adopted and the child may not know or not want that information to be public. It could also mean that the child's biological father (or mother) is not the same person they call "Mommy" or "Daddy." Is the trauma associated with that discovery worth the benefits of the experiment?

I have a blog post on The Genetics of ABO Blood Types. It's quite popular and every few weeks I get a letter from a distraught parent who has just discovered that the blood type of their children doesn't match the blood type of the parents. Here's the latest example (posted with permission) ...

Dear Professor Moran: I hope you don't mind my writing to you, but I just came across your blog, Sandwalk after doing some research about blood types and wondered if you might have an opinion....

My daughter, in 7th grade is working on a blood type project at school and came home quite upset yesterday after telling the teacher that she was type A+ and both her Dad and I are O+. The teacher (whom I have not yet dragged over hot, burning coals....) told her that that was impossible - that she would either have to have been adopted or have a genetic defect.... It got me thinking that perhaps I had made a mistake somewhere along the way and we spent some time last night digging through info to try to figure it out. I checked with our doctors this morning and our daughter's pediatrician and all blood types have been confirmed. Both my husband and I are O+ and our daughter is A+ She is definitely not adopted and unless she was switched at birth, then there is no doubt as to parentage -- should I be concerned? I do recall that when she was born she had mild jaundice which one doc explained was due to blood type incompatibility.

If high school teachers aren't knowledgeable enough to handle these situations then they should avoid these "experiments."

These "anomalies" are quite frequent and they have simple explanations once you know the real genotype. For example, one parent could be heterozygous for two different O alleles. One with a mutation near the beginning of the gene and the other with a mutation near the end of the gene. Any germ cell recombination event between the two alleles could generate an A allele or a B allele depending on the origin of the O allele.

I think it's also possible for one of the parents to actually be AO or BO but the functional allele is expressed at a very low level giving an O-type phenotype. The A or B allele could, by chance, be much more active in the child. There could be epistatic effects such that splicing or transcription is defective in the parent but compensated for by enhanced activity in the child due to unlinked mutations. (These are known as "suppressors" in bacterial genetics.)

There are many other possibilities. They're rare but it's certain that they will show up in some school class somewhere. It's usually not a good idea to investigate the personal genomics of students because of these problems.

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Jerry Coyne Is at it Again!

Jerry Coyne has discovered that some obscure Professor in some American college is teaching from a Christian viewpoint in his class on "The Boundaries of Science." Jerry thinks that he can stop this Professor from teaching things that he (Coyne) disagrees with by threatening the university with a lawsuit. PZ Myers and I disagreed, pointing out that academic freedom in the universities is an important principle that should not be ignored [see Is It Illegal to Teach Intelligent Design Creationism in American Universities?].

Jerry stands by his position: The Freedom from Religion Foundation to Ball State University: cease and desist your religious indoctrination. Nobody is arguing that Professors shouldn't be criticized for bad teaching and nobody is arguing that the instructor's colleagues and department can't reassign courses to keep a bad teacher away from students. That's not the situation here. The Chair of the department is aware of the situation and doesn't object.

It's dangerous for outsiders to start dictating what a Professor can and can't teach and it's especially dangerous to use legal threats to enforce your own perspective on another university. I strongly disagree with the letter that the Freedom from Religion Foundation sent to the President of Ball State University [see Coyne's blog website]. If this were my university I would expect it to fight such a demand with all the resources at their disposal and I'm certain that my union and the Canadian Association of University Teachers (CAUT) would support my university. So would I.

CAUT actively defends academic freedom as the the right to teach, learn, study and publish free of orthodoxy or threat of reprisal and discrimination. Academic freedom includes the right to criticize the university and the right to participate in its governance. Tenure provides a foundation for academic freedom by ensuring that academic staff cannot be dismissed without just cause and rigorous due process.

I have defended the academic freedom of racists and holocaust deniers in the past. I've even defended the right of an extreme free-market capitalist to indoctrinate business students. In the name of academic freedom, I will even tolerate adaptationists who teach evolution incorrectly.

The purpose of academic freedom is to protect the rights of those who disagree with the majority. Those rights must be protected for everyone, including those who you think are wrong. Otherwise it's not academic freedom.

I teach a course where I promote an atheist view of evolution and the idea that science and religion are incompatible. If the Freedom from Religion Foundation ever wrote a letter to my President demanding that I cease and desist they would be be ignored except, perhaps, for a few laughs over coffee.

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Michael Denton on Junk DNA

I was reading the latest spiel from Sal Cordova (scordova) when I noticed a reference to Michael Denton. Cordova was ranting about how Taxonomic nested hierarchies don’t support Darwinism and he began with ...

Taxonomic nested hierarchies don’t support Darwinism or common descent, actually the opposite. Michael Denton convincingly argued that nested hierarchies can be used to argue against macro evolution. If the fish are always fish, then they will never be birds, reptiles, apes, or humans.

I knew that this was a misrepresentation of Denton's views since he (Denton) supports the idea that nested hierarchies represent the true history of common descent.

Michael Denton thinks that evolution was directed and that explains why fish and mammals are so different even though they contain a common ancestor. He accepts common descent but rejects spontaneous mutation and mechanistic fixation of alleles as the explanation. I checked his latest book Nature's Destiny (1998) to confirm that I was right.

Denton supports a teleological view where God created conditions (first cause) that would lead to humans (final cause) but that the process included evolution from common ancestors. In Denton's case the "design" was inherent in the laws of physics and chemistry and the rules of mutation and gene expression.

While refreshing my memory, I came across this paragraph that I had highlighted in his book fifteen years ago.

If it is true that a vast amount of the DNA in higher organisms is in fact junk, then this would indeed pose a very serious challenge to the idea of directed evolution or any teleological model of evolution. Junk DNA and directed evolution are in the end incompatible concepts. Only if the junk DNA contained information specifying for future evolutionary events, when it would not in a strict sense be junk in any case, could the finding be reconciled with a teleological model of evolution. Indeed, if it were true that the genomes of higher organisms contained vast quantities of junk, then the whole argument of this book would collapse. Teleology would be entirely discredited. On any teleological model of evolution, most, perhaps all, the DNA in a genome of higher organisms should have some function. (pp. 289-290

I wonder what Intelligent Design Creationists think of this argument?

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The Positive Values of a Roman Catholic Education?

The Ontario government funds Roman Catholic Schools but not schools of any other religion. I've just returned from a high school reunion at one of the "public" schools (nonreligious) so I've been thinking about the education I received in an environment that was free of religious indoctrination.

My friends all seem to be pretty moral and they seem to be at least as good at practicing the Golden Rule as any other citizens. When we were students we organized contributions to charity and helped the needy. We made lifelong friends in the public schools.

Most of my high school friends are pretty secular in their outlook and a large percentage are nonbelievers. The percentages aren't much different among my friends who went to Roman Catholic schools.

Here's a bit of propaganda from one who supports government funding of Roman Catholic schools. They need all the support they can get because Roman Catholic values are coming under heavy criticism lately. Roman Catholic students have been bussed to anti-abortion protests and school clubs for gays and lesbians have been banned in the Roman Catholic schools system. "Sex education" is a joke.

What do you think? Does this make you want to continue sending your tax dollars to the Roman Catholic schools?

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Scientific Authority and the Role of Small RNAs

A few weeks ago I criticized Philip Ball for an article he published in Nature: DNA: Nature Celebrates Ignorance. Phil has responded to my comments and he has given me permission to quote from his response. I think this is going to stimulate discussion on some very interesting topics.

The role of small RNAs is one of those topics. There are four types of RNA inside cells: tRNA, ribosomal RNA (rRNA), messenger RNA (mRNA), and a broad category that I call “small RNAs.”

The small RNAs include those required for splicing and those involved in catalyzing specific reactions. Many of them play a role in regulating genes expression. These roles have been known for at least three decades so there haven’t been any conceptual advances in the big picture for at least that long.

What’s new is an emphasis on the abundance and importance of small regulatory RNAs. Some workers believe that the human genomes contains thousands of genes for small RNAs that play an important role in regulating gene expression. That’s a main theme for those interpreting the ENCODE results. Several prominent scientists have written extensively about the importance of this “new information” on the abundance of small RNAs and how it assigns function to most of our genome.

High School Reunion

We attended the Nepean High School 90th Anniversary Celebration in Ottawa (Ontario, Canada) on the weekend. It was wonderful to see old friends, especially those I hadn't seen in almost five decades. (I graduated 49 years ago.)

Here are some friends that I have seen more recently but it was good to get together anyway. Brian (standing) is an old friend—we first met sixty years ago. Chuck (sitting) and his wife Helen (beside him) have been friends since high school. Chuck was best man at my wedding and Brian was also in the bridal party.

Two other members of my bridal party are also high schools friends. Leslie (front) was the bride and Karen (trying to hide on the left) was a bridesmaid.

Ms. Sandwalk has posted a photo of herself as a high school student and cheerleader. One of the other cheerleaders was at the reunion but nobody could convince them to do a cheer.

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[Photo Credit: Sharon took the photo.]

Monday's Molecule #205

Last week's molecule was the lipoamide swinging arm of pyruvate dehydrogenase [Monday's Molecule #204]. The winners were Alex Ling and Michael Florea.

Today's molecule is a major component of something you are all familiar with. Identify the molecule (common name only) and where it's most likely to be found. (Hint: not in humans.)

Email your answers to me at: Monday's Molecule #205. I'll hold off posting your answers for 24 hours. The first one with the correct answer wins. I will only post mostly correct answers to avoid embarrassment. The winner will be treated to a free lunch.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your email message.)

Almaleea subumbellata

Jerry Coyne says he will post a picture of a plant if he can find a cute one [A vertebrate]. I decided to help him out by pointing you to the latest Botany Photo of the Day.

This is Almaleea subumbellata, or wiry bushpea, from Tasmania, Australia. You can read all about it at the UBC Botanical Garden website. They have a high resolution photo.

Prettier than cats and they don't pee on your rug or scratch your furniture.

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Andyjones Replies

Andyjones has responded to my post on failing to educate him about science. His response is: Failure to Educate? Failure to Persuade. I'm reposting his entire response ....

Larry Moran replied to my latest post with an admission of failure. He thinks he has failed to educate, but I think rather he is confusing the word ‘persuade’ with the word ‘educate’.

He thinks I am rationalising junk DNA with a pile of ‘what-ifs’. But the fact is that most of my ‘what-ifs’ are already known to have some basis in reality. I am not denying any obvious reality. Indeed, the basic machinery of life looks like design, far more than when Paley was around. Yes, there could also be a great deal of junk. That’s why I have said a number of times that ID is not committed to the idea that there is no junk.

Yet, from my point of view, I see a whole pile of Darwinian/post-Darwinian materialists who have only partly explored the genome, working from an assumption that the genome was not designed, and thus are jumping the gun on the evidence. For example, Larry still seems to think that pseudogenes are of themselves ‘solid evidence’ of broken genes despite the fact that we know that at least some pseudogenes influence the rate of translation of real genes by competing with them; a simple design reason why there should be ‘false genes’ = pseudogenes. Who has explored the rest of them?

From his emotive response to my perfectly valid, albeit speculative suggestions (though they were not plucked out of the air either), I don’t trust this guy to think clearly and calmly about the possibility of design. That’s the real problem.

This is all very frustrating. Why do IDiots who have no serious training in biochemistry and molecular biology think they know more than the experts?

And why do they refuse to learn when we attempt to educate them?

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An Example of IDiot "Civility"

Do you remember when Stephen A. Batzer listed several reason why "Darwinists" are so uncivil? [Why Darwinism and Incivility Seem to Go Together] I blogged about it at: Why Are "Darwinists" So Uncivil?. We all had a good chuckle about hypocrisy and stupidity.

You've also seen many IDiots defend their use of "Darwinism" by claiming that it's nothing more than an accurate description of the most important scientific prerspective on evolution.

Here's what David Klinghoffer wrote today in Scientific Anti-Humanism Is Being Refuted by Science Itself.

Scientific anti-humanism refers to the cheapening of human dignity and of the value of human life in the name of science. Among many other pieces of novel information on that theme, the most important point that came out of Michael Medved's discussion with John West just now on the Science and Culture Update is that this corrosive tendency is being refuted by science itself.

Darwin persuasively taught that life is the product of blind, meaningless, purposeless churning, making all life, not just human, hardly anything more special or dignified than cosmic refuse. Indeed in a Darwinian worldview, life is cosmic refuse. While accused abortion butcher Kermit Gosnell may be an outlier, he is an emblematic personality in our Darwin-tutored culture.

How civil of him to link Darwinism with Kermit Gosnell.

Remember, this is Evolution News & Views (sic), sponsored by the Discovery Institute. This is not some backwoods hack operating on his own. It's mainstream civility for the leading Intelligent Design Creationists.

UPDATE Klinghoffer posted the following a short time later in Darwinism Versus Reality: The Painful Divorce. It's just another example of how the IDiots link "Darwinism" with immorality and it puts the lie to the claim that "Darwinism" is just another word for "evolutionary biology."

I wanted to highlight what Josh Youngkin said yesterday in his very perceptive comments about the Jodi Arias verdict. Darwinian materialists like Jerry Coyne end up asserting there's no free will, therefore no such thing as moral responsibility. A murderer may be locked up for everyone else's safety, but not because we're correct to seek to impose retribution. We have no moral right to do so.

As Josh says, this casts the human being who murders as a fundamentally blameless animal, like a man-eating tiger. We would cage or even shoot such a tiger, but we could not blame it for acting as it does.

Profoundly, I thought, Josh's article suggests how remote from human experience a guy like Coyne must travel if he wants to carry his Darwinian materialism to its seemingly logical conclusions.

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