Tuesday, July 02, 2013

Monday's Molecule #207

Last week's molecule was N-acetylmuramic acid (MurNAc) one of the components of the polysaccharide in bacterial cell walls [Monday's Molecule #206]. The winner was Michael Florea. He should contact me by email to collect his winnings.

Today's (Tuesday's) molecule is a new addition to biochemistry textbooks because its structure was only solved a few years ago. There are plenty of hints in the figure. You have to identify the molecule AND each of the seven activities that are labelled. Bonus points for the PDB identification number and the species.

Email your answers to me at: Monday's Molecule #207. I'll hold off posting your answers for 24 hours. The first one with the correct answer wins. I will only post mostly correct answers to avoid embarrassment. The winner will be treated to a free lunch.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your email message.)

Some past winners are from distant lands so their chances of taking up my offer of a free lunch are slim. (That's why I can afford to do this!)

In order to win you must post your correct name. Anonymous and pseudoanonymous commenters can't win the free lunch.

Winners will have to contact me by email to arrange a lunch date. Please try and beat the regular winners. Most of them live far away and I'll never get to take them to lunch. This makes me sad.

Comments are now open.

UPDATE:Matt McFarlane got it right. Here's his complete answer.
Fatty acyl synthase is an enzyme important for fatty acid biosynthesis,
the mammalian FAS structure was solved using protein natively purified
from pigs, PDB=2VZ8.

Fatty acid synthesis involves MAT (malonyl-acetyl transferase) loading an
acetyl group from acetyl-CoA onto ACP (acyl carrier protein) which then
transfers the acetyl moiety to active site Cys of the β-ketoacyl
synthase (KAS). The now empty ACP is reloaded with an acetyl group by MAT from a malonyl-CoA and condensation and release of CO2 forms the β-ketoacyl product attached to the ACP. The ACP delivers this product to KR (Ketoreductase) which reduces the keto group to an alcohol, then DH (dehydratase) introduces a double bond with loss of water, ER (enoyl reductase) reduces the double bond then ACP delivers the product back to KAS with additional acetyl groups added by using more malonyl-CoA. The process is repeated until 16 carbon chain, palmitic acid, is released by TE (thioesterase).

Winners
Nov. 2009: Jason Oakley, Alex Ling
Oct. 17: Bill Chaney, Roger Fan
Oct. 24: DK
Oct. 31: Joseph C. Somody
Nov. 7: Jason Oakley
Nov. 15: Thomas Ferraro, Vipulan Vigneswaran
Nov. 21: Vipulan Vigneswaran (honorary mention to Raul A. Félix de Sousa)
Nov. 28: Philip Rodger
Dec. 5: 凌嘉誠 (Alex Ling)
Dec. 12: Bill Chaney
Dec. 19: Joseph C. Somody
Jan. 9: Dima Klenchin
Jan. 23: David Schuller
Jan. 30: Peter Monaghan
Feb. 7: Thomas Ferraro, Charles Motraghi
Feb. 13: Joseph C. Somody
March 5: Albi Celaj
March 12: Bill Chaney, Raul A. Félix de Sousa
March 19: no winner
March 26: John Runnels, Raul A. Félix de Sousa
April 2: Sean Ridout
April 9: no winner
April 16: Raul A. Félix de Sousa
April 23: Dima Klenchin, Deena Allan
April 30: Sean Ridout
May 7: Matt McFarlane
May 14: no winner
May 21: no winner
May 29: Mike Hamilton, Dmitri Tchigvintsev
June 4: Bill Chaney, Matt McFarlane
June 18: Raul A. Félix de Sousa
June 25: Raul A. Félix de Sousa
July 2: Raul A. Félix de Sousa
July 16: Sean Ridout, William Grecia
July 23: Raul A. Félix de Sousa
July 30: Bill Chaney and Raul A. Félix de Sousa
Aug. 7: Raul A. Félix de Sousa
Aug. 13: Matt McFarlane
Aug. 20: Stephen Spiro
Aug. 27: Raul A. Félix de Sousa
Sept. 3: Matt McFarlane
Sept. 10: Matt Talarico
Sept. 17: no winner
Sept. 24: Mikkel Rasmussen
Oct. 1: John Runnels
Oct. 8: Raúl Mancera
Oct. 15: Raul A. Félix de Sousa
Oct. 22: Mikkel Rasmussen
Nov. 12: Seth Kasowitz, Bill Gunn
Nov. 19: Michael Rasmussen
Dec. 4: Paul Clapham, Jacob Troth
Dec. 10: Jacob Troth
Dec. 17: Bill Chaney, Dima Klenchin, Bill Gunn
Jan. 14: Evey Salara
Jan. 21: Piotr Gasiorowski
March 11: Bill Gunn, River Jiang
March 18: Bill Gunn
April 8: Michael Florea
April 15: no winner
April 29: Anders Ernberg
May 6: Alex Ling, Michael Florea
May 13: Bill Chaney
June 24: Michael Florea
July 2: Matt McFarlane


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