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Sunday, December 31, 2006

Old Professors

Jonah Lehrer is an editor for Seed magazine. On his blog, The Frontal Cortex, he has resuscitated an old argument that I though we had settled. The issue is whether Professors over 60 should be put out on an ice flow to make room for, presumably smarter, young scientists [Old Professors].

The article defines old Professors as those over 60. I'm going to assume that young Professors are under 40. Since I'm 60 years old, that makes me still middle-aged and in a good position to present a totally unbiased opinion concerning the stupidity and naivety of youth.

It might be helpful to have some examples of old dotty Professors who clearly lost all ability to contribute to science once they turned 61. In the field of evolutionary biology we have; Ernst Mayr (101 when he died last year), Jared Diamond (69), E.O. Wilson (77), Richard Dawkins (65), and Stephen Jay Gould (61 when he died in 2002).


My faculty union and the University of Toronto recently concluded an agreement to abolish mandatory retirement at age 65 and the Province of Ontario has recently passed legislation abolishing mandatory retirement in the public sector. Let's not argue about whether Professors should be forced to leave their jobs on their 65th birthday. This is a rights issue. It is ethically wrong to discriminate on the basis of age. There is no justification for such discrimination in this day and age and it's about time that we did away with it. (Most American schools abolished mandatory retirement many years ago.)

Are there any conceivable arguments for reinstating mandatory retirement that meet the test of rationality? No there aren't. So why is there still a debate?

Lehrer quotes from an article in the Boston Globe on the Graying of US Academia. The article points out that since the abolition of forced retirement, the average age of Professors is increasing (duh!) and this is a bad thing.

Why is it a bad thing? The perceived wisdom is that old Professors are taking up space that should be going to younger faculty. Well, it turns out that this isn't very significant. It will always be the case that a new faculty member will be hired every time a Professor retires. Assuming a steady state, the rate of new hires won't be much different if some of the Professors stay on past 65 or 70. (Less than 25% of Professors continue to work after they turn 65.) That argument doesn't really cut the mustard. The real problem is that the number of Professors is not expanding very much so that new opportunities for junior faculty aren't being created. In our department, for example, budget cuts are forcing us to cut back on the number of Professors.

But even if the argument were true there is no ethical way to improve the situation by getting rid of old Professors. You can't just knock on the door of Professor Dawkins and tell him to get the hell out of Oxford because there's some 32 year old post-doc who wants his job. Be reasonable, people.

There's an underlying assumption in these discussions that I find troubling. If you read John Lehrer's posting and the comments that follow, you'll see lots of discussion about whether old Professors can still do their job. Lots' of people think that young Professors are better teachers, for example. That's nonsense. I've not seen any evidence to support that assumption in my forty years of experience in universities. Some young Professors are excellent teachers and some aren't. Some old Professors are excellent teachers and some aren't.

I can tell you one thing that seems to be a general rule. Whenever we sit down as a group to discuss teaching, the older Professors bring a great deal more to the table than the younger ones. I was reminded of this last month when we discussed changes to our undergraduate and graduate programs. This is a time when wisdom counts. My older colleagues know how to effect real change and they know how to avoid fads that will get us into trouble later on. They know how to work the system for maximum benefit.

(I should point out that in science departments teaching is a minor part of the job so it doesn't play a big role in deciding whether old Professors are better than young ones.)

Administrative tasks are a major part of the average Professor's job. There's no question about the fact that the longer you've been at a university the more capable you are of handling administrative tasks. This applies to local jobs like departmental chair, associate chair, and managing undergraduate and graduate programs. It also applies to higher level jobs like chairing university committees and becoming a Dean or assistant Dean.

Research is the big bogeyman. There's this persistent myth out there that young people are ever so much better at it that the old fuddy-duddys who already have one foot in the grave. There is no evidence to support this myth, even in mathematics where it originated. If you want to maximize research productivity in a department you don't do it by forcing out highly productive scientists just because they turn 65.

Please don't misinterpret me. Of course there are old Professors who are not being productive. There are ways of encouraging them to retire and if they don't take the hint there are ways of firing them even if they have tenure. This won't be required nearly as often as people imagine, but it will happen and it should probably happen more often. On the other hand, let's not forget that there are lots of younger people who don't make the cut. It's not a direct function of age.

This is an issue that demands more sensitivity than it gets. I find it very unsettling to hear people calling for the firing of old Professors just because we need to make room for younger ones. What do you imagine those old Professors are going to do when they are fired? In many cases they have been working for much lower wages than they could have gotten in the private sector and they still have mortgages to pay and kids to put through college. They often have decent pensions but still not enough to maintain their lifestyle. (I'm not talking about Harvard, I'm talking about state schools.) Do we really want to move to a cut-throat corporate model where youth and lower wages trump wisdom and maturity? Is that the kind of university we want?

The Three Domain Hypothesis (part 6)

[Part 1][Part 2][Part 3][Part 4][Part 5]

Evolving Biological Organization

Carl Woese discovered archaebacteria and he made them fit into a separate super-kingdom, or “domain.” He is the man behind the claim that archaebacteria are so different from other bacteria that they deserve equal taxonomic status with eukaryotes. Woese is the father of the Three Domain Hypothesis, which not only claims domain-level recognition for archaebacteria, but also claims that eukaryotes descend from a primitive archaebacterium.

Back in 1995, when evidence against the Three Domain Hypothesis was mounting, I made a bet with Steven LaBonne that Woese would recant by January 1997.

I lost that bet, but eight years later Woese has finally come to his senses ... at least partly ....

I’m reviewing articles that appeared in Microbial Phylogeny and Evolution edited by Jan Sapp. Carl Woese’s contribution (“Evolving Biological Organization”) describes his current thoughts about the emergence of defined species from the pool of primitive gene-swapping cells that characterized the early history of life.

Woese’s idea, which has been evolving of a period of ten years, is that primitive life existed as a community of cells that freely exchanged genes. They shared a basic translation system for making proteins, but had little else in common. These cells evolved as a community and not as distinct lineages.

Woese refers to this time as the “progenote era” where the word “progenote” refers to a cell that has not yet established a definite link between a stable genotype and a heritable phenotype. At some point in time, certain cells make the transition from progenote to the founders of a stable lineage. The transition point is known as the “Darwinian threshold.”
The real mystery, however, is how this incredibly simple, unsophisticated, imprecise communal progenote—cells with only ephemeral genealogical traces—evolved to become the complex, precise, integrated, individualized modern cells, which have stable genealogical records. This shift from a primitive genetic free-for-all to modern organisms must by all acounts have been one of the most profound happenings in the whole of evolutionary history. Although we do not yet understand it, the transition needs to be appropriately marked and named. “Darwinian threshold” (or “Darwinian Transition”) seems appropriate: crossing that threshold means entering a new stage, where organismal lineages and genealogies have meaning. where evolutionary descent is largely vertical, and where the evolutionary course can begin to be described by tree representation. (p. 109)
According to Woese, bacteria were the first species to emerge from the pool. From that point onwards, the evolution of bacteria was “Darwinian” and could be represented by a bifurcating tree.

What about archaebacteria and eukaryotes? They emerged later ...
At that point, though, both the archaeal and eukaryotic designs remain in the pre-Darwin progenote, condition: still heavily immersed in the universal HGT field, still in the throes of shaping major features of their representative designs; and so, their evolutions cannot be represented in tree form. In other words, the node in the conventional phylogenetic tree that denotes a common ancestor of the archaea and eukaryotes does not actually exist. The two cell designs are not specifically related; it is just that the tree representation made them “sisters by default.” (p.111)
Woese suggests that the archaebacteria were the next to cross the Darwinian threshold followed by eukaryotes. This explains why archaebacteria have simpler cell components and eukaryotes are more complex. (The precursors of the eukaryote lineage spent more time in the progenote era and accumulated more innovative structures, such as nuclear membranes.)

The progenote community may have spawned other “domains” but these are now extinct, although Woese suggests there are some clues pointing to their previous existence. I assume that the progenote community itself petered out shortly after the emergence of eukaryotes.

This new theory of Woese is not very satisfying. I find the explanation somewhat confusing. Woese is trying to preserve the distinctiveness of the Three Domains while denying that their relationship can be discerned. In other words, he wants to have his cake and eat it too.

In order to defend the monophyletic domains, especially archaebacteria, he has to postulate that each one descends from a single cell, or lineage, that pops out of the progenote community. That’s why each domain has a defined root (i.e. monophyletic). But in order to account for the massive amounts of data that show eukaryotes closer to bacteria than to archaebacteria, he postulates an extended period of evolution where cells exchanged genes in a communal pool. This is not unlike the ideas of many other workers in the field except that for Woese it represents a denial of one of the basic tenets of the original Three Domain Hypothesis.

Woese is very clear about this. He makes the case that the branches at the base of the ribosomal RNA tree are not meaningful. It is wrong to assume that archaebacteria and eukaryotes share a common ancestor. I’ll close this part with an extended quote from Woese to show you just how far he’s willing to go to make the case. (Note how much he has come to agree with people like Ford Doolittle [Part 5] who have been challenging the Three Domain Hypothesis for over a decade.)
Classical biology has also saddled us with the phylogenetic tree, an image the biologist invests with a deep and totally unwarranted significance. The tree is no more than a representational device, but to the biologist it is some God-given truth. Thus, for example, we agonize over how the tree can accommodate horizontal gene transfer events, when it should simply be a matter of when (and to what extent) the evolution course can be usefully represented by a tree diagram. Evolution defines the tree, not the reverse. Tree imagery has locked the biologist into a restricted way of looking at ancestors. It is the tree image, almost certainly, that has caused us to turn Darwin’s conjecture that all organisms might have descended from a simple primordial form into doctrine: the doctrine of common descent. As we shall discuss below, it is also the tree image that has caused biologists (incorrectly) to take the archaea and the eukaryotes to be sister lineages. Much of the current “discussion/debate” about the evolutionary course is couched in the shallow but colorful and cathected rhetoric of “shaking,” “rerooting,” “uprooting,” or “chopping down” the universal phylogenetic tree. (p.102)


Microbobial Phylogeny and Evolution: Concepts and Controversies Jan Sapp, ed., Oxford University Press, Oxford UK (2005)

Jan Sapp The Bacterium’s Place in Nature

Norman Pace The Large-Scale Structure of the Tree of Life.

Woflgang Ludwig and Karl-Heinz Schleifer The Molecular Phylogeny of Bacteria Based on Conserved Genes.

Carl Woese Evolving Biological Organization.

W. Ford Doolittle If the Tree of Life Fell, Would it Make a Sound?.

William Martin Woe Is the Tree of Life.

Radhey Gupta Molecular Sequences and the Early History of Life.

C. G. Kurland Paradigm Lost.


Saturday, December 30, 2006

Creation Sunday

 Looking for some entertainment in February? Check out Creation Sunday in Orangeville, Ontario (north of Toronto). On Sunday Feb. 11th and Monday Feb. 12th you can hear three of the leading IDiots from Creation Ministries International speaking on "Authority Begins With Genesis," "Genesis and the Gospel Connection," "Codes and Creation," and "What the Bible and Science say about the Age of the Earth."

It ought to be a barrel of laughs. Bring lots of popcorn.

Capital Punishment Is Barbaric

 With the hanging of Saddam Hussein, Iraq affirms its membership in the group of nations that don't deserve to be called civilized.

Thursday, December 28, 2006

New But Not New

 
Another major breakthrough in molecular biology has just been reported [Jefferson researchers discover new way nature turns genes on and off]. (I've lost track of how many times traditional molecular biology has been overturned in 2006—has anyone kept a list?)

Here's the startling news,
Peering deep within the cells of fruit flies, developmental biologists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia may have discovered a new way that genes are turned on and off during development.
Reading a bit further, we find,
According to Dr. Mazo, the researchers found that one of the likely mechanisms behind ncRNAs' ability to regulate essential coding genes is through a "transcription interference" mechanism. "Such mechanisms are known in bacteria and yeast, but not much is known in higher organisms," he explains.
In other words, it's not new at all. I've been teaching transcriptional interference during bacteriophage lambda development since 1979 and it's in many textbooks, including mine (1994).

Question: What the heck is a "higher organism?"
Answer: It's a term we look for in order to identify people who don't understand evolution.

Tuesday, December 26, 2006

Can You Be a Theist and Believe In Evolution?

 
John Wilkins wonders about this in God, evolution and variation. I think it all boils down to purpose. Science doesn't reveal purpose but most religions demand it. (We're talking about interventionist Gods here.) Real evolution incorporates a large degree of accident and randomness and that's just not consistent with a God who has a plan. (Yes, I'm aware of the confused rationalizations of some theistic evolutionists.)

A Challenge to Denyse O'Leary

 
Denyse O'Leary writes in Thoughts on recent books on the intelligent design controversy: Some ways to spend your holiday cash.
Case in point: North American mainstream media report that the vast majority of Americans do not believe Darwinism, with the clear implication that there must be something wrong with them. It is almost inconceivable that media boffins, for whom materialism is the normal way of thinking, would actually be interested in knowing why so many who are at liberty to doubt take up that option. And the media boffins are not likely to change. The media they govern are more likely to simply decline in importance as a source of information.
Denyse, you claim to be a journalist. I challenge you to come up with a reasonable explanation. Keep in mind that you also have to explain one additional fact; the majority of Canadians and Europeans believe in evolution and they have just as much freedom to doubt as Americans. Possibly, more.

So, give it your best shot. If you think the "media" aren't interested in knowing why so many Americans are fooled by the IDiots then here's your chance to get them interested. More importantly, here's your big chance to do what nobody else has been able to do—explain why so many people in the USA are anti-science. You could be famous.

P.S. Why are you still using the term "Darwinism" to describe acceptance of the scientific facts of evolution? You haven't been paying attention, have you?

Monday, December 25, 2006

Looking for the Ideal Christmas Present?

 

Check out dnaPortraits(TM). For only a few hundred dollars they create artwork based on your personal DNA fingerprint. An ideal gift for any biochemist (hint, hint).

SEASON'S GREETINGS!

From M-LAW via Jim Lippard with one minor alteration.


Please accept with no obligation, implied or implicit, our best wishes for an environmentally conscious, socially responsible, low stress, non-addictive, gender neutral celebration of the winter solstice holiday, practiced with the most enjoyable traditions of religious persuasion or secular practices of your choice with respect for the religious/secular persuasions and/or traditions of others, or their choice not to practice religious or secular traditions at all. We also wish you a fiscally successful, personally fulfilling and medically uncomplicated recognition of the onset of the generally accepted calendar year 2007, but not without due respect for the calendars of choice of other cultures whose contributions to society have helped make our country great (not to imply that Canada is necessarily greater than any other country) and without regard to the race, creed, color, age, physical ability, religious faith or sexual preference of the wishee.

By accepting this greeting, you are accepting these terms: This greeting is subject to clarification or withdrawal. It is freely transferable with no alteration to the original greeting. It implies no promise by the wisher to actually implement any of the wishes for her/himself or others and is void where prohibited by law, and is revocable at the sole discretion of the wisher. This wish is warranted to perform as expected within the usual application of good tidings for a period of one year or until the issuance of a subsequent holiday greeting, whichever comes first, and warranty is limited to replacement of this wish or issuance of a new wish at the sole discretion of the wisher.

Disclaimer: No trees were harmed in the sending of this message; however, a significant number of electrons were slightly inconvenienced.

10 Truths About Atheism

 
From yesterday's Los Angeles Times: 10 myths—and 10 truths—about atheism by Sam Harris.

I'd like to express my disagreement with #4 "Atheists think everything in the universe arose by chance." Harris says,
The notion that atheists believe that everything was created by chance is also regularly thrown up as a criticism of Darwinian evolution. As Richard Dawkins explains in his marvelous book, “The God Delusion,” this represents an utter misunderstanding of evolutionary theory. Although we don’t know precisely how the Earth’s early chemistry begat biology, we know that the diversity and complexity we see in the living world is not a product of mere chance. Evolution is a combination of chance mutation and natural selection. Darwin arrived at the phrase “natural selection” by analogy to the “artificial selection” performed by breeders of livestock. In both cases, selection exerts a highly non-random effect on the development of any species.
That's not quite right.

Nobody denies the power of natural selection and nobody claims that natural selection is random or accidental. However, the idea that everything is due to natural selection is the peculiar belief of a relatively small number of people, of whom Richard Dawkins is the most outspoken.

A great deal of evolution is the result of chance or accident, as is a great deal of the rest of the universe. It's perfectly okay to say, as a first approximation, that lots of evolution is random or accidental. This is a far closer approximation to the truth than saying it's the all the result of design by natural selection.

See Evolution by Accident. As far as I'm concerned, it's Harris and Dawkins who represent an "utter misunderstanding of evolutionary theory."

Closed on December 25th

Imagine, my Timmy's is closed on the one day you need it the most.

Merry Christmas Everyone!


Sunday, December 24, 2006

Will Santa be Affected by Solar Flares?

An article posted on the Natural Sciences and Engineering Research Council of Canada (NSERC) website has the answer [Santa Claus and Solar Flares]. Learn the size of Santa's sled and how he manages to deliver all the presents.

The Hypocrisy of Scientific American

 
The editors of Scientific American are worried about PLoS ONE, the new online journal of science [Peer Review Is Sooooo Old School. They claim this is a big step backwards since the PLoS ONE articles reportedly circumvent peer review. Scientific American set itself up as the protector of scientific integrity and they vow to uphold these high standards in spite of the fact that the scientific community is letting them down.

This is wrong on so many levels that I hardly know where to begin. The real problem with science education is Scientific American, not PLoS ONE.


Here's what the Scientific American editors say,
With the burden of proof off of the reviewers, we in the science press will have to be more vigilant than ever. We can't rush to put stories out until we've focus- grouped findings with a number of experts in a study's particular field. It will force us to become better reporters and to resist the urge to sensationalize and invoke hyperbole--which, while it may not move magazine units or generate hits, will make our service more noble. We'll put in contingencies in order to avoid situations like the false alarm that plagued Lehigh mathematician Penny Smith--the poor woman who posted a flawed proof of the Navier-Stokes equations this fall on arXiv.

SciAm has already started on this path, by the way, as evidenced by JR Minkel's write-up of this morsel from the journal's inaugural issue: Rest easy, creationists, turns out we're a little less like chimps than we previously thought.

PLoS ONE is opening a possible Pandora's box into a brave new world of publishing that's as terrifying as it is exciting. From this point forth, information going from the lab to the journalist's wire (and then onto the public) will be less and less scrutinized and fact-checked. It's the dissemination of scientific information sped up to the breakneck velocity of the 21st century. Here we go...
Bullshit! This is not the end of peer review. The review of PLoS ONE articles is no different than that of many other scientific journals. I will be very surprised if the quality of papers ends up being any different than those published in Cell, Journal of Biological Chemistry, or Nature. All of these journals publish unadulterated rubbish from time to time and brilliant papers as well. The quality of papers in the leading "peer-reviewed" journals ranges from embarrassing to excellent.

PLoS ONE won't be any different.

I'm very upset by the fact that Scientific American editors see themselves as the guardians of scientific integrity, and I'm flabbergasted that they think they can recognize good science from bad science. Their record over the past few years proves them wrong. They have published all kinds of trash in my field, and probably other fields as well. They have hyped stories that don't deserve to be featured in Scientific American proving that their editors are suckers for press releases and self-promotion [The Alternative Genome, Why Are Some Animals So Smart?, The Real Life of Pseudogenes].

In the recent past, the "vigilance" of Scientific American editors and staff writers has left a great deal to be desired. If this crazy false alarm over PLoS ONE makes them pull up their socks and consult more widely before publishing then that's going to be good for science education.

I'm not holding my breath.

(RPM at Evolgen is also upset with Scientific American: Science Reporters Lament the Advent of PLoS ONE.)




E-Z Answer Squirrel

The E-Z Answer Squirrel will answer your most profound questions about religion, like "Does God hate me because I'm gay?"

Brought to you by the United Church of Canada, a church that understands sarcasm.

You Can Call Me Pope Larry !

I'm Pope Stephen! Hurrah.
Which Historical Lunatic Are You?
From the fecund loins of Rum and Monkey.