Reserpine

Reserpine is a powerful plant alkaloid that used to be used to control psychotic behavior and treat certain cancers. Unfortunately, it's severe side effects and unpredictable behavior has limited it's usefulness. The drug has been replaced by more reliable treatments.

Many plants contain mildly toxic alkaloids but in most cases the concentrations are not high enough to cause a problem.¹ Reserpine is concentrated in Rauwolfia serpentina (Indian snakeroot) and this plant has been used for several thousand years in treating a number of aliments. One of the main effects of reserpine is to block the action of dopamine. This blockage causes symptom's that resemble Parkinson's disease. They can be relieved by treating the patient with L-dopa [Monday's Molecule #70].

My first exposure to research was a summer job (1966) in the lab of George Setterfield at Carleton University in Ottawa (Canada). The project was to identify crystal-like inclusions in the cells of Rauwolfia serpentina. The hypothesis was that these inclusions were composed of alkaloids, especially reserpine. As I recall, I didn't make much progress. The inclusions weren't always visible and my suspicion was that they could have been an artifact of the fixation process.

I haven't been able to find any mentions of plant alkaloid inclusions in the literature. Does anyone know this field?

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1. It's much safer to eat meat.

Terms & Conditions on Nature Network

 
Eva Amsen has an interesting question about how you would fund research if you were in complete control of all the money in the world [see, Would you rather?].

I was all set to post a comment when I realized that I had to sign in to Nature Network in order to do so. That reminded me about the terms and conditions. That's way more hassle than I'm prepared to put up with. I prefer the rough and tumble of unrestricted blogs.

My question is, does anyone else feel this way? What's the future of science blogging? Is it the strictly controlled environment of Nature Networks where the fora are part of a for-profit venture? Or is it the free-for-all environment of some of the other science blogs? Or is it something in between like the relatively unrestricted environment of the blogs run by SEED magazine?

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Monday's Molecule #70

 
It's been a while since you had to identify a molecule and give it's correct IUPAC name so here's a molecule that will give you some practice. First, you should assume that this is the L- form of this molecule and not the D- form. (This isn't obvious from the chemical structure.)

Give the common name of the molecule and the complete IUPAC name.

Identify the two Nobel Laureates who were awarded a Nobel Prize, in the same year, for discovering the fundamental properties of this molecule.

The first person to correctly identify the molecule and name the Nobel Laureates wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first collected the prize. There are only two ineligible candidates for this week's reward.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureates. Note that I'm not going to repeat Nobel Laureates so you might want to check the list of previous Sandwalk postings.

Correct responses will be posted tomorrow. I may select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.

UPDATE: This week's winner is Maria Altshuler from the University of Toronto. She identified the molecule as L-dopa ((S)-2-amino-3- (3,4-dihydroxyphenyl) propanoic acid) and the Nobel Laureates are Arvid Carlsson and Paul Greengard. Congratulations Maria, you beat out several others who came up with the correct answer. The University of Toronto is thumping all other schools in this contest!¹

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1. That might have something to do with the fact that you have to be in Toronto to collect the prize, ya think? Maybe I should have another prize for people who can't come to Toronto? How about a Tim Horton's gift certificate?

Evolution of Sex & Recombination

 
I've been wondering if John Logsdon was still alive. There have been very few postings on his blog Sex, Genes, & Evoluton. Now we know why. He has been organizing a meeting about Sex in Iowa. (Is that an oxymoron?)

This looks like a very interesting meeting. Most of the key players are going to be there. Looking over the list of speakers makes you realize that the problem of sex is still very complicated. We don't have a consensus on the evolutionary advantages of sex (if any). This is an important point since many on the evolutionist side think otherwise. They believe that the evolutionary advantages of sex have been proven and it's no longer an open question.

I hope we'll hear a summary of the talks once the meeting is over.

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Tangled Bank #104

 
The latest issue of Tangled Bank is #104. It's hosted at Dammit Jim! [Tangled Bank #104].

Welcome to the 104th edition of the Tangled Bank blog carnival (a biweekly showcase of good biology posts selected by the authors themselves). Rigorous calculations and archaelogical research have revealed that this is the Tangled Bank’s 4th birthday. In the birthday spirit, several people sent appropriately themed presents.

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If you want to submit an article to Tangled Bank send an email message to host@tangledbank.net. Be sure to include the words "Tangled Bank" in the subject line. Remember that this carnival only accepts one submission per week from each blogger. For some of you that's going to be a serious problem. You have to pick your best article on biology.

Effective Population Size of Our Ancestors in Africa

 
John Hawks has posted an interesting discussion of the effective population size of human ancestors. He concludes that N_e=34,000 during the late stone age (about one million years ago). According to Hawks, this means there were about 100,000 to 300,000 individuals spread throughout Africa at this time [Did humans face extinction 70,000 years ago?].

I don't understand the math, or the data. As a general rule, I'm skeptical of these calculations because so many papers seem to reach different conclusions. The really nice part of John's posting is that he tries to explain the assumptions and possible sources of error. It's worth a read just to get a feel for the kinds of things that are going on in population genetics.

There are no comments allowed on john hawks weblog. I'm sure if you post questions here he will answer.

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Atheism, Agnosticism and Religious Dissent in Ancient Western Civilization

 
Come to the Centre for Inquiry's lecture by David Hitchcock tomorrow night. I'm really looking forward to this 'cause I've often confronted theists who claim that atheism is a relatively new phenomenon. Many of them think it's caused by modern science.

Starts
Friday, May 2nd at 7:00 pm
Ends
Friday, May 2nd at 9:00 pm
Location
Centre for Inquiry Ontario, 216 Beverley St, Toronto ON (1 minute south of College St at St. George St)

Summary

Agnosticism, atheism and religious scepticism have a longer history in western thought than is often recognized. I survey the history of such thinking in the ancient Greek philosophical tradition from the 5th century BCE to the 2nd century CE. The views surveyed include arguments against the anthopomorphism of popular religion, explicit agnosticism, naturalistic explanations of the origin of religion, arguments that truly divine beings would be indifferent to human doings and sufferings, and sceptical attacks on the most common arguments for the existence of gods.

Brief biography of David Hitchcock

David Hitchcock is professor of philosophy at McMaster University in Hamilton, Canada. Born in 1942 in England, he was brought by his parents to Hamilton at the age of 5 and has lived there ever since, except for a year in England as a child and four years in California as a graduate student. His research falls into three main areas: the philosophy of argument, ancient philosophy, and the history of logic. He is the author of a textbook on critical thinking, as well as co-author of a textbook on logic and critical thinking in medicine. He has also co-edited a volume of original papers on the use of the "Toulmin model" for the analysis and evaluation of arguments. He is the author of dozens of book chapters, journal articles and conference proceedings papers. They deal with such topics as the evaluation of inferences, the concept of relevance, practical reasoning, the effectiveness of computer-assisted instruction in critical thinking, Plato's conception of the good, the relation between fallacies and formal logic in Aristotle's thought, Aristotle's theory of argument evaluation, the reconstruction of Stoic propositional logic, and the Polish version of Alfred Tarski's classic paper on the concept of logical consequence.

Dr. Hitchcock received his B.A. in Honours Philosophy in 1964 from McMaster University and his Ph.D. in philosophy in 1974 from Claremont Graduate School in Claremont, California. His Ph.D. dissertation dealt with the role of myth in Plato's dialogues and its relation to rational argument. He has been a full-time faculty member at McMaster since July 1968.

Dr. Hitchcock was the founding president (1983-85) of the Association for Informal Logic and Critical Thinking, an international scholarly association, and is currently serving a two-year term (2007-09) on its board.

Dr. Hitchcock has been a member of the New Democratic Party of Canada since 1963. He was the NDP candidate for Member of Parliament in the constituency of Hamilton -Wentworth in three federal elections, in 1979, 1980 and 1984. He is currently membership organizer in the Ancaster -Dundas -Flamborough -Westdale New Democratic Party Provincial Riding Association. He is also the official agent of Gordon Guyatt, who has been nominated as the NDP candidate in the constituency of Ancaster -Dundas -Flamborough -Westdale in the next federal election.

He is married and has two daughters, one stepson and four granddaughters.

$5 regular, $4 general, FREE for Friends of the Centre

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Sophisticated Religion

 
One of the arguments used against atheists is that they haven't studied religion. The theists maintain that there are very sophisticated arguments for the existence of God and that we atheists are just ignoring all those good argumnts in order to score points against the simplistic arguments of the hoi polloi.

I've been asking for examples of these "sophisticated" arguments for some time without success. Today, one of the Sandwalk readers posted an answer in the comments section. It's a talk given by Alvin Plantinga at Biola Unioversity [An Evolutionary Argument Against Naturalism].

This is old news [A Sophisticated Christian Philosopher Critiques The God Delusion]. If this is the best they can do then theism is in big trouble.

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Google and Blogger Screw Up Bigtime!

 
Starting about 10 days ago, a number of blogs on Blogger have been blocked because they are suspected of being spam. Apparently, the blogger/blogspot crew installed some new software to detect spam and the result was that many blogs were removed (blocked) without warning. You can imagine how upset some bloggers are about this.

The blogs are gradually being restored (unblocked) [e.g. ERV].

Here's the message at the help center. It looks like the Blogger employees have gotten the message ...

Hello Bloggers,

It seems that a few of you feel you aren't getting the proper TLC that you deserve when requesting a spam appeal. So to make sure that no one falls through the cracks, we have created a form where you can submit your locked URL for another manual review by a human being.

If you've already submitted a request from your dashboard and you have not heard back from us after four business days, please re-submit your blog's address at the form below:

https://spreadsheets.google.com/viewform?key=pZHHZdeYKeHjcTRpnBYV0Qw&...

Thanks,
Dana

PS If doing that doesn't work, then your blog has probably been determined to be spam :(

Some readers have noticed that posting comments has become a problem. I don't know exactly what Blogger has done to cause this problem. There were complaints about the new format for word verification so I've turned off that feature for now. Many people found it impossible to decipher the letters. (Blogger has since restored the old version.)

This isn't the only problem. Don't try to post a comment by clicking on "Publish this comment" under the comment that you are previewing. That doesn't seem to work. Click on the orange button "PUBLISH YOUR COMMENT" in the upper right-hand corner of the comment page. That seems to work most of the time.

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Ben Stein Is an IDiot

 
I know, I know, ... I'm not telling you something you don't already know. Ben Stein's role in Expelled: No Intelligence Allowed is more than sufficient to demonstrate that, indeed, intelligence is not permitted in that movie.

In case you didn't know how stupid Stein really is, there's even more proof in his various interviews. John Derbyshire has just posted an excerpt from an interview with Paul Crouch Jr. on the Trinity Broadcasting Network [see Science Equals Murder]. Stein's views need to be widely known. Here's what he said ...

Stein: When we just saw that man, I think it was Mr. Myers [i.e. biologist P.Z. Myers], talking about how great scientists were, I was thinking to myself the last time any of my relatives saw scientists telling them what to do they were telling them to go to the showers to get gassed … that was horrifying beyond words, and that’s where science — in my opinion, this is just an opinion — that’s where science leads you.

Crouch: That’s right.

Stein: …Love of God and compassion and empathy leads you to a very glorious place, and science leads you to killing people.

Crouch: Good word, good word.

Like the man says, when you're an IDiot, there's no intelligence allowed.

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Nobel Laureate: Bernardo Houssay

 

The Nobel Prize in Physiology or Medicine 1947.

"for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar"

Bernardo Alberto Houssay (1887 - 1971) received the Nobel Prize in Physiology or Medicine for his work on pituitary gland hormones that affect carbohydrate metabolism. He shared the prize with Carl and Gerty Cori.

Houssay was mainly responsible for recognizing that the anterior lobe of the pituitary gland secreted a peptide hormone that antagonized insulin. We now know that this hormone is growth hormone [Monday's Molecule #69]. It has general effects on growth and development as well as regulating carbohydrate metabolism in adults.

Bernardo Houssay was a citizen of Argentina. He was known as an outspoken liberal and an advocate of democracy. Houssay was fired from his academic position when Juan Perón took over as dictator in 1945 but he remained in Argentina working in a private laboratory. The Nobel Prize award in 1947 was seen, quite rightly, as a repudiation of Juan Perón and his policies. This was very controversial in Argentina [see Bernardo Alberto Houssay for one of many biographies].

THEME:

Nobel Laureates
The presentation speech was given by Professor H. Theorell, Head of the Biochemical Nobel Department of the Royal Caroline Institute.

Your Majesty, Your Royal Highnesses, Ladies and Gentlemen.

The teaching body of the Caroline Institute has decided to award one half of the 1947 Nobel Prize for Physiology or Medicine to Professor Carl Cori and Dr. Gerty Cori «for their discovery of the course of the catalytic conversion of glycogen», and the other half to Professor Bernardo Houssay «for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of sugar».

The work of these prize-winners is within the same centrally important sphere, namely the metabolism of sugar in the body. They have elucidated the enzymatic reactions between glucose and glycogen, and have shown how these reactions are controlled by physiological factors. Faulty sugar metabolism may lead to diabetes, with its universally known symptoms. Everyone now knows, too, that in the majority of cases it has been possible to keep this disease in check by insulin since its discovery by Banting and MacLeod, to whom the Nobel Prize was awarded in 1923. It would be a grave mistake, however, to believe that this brilliant discovery unravelled the immense complex of problems concerning sugar metabolism. Certainly it is long known that insulin decreases the blood sugar level, but until recently the mechanism of this effect was veiled in mystery.

The task of sugar metabolism is to supply energy for the activities of life. One cannot make the slightest muscular movement without the combustion of an appropriate amount of sugar. It is readily understandable that one of our most urgent tasks is to elucidate this branch of metabolism. A clear light has been thrown on previously obscure points in our knowledge, by the discoveries for which the prizes are awarded this year.

Ninety years ago the great French physiologist, Claude Bernard, discovered that the liver and muscles contain a starch-like substance, which he called glycogen, the «sugar former». Every molecule of glycogen consists of a large number of grape sugar molecules, which are united together to be stored up in that form until they are needed. When needed, the glycogen disintegrates again into grape sugar, or glucose, to use a more scientific name. In this way the glucose content of the blood can be kept fairly constant in spite of an uneven supply. The credit for having revealed how the interplay between the glucose and the glycogen takes place falls to Professor and Doctor Cori. From the works of Robison and Embden in the 1920's it was known that the sugar in living cells and tissues, e.g. in yeast and in muscle, appears under certain circumstances bound to phosphoric acid. Closer analysis showed that in these combinations the phosphoric acid was bound to the sixth in the chain of the six carbon atoms of the sugar molecule.

...

This latest work of the Cori's is directly connected with the discovery of the effect of the hypophysis on the utilization of sugar by Professor Bernardo A. Houssay, who has also been awarded a prize. The hypophysis, or the pituitary gland, is a small secreting gland at the base of the brain, where it lies sunk in a bony hollow in the most sheltered spot in the whole body. Its importance justifies its sheltered position, but its size is far from impressive: that of a bean in man, a pea in the dog, and a radish seed in the toad Bufo marinus.

People sometimes cite, more or less jokingly, the statement by Cartesius, the famous philosopher, that the soul lies in the pineal gland. Now it does so no more than in any other individual organ, but if Cartesius had chanced, instead, to guess at the hypophysis, which looks much the same and is situated immediately in front of the pineal gland, he would have been nearer the truth, for in spite of its diminutive size the hypophysis exercises a number of vital functions and occupies a commanding position in relation to the other endocrinous glands. By means of its hormones the hypophysis controls the thyroid, the sex glands and the cortex of the suprarenal glands; it regulates the formation of milk and the growth of the whole body. By means of extremely beautiful experiments Houssay has shown that it also plays a prominent role in the conversion of sugar.

It was the discovery of insulin which aroused Houssay's interest in the hypophysis. As early as in the 1880's the great French research worker, Pierre Marie, had found that the excretion of sugar in the urine was a regular symptom in acromegalia, which is due to a disturbance in the function of the hypophysis, and therefore a connection between the function of the hypophysis and the metabolism of sugar might be suspected.

Houssay has worked chiefly with dogs and a large kind of toad, Bufo marinus, which is plentiful in the Argentine. In many series of experiments the hypophysis, or sometimes only its anterior lobe, was removed by operation. In the case of dogs, especially, the operation calls for highly developed technical skill if the result is not to be «the operation was successful, but the patient died». Houssay then found that the animals which had been operated on were abnormally sensitive to insulin and died with symptoms of bloodsugar deficiency from doses which were quite harmless for normal animals. In conformity with this, the glycogen content in the liver was abnormally low. A corresponding pathological picture is met with in the case of Simmond's disease in man. Dogs and toads exhibited the same kind of reaction, as have all the rest of the vertebrates hitherto investigated. This proves that Houssay had discovered a universal biological mechanism.

The discovery that a daily implantation of anterior lobe of hypophysis from toads on the operated animals protected the latter from the dangerous effect of insulin, was also of immense importance.

Thus the hormone of the anterior lobe of the hypophysis was clearly antagonistic to the hormone of the pancreas, insulin. This was confirmed and illustrated by a further series of ingenious experiments. Davidoff and Cushing had observed already in 1927 that if diabetes was provoked in dogs by the removal of a part of the pancreas, the symptoms were moderated if part of the hypophysis was also taken away. However, these experiments were not entirely conclusive, since as a rule the diabetes provoked in this way may disappear spontaneously. Houssay and Biasotti obtained definite elucidation by means of a more radical procedure. The whole hypophysis was first removed and subsequently the pancreas. For three whole days after the latter operation no sugar appeared in the urine, which is always the case if the pancreas is removed from an animal which still has its hypophysis.

In 1931, in the course of their work on the growth hormone of the hypophysis, H. M. Evans and his co-workers in U.S.A. found that the extract which naturally was still impure - provoked diabetes if injected into animals. At the same time and independently of Evans, Houssay and his co-workers arrived at similar results. After injections of extract from the anterior lobe of the hypophysis, the diabetes persisted, in many cases for months, and this was found to be due to injury to the insulin-producing cells in the pancreas.

The active factor in the hypophysis is so extremely sensitive that all the preparations must be made at a low temperature, if they are not to be spoiled. Therefore a number of research workers, who were less careful than Houssay on this point, did not at first succeed in confirming his results. It may be added that the Cori's had to grapple with the same difficulties in the preparation of their extract of hypophysis, which to some extent confirms that both groups of workers were dealing with the same active substances.

A short description of the most important results of many years of scientific work can never give a complete idea of the days and nights of labour which is most frequently fruitless. Diligence and patience are indispensable components in the mental equipment of the research worker. These alone seldom or never lead to pioneer discoveries, however, because it is impossible to deal thoroughly and systematically with all the conceivable alternatives, at least in the case of biological problems. The possibilities are all too many. Intuition is the indispensable lode-star, promising new goals to be reached by a labyrinth of paths, the majority of which are blind alleys.

In work characterized by unremitting diligence, brilliant skill, and masterly acumen, today's prize-winners in physiology or medicine have shown themselves to possess all the qualities of the great research worker in natural sciences. They have thrown light on previously undreamt of connections between the inaccessible world of the enzymes and the hormones. The task of the doctor to prevent, heal or alleviate disease demands a knowledge of the functions of the body; this year's prize-winners have opened new fields in which Ernest Starling's happy expression «The physiology of today is the medicine of tomorrow» will prove its truth.

Professor Carl Cori and Doctor Gerty Cori. During the past decade the scientific world has followed your work on glycogen and glucose metabolism with an interest that has gradually increased to admiration. Since the discovery of glycogen by Claude Bernard ninety years ago, we have been almost totally ignorant of how this important constituent of the body is formed and broken down. Your magnificent work has now elucidated in great detail the extremely complicated enzymatic mechanism involved in the reversible reactions between glucose and glycogen. Your synthesis of glycogen in the test tube is beyond doubt one of the most brilliant achievements in modern biochemistry. Your discovery of the hormonal regulation of the hexokinase reaction would seem to lead to a new conception of how hormones and enzymes cooperate.

In the name of the Caroline Institute I extend to you hearty congratulations on your outstanding contribution to biochemistry and physiology.

Professor Houssay. That great philanthropist, Alfred Nobel, had a great personal interest in physiology. Few things gave him so great a pleasure as being able to witness the brilliant development of this science in the nineteenth century. In the development of physiology, Professor Houssay, you have played a very active part, particularly regarding the work which you have brought into prominence and which is now to be honoured by the Nobel Prize.

The hypophysis is a small gland, but its importance is not related to its size, since it regulates many of our most important functions. Amongst these functions, which you have studied and analysed in a clear and striking manner, is the dominant role the gland plays in our metabolic processes.

On behalf of the Caroline Institute I congratulate you on receiving the Nobel Prize which is presented to you today, and which is a sure sign that your name will ever remain engraved in the annals of physiology.

Professor Carl Cori and Doctor Gerty Cori; Professor Houssay. I now have the honour of asking you to accept the prize from the hands of His Majesty our gracious King.

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Richard Dawkins—polite and gracious to a fault

 
Some of you might remember Peter McKnight. He's a columnist for the Vancouver Sun (Canada) and he wrote a piece last year defending Marcu Ross and his Ph.D. degree [Peter McKnight on the Marcus Ross Issue].

My interactions with Peter McKnight have been quite enjoyable so it is with considerable satisfaction that I point you to his latest article on Richard Dawkins [How to reconcile Richard Dawkins?]. Peter puts his finger squarely on the discrepancy between what Dawkins says in public about religion and what he says in private.

I like the private Richard Dawkins when it comes to a position on religion as the root of all evil, and atheists as being free of violence.

Unlike the public Dawkins, I don't oppose superstitious beliefs because they lead to evil—I oppose them because there's no evidence that those beliefs are correct.

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[Hat Tip: RichardDawkins.net]

Should Undergraduate Programs Be Easier?

 
We have a biochemistry program for undergraduates. It would be called a major at most universities but at the University of Toronto we call it a Biochemistry Specialist Program. Here's an outline with the number of credits, where (1) is a standard two-semester course ...

1st year
Calculus (1), Biology (1), Physics (1), Chemistry (1)

2nd year
Biochemistry (1), Organic Chemistry (0.5), Physical Chemistry (0.5), Cell & Molecular Biology (1)

3rd year
Biochemistry Laboratory (0.5), Proteins (0.5), Nucleic Acids (0.5), Molecular Biology (1), 1.5 extra credits from a list of science courses

4th year
Advanced Biochemistry Laboratory (1), four (0.5) credit courses from a list of biochemistry and molecular biology courses

Here's the problem. Enrolment in this program is dropping because the students perceive it as being too hard. A number of easier, less rigorous, programs have recently become available in other departments. These other programs are being promoted as excellent choices for an undergraduate degree. Students are being told that these easy program will be just as acceptable as the more difficult ones when they apply to graduate school. (That won't be true in our department.)

Students believe that they will get higher grades in these other programs and that will make it easier to get into medical school or graduate school.

What should we do? There's a possibility that our program will disappear if we do nothing. On the other hand, making it a lot easier by dumbing down the material and giving higher grades goes against the principles that many of us believe in.

Have any other schools faced this situation? What did you do? What do the students think?

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Who Do You Know?

 
The Friendly Atheist asks ...

Who is the most famous person you know (who would admit to knowing you back)?

You can see my answer over there. Sandwalk readers might like to jump in and drop a few names.

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Monday's Molecule #69

 
This colorful molecule plays an important role in regulating carbohydrate metabolism, among other things. Your task for today is to identify the molecule. Be as specific as possible (what species?).

Identify the Nobel Laureate(s) who was/were awarded a Nobel Prize for discovering fundamental properties of this molecule without knowing the sequence or the structure. [Hint: The award was very controversial in the home country of the Nobel Laureate(s).]

Here's part of the PDB file to help you.

SEQRES 1 A 191 PHE PRO THR ILE PRO LEU SER ARG LEU PHE GLN ASN ALA
SEQRES 2 A 191 MET LEU ARG ALA HIS ARG LEU HIS GLN LEU ALA PHE ASP
SEQRES 3 A 191 THR TYR GLU GLU PHE GLU GLU ALA TYR ILE PRO LYS GLU
SEQRES 4 A 191 GLN LYS TYR SER PHE LEU GLN ALA PRO GLN ALA SER LEU
SEQRES 5 A 191 CYS PHE SER GLU SER ILE PRO THR PRO SER ASN ARG GLU
SEQRES 6 A 191 GLN ALA GLN GLN LYS SER ASN LEU GLN LEU LEU ARG ILE
SEQRES 7 A 191 SER LEU LEU LEU ILE GLN SER TRP LEU GLU PRO VAL GLY
SEQRES 8 A 191 PHE LEU ARG SER VAL PHE ALA ASN SER LEU VAL TYR GLY
SEQRES 9 A 191 ALA SER ASP SER ASP VAL TYR ASP LEU LEU LYS ASP LEU
SEQRES 10 A 191 GLU GLU GLY ILE GLN THR LEU MET GLY ARG LEU GLU ASP
SEQRES 11 A 191 GLY SER PRO ARG THR GLY GLN ALA PHE LYS GLN THR TYR
SEQRES 12 A 191 ALA LYS PHE ASP ALA ASN SER HIS ASN ASP ASP ALA LEU
SEQRES 13 A 191 LEU LYS ASN TYR GLY LEU LEU TYR CYS PHE ARG LYS ASP
SEQRES 14 A 191 MET ASP LYS VAL GLU THR PHE LEU ARG ILE VAL GLN CYS
SEQRES 15 A 191 ARG SER VAL GLU GLY SER CYS GLY PHE

The first person to correctly identify the specific molecule and name the Nobel Laureate(s) wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first collected the prize. There is only one ineligible candidates for this week's reward.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureates so you might want to check the list of previous Sandwalk postings.

Correct responses will be posted tomorrow along with the time that the message was received on my server. I may select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.

UPDATE: This week's winner is David Schuller of Cornell University (again). He correctly identified the molecule as human growth hormone and the Nobel Laureate is Bernardo Houssay (1947). Thanks to all the others who sent in their guesses.

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