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Tuesday, November 29, 2011

David Berlinksi Prays for Me!!!!

 
Over at Evolution News & Views, Casey Luskin is ranting again about not getting no respect [The Uncivil Style of Intelligent Design Critics]. While checking out recent postings on that site to see whether the evil Darwinists were being treated respectfully, I came across a post by David Berlinski on Phillip Johnson. Imagine my surprise when I read this ....
At the Discovery Institute we often offer an inter-faith Prayer of Thanksgiving to the Almighty for the likes of P.Z. Myers, Larry Moran, Barbara Forrest, Rob Pennock and Jeffrey Shallit.
Thank-you to all the inmates at the institute. I really appreciate your thoughts and prayers.

Next time, could you ask him to send money?


Monday, November 28, 2011

On Being a Sophisticated Atheist

We atheists really have a hard time pleasing theists and philosophers who insist that we immerse ourselves in the study of gods before declining to believe in any of them. Apparently it's not sufficient to simply reject as unconvincing all of the arguments for the existence of god. We also have to study apologetics, which takes the existence of god as a premise!

As if that weren't bad enough, we now have a group of philosopher types who insist that we study every atheist who ever lived. One of those philosopher types is R. Joseph Hoffman, a graduate from Harvard Divinity School and the University of Oxford. He is mainly interested in early Christianity. Hoffman is a nonbeleiver who posts at The New Oxonian. His latest post is: Atheism’s Little Idea.

Is the Burzynski Clinic Full of Quacks?

The Burzynski Clinic is located in Houston, Texas, United States. It charges a lot of money to treat cancer patients and the treatment is probably not effective according to Andy Lewis at The Quackometer: The False Hope of the Burzynski Clinic.

Andy Lewis received a letter from someone named Marc Stephens who claims to represent the Burzynski Clinic. You have to read this letter to understand what's going on [The Burzynski Clinic Threatens My Family].
Le Canard Noir / Andy Lewis,

I represent the Burzynski Clinic, Burzynski Research Institute, and Dr. Stanislaw Burzynski. It has been brought to our attention that you have content on your websites http://www.quackometer.net/blog/2011/11/the-false-hope-of-the-burzynski-clinic.html that is in violation of multiple laws.

Please allow this correspondence to serve as notice to you that you published libelous and defamatory information. This correspondence constitutes a demand that you immediately cease and desist in your actions defaming and libeling my clients.

Please be advised that my clients consider the content of your posting to be legally actionable under numerous legal causes of action, including but not limited to: defamation Libel, defamation per se, and tortious interference with business contracts and business relationships. The information you assert in your article is factually incorrect, and posted with either actual knowledge, or reckless disregard for its falsity.

The various terms you use in your article connote dishonesty, untrustworthiness, illegality, and fraud. You, maliciously with the intent to harm my clients and to destroy his business, state information which is wholly without support, and which damages my clients’ reputations in the community. The purpose of your posting is to create in the public the belief that my clients are disreputable, are engaged in on-going criminal activity, and must be avoided by the public.

You have a right to freedom of speech, and you have a right to voice your opinion, but you do not have the right to post libelous statements regardless if you think its your opinion or not. You are highly aware of defamation laws. You actually wrote an article about defamation on your site. In addition, I have information linking you to a network of individuals that disseminate false information. So the courts will apparently see the context of your article, and your act as Malicious. You have multiple third parties that viewed and commented on your article, which clearly makes this matter defamation libel. Once I obtain a subpoena for your personal information, I will not settle this case with you. Shut the article down IMMEDIATELY.

GOVERN YOURSELF ACCORDINGLY.

Regards,

Marc Stephens
Burzynski Clinic
9432 Katy Freeway
Houston, Texas 77055
What would a normal person do after receiving such a letter? Ask for more information about the "defamatory" content. That's what Andy Lewis did and here's part of the response.
If you had no history of lying, and if you were not apart of a fraud network I would take the time to explain your article word for word, but you already know what defamation is. I’ve already recorded all of your articles from previous years as well as legal notice sent by other attorneys for different matters. As I mentioned, I am not playing games with you. You have a history of being stubborn which will play right into my hands. Be smart and considerate for your family and new child, and shut the article down..Immediately. FINAL WARNING.

Regards,

Marc Stephens
Yep, that's a threat you see in that paragraph.

Here's a few people who think that the Burzynski Clinic deserves more publicity.


"Yes," "No," and "I Don't Know"

John Wilkins has continued the discussion about agnosticism, atheism, and the meaning of debate [Once more into the fray, dear agnostics]. I'll try and respond to the specific points he makes in a minute or two, but first I need to make my own position (more) clear.

I teach a course on critical thinking about scientific issues such as evolution/creationism. Most (all?) of the "scientific" debates that enter the public realm can be divided into two groups: those where one side is right and the other side is wrong, and those where the issue is controversial. From a personal perspective, that means you can have three responses when asked if you agree with a scientific argument: "yes," "no," and "I don't know."

Monday's Molecule #151

 
This is a very complicated molecule so I'm not going to ask for the IUPAC name. You can win with the common name but be sure to get it right!

This molecule has played a very important role in elucidating some basic concepts in molecular biology but its structure is rarely shown in 21st century biochemistry textbooks.

Post your answer in the comments. I'll hold off releasing any comments for 24 hours. The first one with the correct answer wins. I will only post correct answers to avoid embarrassment.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your comment.) Every undergraduate who posts a correct answer will have their names entered in a Christmas draw. The winner gets a free autographed copy of my book! (One entry per week. If you post a correct answer every week you will have ten chances to win.)

Some past winners are from distant lands so their chances of taking up my offer of a free lunch are slim. (That's why I can afford to do this!)

In order to win you must post your correct name. Anonymous and pseudoanonymous commenters can't win the free lunch.

UPDATE: The molecule is rifampicin, an inhibitor of bacterial RNA polymerase. The winner is Philip Rodger. Congratulations Philip, please send me an email message so we can arrange lunch.

Winners
Nov. 2009: Jason Oakley, Alex Ling
Oct. 17: Bill Chaney, Roger Fan
Oct. 24: DK
Oct. 31: Joseph C. Somody
Nov. 7: Jason Oakley
Nov. 15: Thomas Ferraro, Vipulan Vigneswaran
Nov. 21: Vipulan Vigneswaran (honorary mention to Raul A. Félix de Sousa)


Sunday, November 27, 2011

NASA Confusion About the Origin of Life

NASA-funded researchers have evidence that some building blocks of DNA, the molecule that carries the genetic instructions for life, found in meteorites were likely created in space. The research gives support to the theory that a "kit" of ready-made parts created in space and delivered to Earth by meteorite and comet impacts assisted the origin of life. [NASA Researchers: DNA Building Blocks Can Be Made in Space]

Most scientists are not thinking critically about the origin of life. It is extremely improbable that asteroids could have delivered enough amino acids or purines to make a difference. Given the known stability of these molecules in the ocean, you would have to achieve an enormous delivery rate to make a concentration sufficient to drive polymerization. It's much more likely that the first complex amino acids, and the first purines and pyrimidines, were synthesized in special environments on Earth using simple inorganic precursors. This is the origin of life scenario promoted as "Metabolism First" [More Prebiotic Soup Nonsense].

I wish NASA astrobiologists would stop making the assumption that all they have to do is discover complex organic molecules in asteroids in order to solve the origin of life. There are a lot of steps between finding purines in asteroids and making a prebiotic soup that could contribute to the origin of life. Those steps need to be spelled out in their press releases so the public can evaluate the discovery.

Here's what I wrote a few years ago .... [Can watery asteroids explain why life is 'left-handed'?]
In order for extraterrestrial organic matter to have fueled the origin of life, a lot of meteorites carrying organic matter had to arrive on the primitive Earth. The problem of amino acid concentrations and stabiltity were discussed in a classic paper by Jeffrey Bada published in 1991.

Some of his calculations are worth remembering.

The current flux of extraterrestrial organic material is about 3 × 108 grams per year from cosmic dust and micrometeorites. About 1% of this is amino acids and most of them are not the ones found in living organisms. This should give rise over time to a concentration in the oceans of about 0.1 nM (10-10 M). That's not sufficient for life to have originated.

The flux in the past was almost certainly much greater and lots of organic material might have been delivered by large meteorites; however, it's unlikely that amino concentrations in the oceans could ever have been more than 10-100 pM for all amino acids combined.

Most amino acids will spontaneously degrade over time. There's a window of opportunity that only lasts about 10 million years because in that time all the water in the oceans will pass through hydrothermal vents and the high temperature will destroy most chemicals—including amino acids.
I don't know whether the NASA astronomers are aware of this problem but have developed a scenario to overcome it, or whether they just haven't thought about the problem.


Bada, J. (1991) Amino acid cosmogeochemistry. Phil trans. R. Soc. Lond. 333:349-358.

Saturday, November 26, 2011

The Implosion of CFI Canada

The Centre for Inquiry - Canada "... promotes and advances reason, science, secularism and freedom of inquiry in all areas of human endeavour." It is affiliated with the Center for Inquiry in the United States, headquartered in Amherst, New York (near Buffalo).

The Canadian Centre for Inquiry was founded in 2007 and the inaugural meeting was held in their rented facilities just south of the University of Toronto and a short walk from my office [Centre for Inquiry: March 10, 2007]. Justin Trottier was the new director.

CFI - Canada has now grown from the original Toronto (Ontario) branch to include branches in Vancouver, Okanagan, Calgary, Saskatchewan, Ottawa, Montreal, and Nova Scotia. There's paid staff in Toronto and there are now paid employees (usually part time) in several other centres.

Friday, November 25, 2011

Zoë Is Coming for Christmas

 
My granddaughter Zoë is coming for Christmas, from Los Angeles. She's bringing her parents. That means two of my little girls (mother and daughter) are coming home for Christmas.

Here's an atheist video from Australia. It's about Christmas, family, love, and a little baby girl who grows up. Can you get through it without shedding a tear? I couldn't.

TimMinchin the songwriter and singer in this video, grew up in Perth, Australia. He lives with his wife, daughter, and son in London, England. The song, White Wine in the Sun was first released in December, 2009.




[Hat Tip: Pharyngula]

De mortuis nil nisi bonum

De mortuis nil nisi bonum is a Latin phrase which indicates that it is socially inappropriate to say anything negative about a (recently) deceased person. Sometimes shortened to nil nisi bonum, the phrase derives from the sentence "de mortuis nil nisi bonum dicendum est" and is variously translated as "Speak no ill of the dead", "Of the dead, speak no evil", "Do not/ Don't speak ill of the dead" or, strictly literally, "Of the dead, nothing unless good".
There are times when social conventions need to be violated. This is one of those times.

Lynn Margulis died last Tuesday (November 22, 2011) at the age of only 73. Margulis is rightly famous for her endosymbiotic theory of the origins of mitochondria and chloroplasts. We known that she was right and she deserves credit for that part of her theory.

However, since then (about 1970) her record has not been stellar and it's only appropriate that we keep this in mind as we reflect on her contribution to science. Here's a video of Lynn Margulis "defending" science by promoting the idea that one of the buildings of the World Trade Center in New York was brought down on Sept. 11, 2001 by explosives that had been planted in the building months before.




[Hat Tip: Why Evolution Is True]

John Wilkins on Sandwalk

 
I like John Wilkins. If he lived in Toronto I would want to talk to him several times a week and I'd even pay for the the coffee and lunches. It's embarrassingly easy to teach me things I don't know, or correct my errors, but John has done way more than his fair share over the past twenty years.

I think he's mad at me [Prescriptions for atheists].
First, Larry points out that arguments about the existence of God require one to take a position on fairies. One can only be agnostic about gods to the extent one is agnostic about fairies. My previous argument that this is comparing unlikes has, in one fell swoop, been demolished! Of course, there must be other reasons for thinking that we can rule fairies out of contention (let us call them faeries to avoid confusion) which do exist but are undetectable. It cannot be the principle that “if it is unscientific it is irrational” for that would be the positivist presumption and that would be unscientific. I know I am wrong about positivism here, because Dan Hicks pointed out that some positivists weren’t positivists about everything. So positivism is never self-defeating, even when the positivist presumption is applied by some to everything.

Larry must have other reasons for showing that faeries do not exist – other than being uninterested in what some people claim; this, as Larry must appreciate, is not about what I the reasoner think is true, but about what others who make these claims must be called. I look forward to him enlightening me on this.

Friendly Atheists and the Other Kind of Atheist


We've been discussing the perceived conflict between agnosticism and atheism. I believe they are compatible. Most prominent atheists are also agnostic about the existence of supernatural beings.

Part of the discussion has to do with how you define atheism. Many philosophers (professional and amateur) maintain that atheism is defined as "the view that there is no God." This is the definition taken from The Internet Encyclopedia of Philosophy, which claims to be a "peer-reviewed academic resource" [Atheism]. It seems to me that this view of atheism is widespread among philosophers, lending support to those who use it to justify rejecting atheism.

Thursday, November 24, 2011

Defining Atheism

 
Most people know that there are two common definitions of atheism/atheist. Here's an excellent example from two different dictionaries.

atheist: a person who denies or disbelieves the existence of a supreme being or beings [dictionary.com]

atheist: a person who does not believe in the existence of God or gods [Oxford Dictionaries]
The first definition defines an atheist as someone who maintains that gods do not exist. The second defines an atheist as someone who is not a theist.

The distinction is relatively unimportant in everyday usage since most of us who are nontheists will argue that gods do not exist. But when you're arguing with a philosopher you need to pick nits since philosophical arguments often turn on definitions. No intelligent atheist wants to be trapped into arguing that gods do not exist since that's like trying to "prove the negative" and we all know that it is impossible to prove the nonexistence of something.

What William the Conqueror's Companions Teach Us about Effective Population Size

My mother has been working on genealogy for several decades. She recently gave me a little book called My Ancestors Came with the Conqueror by Anthony J. Camp, first published in 1988. Camp is a professional genealogist. Before discussing this book, I should let you know that the relationship between professional genealogists and the amateur genealogy found on ancestry.com is similar to the relationship between scientists and Intelligent Design Creationism.

It's estimated that half the population of Great Britain claims to have descended from William the Conqueror who defeated King Harold at the Battle of Hastings in 1066. Not all claims meet the rigorous standards of professional genealogists but it's quite reasonable that there are millions of direct descendants of William.

Back in 1400 it was less likely that you were a descendant of William because there were fewer generations and fewer descendants. This was a problem for aspiring nobility and minor landholders so they tended to settle for the next best thing—they claimed descent from one of the companions of William who accompanied him from Normandy and fought at the Battle of Hastings. Gradually the list of companions grew and grew because if you couldn't prove you were related to an existing companion, you just made one up.

Many genealogists and historians have analyzed the various lists of companions. Some lists have over three hundred names but there are only about 20 companions who are definitely known to have been present at the Battle of Hastings in 1066 [William the Conqueror's Companions, The Companions of the Conqueror]. The Order of the Conqueror’s Companions is part of a genealogical society that traces descendants of the companions of William the Conqueror. They list 39 known companions.

Let's assume that there are 20 well-documented companions. Only one of these (William Mallet) has possibly passed on his Y chromosome to the present time and even that male line of descent is disputed. This is fully consistent with our understanding of genetics when you consider that most male lines are likely to die out in a few generations. Those that survive ten generations or so are unlikely to become extinct since there will likely be several male lines at that time.

Only 10 of the companions have descendants who are alive today. This could be due to the fact that genealogists don't have perfect records for all the companions and their families but it's also quite in line with expectations.1 You don't expect that all 20 families will avoid extinction. What this means is that for a random "population" of 40 individuals (20 companions plus their wives), only 20 of them contributed alleles to the present population after 50 generations.2

The take-home lesson from these genealogical studies is that the actual population size at a given point in time is not the same as the actual number of individuals who contribute to the gene pool over the long term.

This has long been known to population geneticists. They define a new term, Ne, called the "effective population size." In order to understand the definition of effective population size, you have to keep in mind that most of the variation in a given population is due to the presence of nearly neutral alleles whose frequency is fluctuating under the influence of random genetic drift. The parameter of interest, Ne, represents the theoretical number of individual in a population of size N who actually contribute to the variation in a population.

The definition is from Sewell Wright [Effective Population Size] ...
Effective population size is "the number of breeding individuals in an idealized population that would show the same amount of dispersion of allele frequencies under random genetic drift or the same amount of inbreeding as the population under consideration."
The effective population size is always less than the actual population (Ne < N). Sometimes it's a lot less. In most vertebrates, for example, the long-term effective population size is calculated to be about 10,000.

Why is this important? It's important because evolution is important for understanding biology and in order to understand evolution you need to understand population genetics. One of the important lessons from population genetics is that the relative important importance of natural selection and random genetic drift is dependent on effective population size. This is a major theme in Michael Lynch's book The Origins of Genome Architecture.

He argues that the effective population size of most large multicellular animals (e.g. Homo sapiens) was small enough to render natural selection impotent for most alleles that might have been somewhat beneficial in larger populations. This led to loss of such beneficial alleles by random genetic drift and to frequent fixation of mildly deleterious alleles by drift. Thus, even if the accumulation of large amounts of junk DNA, for example, was slightly deleterious, it cannot be eliminated by natural selection when the effective population size is small.

Furthermore, many alleles with small beneficial effects cannot possibly become fixed in such a population so it's silly to construct a model that relies on fixation of alleles with a small advantage. This leads to his theory of the evolution of genome complexity by nonadaptive processes. According to Lynch, the default explanation is random genetic drift and because this accounts for much of genome architecture, there's no reason to invoke natural selection to explain what we observe.

Lynch devotes an entire chapter (Chapter 4) to Why Population Size matters. I'm hoping to get more people interested in this subject by giving them a simple example of the difference between actual population size (N) effective population size (Ne).

This isn't only important in genome evolution. As most of you know, the effective population size is an important consideration in recent human evolution [From genes to numbers: effective population sizes in human evolution] and many other disciplines.


1. The reason we focus on nobility isn't because they are more important, genealogically, than the 8,000 other soldiers at the battle. It's because we don't have any records of those other potential ancestors.

2. This doesn't mean that all of the alleles in the other 20 individuals were lost because many of them could have been passed down from siblings, aunts, uncles etc.

Tuesday, November 22, 2011

Trying to Understand Agnostics

 
John Wilkins has tried, again, to explain the difference between an atheist and an agnostic [Positivism about agnosticism].

My position is similar to that of Richard Dawkins, and many others. I am an atheist (i.e. not a theist) because there is no convincing evidence for gods, in my opinion. Thus, I do not believe in them (not-a-theist).

There is always a possibility that gods actually exist even though I see no evidence for them. I cannot prove that they are all non-existent. Thus, I am, in a sense agnostic on the possibility of gods existing, although I think the odds are incredibly small.

Like Dawkins, "I am agnostic only to the extent that I am agnostic about fairies at the bottom of the garden." I am a practicing atheist because I do not believe in gods but I am philosophically agnostic as well. I have theist friends who believe in God but are also agnostic.

John says,
Let me be quite clear on this: I do not think there is evidence for a God, as an agnostic. And I certainly think there is evidence against many stories and characterisations of gods. But, and this seems to be the point that strong “skeptics” like Hecht cannot get into their heads, not all. So long as there is a formal possibility that some gods might exist, and no general evidence against it, the rational thing to do is hold off judgement on the (empirically permissible) claims. So Thor doesn’t exist, but Leibniz’s deity might.
Like me, John, doesn't believe in gods—he is not a theist. But he is not an a-theist in spite of the fact that if you followed him around for several days you could not distinguish his bevavior from that of any other non-believer.

We agree that there's a possibility that some sort of gods exist but we both have declined to become believers (theists). Yet, I am a strong atheist/agnostic while John is a nonbeliever but only an agnostic.

Have I got that right, John?

As an amateur philosopher, it seems to me that you could apply the same logic to the existence of fairies or UFO astronauts with a fixation on body openings. There's no evidence that they exist so we don't believe in them. But as long as there's a formal possibility that they exist—and there is—we have to be agnostic about their existence.

For some reason we don't go around announcing to the world that we are agnostic about the existence of fairies, UFOs, and Santa Claus. Why? Doesn't the formal possibility of their existence merit consideration? Don't we recognize that we could never PROVE that fairies don't exist?

The word "agnostic" only ever applies to the belief in gods and never—in common speech—to fairies. We all know the reason for this. It's accommodationism. It's a way to avoid insulting our religious friends by proclaiming you don't believe in their gods. Too bad it's almost always atheists who are so sensitive. You don't see many theists avoiding the word "theist" in favor of "agnostic."

Part of the problem is that agnostics like John tend to use a different definition of "atheist" than we do. He seems to think that it means we deny the possibility that gods exist. I think that's why he considers "atheist" and "agnostic" to be non-overlapping sets.


Gobind Khorana (1922 - 2011)

 
Har Gobind (Hargobind) Khorana was a biochemist specializing in polynucleotide synthesis. He was awarded the Nobel Prize in Physiology or Medicine in 1968 along with Robert Holley and Marshall Nirenberg "for their interpretation of the genetic code and its function in protein synthesis."

Khorana was born in Raipur, Pujab, British India (now Pakistan) in 1922. After graduating from Punjab University in Lahore (British India) he went to the University of Liverpool (United Kingdom) to complete a Ph.D. Following several post-docs in Zurich (Switzerland) and Cambridge (UK) he accepted a job at the British Columbia Research Council, in Vancouver, Canada in 1952.

According to his colleague, Uttam Rajbhandary,
Gobind was so excited that he was going to start a lab of his own. He looked at the map of Canada, saw where Vancouver was for the first time, and off he went ...
In 1960 he moved to the University of Wisconsin, Madison (United States) and in 1970 he moved again, this time to the Massachusetts Institute of Technology in Boston (United States). Gobind Khorana died in Concord, Massachusetts on Wednesday, November 9, 2011.