THE GAIRDNER FOUNDATION 50TH
ANNIVERSARY TORONTO SYMPOSIUM:Wednesday, October 28- Friday, October 30, 2009
WEDNESDAY, OCTOBER 28, 2009
Gairdner 50th Anniversary Symposium on Stem Cells, Disease Mechanisms and Future Therapies in collaboration with the McEwen Centre for Regenerative Medicine.
Location: Macleod Auditorium, University of Toronto
Time: 9am -12:45pmCo-Chairs: Dr. Janet Rossant, Sick Kids Hospital, Toronto, ON
Dr. Gordon Keller,Director, McEwen Centre for Regenerative Medicine, UHN, TorontoIntroduction: Dr. John Dirks, President and Scientific Director,
the Gairdner Foundation9.00-9:30
Shinya Yamanaka, Professor, Department of Stem
Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, JapanInduction of pluripotency by defined factors
9.30-10:00
Gordon Keller, Director, McEwen Centre for Regenerative Medicine, Toronto, ON.Directed differentiation of pluripotent stem cells to functional tissues
10.00-10:30
Andras Nagy, Senior Investigator Samuel Lunenfeld Research Institute, and Canada Research Chair in Stem Cells and Regeneration ,Toronto, ONTransposon-mediated reprogramming provides a powerful exploratory tool for understanding stem cell induction
10.30-10:45 Break
10.45-11:15
Mario Cappechi, Distinguished Professor of Human Genetics and Biology, University of Utah School of Medicine, Salt Lake City, UtahStem cells of the intestine
11.15-11:45
Phillip Sharp,Institute Professor, Massachusetts Institute of Technology, Boston MAThe roles of small RNAs in stem cells
11.45-12:15
Samuel Weiss, University of Calgary, ABAdult neurogenesis and the formation of social memories
12.15-12:45
Oliver Smithies, Excellence Professor of Pathology and Laboratory Medicine, University of North Caroline, Chapel Hill, NCOn being a scientist for 60 years
12.45 Reception
1:15-4:45 - Gairdner Global Health Symposium
Location: Dalla Lana School of Public Health, University of Toronto, 155 College Street, 6th Floor, Toronto, ON M5T 3M7 Canada,1:15-1:25
Introduction: Dr. John Dirks, President & Scientific Director, The Gairdner Foundation
Welcome: Dr. Jack Mandel, Director, Dalla Lana School of Public Health, University of TorontoThe Global Health Stage
Chair: Kiyoshi Kurokawa, Professor, National Graduate Institute for Policy Studies, Tokyo
1:25-1:40
Jeff Koplan, Director of Global Health, Emory University
What's global health and why is it important?1: 40-1:55
Tachi Yamada, President of Global Health Program, Gates Foundation
Innovation and access in global health1:55-2:10Mark Walport,Director, Wellcome Trust.
Building capacity2:10-2:25
Peter Singer, Director, McLaughlin-Rotman Centre
for Global Health, University Health Network and University of Toronto
Global health: why Canada should care and what Canada should
do.2:25-2:45
Discussion2:45-3:00 Break
The Challenge of Chronic
DiseaseChair:Alan Bernstein, Executive Director, Global HIV Vaccine Enterprise
3:00-3:20
Nubia Munoz, Inaugural Canada Gairdner Global Health award recipient
Burden of cancer associated with infectious agents in developing countries.3:20-3:35
John Sulston, Cambridge, UK
What is Science for anyway?3:35 -3:50
Margaret G. McGlynn, President, Merck Vaccines, Merck and Company Inc.
The evolving global vaccine landscape3:50-4:05 Prabhat Jha, Director, Centre for Global Health Research, University of Toronto
Death and tobacco taxes4:05-4:20
Richard Peto,Professor of Medical Statistics and Epidemiology, Co-Director, CTSU, Oxford University
Halving adult mortality worldwide4:20-4:40 Discussion
4:40-4:45 Conclusion
Dr. John Dirks, President and Scientific Director, the Gairdner Foundation
1:30-4:45 -The Cell: An Endless Frontier
Location: Macleod auditorium,
University of Toronto1:30-1:40 Introduction
1:40-2:00pm
Elizabeth Blackburn, Morris Herzstein Endowed Professor in Biology & Physiology, Department of Biochemistry & Biophysics University of California, San Francisco
How cells - and organisms - respond to perturbing their telomere maintenance
2:00-2:20pm
Ulrich Hartl, Max- Planck Institute for Biochemistry, Martinsried, Germany
The cellular machinery of protein folding: Molecular chaperones in health and disease2:20-2:40
Avram Hershko, Technion Institute of Technology, Haifa
Roles of ubiquitin-mediated protein degradation in cellular regulation2:40-2:55 Coffee Break
2:55-3:15pm
Bob Horvitz, David H. Koch Professor of Biology, Massachusetts Institute of Technology, Boston and Investigator, Howard Hughes Medical Institute
Genetic control of programmed cell death in C. elegans3:15-3:35pm
Victor Ambros,Professor, Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA
Small RNAs in every corner of the cell3:35- 3:55
Gary Ruvkun,Professor of Genetics, Harvard Medical School
A C. elegans endocrine system that couples detection of xenobiotic drugs to regulation of reproduction and longevity3:55 - 4:15
Robert G. Roeder, Arnold and Mabel Beckman
Professor, Laboratory of Biochemistry and Molecular Biology, Rockefeller University, NY
Transcriptional regulatory mechanisms in animal cells4:15- 4:35pm Richard Axel, Investigator, Howard Hughes Medical Institute and University Professor, Columbia University, NY
Topic TBA
4:35pm Concluding RemarksTHURSDAY, OCTOBER 29, 2009
7:15 - 9:00am -
Gairdner Industry Breakfast, Unclogging the Pipeline: Rejuvenating drug discovery
Location: MaRS Centre, MaRS Collaboration Centre Auditorium
Moderator:Cal Stiller, Chair, Genome Canada/Bioquest Innovations Inc. /Ontario Institute for Cancer Research and Professor Emeritus, University of Western Ontario; Toronto, ON
Speakers:
Philip Sharp, Institute Professor, Massachusetts Institute of Technology; Cambridge, MA
Corey Goodman, Past President, Biotherapeutics and Bioinnovation Center, Pfizer Inc.; San Francisco, CA
David Baltimore, President Emeritus, Robert Andrews Millikan Professor of Biology, California Institute of Technology; Pasadena, CAPlease RSVP by email tothegairdner@gairdner.org, include the first and last name of the total number of guests attending.
9:00 - 3:00 -2009 Canada Gairdner Recipients' Lectures, The Charles Hollenberg Symposium
Location: JJR Macleod auditorium, University of Toronto9:00am Dr John Dirks, Welcoming remarks
9:15 -9:45am Dr. Peter Walter, Professor, Department of Biochemistry, University of California, San Francisco Investigator of the Howard Hughes Medical Institute, CA,
Protein homeostasis in health and
disease9:45-10:15am Dr. Kazutoshi Mori, Professor, Department of Biophysics, Graduate School of Science, Kyoto University, Japan
The unfolded protein response: To
mammals and beyond10:15-10:30 Coffee Break
10:30-11:00am Dr. Lucy Shapiro, Director, Beckman Center for Molecular and Genetic Medicine,Professor, Developmental Biology, Stanford University School of Medicine, Stanford, CA
The systems architecture of the bacterial cell cycle11:00-11:30am Dr. Richard Losick, Professor, Microbial Development and Gene Regulation, Harvard University, Cambridge, MA
Developmental biology of a simple organism11:30-12:00pm Dr. David Sackett, Professor Emeritus, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON
On the tribulations of not performing
randomized trials12:00-1:00pm Lunch Break
1:00-1:05 John Dirks, Introduction of the Inaugural Canada Gairdner Global Health Award
1:05-1:45 Dr. Nubia Munoz, Emeritus Professor, National Cancer Institute, Bogota, Colombia and Visiting Scientist, Catalan Institute of Oncology, Barcelona
From causality to prevention: the case of cervical cancer1:45-2:15 Dr. Shinya Yamanka, Professor, Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Japan
Induction of pluripotency by defined factors2:15- 2:45 Dr. Sydney Brenner, Distinguished Professor, The Salk Institute, San Diego
Humanity's genesFRIDAY OCTOBER 30, 2009
8:45-3:00-Gairdner/Nobel and Gairdner Laureate Forums
Location: Convocation Hall, University of Toronto
All sessions will present a moderated panel discussion,
followed by Q&A from the audience.Friday's events are free but registration is required.
Click here.
8:45-10:15amAttack and Repulsions: Infections and the Immune System
Dr. David Baltimore (Moderator), Robert Andrews Millikan Professor of Biology, California Institute of Technology, CADr. Ralph Steinman, Henry G. Kunkel Professor & Sr. Physician, The Rockefeller University, New York
Dr. Emil Unanue, Paul & Ellen Lacy Professor, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO
Dr. Rolf Zinkernagel, University of Zurich, Zurich, Switzerland
10:30-12:00pm The Metabolome: Food and Fuel for ThoughtDr. Joe Goldstein (Moderator), Julie and Louis A. Beecherl Distinguished Chair in Biomedical Science, Southwestern Medical Center, University of Dallas, TX
Dr. Jeff Friedman, Marilyn M. Simpson Professor, The Rockefeller University, New York
Dr. Tony Pawson, University Professor, Program in Molecular Biology &Cancer, Samuel Lunenfeld Research Institute, Toronto
Dr. Michael Brown, Paul J. Thomas Chair in Medicine, Southwestern Medical Center, University of Texas, Dallas, TX
Dr. Ron Evans, Professor, Salk Institute for Biological Studies, La Jolla California
2:00-3:30pm Cancer: Can New Insights into Biology Yield Better Results?
Dr. Michael Bishop (Moderator) Chancellor, University of California, San Francisco
Dr.Harald zur Hausen, Professor Emeritus, German Cancer Research institute, Heidelberg, Germany
Dr.Dennis Slamon, Chief, Department of Hematology, Oncology, University of California, Los Angeles
Dr. Bob Weinberg, Professor of Biology, Member, Whitehead Institute, MIT, Cambridge, MA
Dr. Barry Marshall, International Research Foundation for Helicobacter and
Intestinal Immunology, Virginia
7:00- 8:30pm
The Personalized Genome: Do I Want to Know?Dr. Michael Hayden, Director and Senior Scientist, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver
Dr. Sydney Brenner, Distinguished Professor, The Salk Institute, San Diego
Charles Sabine, Award winning NBC News correspondent and carrier of the gene for Huntington's DiseaseIf you need more information please contact Sheila Robinson at
Thursday, September 17, 2009
Oct. 28-30: Reserve These Dates!
Oklahoma Museum of Natural History vs. The Discovery Institute
The anti-science movie Darwin's Dilemma is an attempt to discredit evolution by pointing to "problems" with the evolution of animals during the early to mid-Cambrian.
The IDiots who promote this movie were clever enough to have arranged for a showing at the Sam Nobel Oklahoma Museum of Natural History, a museum associated with the University of Oklahoma. The IDiot IDEA Club of the university knew full well that the museum is legally obligated to host public lectures regardless of how unscientific they might be.
Here's a brief description of Student's IDEA Clubs from their website.
Intelligent Design and Evolution Awareness (IDEA) Clubs are student-initiated clubs on high school and college campuses where students can promote scientific evidence that supports intelligent design. IDEA Clubs are a growing network of student-led clubs on university and high school campuses around the United States, and worldwide.Naturally, the scientists at the museum are upset about this. It prompted the Museum Director, Michael A. Mares, to issue a disclaimer on the museum's website: An Open Letter from Dr. Michael A. Mares, Museum Director.
Today there is a great inequality in the science classroom. Students in most public or private high schools and universities are not exposed to the full range of scientific evidence and opinions about how living organisms arose and diversified. IDEA Clubs help fill the gaps in science education by providing the opportunity for students to educate their fellow students, friends, and even faculty about scientific evidence for intelligent design theory and problems with evolutionary theory. By this, people are naturally challenged by the metaphysical implications of the scientific evidence.
The Sam Noble Oklahoma Museum of Natural History is dedicated to science and to elucidating the remarkable evolutionary history of life on Earth. The museum actively engages in public programs, undergraduate and graduate education, outreach education, and other efforts to increase the scientific literacy of visitors to the museum and the people of Oklahoma.Well said, and opening up the museum free of charge before and after the movie is a brilliant move.
Although the museum does not support unscientific views masquerading as science, such as those espoused by the Discovery Institute, the museum does respect the religious beliefs of all people. Moreover, the museum is obligated to rent its public space to any organization that is engaged in lawful activities, free speech and open discourse. The museum does not discriminate against recognized campus organizations based on their religious beliefs, political philosophy, scientific literacy, or any other factors.
We invite everyone interested in an accurate description of how life developed over the last four billion years to visit our galleries. The well-organized and scientifically accurate exhibits illustrate – through real specimens and scientific methods – the fact of evolution by natural selection as first described by Charles Darwin and continually supported by all branches of science ever since that time. The museum also recommends that people interested in evolutionary science review the more than 1,000 publications by our curators and professional staff that are based in evolutionary biology.
The museum's many galleries will be open for free before and after the showing of the Discovery Institute’s film "Darwin’s Dilemma" on Sept. 29 so the public can see that there is no scientific controversy in evolutionary science's explanation of the development and history of Earth's biodiversity.
This calendar year – the 150th anniversary of the publication of Darwin’s On the Origin of Species – the museum, in partnership with OU departments of Zoology, the Department of Botany and Microbiology, the Department of Anthropology, and the History of Science and History of Science Collections of the OU Library, has presented more than 15 public education programs related to evolution, with many more on the calendar ahead. We encourage the public to take part in these programs, many of which are free, to educate themselves about the true nature of the science of evolutionary biology.
Now the next question is, when are the IDiots actually going to get around to fulfilling their promise to present real evidence for Intelligent Design Creationism? So far, all we've seen is scientifically amateurish attempts to discredit evolution.1.
1. While the attempts are scientifically at a kindergarten level, they are often dressed up in all the glitz and glamor of a Hollywood production. Most people aren't fooled by this, right? Please tell me I'm right.
Mary Travers (1937 - 2009)
The first video is an anti-war protest in Washington in March 1971. The second is a very special appearance of Peter, Paul, & Mary with John Denver singing Leaving on a Jet Plane.
Tuesday, September 15, 2009
Darwin's Dilemma
The students in my class have to read Icons of Evolution by Jonathan Wells. (Nobody said university was going to be fun!)
One of the "icons" is Chapter 3: Darwin's Tee of Life where he discusses the Cambrian explosion and why it refutes evolution. Scientists know this isn't true but the IDiots persist in their attmepts to use any means possible to challenge evolution.
The latest attempt is Darwin's Dilemma, a movie that's promoted on the IDiot web sites [Darwin's Dilemma, New Intelligent Design Film, Due Out Sept. 15]. It's about to be released. If you pay good money to buy the DVD then make sure you take something to settle your stomach. Oh yes, don't forget that if you see the movie in public, you mustn't laugh out loud, that's not polite.
A Good Example of Framing?
This video is making the rounds on all the
Will a message like this ever be seen on television in the other countries that need to hear it?
Chromosomes, Drift, and Demes
One of the characteristics of evolution is change in chromosome number and organization. These large-scale changes are often associated with speciation events although it would be a mistake to assume that there's a causal relationship.One particular chromosomal rearrangement has been getting a lot of press recently because it has been featured on blogs and in some recent trade books on evolution.
Humans (H) have only 23 pairs of chromosomes while most other apes, such as the chimpanzee (C), have 24 pairs. Evidence for a fusion of two of these ancestral chromosomes into a single chromosome 2 in humans has been well supported by genome sequence data. Our fusion chromosome contains remnants of telomeres at the fusion point and it has another centromere-like region at just the right position.
Intelligent design proponents have a hard time explaining this event. They don't propose an explanation based on their concept of intelligent design—that would be too ridiculous—instead they concentrate on raising questions about evolutionary explanations. One of the common objections is that the new fusion chromosome would screw up mitosis and meiosis because it would initially have two centromeres. According to them, the chromosomal rearrangement would be detrimental and could never be fixed by natural selection.
As it turns out, the latter part of this statement is correct. Natural selection is not responsible for this kind of evolution. But no serious scientist would suggest otherwise.
The first part of the statement isn't as serious as the IDiots would like to think. Rearrangements of this sort aren't much of a problem. Many species are heterozygous for such rearrangements and we can see that it has little effect on the viability of dividing cells. Nevertheless, a newly rearranged chromosome is unlikely to be completely neutral. It's probably slightly deleterious with respect to the ancestral chromosome(s).
So, how does a slightly deleterious mutation become fixed in a population? The answer, of course, is random genetic drift. But in order to understand the importance of random genetic drift you have to understand the substructure of species. Species are usually subdivided into many smaller, locally inbreeding, populations or "demes." Slightly deleterious (nearly neutral) mutations can easily become fixed in a deme by accident.
Over at Panda's Thumb, Dave Wisker
This is a nice, short, explanation of a very important mechanism of evolution. I urge everyone to get on over to Panda's Thumb and read it right now.
[Image Credit: This drawing is from: Chromosome Fusion: Chance or Design?. I don't know the original source.
The Old Cavendish Laboratory: Maxwell to Watson & Crick
For scientists, some places are more "holy" than others. Here's the story of one such place. "The moral of the story is that 'place matters'."
How Granting Agencies Destroy Young Scientists
Peter Lawrence has an article in the latest issue of PLoS Biology: Real Lives and White Lies in the Funding of Scientific Research.He's not saying anything we don't already know but he says it so well. Peter describes the typical example of a young researcher (K.) who is frustrated and discouraged by the way science is funded in the UK. The details may differ but it's the same basic story at universities in North America and everywhere else.
He then describes his own experience and highlights the problem.
After more than 40 years of full-time research in developmental biology and genetics, I wrote my first grant and showed it to those experienced in grantsmanship. They advised me my application would not succeed. I had explained that we didn't know what experiments might deliver, and had acknowledged the technical problems that beset research and the possibility that competitors might solve problems before we did. My advisors said these admissions made the project look precarious and would sink the application. I was counselled to produce a detailed, but straightforward, program that seemed realistic—no matter if it were science fiction. I had not mentioned any direct application of our work: we were told a plausible application should be found or created. I was also advised not to put our very best ideas into the application as it would be seen by competitors—it would be safer to keep those ideas secret.You know, what's really puzzling about this phenomenon is not that we are unaware of the problem—it's that we haven't done anything about it. If the system isn't working then let's fix it.
The peculiar demands of our granting system have favoured an upper class of skilled scientists who know how to raise money for a big group [3]. They have mastered a glass bead game that rewards not only quality and honesty, but also salesmanship and networking. A large group is the secret because applications are currently judged in a way that makes it almost immaterial how many of that group fail, so long as two or three do well. Data from these successful underlings can be cleverly packaged to produce a flow of papers—essential to generate an overlapping portfolio of grants to avoid gaps in funding.
Thus, large groups can appear effective even when they are neither efficient nor innovative. Also, large groups breed a surplus of PhD students and postdocs that flood the market; many boost the careers of their supervisors while their own plans to continue in research are doomed from the outset. The system also helps larger groups outcompete smaller groups, like those headed by younger scientists such as K. It is no wonder that the average age of grant recipients continues to rise [4]. Even worse, sustained success is most likely when risky and original topics are avoided and projects tailored to fit prevailing fashions—a fact that sticks a knife into the back of true research [5]. As Sydney Brenner has said, “Innovation comes only from an assault on the unknown” [6].
There are several innovations that could fix the problem. Peter suggests that only the best papers from a lab should be evaluated and that young investigators could be interviewed by the granting agencies to evaluate promise. Others suggest that funds could be given to departments and the departments could distribute the money in the most efficient and effective manor.
Many scientists advocate shorter grant proposals with more of an emphasis on past productivity than on what's in the actual proposal. If you've been successful in the past then you will probably be successful in the future. It's time to stop rewarding grantsmanship and start rewarding science.
Hawks on Campus
It's probably just a coincidence but now that students have returned from their summer break there are more and more reports of hawks flying over the main open space on campus just outside my office. I seen them (it?) as well. The latest issue of the University of Toronto eBulletin has a photo of a red tailed hawk—one of the regular visitors. Darryl Chow took the picture.
Does this explain the noticeable lack of doves on campus? I haven't seen any significant gathering of doves for many years. It used to be a regular occurrence on university campuses.
Monday, September 14, 2009
Evolution and "Modern" Religion
Karen Armstrong, a former Roman Catholic nun, was asked to write an article about evolution for The Wall Street Journal. They also asked a scientist [Man vs. God]We commissioned Karen Armstrong and Richard Dawkins to respond independently to the question "Where does evolution leave God?" Neither knew what the other would say. Here are the results.Most us have heard what Dawkins has to say, so let's concentrate on Karen Armstrong's defense of religion in the light of modern science. She starts off with ...
Richard Dawkins has been right all along, of course—at least in one important respect. Evolution has indeed dealt a blow to the idea of a benign creator, literally conceived. It tells us that there is no Intelligence controlling the cosmos, and that life itself is the result of a blind process of natural selection, in which innumerable species failed to survive. The fossil record reveals a natural history of pain, death and racial extinction, so if there was a divine plan, it was cruel, callously prodigal and wasteful. Human beings were not the pinnacle of a purposeful creation; like everything else, they evolved by trial and error and God had no direct hand in their making. No wonder so many fundamentalist Christians find their faith shaken to the core.That seems to be the inescapable conclusion. Religious people who want to accept science have no choice but to fall back on a wishy-washy kind of religion where God plays no direct role and life has no purpose.
What kind of religion is that? Well, you'll have to read the rest of her article in order to appreciate the kind of mental gymnastics required to "evolve" a "modern" religion that doesn't conflict with science. Here's a taste ...
The best theology is a spiritual exercise, akin to poetry. Religion is not an exact science but a kind of art form that, like music or painting, introduces us to a mode of knowledge that is different from the purely rational and which cannot easily be put into words. At its best, it holds us in an attitude of wonder, which is, perhaps, not unlike the awe that Mr. Dawkins experiences—and has helped me to appreciate —when he contemplates the marvels of natural selection.This is typical of so-called "modern" and "sophisticated" theology. It's so "sophisticated," in fact, that the only people who understand it are those who practice it. Those people are completely incapable of explaining their version of spiritualism and mysticism to the rest of us because it's a very personal feeling. It's that feeling you get when you appreciate natural beauty or the awesome knowledge that comes from science.
Problem is, Richard Dawkins also has that feeling, and so do I. If the "God" feeling is indistinguishable from that of atheists then what's the point? Why not just cut out the middle man?
[Photo Credit: Reuters]
It seems like I'm not the only one who recognizes a vacuum when I see one.
Jerry Coyne: Dawkins 17, Armstrong 0
PZ Myers: Saving gods by making them even emptier of meaning
Richard Dawkins Speaks About Evolution
During last week's class I asked my students if they had heard of Richard Dawkins. Very few hands were raised.
Here's a recent video of Dawkins speaking about evolution and his latest book, The Greatest Show on Earth—Evidence for Evolution. I leave it as an exercise to identify those ideas of Dawkins where there is legitimate scientific controversy. (The course is about controversies and misconceptions.)
[Hat Tip: RichardDawkins.net
Monday's Molecule #136
Today's "molecule" is an easy one in celebration of the start of a new academic year for many university students. Name this structure and provide a very brief description of it's function.The Nobel Laureate should be obvious.
The first person to describe the "molecule" and name the Nobel Laureate wins a free lunch. Previous winners are ineligible for six weeks from the time they first won the prize.
There are only three ineligible candidates for this week's reward: Markus-Frederik Bohn of the Lehrstuhl für Biotechnik in Erlangen, Germany, Maria Altshuler of the University of Toronto, and Philip Johnson of the University of Toronto.
I have an extra free lunch for a deserving undergraduate so I'm going to continue to award an additional prize to the first undergraduate student who can accept it. Please indicate in your email message whether you are an undergraduate and whether you can make it for lunch.
THEME:
Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule(s) and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Prizes so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.
Correct responses will be posted tomorrow.
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