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Saturday, April 02, 2011
Cat Bowling
Jerry Coyne posted this [Caturday felids: Lasers!] but I just have to put it on Sandwalk for others to see. You need a cat and a laser pointer ...
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Humor
Carnival of Evolution #34
This month's Carnival of Evolution is hosted by Stephen Matheson at Quintessence of Dust [Carnival of Evolution: #34].
It's the April 1, 2011 version but don't be fooled. Some of the postings are serious!
Friday, April 01, 2011
Junk & Jonathan: Part 2— What Did Biologists Really Say About Junk DNA?
This is the second in a series of postings about a new book by Jonathan Wells: The Myth of Junk DNA. The book is published by Discovery Institute Press and it should go on sale on May 31 2011. I'm responding to an interview with Jonathan Wells on Uncommon Descent [Jonathan Wells on his book, The Myth of Junk DNA – yes, it is a Darwinist myth and he nails it as such].
Denyse O'Leary asks, "Interestingly, in the “nail dump is Ming vase” story, no one insists that nobody ever thought it was just another piece of junk. They almost always say, “Yes, we thought so but had no idea …” So what’s behind the failure to admit an error in this case?" It's hard to figure out what she means but I think she's wondering why biologists don't just admit they were wrong about junk DNA. Jonathan Wells interprets the question differently.
The truth is somewhat different. Wells says, "Some people revise history by claiming that no mainstream biologists ever regarded non-protein-coding DNA as “junk.”" The truth is that the mainstream biologist community never, ever claimed that all non-coding DNA was junk. Most of them didn't even believe that a majority of our genome was junk.
The issue has come up many times over the past few years on blogs and newsgroups. The last time I took a poll was a few years ago and here are the results.
As you can see, there's a wide range of opinion among people who read Sandwalk. I think this is a pretty good reflection of the opinions of most biologists.
In responding to the question, Wells makes one serious error when he claims that biologists promoted junk DNA because it "provides evidence for Darwinian evolution." It does nothing of the sort. In fact, it goes against any prediction of Darwinian evolution by natural selection. The reason why the concept of (huge amounts of) junk DNA was resisted by so many biologists was because of this conflict.
Wells also says that junk DNA was promoted by some biologists because it "provides evidence ... against intelligent design." This is partly true, especially when the arguments center on conserved pseudogenes. That part of junk DNA (pseudogenes) is accepted by almost all biologists but it's only a tiny part of our genome. There is no evidence to suggest that pseudogenes are anything but junk and all the evidence indicates that we have thousands of them in our genome. (If they have a function then they aren't pseudogenes.)
Many mainstream biologists have supported the idea that a majority of our genome is junk. There's no denying that. I agree with them. None of them are changing their minds in spite of what Jonathan Wells is telling you. What Wells is doing is picking sides in a genuine scientific dispute. He could have done this 30 years ago and the result would have been the same. The genuine scientific controversy is not about to be resolved and there's no new evidence that seals the case one way or the other.
In my opinion, our genome is almost 90% junk DNA and that's the view that's going to win in the end.
Denyse O'Leary asks, "Interestingly, in the “nail dump is Ming vase” story, no one insists that nobody ever thought it was just another piece of junk. They almost always say, “Yes, we thought so but had no idea …” So what’s behind the failure to admit an error in this case?" It's hard to figure out what she means but I think she's wondering why biologists don't just admit they were wrong about junk DNA. Jonathan Wells interprets the question differently.
Some people revise history by claiming that no mainstream biologists ever regarded non-protein-coding DNA as “junk.”It's in the best interests of the IDiots to promote the idea that all "Darwinists" believed in the "myth" of junk DNA and that it wasn't until the predictions of the IDiots were confirmed (not) that the biologists changed their minds.
This claim is easily disproved: Francis Crick and Leslie Orgel published an article in Nature in 1980 (284: 604-607) arguing that such DNA “is little better than junk,” and “it would be folly in such cases to hunt obsessively” for functions in it. Since then, Brown University biologist Kenneth R. Miller, Oxford University biologist Richard Dawkins, University of Chicago biologist Jerry A. Coyne, and University of California–Irvine biologist John C. Avise have all argued that most of our DNA is junk, and that this provides evidence for Darwinian evolution and against intelligent design. National Institutes of Health director Francis Collins argued similarly in his widely read 2006 book The Language of God.
It is true that some biologists (such as Thomas Cavalier-Smith and Gabriel Dover) have long been skeptical of “junk DNA” claims, but probably a majority of biologists since 1980 have gone along with the myth. The revisionists are misinformed (or misinforming).
The truth is somewhat different. Wells says, "Some people revise history by claiming that no mainstream biologists ever regarded non-protein-coding DNA as “junk.”" The truth is that the mainstream biologist community never, ever claimed that all non-coding DNA was junk. Most of them didn't even believe that a majority of our genome was junk.
The issue has come up many times over the past few years on blogs and newsgroups. The last time I took a poll was a few years ago and here are the results.
As you can see, there's a wide range of opinion among people who read Sandwalk. I think this is a pretty good reflection of the opinions of most biologists.
In responding to the question, Wells makes one serious error when he claims that biologists promoted junk DNA because it "provides evidence for Darwinian evolution." It does nothing of the sort. In fact, it goes against any prediction of Darwinian evolution by natural selection. The reason why the concept of (huge amounts of) junk DNA was resisted by so many biologists was because of this conflict.
Wells also says that junk DNA was promoted by some biologists because it "provides evidence ... against intelligent design." This is partly true, especially when the arguments center on conserved pseudogenes. That part of junk DNA (pseudogenes) is accepted by almost all biologists but it's only a tiny part of our genome. There is no evidence to suggest that pseudogenes are anything but junk and all the evidence indicates that we have thousands of them in our genome. (If they have a function then they aren't pseudogenes.)
Many mainstream biologists have supported the idea that a majority of our genome is junk. There's no denying that. I agree with them. None of them are changing their minds in spite of what Jonathan Wells is telling you. What Wells is doing is picking sides in a genuine scientific dispute. He could have done this 30 years ago and the result would have been the same. The genuine scientific controversy is not about to be resolved and there's no new evidence that seals the case one way or the other.
In my opinion, our genome is almost 90% junk DNA and that's the view that's going to win in the end.
Thursday, March 31, 2011
Junk & Jonathan: Part 1—Getting the History Correct
This is the first in a series of postings about a new book by Jonathan Wells: The Myth of Junk DNA. The book is published by Discovery Institute Press and it should go on sale on May 31 2011. I'm responding to an interview with Jonathan Wells on Uncommon Descent [Jonathan Wells on his book, The Myth of Junk DNA – yes, it is a Darwinist myth and he nails it as such].
The first question is "what is junk/noncoding DNA?" And the answer is,
There was never a time when knowledgeable molecular biologists equated "junk" DNA and "noncoding" DNA. That doesn't mean that there weren't slip-ups from time to time as less knowledgeable scientists published articles on genome organization. There are even modern scientists (and science writers) who make the mistake of confusing "noncoding" with "junk."
My point is that if you are going to answer the question accurately then you should represent the consensus view of most scientists who know that lots of noncoding DNA has a function. You should also attempt to present the modern view of junk DNA instead of implying that forty year old concepts still hold sway. The modern view is that junk DNA is that part of our genome that has no known function. It does not include noncoding regions like regulatory sequences, RNA genes, centromeres. telomeres, origins of replication, recombination hotspots, splice sites, minimal intron length, and scaffold attachment regions (SARs).
The interviewer is Denyse O'Leary and her sympathies are clear in the followup question, "Why was it called “junk” in the first place? And why does all this remind me of one of those auction program episodes where someone is storing leftover carpet nails in what turns out to be a Ming dynasty vase? My mom loves those."
Jonathan Wells answers,
Denyse's last question is about me. "Can you interpret this for me, from Larry Moran (University of Toronto evolutionary biologist): “I don’t demand civility, but I do demand accuracy. When Denyse and her friends say that Darwinists promoted junk DNA I have to draw the line.” But he must be referring to my observation that originated in Francis Collins’s (US government’s chief 2000 genome mapper’s [!]) statements in a well-received and widely read book. Are there two types of truths at work here? Evidence, and … what? "
But that's not what the scientific debate is about. Pseudogenes are not a myth. They are a fact, and they make up as much as 2% of the mammalian genome. The scientific debate is about whether most of our genome is really junk DNA. I think Francis Collins supports this idea, with some reservations, but I don't know about Jerry Coyne or Kenneth Miller or Richard Dawkins. John Avise is, of course, one the main proponents of junk DNA being a majority of our genome. His book Inside the Human Genome: A Case for Non-intelligent Design was published just last year (2010). It's for those needing an antidote after reading the upcoming train wreck by Jonathan Wells.
It is extremely misleading to claim that "Darwinists" promoted the idea that most of our genome is junk. Most biologists are skeptical of that claim and that's especially true of those who would be comfortable calling themselves "Darwinists."
Denyse closes with one of her characteristic comments.
The first question is "what is junk/noncoding DNA?" And the answer is,
“Non-coding” in this context means “non-protein-coding.” An important function of our DNA is to specific the sequences of subunits (amino acids) in the proteins that (along with other types of molecules) make up our bodies. When molecular biologists discovered in the 1970s that about 98% of our DNA does not code for proteins, some biologists called non-protein- coding DNA “junk.”This is misleading. You can consult the excellent article by Ryan Gregory on the origin of the term "junk DNA" to see what it meant in 1972: A word about "junk DNA". The bottom line is that the original meaning of the term "junk DNA" was much closer to what we now call pseudogenes. "Non-coding DNA" is that portion of the genome that does not encode amino acids. In the original paper by Susumu Ohno (1972) there was plenty of discussion about functional noncoding DNA (centromeres, regulatory sequences, spacer DNA). In addition, every scientist in 1972 knew that there were functional genes for tRNAs and ribosomal RNAs in the noncoding DNA.
There was never a time when knowledgeable molecular biologists equated "junk" DNA and "noncoding" DNA. That doesn't mean that there weren't slip-ups from time to time as less knowledgeable scientists published articles on genome organization. There are even modern scientists (and science writers) who make the mistake of confusing "noncoding" with "junk."
My point is that if you are going to answer the question accurately then you should represent the consensus view of most scientists who know that lots of noncoding DNA has a function. You should also attempt to present the modern view of junk DNA instead of implying that forty year old concepts still hold sway. The modern view is that junk DNA is that part of our genome that has no known function. It does not include noncoding regions like regulatory sequences, RNA genes, centromeres. telomeres, origins of replication, recombination hotspots, splice sites, minimal intron length, and scaffold attachment regions (SARs).
The interviewer is Denyse O'Leary and her sympathies are clear in the followup question, "Why was it called “junk” in the first place? And why does all this remind me of one of those auction program episodes where someone is storing leftover carpet nails in what turns out to be a Ming dynasty vase? My mom loves those."
Jonathan Wells answers,
According to Charles Darwin’s theory, all living things are descendants of common ancestors that have been modified solely by unguided natural processes that include variation and selection. In the modern version of his theory—neo-Darwinism— genes control embryo development, variations are due to differences in genes, and new variations originate in genetic mutations. In the 1950s, neo-Darwinists equated genes with DNA sequences (Francis Crick called DNA “the secret of life”) and assumed that their biological significance lay in the proteins they encoded. The 98% of our DNA that does not code for proteins was attributed to molecular accidents that have accumulated in the course of evolution.There's so much wrong with this answer that it's difficult to know where to begin. Maybe I'll just summarize in point form and elaborate in the comments if anyone wants to discuss it further.
“The amount of DNA in organisms,” neo-Darwinist Richard Dawkins wrote in 1976, “is more than is strictly necessary for building them: A large fraction of the DNA is never translated into protein. From the point of view of the individual organism this seems paradoxical. If the ‘purpose’ of DNA is to supervise the building of bodies, it is surprising to find a large quantity of DNA which does no such thing. Biologists are racking their brains trying to think what useful task this apparently surplus DNA is doing. But from the point of view of the selfish genes themselves, there is no paradox. The true ‘purpose’ of DNA is to survive, no more and no less. The simplest way to explain the surplus DNA is to suppose that it is a parasite, or at best a harmless but useless passenger, hitching a ride in the survival machines created by the other DNA.” (The Selfish Gene, p. 47)
Since the 1980s, however, and especially after completion of the Human Genome Project in 2003, biologists have discovered many functions for non-protein-coding DNA. If the Ming vase is a living cell and the leftover carpet nails are “junk DNA,” it turns out that the nails are not only made of gold, but they also make an essential contribution to the beauty of the vase.
- Implying that junk DNA has anything to do with Darwin's theory of evolution by natural selection is totally wrong. No matter how you define "neo-Darwinism" the fact remains that most biologists who believed in adaptation were very skeptical of junk DNA precisely because it didn't fit with Darwin's view of evolution. The idea that as much as 90% of our genome could be junk was very much a minority view in the 1970s and it's probably still a minority view.
- Dawkins was writing about selfish DNA when he wrote that passage in The Selfish Gene. Selfish DNA is not junk DNA. It has an adaptive purpose and a function. It is completely wrong to claim that Richard Dawkins was a big fan of junk DNA in the 1970s. Dawkins makes that very clear in The Extended Phenotype when he proposes various explanations for the extra DNA in our genome.1
- The statement, "The 98% of our DNA that does not code for proteins was attributed to molecular accidents that have accumulated in the course of evolution" is wrong. There was never a group of knowledgeable scientists who thought that all noncoding DNA was due to accidents. Beginning in the 1970s, there were some who thought that a majority of our genome is junk and some (I am one) still think that as much as 90% could be junk. It's worth emphasizing that this view (that most of our genome is junk) was promoted by a relatively small number of scientists and never adopted as the consensus view of the majority of biologists.
- It is misleading to imply that many functions of noncoding DNA have been recently discovered. The only discovery that could even remotely fall into that category would be additional categories of small RNAs that weren't known before. The well-characterized examples account for less than 2% of the genome. Everything else is speculative and controversial.
In a word, evidence. The first to emerge was the fact that almost all of an organism’s DNA is transcribed into RNA. (So although most of it may be non-protein-coding, it codes for RNA.) From a Darwinian perspective, this is surprising: Why would an organism struggling to survive devote so many of its internal resources to producing supposedly useless RNA? Indeed, since 2003 it has become clear that non-protein-coding RNAs perform many essential functions in living cells.Among those of us who advocate junk DNA there are very few who have changed their minds in the past decade. Why is that? It's because we simply don't believe that the "evidence" of widespread transcription is meaningful. Those scientists who oppose the concept of plentiful junk DNA may have taken comfort from the transcription data but their minds weren't changed either. The truth is that there was, and is, a genuine scientific controversy and it has not been settled in spite of what the Intelligent Design Creationists tell you.
Pseudogenes constitute one type of so-called “junk DNA.” These are segments of DNA that resemble segments that elsewhere (or in other organisms) code for protein. Yet RNAs transcribed from some pseudogenes have been found to function in regulating how much protein is produced by the DNA segments they resemble.Even if you added up all of the known examples of this phenomenon from every investigated species and stuffed them into a single genome it wouldn't amount to more than 0.01% of the genome. And there's no reason to think that the phenomenon is anything more than an interesting exception.
Repetitive DNA, in which a non-protein-coding sequence is repeated many times, is another type of so-called “junk DNA.” Yet repetitive DNA is now known to regulate many essential functions, including embryo implantation in mammals.Also misleading. A few examples from diverse species do not make a difference. Indeed these exceptions tend to "prove the rule" rather than overthrow it. Wells is deliberately misleading his audience but he's in good company since there are many scientists who do the same thing. In order to have a serious impact on the junk DNA debate it's not sufficient to show that a few bits of repetitive DNA have gained a function in some species. You have to show that this generalizes to the 50% of the genome that's made up of repeated DNA of various sorts.
There is also growing evidence that non-protein-coding DNA can perform functions that are independent of its sequence. One example is the region of a chromosome (called a “centromere”) that attaches it to other structures in the cell. Another example is the retina in the eyes of nocturnal mammals, in which non-protein-coding DNA acts like a liquid crystal to focus scarce rays of light.There are many known functions of noncoding DNA. They've been known for decades. As a general rule, the proponents of junk DNA seem to be better informed about these regions of the genome than their opponents. It hasn't made a difference in the past and it doesn't now. (Centromeres account for about 2% of the genome. They fall into the 10% that's known not to be junk.)
Denyse's last question is about me. "Can you interpret this for me, from Larry Moran (University of Toronto evolutionary biologist): “I don’t demand civility, but I do demand accuracy. When Denyse and her friends say that Darwinists promoted junk DNA I have to draw the line.” But he must be referring to my observation that originated in Francis Collins’s (US government’s chief 2000 genome mapper’s [!]) statements in a well-received and widely read book. Are there two types of truths at work here? Evidence, and … what? "
When I use the term “Darwinist,” I mean someone who accepts and defends the theory I describe in my answer to Question 2. Crick and Orgel were Darwinists in this sense; so are Miller, Dawkins, Coyne, and Avise—all of whom have promoted the myth of junk DNA. When Collins published The Language of God in 2006, he not only promoted junk DNA but also wrote that “Darwin’s theory of evolution, that is, descent from a common ancestor with natural selection operating on randomly occurring variations” is “unquestionably correct” (pp. 127, 141). Sure sounds like a Darwinist to me.Several of these scientists have written about pseudogenes and the fact that their existence provides strong support for evolution and strong evidence against the existence of an intelligent designer. Most (all?) biologists understand that pseudogenes are an example of junk DNA. Wells has chosen the one example of junk DNA where there's an overwhelming consensus. They are junk.
Collins also wrote that intelligent design is a “God of the gaps” position that is doomed to collapse with further advances in science (p. 193). But Collins has it exactly backwards: He and other promoters of the myth of junk DNA have put their faith in a “Darwin of the gaps” argument that must now retreat in the face of new advances in genome research.
But that's not what the scientific debate is about. Pseudogenes are not a myth. They are a fact, and they make up as much as 2% of the mammalian genome. The scientific debate is about whether most of our genome is really junk DNA. I think Francis Collins supports this idea, with some reservations, but I don't know about Jerry Coyne or Kenneth Miller or Richard Dawkins. John Avise is, of course, one the main proponents of junk DNA being a majority of our genome. His book Inside the Human Genome: A Case for Non-intelligent Design was published just last year (2010). It's for those needing an antidote after reading the upcoming train wreck by Jonathan Wells.
It is extremely misleading to claim that "Darwinists" promoted the idea that most of our genome is junk. Most biologists are skeptical of that claim and that's especially true of those who would be comfortable calling themselves "Darwinists."
Denyse closes with one of her characteristic comments.
Okay, everyone, back to work tomorrow in Darwinworld, where facts like these do not matter in the least.That's why I call them "IDiots." Facts matter to real scientists. The tough part about being a scientist is deciding what's a fact and what's not. Well showed us that he was not up to the task of behaving like a real scientist when he wrote Icons of Evolution and I suspect he's about to provide us with another example of misinformation and selective reading of the scientific literature.
1. Dawkins recognizes that there is some junk in our genome—pseudogenes are a good example—but that does not mean he buys into the idea that a huge percentage of our genome is just junk.
Sunday, March 27, 2011
Stephen Harper on Coalitions
September 9, 2004
Her Excellency the Right Honourable Adrienne Clarkson,
C.C., C.M.M., C.O.M., C.D.
Governor General
Rideau Hall
1 Sussex Drive
Ottawa, Ontario K1A 0A1
Excellency,
As leaders of the opposition parties, we are well aware that, given the Liberal minority government, you could be asked by the Prime Minister to dissolve the 38th Parliament at any time should the House of Commons fail to support some part of the government’s program.
We respectfully point out that the opposition parties, who together constitute a majority in the House, have been in close consultation. We believe that, should a request for dissolution arise this should give you cause, as constitutional practice has determined, to consult the opposition leaders and consider all of your options before exercising your constitutional authority.
Your attention to this matter is appreciated.
Sincerely,
Hon. Stephen Harper, P.C., M.P.
Leader of the Opposition
Leader of the Conservative Party of Canada
Gilles Duceppe, M.P.
Leader of the Bloc Quebecois
Jack Layton, M.P.
Leader of the New Democratic Party
[Hat Tip: Ryan Gregory]
Intelligent Design Creationism Isn't about God
David Klinghoffer, posting on the Discovery website, says that his worldview might be attractive to atheists [What Intelligent Design Offers to Agnostics].
Intelligent design has as much to offer to the unbeliever or the unorthodox searcher as to the confirmed traditional believer. It might even have more. Does that surprise you?Wow! That's what I call real NEWS for evolution. The idea that intelligent design might actually have nothing to do with a creator is truly astonishing.
Could it be a trend, with critics of intelligent design and others outside the familiar world of ID's friends and advocates at last realizing that ID isn't merely NOT the same thing as creationism? More than that, a couple have noted lately, intelligent design isn't necessarily even theistic.
Let's see how this plays out later on in his posting ...
Every real solution to this problem of despair assumes a reality beyond our mundane, one-dimensional and material one. How could it not? We are in despair, or fear falling into it -- whether we're religious or otherwise -- over the limitations of our own lives.This is why philosophy is so confusing. Let's see if I've grasped the logic here. Intelligent design is anti-materialistic but not religious. It implies the existence of "something" that is out there that gives David Klinghoffer some sort of purpose in life and makes him feel less afraid of death. That "something" can't be God because intelligent design isn't necessarily theistic.
The ultimate limit is imposed by death, which we fear as no generation in memory seems to have done despite the overwhelming safety of our existence. In the meantime, while we are still alive, the lack of a sense of ultimate purpose and meaning that goes with the culture of materialism feeds the anxiety that underlies so much of that culture.
Materialism corrodes the confidence we might otherwise have that any search for meaning that we undertake is not necessarily in vain. Intelligent design offers the hope, by the refutation of materialist science, that "something is out there," whatever it might be, capable of granting genuine purpose to our existence. An agnostic like James Kirk Wall or a -- I don't know what exactly -- like Jack Scanlan should easily appreciate this.
You can't make this stuff up. All you have to do is read what the IDiots, themselves, write on the leading Intelligent Design Creationist blogs.
Saturday, March 26, 2011
Creationism Attacked in the Canadian Parliament
Yesterday the Canadian government under Stephen Harper was defeated for contempt of parliament [Canadian Government Falls]. This is the first time that this has happened in the history of the British Commonwealth.
During the debate preceding the vote, the Leader of the Bloc Québécois party, Gilles Duceppe, had this to say about the government leaders, [Hansard]
This government is very transparent. When we look at the Conservatives, we know exactly what they are thinking. We can see right through them. Quite apart from the image they like to project, if you look closely, you can see right through them. The Minister of State for Science and Technology is a creationist and believes that dinosaurs walked the earth with humans. He thinks that The Flintstones was a documentary and Dino was the star. We can see their old Reform roots, which are likely what inspired the Tea Party.This actually resonates within the House of Commons and with Canadians. Creationists don't get much respect in Canada.
I'd definitely vote for this guy if he wasn't a separatist.
Friday, March 25, 2011
Canadian Government Falls
This is how a parliamentary system of government works.
The following motion just passed in the Canadian House of Commons by a vote of 156-145.
Mr. Ignatieff (Etobicoke—Lakeshore) — That the House agree with the finding of the Standing Committee on Procedure and House Affairs that the government is in contempt of Parliament, which is unprecedented in Canadian parliamentary history, and consequently, the House has lost confidence in the government.This was immediately followed by a motion from the Prime Minister to adjourn the House. That motion carried.
Michael Ignatieff, who moved lack of confidence, is the Leader of Her Majesty's Loyal Opposition (Leader of the Opposition) and the leader of the Liberal Party.
The defeat of the government on this confidence motion means that the Prime Minister (Stephen Harper) must resign. He will probably go to the Governor General (the de facto Head of State1) and seek permission to dissolve the House of Commons and call for a general election. In the absence of any party or coalition that could command the confidence of Parliament, that request will be granted.
1. Officially, the Governor General is the Canadian representative of the Queen of Canada who lives in the United Kingdom. The Governor General will not be phoning the Queen to ask her advice. The current Governor General is His Excellency the Right Honourable David Johnston.
Thursday, March 24, 2011
How Big Is the Human Genome?
The earliest direct estimates of the size of human genome clustered around 3,000 Mb (megabase pairs) or 3.0 ×109 bp (base pairs). The textbooks settled on about 3,200 Mb based mostly on reassociation kinetics. According to those results from the 1970s, roughly 10% of the genome consists of highly repetitive DNA, 25-30% is moderately repetitive and the rest is unique sequence DNA.
A study by Morton (1991) looked at all of the estimates of genome size that had been published to date and concluded that the average size of the haploid genome in females is 3,227 Mb. This includes a complete set of autosomes and one X chromosome. The sum of autosomes plus a Y chromosome comes to 3,122 Mb. The average is about 3,200 which corresonds to 3.5 pg (picograms) and that's the value on Ryan Gregory's Animal Genome Size Database.
In the past decade or so the common assumption about the size of the human genome has dropped to about 3,000 Mb. This is because the draft sequence of the human genome came in at 2,800 Mb and the so-called "finished" sequence was still considerably less than 3,200 Mb. Most people didn't realize that there were significant gaps in the draft sequence and in the "finished" sequence.
The latest information on the human genome from the human genome consortium is 3,156,105,057 bp (3,156 Mb) (Build 37 version 2, patch 2=GRCh37.p3 (November 2010)). I believe this build still has gaps around the centromeres of the chromosomes. That region consists of highly repetitive sequences that are almost impossible to clone and sequence. These regions, also known as heterochromatin, were not targets of the original sequencing project. Their total size was estimated at 198 Mb (International Human Genome Sequencing Consortium, 2004) corresponding to about 6% of the genome.
The estimate may have been too large to begin with and, in addition, I'm pretty sure that some of these heterochromatic regions are included in the total size of Build 37 v2. That means that the total size of the human genome is very likely to be ~3,200 Mb or 3.2 ×109 bp.
[Image Credit: Wikipedia: Creative Commons Attribution 2.0 Generic license]
Morton, N.E. (1991) Parameters of the Human Genome. Proc. Natl. Acad. Sci. (USA) 88:7474-7476 [free article on PubMed Central]
International Human Genome Sequencing Consortium (2004) Finishing the euchromatic sequence of the human genome. Nature 431:931-945 [doi:10.1038/nature03001]
A study by Morton (1991) looked at all of the estimates of genome size that had been published to date and concluded that the average size of the haploid genome in females is 3,227 Mb. This includes a complete set of autosomes and one X chromosome. The sum of autosomes plus a Y chromosome comes to 3,122 Mb. The average is about 3,200 which corresonds to 3.5 pg (picograms) and that's the value on Ryan Gregory's Animal Genome Size Database.
In the past decade or so the common assumption about the size of the human genome has dropped to about 3,000 Mb. This is because the draft sequence of the human genome came in at 2,800 Mb and the so-called "finished" sequence was still considerably less than 3,200 Mb. Most people didn't realize that there were significant gaps in the draft sequence and in the "finished" sequence.
The latest information on the human genome from the human genome consortium is 3,156,105,057 bp (3,156 Mb) (Build 37 version 2, patch 2=GRCh37.p3 (November 2010)). I believe this build still has gaps around the centromeres of the chromosomes. That region consists of highly repetitive sequences that are almost impossible to clone and sequence. These regions, also known as heterochromatin, were not targets of the original sequencing project. Their total size was estimated at 198 Mb (International Human Genome Sequencing Consortium, 2004) corresponding to about 6% of the genome.
The estimate may have been too large to begin with and, in addition, I'm pretty sure that some of these heterochromatic regions are included in the total size of Build 37 v2. That means that the total size of the human genome is very likely to be ~3,200 Mb or 3.2 ×109 bp.
[Image Credit: Wikipedia: Creative Commons Attribution 2.0 Generic license]
Morton, N.E. (1991) Parameters of the Human Genome. Proc. Natl. Acad. Sci. (USA) 88:7474-7476 [free article on PubMed Central]
International Human Genome Sequencing Consortium (2004) Finishing the euchromatic sequence of the human genome. Nature 431:931-945 [doi:10.1038/nature03001]
Saturday, March 19, 2011
Punctuated Equilibria
This is an old video from 1991 but it does an excellent job of explaining punctuated equilibria. That's because it features Niles Eldridge and Stephen Jay Gould.
There are two important lessons for creationists in this video. Let's hope they learn them.
1. The evidence for punctuated equilibria is based on thousands and thousands of fossils covering millions of years. It required a complete fossil record. It has nothing whatsoever to do with gaps in the fossil record. It's the exact opposite of gaps!
2. Evolution is observed when a single species splits into two species and that takes place over a relatively short period of time. "Relatively short period of time" does not mean that the new species poofs into existence. It means 50,000-100,000 years.
Whenever your creationist friends start lying to you about punctuated equilibria you can ask them to watch this video. You'd think that would stop them from spreading misinformation but then you realize that this video is 20 years old.
Facts don't seem to matter to creationists.1
There are two important lessons for creationists in this video. Let's hope they learn them.
1. The evidence for punctuated equilibria is based on thousands and thousands of fossils covering millions of years. It required a complete fossil record. It has nothing whatsoever to do with gaps in the fossil record. It's the exact opposite of gaps!
2. Evolution is observed when a single species splits into two species and that takes place over a relatively short period of time. "Relatively short period of time" does not mean that the new species poofs into existence. It means 50,000-100,000 years.
Whenever your creationist friends start lying to you about punctuated equilibria you can ask them to watch this video. You'd think that would stop them from spreading misinformation but then you realize that this video is 20 years old.
Facts don't seem to matter to creationists.1
1. In the interests of fairness, I should note that there are a great many evolutionists who also don't understand punctuated equilibria. I'm really posting this video for them and not for the creationists.
[Hat Tip: Greg Laden]
Thursday, March 17, 2011
Happy St. Patrick's Day!
One of the cool things about studying your genealogy is that you can find connections to almost everyone. This means you can celebrate dozens of special days. In my case it was easy to find ancestors from England, Scotland, Netherlands, Germany, France, Spain, Poland, Lithuania, Belgium, Ukraine, Russia, United States, and, of course, Ireland.
We will be celebrating St. Patrick's Day tomorrow at the pub. It's rather hectic keeping up with all the national holidays but somebody has to keep the traditions alive!
Here's my Irish connection.1 The shortest connection is to the parents of my grandmother. My great-grandfather was Thomas (Keys) Foster, born in County Tyrone on September 5, 1852. He immigrated to Canada in 1876. Thomas married Eliza Ann Job, born in Fintona, County Tyrone on August 18, 1852. She immigrated to Canada in 1877.
Thomas and Eliza settled in Saskatchewan in 1883 and that's where my grandmother was born. Other ancestors in this line came from the adjacent counties of Donegal (surname Foster) and Fermanagh (surnames Keys, Emerson, Moore) and possibly Londonderry (surname Job).
Happy St. Patrick's Day 2010
Happy St. Patrick's Day (2009)
Happy St. Patrick's Day (2008)
Happy St. Patrick's Day (2007)
Niall Nóigiallach - Niall of the Nine Hostages
1. You don't have to be Irish or have Irish ancestors to celebrate St. Patrick's Day.
Monday, March 14, 2011
Five Things that Cannot Be Justified by Science
Bill Dembski thinks that in this video William Lane Craig makes a very good case against science. This is from 1998. (The other two people are atheist Peter Atkins and William F. Buckley.) Posted on Uncommon Descent: Oldie but goodie: William Lane Craig vs. Peter Atkins. Craig list five things science cannot account for. Do you believe him?
I'd probably have the same look on my face as Peter Atkins. It's not that these five things are devastating arguments against the power of science, it's that each one would take at least an hour to explain. The audience isn't going to wait that long so you know you're going to have to pass and leave Craig (and Dembski) to smugly assume that he's won.
It's typical anti-science trickery and Atkins probably wasn't expecting such a cheap shot in that environment.
Who is Omar Alghabra?
This is the Liberal candidate for Federal Parliament in my riding. I've gotten to know him over the past few years and I can affirm that he really does support education and world peace. I'm not so sure about the blind puppies ...
Saturday, March 12, 2011
The Lost Art of Wit and Sarcasm
PZ Myers on Salon reviews a book that I'm never going to read [David Brooks' dream world for the trust-fund set]. Unfortunately he uses language and style that's probably far above the heads of those who need convincing. But it's loads of fun.
I made it almost a third of the way through the arid wasteland of David Brooks' didactic novel, "The Social Animal: The Hidden Sources of Love, Character, and Achievement," before I succumbed. I had begun reading it determined to be dispassionate and analytic and fair, but I couldn't bear it for long: I learned to loathe Harold and Erica, the two upscale avatars of upper-middle-class values that Brooks marches through life in the story. And then I began to resent the omniscient narrator who narrates this exercise in unthinking consumption and privilege that is, supposedly, the ideal of happiness; it's like watching a creepy middle-aged man fuss over his Barbie and Ken dolls, posing them in their expensive accessories and cars and houses and occasionally wiggling them in simulated carnal relations (have no worries, though: Like Barbie and Ken, no genitals appear anywhere in the book), while periodically pausing to tell his audience how cool it all is, and what is going on inside his dolls' soft plastic heads.
I did manage to work my way through the whole book, however, by an expediency that I recommend to anyone else who must suffer through it. I simply chanted to myself, "Die, yuppie scum, die," when I reached the end of each page, and it made the time fly by marvelously well. In addition, there is a blissful moment of catharsis when you reach the last page and one of the characters does die, although it isn't in a tragic explosion involving a tennis racket, an overdose of organic fair-trade coffee, and an assassination squad of rogue economists at Davos, as I was hoping. That's not a spoiler, by the way; the book is supposed to be all about the happy, productive life histories of Harold and Erica, from birth to death, so it's no surprise that at least one dies. It is incomplete, in that the other one survives ... an unsatisfying ending that I could happily resolve with one more bloody page, and that represents the only case I can imagine in which I'd ever ask David Brooks to write another word.
Friday, March 11, 2011
One School System and Abortion
Ontario has two schools systems—both publicly funded. The "public schools" are open to all comers but the "Roman Catholic" ("Separate") school system isn't.
I support the One School System Network.
The organizations represented by the One School System Network [OSSN] are united in the conviction that:Here's one of the reasons why we need to merge the Roman Catholic schools into a single, secular, public school system: Students sent home.
Ontario's publicly funded school system bring students of all backgrounds together in an environment that fosters mutual respect and understanding while respecting their fundamental equality and helping them to realize their full potential as citizens.
To realize that vision, OSSN seeks the establishment of a single secular school system for each official language, namely English and French public school boards.
Furthermore, OSSN seeks the elimination of costly duplication in the Ontario school system in order to minimize infrastructure costs and to maximize opportunities for student development.
Publicly funded schools in Ontario shall not discriminate on the basis of religion in any form including: school environment, enrolment of students, opportunities for all students, evaluation of students, employment and advancement of teachers and all other school board personnel, adherence to Ministry of Education curriculum guidelines including courses in World and Comparative Religions.
Publicly funded school boards may, where appropriate, permit voluntary religious programs for students provided by local faith groups outside regular instructional hours.
Alexandria Szeglet added a strip of green tape to her St. Patrick High School uniform Thursday with the word “choice” written on it and was sent home for the day after refusing to take it off.Alexandria and about 35 other students were send home for wearing the green tape. None of the students who wore red tape with the word "life" were sent home or asked to remove the tape.
The Grade 10 student wore the green tape in response to a pro-life event at the school, where some students wore a red piece of tape with “life” written on it and didn’t talk for the day to display their belief in the injustice of abortion.
Two of the comments below the article deserve more publicity.
Ann says:John de Faveri is the director of education for the Thunder Bay Catholic District School Board.
Alexandria is my daughter. Her father and I are raising and guiding her and her sister into formulating independent thought and opinion. Alex went to school today wearing a green piece of tape in response to a pro-life scheduled event that she knew was already happening. It was JUST a piece of tape. Very quickly, she was informed that she wasn't allowed to imply her opinion ~ but others wearing "red" were. "Pro-choicers", like Alex, believe in simply that. If a woman chooses abortion, then Alex would support that. If a woman chooses to have the child, Alex would support that too. I know for a fact that she did this not expecting the out pouring of support she has been receiving, but to just put her opinion out there like all the rest. This IS a very touchy subject with a lot of people, and knowing that the School Board allows this in their halls ... I'm speechless. We're very proud of you, Alex.
Kerri says:
Alexandria is my niece and we are very proud of her ability to speak her own mind. This demonstration was done peacefully and without malice unlike some of the pro life demonstrations that have happened in the past. I am born and raised a Catholic woman, am well educated. Having attended a Catholic school myself, I am appaled at the ridiculousness of this situation and the stand that the school and school board have taken on this subject when Alex simply held true to her beliefs. Isn't that what we teach our children? To have independence, a mind of their own and to be secure in all the decisions they make?
Ask yourself this question: Would you want to be the person to explain who your childs dad was if you were a victim of rape or incest? OR What if your life was in mortal danger? PRO CHOICE means just that...a woman's choice. It's not a form of birth control nor is it a decision any woman would want to make. I know in my heart and in my wonderful niece's heart that she is intelligent enough to know what is right or wrong for her own self. We are proud of her if every sense and we will continue to support her throughout her life. It's a shame that the world is still stuck in the dark ages and that a woman still does not have the right to choose...This is a touchy subject that someone thought was ok for high schoolers to demonstrate...with the advent of Facebook and social media, what did they think would happen when people caught wind of today's events?
“On the issue, pro-life is part of the Catholic stand,” said de Faveri during a phone interview with Dougall Media Thursday afternoon. “The pro-choice students were not appropriate in the context of a Catholic school.”That's exactly why we need to convert all these schools into secular schools.
It will be interesting to see what happens in Catholic high schools over the next few days. I expect that many Principals and Vice-Principals are in for a hard time.
[Hat Tip: Canadian Atheist: The easiest way to get kicked out of Catholic school…]
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