Stop Taking Vitamin Supplements!

Here's a post for all my friends and acquaintances who think they have to load up on vitamin supplements ever day. You don't need them (unless you are ill or pregnant).

If you think you do, then chances are you've fallen victim to one of the biggest scams of modern times. It's not much different than the pitches made by snake oil salesmen over one hundred years ago. There are people making big money by convincing gullible citizens that they have vitamin deficiencies. Some of those people are doctors and many of the enablers are family physicians who don't know the scientific evidence behind vitamin supplements.

"There's a sucker born every minute."

David Hannum
(frequently attributed to P.T. Barnum)The Atlantic has published a nice summary of the current evidence: The Vitamin Myth: Why We Think We Need Supplements. Most of the article is about Linus Pauling and why he was spectacularly wrong about vitamin supplements. Here's the bottom line ...

On October 10, 2011, researchers from the University of Minnesota found that women who took supplemental multivitamins died at rates higher than those who didn't. Two days later, researchers from the Cleveland Clinic found that men who took vitamin E had an increased risk of prostate cancer. "It's been a tough week for vitamins," said Carrie Gann of ABC News.

These findings weren't new. Seven previous studies had already shown that vitamins increased the risk of cancer and heart disease and shortened lives. Still, in 2012, more than half of all Americans took some form of vitamin supplements.

I'm not convinced that moderate amounts of vitamin supplements will actually cause you much harm—the jury's still out on that IMHO. However, it's now abundantly clear that, for the average healthy person, spending money on vitamin supplements is no different that flushing that money down the toilet, which, coincidentally, is where most of the vitamins you take will eventually end up.

See also: What Kind of People Take Vitamins?.

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Re-learning Russian

Ms. Sandwalk and I are going to be in St. Petersburg (Russia) in a few weeks. We plan on spending four hours in the building on the right (and adjacent buildings) although I'm told that's not nearly enough time.

I'm trying to remember my Russian. I last studied it in high school 50 years ago. We've been watching videos of the main tourist spots in St. Petersburg and I can usually figure out what the signs are saying. For example, it was pretty easy to recognize the sign below. In fact, most of you could probably figure it out even if you haven't taken Russian.

Here's the problem. The language in most Western European cities is quite casual compared to the way it was in the past. A typical greeting might be similar to "hi" instead of "How are you?" The comparable words in Russian are Привет and Здравствуйте. Which one is more appropriate in Russia today? And which pronunciation of Здравствуйте should I use?

Similarly, I was taught to say Как вы поживаете (How are you?) but that's a very formal phrase. I get the impression that it's now thought to be archaic and you can easily skip the pronoun by saying Как поживаете. Can you get away with addressing a stranger using the informal first person version of "you," e.g. Как поживаешь?

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Monday's Molecule #210

Last week's molecule was the "go" conformation of the leader sequence in the E. coli trp operon. The winners were Rosie Redfield and Quyen Huynh. [Monday's Molecule #209].

Today's molecule isn't very complicated but it has a big effect. You need to be very specific in identifying the exact molecule shown in the figure. I won't accept answers that are ambiguous.

Email your answers to me at: Monday's Molecule #210. I'll hold off posting your answers for 24 hours. The first one with the correct answer wins. I will only post mostly correct answers to avoid embarrassment. The winner will be treated to a free lunch.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your email message.)

The Many Faces of Sal Cordova

The IDiots are getting all excited about Nick Matzke because he dared to criticize Darwin's Doubt, a book about evolution written by a philosopher.

The latest post is by Salvador Cordova (scordova) on Uncommon Descent [Two-faced Nick Matzke].

I don't think I can do full justice to the stupidity in this post, you have to read it yourself. Here's the gist ...

Matzke said, quite correctly, that phylogenetic methods can only detect sister groups, not ancestors. This is pretty obvious in the case of sequences because, in most cases, we don't have access to DNA or proteins from extinct ancestors.

Salvador Cordova thinks he was the first one to realize this ...

Not much difference between what Matzke said and I said! I’ve been telling him that since 2006, and now he finally acknowledges it publicly.

Now that's good for a laugh at the expense of IDiots but it gets even funnier. The IDiots think that the absence of living ancestors proves that god(s) created modern species.

I’ve said that it was creationists (like Linnaeus) before Darwin’s time who lumped humans along with the primates, and the primates along with the mammals, etc. The creationists perceived the “sister groups” with no physical ancestor (which suggests the “parent” was an idea in the mind of God, not a physical common ancestor).

The reason Darwinists have all these phylogenetic conflicts is that the ancestors which would resolve all the conflicts are the very ones they will not admit a priori because those ancestors are conceptual, not physical, and conceptual ancestors are anathema to Darwinsits because conceptual ancestors imply ID.

Like I said, you have to read the whole thing ... if you can stomach it.

I wonder why we call them IDiots?

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Bill Maher Shows Us that "Smart" People Can Believe Really Stupid Things

Bill Maher thinks he's a smart person ... maybe even an intellectual. Here's a video of him attacking smart people who believe really stupid things. It drips with sarcasm and mockery. At the end of the video you wonder how in the world people could be so stupid. Maher is upset about the resurgence of the "smart-stupid person." One of his targets is a former Prime Minister of Canada.

Hermant Mehta liked this video [Bill Maher Goes After Dr. Eben Alexander and Other Brilliant Scholars Who Believe in Complete Nonsense].


Speaking of smart-stupid people. Here's a video of Bill Maher talking complete nonsense about vaccines. He is corrected by a really smart person, Bill Frist. This is an example of irony and an example of hypocrisy. The hypocrisy is worse than the irony.

IDiot Irony

Sometimes I really wonder what goes on at the Discovery Institute.

As most of you know by now, Stephen Meyer has written a new anti-evolution book where he criticizes the expert scientific opinion on the Cambrian Explosion. He says that the experts are all wrong and the evidence shows that evolution is impossible. The only reasonable alternative is that god(s) made the primitive animals. Meyer has an undergraduate degree in physics and earth science (1981) and got a Ph.D. in history and philosophy of science ten years later (1991). He is not a scientist and he is not an expert on evolution.

Casey Luskin has a Master's degree in earth sciences but later on he got a law degree and he is primarliy a lawyer. He is not a scientist and he is not an expert on evolution.

David Klinghoffer is a writer. He is not a scientist and he is not an expert on evolution.

Nick Matzke is a graduate student who is finishing up his Ph.D. in evolutionary biology. He is a scientist and he is an expert on evolution. He is also an expert on Intelligent Design Creationism.

Nick Matzke wrote a long review of Darwin's Doubt—a book written by a philosopher [Meyer’s Hopeless Monster, Part II].

Casey Luskin, a lawyer, took it upon himself to critique Matzke's review [How "Sudden" Was the Cambrian Explosion? Nick Matzke Misreads Stephen Meyer and the Paleontological Literature; New Yorker Recycles Misrepresentation]. Luskin says,

Since Matzke published his review, The New Yorker reviewed Meyer's book. Gareth Cook, the science writer who wrote the piece, relied heavily on Matzke's critical evaluation, even though Matzke is a graduate student and not an established Cambrian expert. Cook uncritically recycled Matzke's claim that the Cambrian explosion took "many tens of millions of years," ...

Do you see the irony? Meyer is a philosopher and Luskin is a lawyer but poor old Nick is just a graduate student about to get a Ph.D. in evolutionary biology. Matzke is not an established Cambrian expert. Neither are Meyer or Luskin but that doesn't seem to stop them from criticizing Matzke and all other evolutionary biologists and all paleontologists.¹

David Klinghoffer just can't wait to contribute his two cents. Klinghoffer isn't a scientist and he certainly isn't an expert on paleontology but that doesn't mean he can't have an opinion [Regarding Matzke, Coyne, and Darwin's Doubt, a Reader Asks].

That is a good question. Casey Luskin has already demonstrated what a non-paleontologist Matzke is.

How could non-scientist Klinghoffer possibly know whether lawyer Casey Luskin had made a good case against evolutionary biologist Nick Matzke? Does Klinhoffer realize that Luskin is a lawyer, not a paleontologist?

Do you wonder why we call them IDiots?

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1. My irony meter survived but it was touch-and-go for a minute or two.

Can You Name These Famous People?

I was cleaning up my files and I came across this photo from seven years ago. It's one of those vanity photos¹ where I try to impress you by having my picture taken with famous people.

Can you name all the people in the photo (hint, I'm the one on the right). You're not allowed to guess if you are one of the people in the photo.

Are you impressed? (You should be.)

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1. That's what Jerry Coyne calls them

Speaking of Trees

My friends and colleagues, David Isenman and Jacqueline Segall, used to have a big tree in their back yard. On Monday July 8th it rained ... a lot. The ground became very soggy and the tree tipped over.

So much for the life of this tree. They need a new shed.

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What Is Humanism?

What the heck is humanism? The short answer is ... I have no idea.

If someone tells me they're a humanist then I can guess that they have some kind of ethical standards that have nothing to do with religion but that's about all I can guess. They might as well have told me that they are an atheist and leave it at that.

Are humanists socialists? Do they all favor socialized medicine and support unions? Do they oppose the death penalty? Are they in favor of gun control and abortion on demand? Do humanists oppose the American war in Afghanistan? Did they support the invasion of Iraq?

Are humanists willing to vote for a Republican or a Conservative? How about a Communist? Do all humanists think gay marriage should be legal? Would they legalize prostitution and pornography? Would they legalize drugs like cocaine and marijuana? How do they feel about euthanasia?

Do humanists support a public school system or are some in favor of vouchers and private schools? Do they all have the same position on immigration? on welfare?

I don't know the answer to any of these questions. I don't know what it means to be a humanist.

Hermant Mehta thinks that Humanism tells us what he believes. Watch this video to see what that means.


Still confused? Go to the American Humanist Association website and you'll be even more confused. Read the Humanist Manifesto and the essays by Fred Edwords. They don't answer any of the questions I asked.

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How to Build a Research Institute

The Francis Crick Institute is under construction in London (UK). When I first heard about this I thought that it would be a wonderful place for theoretical biologists—a sort of Institute for Advanced Study for biologists. That would be in keeping with the career of Francis Crick. It's also something that sorely needed in the 21st century because most biology has degenerated into data collection and mining with little attention to ideas and concepts.

Alas, the director, Paul Nurse, had other ideas. He wanted to create "a world-leading centre of biomedical research and innovation." In other words, translation research.

Paul Nurse and two research directors (Richard Treisman and Jim Smith) wrote an editorial in a recent issue of Science [Building Better Institutions]. They take it as a given that what Great Britain needs is a research institute that concentrates on medical research. They also believe that mixing scientists, clinicians, and representatives of the pharmaceutical industry will lead to better results. You better throw in a few physical scientists for good measure because physical scientists have good ideas.

Despite the recent growth in scientific knowledge, conventional discipline-based methods have not been suffi ciently effective at developing new understanding and treatments. Researchers need to be encouraged to identify important questions and tackle them with multidisciplinary approaches. Contemporary biomedical research has to integrate biological, nonbiological, and clinical disciplines, and its application requires interactions with hospital and commercial partners. This can be facilitated by research institutions with an environment that supports strong interdisciplinary interactions between scientists: a place where laboratory biologists are encouraged to collaborate with clinical researchers to understand the medical implications of their work, with pharmaceutical companies for the translation of discoveries into treatments, and with physical scientists to expand their thinking and repertoire of experimental approaches. Such an institution must be continually open to new ideas and permeable to interactions with outside researchers and organizations.

We've been doing exactly that at our hospital research institutes here at the University of Toronto. The industrial relationship has been helped by something we call the MaRS Discovery District. The experiment has been running for over a decade and, as I'm sure you all know, it has been hugely successful. Toronto has been churning out new medical discoveries on a daily basis. (Not!)

The Francis Crick Institute will support young investigators because scientists at the beginning of their career have such a tremendous track record of creativity and originality. (?) In fact, the new institute believes so strongly in young investigator that 80 out of 120 positions will be set aside for them. But what happens when they reach their mid-forties?

These appointments will be of up to 12 years, supported by the Crick's funding partners (the Medical Research Council, Cancer Research UK, and the Wellcome Trust). Group leaders will then leave the institute to establish a research group elsewhere; the aim is to give researchers who are effective and remain in the United Kingdom a transition package to support their moves, creating a thriving network of highly trained researchers.

Science is a risky business so every year there will likely be three or four investigators whose time is up but whose scientific output is just average. What happens when they're tossed out of the institute?

Does anyone think this is a good idea?

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What Should We Teach About the "Tree of Life"?

As most of you already know, I think the Three Domain Hypothesis is dead. The history of life is better explained as a net with rampant transfer of genes between species [The Web of Life]. This idea has been widely promoted by Ford Doolittle.

The debate over the tree of life has implications concerning the distinction between "prokaryote" and "eukaryote." I was checking some recent papers and came across one by Doolittle and Zhaxybayeva (2013) that seems particularly relevant. They discuss the evidence for and against the division of life into three domains and the attempt by Norm Pace to ban the word "prokaryote."

The authors point out, once again, that eukaryotic genes are most closely related to genes from cyanobacteria, proteobacteria, and archaebacteria, in that order. The majority, by far, have their closest homologs in bacteria, not archaebacteria. The most likely explanation is that euakryotes are chimeras resulting from fusion of an archaebacterium and a eubacterium plus genes transferred from mitochondria and chloroplast to the nuclear genome.

The Largest Prokaryotic Genomes

Some bacterial genomes are quite large. A few are larger than the smallest eukaryotic genomes.

Many species of cyanobacteria are complex, multicellular organisms [Multicellular Bacteria]. Those species tend to have large genomes.

Recently Degan et al. (2013) sequenced the genomes of six new cyanobacteria species and one of them turns out to have a large genome.¹ (see Contradictory Phylogenies for Cyanobacteria for more information on that paper.) The species is Scytonema hofmanni and its genome is 12,073,012 bp in size. It has 12,356 potential protein-coding genes. If all of them are correctly identified then the total, counting non-protein-coding genes, is likely to be 12,500 genes. That's a record for prokaryotes.

Half of these genes are only found in Scytonema and that's very strange.

There are bacteria with larger genomes, notably the soil bacterium Ktedonobacter racemifer with a genome size of 13,661,586 bp.

For comparison, the genome of the yeast, Saccharomyces cerevisiae, is 12,156,677 bp in size and it has 6,200 genes.

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Photo Credit: Scytonema hofmanni from cyanobacteria slides.

1. Some of you might be under the impression that I give a shit about Norm Pace and his attempt to banish the word "prokaryote" (Pace, 2009). Don't bother to try and convince me because it requires that I accept the false Three Domain Hypothesis and that ain't gonna happen.

Dagan, T., Roettger, M., Stucken, K., Landan, G., Koch, R., Major, P., Gould, S. B., Goremykin, V.V., Rippka, R., de Marsac, N.T., Gugger, M., Lockhart, P.J., Allen, J.F., Brune, I., Maus, I., Pühler, A. and Martin, W.A. (2013) Genomes of stigonematalean cyanobacteria (Subsection V) and the evolution of oxygenic photosynthesis from prokaryotes to plastids. Genome biology and evolution 5:31-44.
[doi: 10.1093/gbe/evs117]

Pace, N.R. (2009) Time for a change. Nature 441:289. [doi:10.1038/441289a]

Contradictory Phylogenies for Cyanobacteria

The cyanobacteria are interesting for a number of reasons. They have a complex photosynthesis pathway with two separate phostosystems and an oxygen evolving complex. That means they can use water as an electron donor and NADP^⊕ as an electron acceptor.

Cyanobacteria probably played an important role in creating an atmosphere with significant levels of oxygen but, contrary to some speculation, they almost certainly arose fairly late in the history of life (i.e. after 500 million years). Cyanobacteria make up a significant proportion of life in the ocean. Primitive cyanobacteria gave rise to chloroplasts in modern plants and algae.

The Shortest Distance ....

I have many pet peeves. One of them concerns the people who build paths and walkways. If you're going to spend a lot of money constructing fancy walkways, then it makes sense to put a little thought into where you're going to put them. As a general rule, you should put the walkway where people are going to walk.

A few years ago (2008), the University of Toronto spent a million dollars on constructing new pathways throughout the downtown campus. The new paths mostly followed the old paths but there were places where that didn't make sense. As I reported back then [If you build it, will they follow?], the old path didn't line up with the new ramp to my building (see photo below). The guys building the path agreed with me that the placement of the walkway made no sense but they were overruled by their supervisor who insisted that the alignment wasn't a problem. People would stay on the new walkway and they would be encouraged to do so by strategic placement of a big rock.



Can you guess what happened? That ramp is now the main entrance to my building for people coming up from the subway exit. Will they follow the path, taking a sharp right turn then a sharp left turn or will they cut straight across the grass making as much of a mess as before the new walkway was constructed?

Here's the result ...

Isn't that ridiculous? Just as predicted, people take the shortest distance between two points and if that means walking over the grass and making an ugly mess, then so be it. What's the point of spending a ton of money to make the campus look nice if this is the result?

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Evidence for Intelligent Design

Remember how the IDiots are always trying to tell us that their movement is scientific? It's all about scientific evidence for design.

The facts say otherwise. Almost all of their arguments are based on "evidence" against evolution and on trashing scientists, especially Darwin. Much of their opposition has nothing to do with scientific evidence of design; instead, it's directed at materialism and atheism and other views that they see as an integral part of something called "Darwinism."

Let's see how bizarre this can get. Friedrich Nietzsche ("God is dead") is hardly someone who the IDiots respect for his philosophical view. But that doesn't matter as long as he said something bad about Charles Darwin [Nietzsche, possibly the Nazis’ favourite well-known philosopher, criticized Darwinism on aesthetic grounds].

But, wait a minute. If Nietzsche was a favorite of the Nazis then Darwin must have been opposed to Nazism because Nazi Neitsche criticized natural selection. I'm confused. What does this have to do with evidence of design?

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