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Monday, October 08, 2012

Monday's Molecule #189

Last week's molecules were cis Δ9-octadecanic acid (oleic acid) and trans Δ9-octadecanic acid (elaidic acid). Last week's winner was John Runnels. He should email me.

Name this week's molecule. Be sure to give an unambiguous name—it can be the common name or the IUPAC name. Why is this molecule important in some species?

Post your answer as a comment. I'll hold off releasing any comments for 24 hours. The first one with the correct answer wins. I will only post mostly correct answers to avoid embarrassment. The winner will be treated to a free lunch.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your comment.)

Friday, October 05, 2012

An Online Course for Intelligent Design Creationists

About 99% of all books and posts by Intelligent Design Creationist consists of criticisms of evolution—which they mistakenly refer to as "Darwinism."

What this usually reveals is that the typical IDiot doesn't understand evolution. But there's at least one Intelligent Design Creationist who recognizes that this is a problem. Jonathan McLatchie (Jonathan M) recommends that his colleagues take an free online course in order to learn about evolution [Free Online Course: Introduction to Genetics and Evolution]. He writes,
Critics of modern evolutionary theory have an intellectual responsibility to strive to understand the paradigm that they are critiquing, preferably to a level where they can clearly articulate the key propositions of evolutionary theory and offer a standard defense of them.

Richard Hoppe, at the Panda’s Thumb blog, drew my attention to a free online course on the subject of genetics and evolution. You can, as I have done, sign up for (and read about) the course at this link.

...

I particularly recommend that those among us who don’t have a strong biology background take this course. It is very important that we ID proponents make sure we have a robust grasp of what evolutionary theory is saying and why it says it, so that no one can say we haven’t given it a fair hearing.
Wouldn't it be nice if most IDiots followed Jonathan McLatchie's advice? In just a few months they could learn that modern evolution and genetics includes all sorts of things that Darwin never knew! Imagine what a relief it would be if they stopped referring to us all as "Darwinists" and started to understand that evolution is a fact.

Not holding my breath.


Visiting the Grand Canyon

Last week we took a helicopter from Las Vegas to Hoover Dam and the Grand Canyon. Check out the photos on Ms. Sandwalk's blog: The Magic Canyon Ride.


Online Training of Competent, Employable, Bioinformatics Professionals

I think that undergraduate education at most universities is done very badly. There are far too many courses that consist of professors giving standard lectures to large classes with evaluations focused on "memorize and regurgitate" exams. Most courses pay no heed to student-centered learning even though there has been sound pedagogical research showing that student participation leads to better learning. Most courses and programs provide no "value-added" component that takes advantage of being physically located in an enriched scholarly environment. Most courses do not teach critical thinking.

Given the horrible status of most university courses, it's not surprising that they can be replaced by online courses where the student never needs to set foot on a university campus to get the same quality of education. This is not an endorsement of online courses, it's a comment on the poor quality of campus-based courses.

David B. Searls is an "independent consultant" who published an article in PLOS Computational Biology: An Online Bioinformatics Curriculum.

Wednesday, October 03, 2012

Carnival of Evolution, Number #52: the Network Edition

This month's Carnival of Evolution is hosted by Sam Wise at SOS Presents%mdash;the Carnival of Evolution #53. Read it at: Carnival of Evolution, Number 52 — the Network Edition
Welcome to the 52nd edition of the Carnival of Evolution, hosted here at The Genealogical World of Phylogenetic Networks blog.

For those of you not familiar with the Carnival of Evolution, at the beginning of every month the Carnival provides a collection of some of the most interesting of the recent blog posts about biological evolution. The Carnival is hosted by a different blog every month: last month's Carnival can be found at The Stochastic Scientist blog; and next month's Carnival will be hosted by the Sorting Out Science blog at the beginning of November.

The theme for the presentations this month is, of course, phylogenetic networks. You can skip straight on to the blog posts if you are familiar with such networks.
There's some cool stuff this month, including a summary of the ENCODE/junk DNA fiasco.

The next Carnival of Evolution (September) will be hosted by Sorting out Science. If you want to volunteer to host others, contact Bjørn Østman. Bjørn is always looking for someone to host the Carnival of Evolution. He would prefer someone who has not hosted before. Contact him at the Carnival of Evolution blog. You can send articles directly to him or you can submit your articles at Carnival of Evolution.


Tuesday, October 02, 2012

Reddit: We are the Encyclopedia of DNA Elements (ENCODE) Consortium.

There's been a lot of talk recently about the discussion on reddit concerning the ENCODE publicity fiasco.

Here's the forum ...
AskScience Special AMA: We are the Encyclopedia of DNA Elements (ENCODE) Consortium. Last week we published more than 30 papers and a giant collection of data on the function of the human genome. Ask us anything!
It's interesting to see how some of the consortium members are responding to criticism. My personal view is that none of them seem to be very knowledgeable about genome biology and the work that has been published over the past 40 years.


Monday, October 01, 2012

Monday's Molecule #188

Last week's molecule was N-formylmethionyl-tRNAfMet [Monday's Molecule #188]. Only three people came close. The winner was Mikkel Rasmussen.

Name these molecules. One of them has a well-known common name that you have to include in your answer. The other one also has a common name but you don't have to find it. You have to give the complete formal names of each molecule. Do you know the significance of these two molecules?

Post your answer as a comment. I'll hold off releasing any comments for 24 hours. The first one with the correct answer wins. I will only post mostly correct answers to avoid embarrassment. The winner will be treated to a free lunch.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your comment.)

Saturday, September 29, 2012

Douglas Axe Explains Molecular Evolution

There are several dozen scientists and graduate students in my department studying various aspects of protein evolution, structure, and folding. They've published dozens of papers but, apparently, they never realized that what they're studying is impossible. Douglas Axe, a leading Intelligent Design Creationist, sets them straight.



[Hat Tip: Evolution News & Views: Axe: Vive la Différence]

Where Am I?

My granddaughter, Zoë, took a picture of me getting a hot dog. Can you guess where I am?



Where Am I?




Wednesday, September 26, 2012

Ewan Birney: Genomics' Big Talker

My copy of Science arrived in the mail last week and I wasn't surprised to see the article by Elizabeth Pennisi on ENCODE Project Writes Eulogy for Junk DNA. Pennisi has long been skeptical about junk DNA. She advocates the position that what makes us human is hidden in the "dark matter" of the genome. She has never lost an opportunity to promote those scientists who claim to have discovered function in junk DNA so it was natural for her to fall hook-line-and-sinker for the recent ENCODE publicity campaign [see Science Writes Eulogy for Junk DNA].

What did surprise me was a three-page spread on Ewan Birney: Genomics' Big Talker, written by Elizabeth Pennisi. This is extraordinary. I don't know of another example where a leading science journal has promoted a young scientist in this manner. Of course, it's doubly extraordinary because, in this case, Science is promoting a scientist who just made some serious mistakes interpreting his own data! The man who is so prominently featured in the Sept. 7, 2012 issue of Science magazine is coming under serious criticism for letting publicity rule his science. He has almost single-handedly1 damaged the reputation of 400 scientists in the ENCODE Consortium and he did it, in part, because he was not knowledgeable about his own field of expertise! [see ENCODE Leader Says that 80% of Our Genome Is Functional and The ENCODE Data Dump and the Responsibility of Scientists]

UPDATE:A reader has reminded me that Science published two pages (online) on Felicia Wolfe-Simon at the time of the arsenic affair. Hmmmm ... is this the beginning of a pattern?

Tuesday, September 25, 2012

Viva Las Vegas!

Ms. Sandwalk and I are in Las Vegas with our friends. Posting may be a bit light for the next few days.



Monday, September 24, 2012

Where Am I #2?

Here's another clue. Where am I today? (Click to embiggen.)



Where Am I #1?

Can you guess where I am today? (Click to embiggen.)



Monday's Molecule #187

Last week's molecule was the core nucleosome complex [Monday's Molecule #186] and nobody who was eligible for a win got it! That's quite shocking. Here's an easy one for today.

Name this molecule, including the name of the "R" group. You'll have to guess but there's really only one possibility in living cells. Don't forget, I need the full name of the most likely molecule given the partial structure that you see.

Post your answer as a comment. I'll hold off releasing any comments for 24 hours. The first one with the correct answer wins. I will only post mostly correct answers to avoid embarrassment. The winner will be treated to a free lunch.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your comment.)