President of Coursera to give plenary lecture at AAAS meeting

The American Association for the Advancement of Science holds a meeting every February. This year the meeting is in San Jose, California. There are four plenary lectures [Plenary Lectures 2015]. Three of them will be given by prominent researchers who will be talking about science. The fourth is by Daphne Koller, President and co-founder of Coursera.

Coursera is a for-profit company offering "universal access to the world’s best education." What they mean by "best education" is MOOCs offered by professors at the "top" universities. There's no evidence to support the claim that the best undergraduate courses for the general audience are those given by professors at Stanford, MIT, Princeton, and Harvard. Indeed, there's quite a bit of evidence that this isn't true.

Daphne Koller is going to talk about The Online Revolution: Learning Without Limits. Keep in mind that at the end of every article published in Science (AAAS publication) there's a small notice stating that, "The authors declare no financial conflict of interest" or statements that clearly spell out the conflicts.

Why is AAAS asking someone to give a plenary lecture about selling online courses from someone with a clear financial interest in promoting her company?

Science education is important and there's plenty of evidence that universities are graduating students who don't understand science and aren't capable of critical thinking. There are hundreds of people whose main research interest is pedagogy and especially science education. They have proposed solutions to the problem and suggestions on how we should change the way we teach. Very few of them think that MOOCs are the answer and very few of them are trying to market their ideas for profit [ Reaching Students: What Research Says About Effective Instruction in Undergraduate Science and Engineering (2015)].

Why not ask some of those experts to address the AAAS meeting and possibly explain what's wrong with canned videotaped lectures? MOOCs are just ways of transferring the way we teach now to the mass market. But what if the traditional way we now teach (lectures) is wrong? Isn't that a question that the delegates at San Jose ought to think about?

Here's Daphne Koller giving a TED talk. Near the end she talks about the importance of "active learning" (student-centered learning). I'm a big fan of student-centered learning. She implies that having students take online courses from "top" educators is consistent with active learning but she's wrong. It's the exact opposite. In my opinion, it's a step backwards and by promoting MOOCs we are going to make it more difficult to convince professors to change the way they teach. Instead, the ones who are good at delivering traditional lectures will bring in money for themselves and their universities.¹ They will be getting the kudos and the teaching awards instead of those who are paying attention to evidence-based methods and trying to improve undergraduate education.


Here's another video. It's an interview with Daphne Koller from June 2013. Listen to the first few minutes and you'll hear a different view of active learning. Here, she explains the concept of the "flipped classroom" where students watch online videos and then come to class to participate in "something that's much more engaging and stimulating, active learning" (4 mins). There's nothing wrong with that except that students could read a textbook instead of watching a video. The important part of the learning is what happens in the classroom and not what happens in the textbook or the taped lecture.

She also explains how they are going to make money (5-6 mins).

Daphne Koller is very fond of repeating the myth that the best courses are the ones taught at the top research universities. (She happens to be a teacher at one of these universities.) I bet she can't prove it unless she's talking about very specialized upper level courses.

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1. For-profit companies like Coursera offer kick-backs to the professors and schools that contribute courses.

Learn biology with Eric Hovind

If you want to learn biology, I suggest you take this course taught by Eric Hovind. It's a good illustration of the importance of MOOCs and how they are eventually going to replace professors at universities.

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About half of all cancers are just bad luck. It's not your fault.

There's been a lot of talk recently about a paper claiming that two thirds of all cancers are due to bad luck [Bad Luck of Random Mutations Plays Predominant Role in Cancer, Study Shows]. The take-home message was that you could get cancer even if you ate "healthy," took lots of vitamins, didn't smoke, and went to the gym every day. That's not what people wanted to hear.

But scientists have known for decades that many cancers are due to random mutations that just happen. These cancers are not hereditary and are not caused by the environment. There's nothing new here.

That didn't stop a number of people from criticizing the article and some of the criticisms were justified. Nevertheless, what the article showed was that cancers tended to occur more often in tissues with lots of cell divisions (and DNA replications). That's exactly what you expect if random mutations due to replication errors are the cause of the cancer mutations.

David Gorski of Science-Based Medicine sorts it all out for us [Is cancer due mostly to “bad luck”?]. Please read his lengthy article if you want to understand the issues. David Gorski concludes ...

It’s understandable that humans crave explanation, particularly when it comes to causes of a group of diseases as frightening, deadly, and devastating as cancer. In fact, both PZ Myers and David Colquhoun have expressed puzzlement over why there is so much resistance is to the concept that random chance plays a major role in cancer development, with Colquhoun going so far as to liken it to ” the attitude of creationists to evolution.” Their puzzlement most likely derives from the fact that they are not clinicians and don’t have to deal with patients, particularly given that, presumably, they do have a pretty good idea why creationists object to attributing evolution to random chance acted on by natural selection and other forces.

Clinicians could easily have predicted that a finding consistent with the conclusion that, as a whole, probably significantly less than half of human cancers are due to environmental causes that can be altered in order to prevent them would not be a popular message. Human beings don’t want to hear that cancer is an unfortunately unavoidable consequence of being made of cells that replicate their DNA imperfectly over the course of our entire lives. There’s an inherent hostility to any results that conclude anything other than that we can prevent most, if not all, cancers if only we understood enough about cancer and tried hard enough. Worse, in the alternative medicine world there’s a concept that we can basically prevent or cure anything through various means (particularly cancer), most recently through the manipulation of epigenetics. Unfortunately, although risk can be reduced for many cancers in which environmental influences can increase the error rate in DNA replication significantly, the risk of cancer can never be completely eliminated. Fortunately, we have actually been making progress against cancer, with cancer death rates having fallen 22% since 1991, due to combined efforts involving smoking cessation (prevention), better detection, and better treatment. Better understanding the contribution of stochastic processes and stem cell biology to carcinogenesis could potentially help us do even better.

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Is Intelligent Design Creationism winning the debate in the scientific community?

Back in 1998 the Intellignet Design Creationists published the Wedge Strategy. They set themselves several goals including some twenty year goals that they hoped to achieve by 2018 (three years from now). They are ...

• to see intelligent design theory as the dominant perspective in science
• to see design theory applications in specific fields, including molecular biology, biochemistry, paleontology, physics and cosmology in the natural sciences, psychology, ethics, politics, theology, and philosophy in the humanities, to see its influence in the fine arts
• to see design theory permeate our religious, cultural, moral, and political, life

They aren't even close to achieving the first two goals but I think it's fair to say that they are well on their way to achieving the third goal in the United States. I don't think they've had much success in other countries. Perhaps readers in Europe, India, Africa, and China could let me know if design theory has permeated their culture and their politics?

Casey Luskin has recently posted a progress report in Evolution News & Views (sic) [In the Darwin Debate, How Long Before the Tide Turns in Favor of Intelligent Design?]. He's very optimistic. He lists thirteen (13) recent victories for Intelligent Design Creationism and concludes ...

Don't expect a revolution overnight. We are in this for the long haul, recognizing that it can take time for the truth to slip past the checkpoints that the Darwin lobby sets up to keep the public uninformed. In the end, though, I'm optimistic because the fundamentals of ID -- the science underlying the inference to design in nature -- are sound. The truth will win out, though it may tarry in doing so. Or to put it another way, the tide of ID is already well on its way in. We need to focus on telling people about it.

They'd better hurry. There's only three years left.

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On the credulity of those posing as the champions of science

Barry Arrington, the chief IDiot on Uncommon Descent, has just published a post on The Credulity of those Posing as the Champions of Science.

Turn off your irony meters. You were warned.

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80% of Americans support mandatory labels on food containing DNA

A recent survey reports that 80.44% of Americans believe that there should be mandatory labels on food containing DNA [Food Demand Syrvay]. Slightly more (82.28%) think there should be mandatory labels of food produced with genetic engineering.

It's easy to mock the respondents for being scientifically illiterate but that's not fair. The real idiots are the people who asked the question.

Ilya Somin has been thinking about what should be said in this mandatory label [Over 80 percent of Americans support “mandatory labels on foods containing DNA”]. Here's one possibility ...

WARNING: This product contains deoxyribonucleic acid (DNA). The Surgeon General has determined that DNA is linked to a variety of diseases in both animals and humans. In some configurations, it is a risk factor for cancer and heart disease. Pregnant women are at very high risk of passing on DNA to their children.

Can anyone think of foods that would not carry this warning? What do you eat if you want to avoid DNA?

Did you notice that 87% of Americans want labels on meat to identify the country of origin? Is that because they don't know where New Zealand lamb comes from? Or is it because they want to make sure they're getting genuine Canadian bacon?

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Francis Collins rejects junk DNA

Francis Collins is the Director of the National Institutes of Health (NIH) in the USA. He spoke recently at the 33rd Annual J.P. Morgan Healthcare Conference in San Francisco (Jan. 12-15, 2015). His talk was late in the afternoon on Tuesday, January 13, 2015. You can listen to the podcast on the conference website [J.P. Morgan Healthcare Conference].

The important bit is at the 30 minute mark where he comments on a question about junk DNA. This is what Francis Collins said last week ...

I would say, in terms of junk DNA, we don't use that term any more 'cause I think it was pretty much a case of hubris to imagine that we could dispense with any part of the genome as if we knew enough to say it wasn't functional. There will be parts of the genome that are just, you know, random collections of repeats, like Alu's, but most of the genome that we used to think was there for spacer turns out to be doing stuff and most of that stuff is about regulation and that's where the epigenome gets involved, and is teaching us a lot.

What seems like "hubris" to Francis Collins looks a lot like scientific evidence to me. We know enough to say, with a high degree of confidence, that most (~90%) of our genome is junk. And we know a great deal about the data that Collins is probably referring to (ENCODE)—enough to conclude that it is NOT saying what he thinks it says.

It would be bad enough if this were just another confused scientist who doesn't understand the data [see Five Things You Should Know if You Want to Participate in the Junk DNA Debate] but he's not just any scientist. He's a powerful man who talks to politicians all the time and deals with the leaders of large corporations (e.g. the J.P. Morgan Conference). If Francis Collins doesn't understand the fundamentals of genome science then he could mislead a lot of people.

Collins has many colleagues surrounding him at NIH and other agencies in Washington. These scientists also make important decisions about American science. I'm assuming that he reflects their opinion as well. If not, then why aren't they educating Francis Collins?

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Hat Tip: Ryan Gregory

Functional RNAs?

One of the most important problems in biochemistry & molecular biology is the role (if any) of pervasive transcription. We've known for decades that most of the genome is transcribed at some time or other. In the case of organisms with large genomes, this means that tens of thousand of RNA molecules are produced from regions of the genome that are not (yet?) recognized as functional genes.

Do these RNAs have a function?

Most knowledgeable biochemists are aware of the fact that transcription factors and RNA polymerase can bind at many sites in the genome that have nothing to do with transcription of a normal gene. This simply has to be the case based on our knowledge of DNA binding proteins [see The "duon" delusion and why transcription factors MUST bind non-functionally to exon sequences and How RNA Polymerase Binds to DNA].

If you have a genome containing large amounts of junk DNA then it follows, as night follows day, that there will be a great deal of spurious transcription. The RNAs produced by these accidental events will not have a biological function.

Richard Lewontin and Tomoko Ohta win the Crafoord Prize in Biosciences

"for their pioneering analyses and fundamental contributions to the understanding of genetic polymorphism"

It is the great irony of modern evolutionary genetics that the spirit of explanation has moved more and more towards optimal adaptation, while the technical developments of population genetics of the past 30 years have been increasingly to show the efficacy of non adaptive forces in evolution.

Richard Lewontin
"A natural selection" Nature May 11,1989 p.107

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The ‘neutral theory’ proposed that most evolutionary changes at the molecular level were caused by random genetic drift rather than by natural selection. Note that the neutral theory classifies new mutations as deleterious, neutral, and advantageous. Under this classification, the rate of mutant substitutions in evolution can be formulated by the stochastic theory of population genetics. Kimura's theory was simple and elegant, yet I was not quite satisfied with it, because I thought that natural selection was not as simple as the mutant classification the neutral theory indicated, and that there would be border-line mutations with very small effects between the classes. I thus went ahead and proposed the nearly neutral theory of molecular evolution in 1973. The theory was not simple, and much more complicated, but to me, more realistic, and I have been working on this problem ever since.

Tomoko Ohta
Current Biology, August 21, 2012

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HatTip: Jerry Coyne (student of Lewontin): Dick Lewontin and Tomoko Ohta nab the Crafoord Prize

The Nature of Science (NOS)

There is a growing recognition among teachers that we need to teach the "Nature of Science" (NOS). Ideally, this should begin in the primary grades and extend all the way through university. Teaching about the nature of science should not be restricted to students who major in science. Every student should learn about the nature of science.

This is not controversial. I'm not aware of anything in the recent pedagogical literature that argues against teaching the nature of science. What's controversial is how to describe what science is all about.

How did the zebra get its stripes? (again)

The National Geographic has just posted an article on Why Do Zebras Have Stripes? New Study Makes Temperature Connection. Here's part of it ...

A leopard may not be able to change its spots, but some zebras change their stripes. Zebras in warmer places have more stripes, a new study shows, which might help answer an age-old question: Why stripes?

The answer probably comes down to keeping zebras cool and fending off disease-causing insects that are more common in hotter climates, researchers reported Tuesday in the journal Royal Society Open Science.

All three species of zebra have bold black and white stripes that stand out among more drab-looking African grazers, like buffalo and antelope, especially against a plain savanna background. And standing out would seem to make a zebra more likely to become a lion's lunch.

This "stripe riddle" has puzzled scientists, including Darwin, for over a century. There are five main hypotheses for why zebras have the stripes: to repel insects, to provide camouflage through some optical illusion, to confuse predators, to reduce body temperature, or to help the animals recognize each other.

There's a fifth possibility: maybe there's no reason at all and stripes are just an evolutionary accident.

The last time I addressed this issue was in 2012 [How Did the Zebra Get Its Stripes?]. At that time I quoted the famous Spandrel's paper where Gould and Lewontin wrote ...

... the rejection of one adaptive story usually leads to its replacement by another, rather than to a suspicion that a different kind of explanation might be required. Since the range of adaptive stories is as wide as our minds are fertile, new stones can always be postulated. And if a story is not immediately available, one can always plead temporary ignorance and trust that it will be forthcoming ....

That's exactly what's happening in the National Geographic article. After almost 100 years of speculation, nobody has come up with a good adaptive explanation of zebra stripes. They never consider the possibility that there may NOT be an adaptive explanation.

Stephen Jay Gould wrote about this problem more than 30 years ago [How the Zebra Gets Its Stripes]. He pointed out back then that stripes are almost certainly due to small changes in just a few genes that alter the timing of differentiation in early embryology. He rails against adaptationist thinking then says ...

For many reasons, ranging from probable neutrality of much genetic variation to the nonadaptive nature of many evolutionary trends, this strict construction [vulgar Darinwism] is breaking down, and themes of unity are receiving attention.... One old and promising theme emphasizes the correlate effects of changes in the timing of events in embryonic development. A small change in timing, perhaps the result of a minor genetic modification, may have profound effects on a suite of adult characters if the change occurs early in embryology and its effects accumulate thereafter.

The point is that the prominence of stripes on zebras may be due to a relatively minor mutation and may be nonadaptive. That's a view that should at least be considered even if you don't think it's correct.

Gould was being very optimistic when he suggested that the old ways were breaking down.

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Gould, S.J., and Lewontin, R.C. (1979) The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme. Proc. R. Soc. Lon. B Biol. Sci. 205: 581-598. [PubMed] [doi: 10.1098/rspb.1979.0086]

Looking for Spandrels

I've just assigned the Spandrels paper to the students in my molecular evolution class. A few of them will have read it already but most haven't. It's such an important paper that it should be required reading for every undergraduate in the biological sciences.

I've mentioned this before on Sandwalk (see links below). While searching through my old posts I came across one from 2008 titled In Search of Spandrels. I'd forgotten about it completely. It reproduced a post that I wrote for talk.origins on Aug. 20, 1998. Nobody knows about talk.origins these days but some of us have fond memories. (It still exists.) Here's what I wrote 17 years ago. It was a different era.

I recently found myself in the catacombs of the library archive far away from the stress of students writing their summer exams. It was very peaceful. It was also a place where creationists never go.

I must confess that my primary motivation for being there was work avoidance—I hate marking exams—but there was another reason as well. My secondary mission was to retrieve a pristine copy of the "Spandrels" paper so I could hand it out to my students. (My own copy had some embarassing margin notes that weren't fit for young eyes.)

There were many bound volumes of the Proceedings of the Royal Society of London (Series B). Did you know that this journal goes back over one hundred years? (That's even before I was born.) Did you know that you have to look in the stacks under "R", for "Royal", and not "P", for "Proceedings"? Did you ever wonder why librarians do that? My own theory is that they really don't want us to take out their books so they make it as difficult as possible to find something.

I was looking for volume 205 (1979). As usual, it was on the bottom shelf; way down at the level of my shoes. I had to get down on one knee and that's a lot of work. But at least volume 205 wasn't missing. With trembling hands I flipped the pages looking for the sacred text. Would it be there or would the pages have been cut out with a razor blade? Chances were good—pre-med students don't read about evolution.

Yes! There it was: "The Spandrels of San Marco and the Panglossian paradigm: a critique of the adaptionist programme" by S.J. Gould and R.C. Lewontin. They even spelled "programme" correctly! Off I went to the photocopy machine. Off I went to buy a new photocopy card. Back I came to the photocopy machine. Let's see now ... how much magnification will I need to fill an 8x11 page so I don't have to close the damn lid every time I copy a page? 125% should do it. Wrrrrr .... flash .... swish .... splat.

Maybe 120% would work ...

At last, page 598 was perfect. (Anyone want extra copies of the references from this paper?) I worked my way forward to page 581 fending off the librarian who insisted that I had to close the lid or I would ruin the photocopier—and my eyes (I'm not sure which was more important to her).

I was lucky there were three or four students to distract her. Behind my back I heard some mumblings about "eccentric" and "stubborn" but unfortunately I couldn't see exactly what was going on.

Hope I didn't miss anything interesting.

I knew that Gould had presented the paper at a meeting in London in December, 1978. Lewontin wasn't there because you have to fly to get to England and Lewontin thinks that if humans were made to fly then we would have evolved wings. So, who else was at the meeting? Did they publish papers in the same issue of the journal? Let's see ...

My thoughts were interrupted by some shouting in the line behind me. Guess I'd better get away from the photocopier. The machine seems to be making people angry.

Off I went to find a desk to sit down at. Found one. Off I went to the photocopier to retrieve my photocopy card. Back I came to the desk.

Someone was there. Found another desk. It had a banana peel on it.

Cool. All the papers are here. The meeting was called "The Evolution of Adaptation by Natural Selection" and it was organized by John Maynard Smith and R. Holliday. Orgel has a paper on evolution in vitro. The Charlesworths write about sex in plants. There's a paper by Maynard Smith on game theory and the evolution of behaviour. George Williams was present (more about him later). And guess who else? - Richard Dawkins!

The Dawkins' paper is titled "Arms races between and within species" (R. Dawkins and J.R. Krebs). It goes on and on about the adaptive significance of arms races and the optimization of animals. I bet the Gould talk was not well received by Dawkins in 1978. :-)

The Williams paper is very interesting ("The question of adaptive sex ratio in outcrossed vertebrates"). He examines two popular theories of the adaptive control of sex ratio (why there are 50% males and 50% females). After looking at the detailed models and the available data he concludes,

Evidence from vertebrates is unfavourable to either theory and supports, instead, a non-adaptive model, the purely random (Mendelian) determination of sex.

Good for him. I wish I could have been at the meeting. Maybe there was a discussion. Flipping to the back of the book I find a petulant summary of the meeting written by A.J. Cain. You can tell he's really annoyed at something that went on in the meeting,

Ever since natural selection appeared on the scene, there have been those who voiced an a priori and dogmatic dislike of it. One classic example is George Bernard Shaw ... I suspect from my own work that natural selection may have been very much more important than anyone has realized up to now. If so, can these emotional and other rejections of it, or, more generally, the tendency of the human race to take a non-objective view of evolution and kindred topics, be explained by natural selection?

There is a possible evolutionary explanation, as yet untested, and no other scientific one that I know of.

Whew! The discussion must have been exciting. Let's see, it should be right at the end. Ah, here it is,

[It has not been possible to include the general discussion in this publication.]

Damn.

Gotta go, the banana peel is making me ill—it looks like it's been here since the day before yesterday. Is that a fruit fly? Off I go.

Back again. (Forgot my pen.) See ya.

Larry Moran

What Does San Marco Basilica Have to do with Evolution?

A Critique of the Adaptationist Programme

An Adaptationist in Piazza San Marco

The Spandrels of San Marco and the Panglossian Paradigm

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Gould, S. J. and Lewontin, R.C. (1979) The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme. Proc. R. Soc. Lond. B 205:581-598. [doi: 10.1098/rspb.1979.0086

Why can't we teach properly?

The popular press usually screws up whenever it writes about universities and education. This time they got it right. Richard Pérez-Peña published an article in The New York Times a few weeks ago about new ways of teaching science [Colleges Reinvent Classes to Keep More Students in Science]. It was reprinted in The New York Times supplement that arrives with my Sunday copy of the The Toronto Star. The new title is Colleges Try to Enliven Science Teaching. (I don't have a link.)

The opening paragraphs set the tone ...

Hundreds of students fill the seats, but the lecture hall stays quiet enough for everyone to hear each cough and crumpling piece of paper. The instructor speaks from a podium for nearly the entire 80 minutes. Most students take notes. Some scan the Internet. A few doze.

In a nearby hall, an instructor, Catherine Uvarov, peppers students with questions and presses them to explain and expand on their answers. Every few minutes, she has them solve problems in small groups. Running up and down the aisles, she sticks a microphone in front of a startled face, looking for an answer. Students dare not nod off or show up without doing the reading.

Both are introductory chemistry classes at the University of California campus here in Davis, but they present a sharp contrast — the traditional and orderly but dull versus the experimental and engaging but noisy. Breaking from practices that many educators say have proved ineffectual, Dr. Uvarov’s class is part of an effort at a small but growing number of colleges to transform the way science is taught.

Evolutionary biochemistry and the importance of random genetic drift

I urge you to read an important paper that has just been published in PNAS.

Lynch, M., Field, M.C., Goodson, H.V., Malik, H.S., Pereira-Leal, J.B., Roos, D.S., Turkewitz, A.P., and Sazer, S. (2014) Evolutionary cell biology: Two origins, one objective. Proc. Natl. Acad. Sci. (USA) 111:16990–16994. [doi: 10.1073/pnas.1415861111]

Here's the bit on random genetic drift. It will be of interest to readers who have been discussing the importance of drift and natural selection in a previous thread [How to think about evolution].

Do you think Lynch et al. are correct? I do. I think it's important to emphasize the role of random genetic drift and I think it's true that most biochemists and cell biologists are stuck in an adaptationist mode of thinking.

A commonly held but incorrect stance is that essentially all of evolution is a simple consequence of natural selection. Leaving no room for doubt on the process, this narrow view leaves the impression that the only unknowns in evolutionary biology are the identities of the selective agents operating on specific traits. However, population-genetic models make clear that the power of natural selection to promote beneficial mutations and to remove deleterious mutations is strongly influenced by other factors. Most notable among these factors is random genetic drift, which imposes noise in the evolutionary process owing to the finite numbers of individuals and chromosome architecture. Such stochasticity leads to the drift-barrier hypothesis for the evolvable limits to molecular refinement (28, 29), which postulates that the degree to which natural selection can refine any adaptation is defined by the genetic effective population size. One of the most dramatic examples of this principle is the inverse relationship between levels of replication fidelity and the effective population sizes of species across the Tree of Life (30). Reduced effective population sizes also lead to the establishment of weakly harmful embellishments such as introns and mobile element insertions (7). Thus, rather than genome complexity being driven by natural selection, many aspects of the former actually arise as a consequence of inefficient selection.

Indeed, many pathways to greater complexity do not confer a selective fitness advantage at all. For example, due to pervasive duplication of entire genes (7) and their regulatory regions (31) and the promiscuity of many proteins (32), genes commonly acquire multiple modular functions. Subsequent duplication of such genes can then lead to a situation in which each copy loses a complementary subfunction, channeling both down independent evolutionary paths (33). Such dynamics may be responsible for the numerous cases of rewiring of regulatory and metabolic networks noted in the previous section (34, 35). In addition, the effectively neutral acquisition of a protein–protein-binding interaction can facilitate the subsequent accumulation of mutational alterations of interface residues that would be harmful if exposed, thereby rendering what was previously a monomeric structure permanently and irreversibly heteromeric (8, 36–39)¹. Finally, although it has long been assumed that selection virtually always accepts only mutations with immediate positive effects on fitness, it is now known that, in sufficiently large populations, trait modifications involving mutations with individually deleterious effects can become established in large populations when the small subset of maladapted individuals maintained by recurrent mutation acquire complementary secondary mutations that restore or even enhance fitness (40, 41).

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1. Note the brief description of how irreversibly complex structures can evolve. This refutes Michael Behe's main point, which is that irreversibly complex structures can't have arisen by natural processes and must have been designed. We've known this even before Darwin's Black Box was published.

The problem of the origin of life has been solved and creationists are terrified

You learn something new every day. Today I learned that a young physics professor at MIT has figured out how life originated without god(s). Salon let's us know about this amazing discovery: God is on the ropes: The brilliant new science that has creationists and the Christian right terrified.

The Christian right’s obsessive hatred of Darwin is a wonder to behold, but it could someday be rivaled by the hatred of someone you’ve probably never even heard of. Darwin earned their hatred because he explained the evolution of life in a way that doesn’t require the hand of God. Darwin didn’t exclude God, of course, though many creationists seem incapable of grasping this point. But he didn’t require God, either, and that was enough to drive some people mad.

Darwin also didn’t have anything to say about how life got started in the first place — which still leaves a mighty big role for God to play, for those who are so inclined. But that could be about to change, and things could get a whole lot worse for creationists because of Jeremy England, a young MIT professor who’s proposed a theory, based in thermodynamics, showing that the emergence of life was not accidental, but necessary. “[U]nder certain conditions, matter inexorably acquires the key physical attribute associated with life,” he was quoted as saying in an article in Quanta magazine early in 2014, that’s since been republished by Scientific American and, more recently, by Business Insider. In essence, he’s saying, life itself evolved out of simpler non-living systems.

Jerremy England's ideas are too complex for me. Watch this video to see for yourself.

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