An Adaptationist in Piazza San Marco

John Wilkins of Evolving Thoughts is currently in Venice, Italy. He has just visited the Basilica San Marco (St. Mark's Basilica) according to What I am doing on my holidays….

This visit is significant since the Spandrels of San Marco are famous in evolutionary biology. They are part of the attack on adaptationism launched in 1979 by Gould and Lewontin. This is a paper that every student of evolution should read. Here's an online version: The Spandrels of San Marco and the Panglossian Paradigm: A Critique of the Adaptationist Programme.

John has been struggling with adaptationism for almost fifteen years. When he first began studying evolutionary biology he, like many others, was unaware of the importance of random genetic drift and other anti-adaptationist perspectives. He certainly didn't know that random genetic drift is by far the dominant mechanism of evolution in terms of frequency of allele fixation. Over time John has developed an unusual perspective on adaptionism—one that I don't really understand.

Here's how he explains it in his latest posting ...

This is interesting, I think, in the context of Gould’s and Lewontin’s paper. It shows that claims of things being adaptive or not depend crucially on what one counts as the “task” of a structure. Since I think that everything is subjected to selection pressure at all times (sometimes not enough to overcome the noise of statistical properties), counting what is, and what isn’t, adaptive is a bit of a personal call, in the absence of access to the historical processes of particular traits. I am becoming more of an adaptationist these days.

The idea that many alleles might be slightly beneficial or slightly detrimental isn't very controversial. But that's not what John is saying. As I understand him, he's saying there can be no such thing as a truly neutral allele. He seems to be saying that anyone who believes otherwise is making a "personal call." A personal call that he believes is wrong since he thinks (i.e. his personal call) that everything is subject to natural selection.

He's also making a somewhat trivial point that doesn't contribute to the debate, as far as I'm concerned. Many alleles that are slightly beneficial are lost due to random genetic drift and many alleles that are slightly deleterious are fixed by random genetic drift. To me, that says that adaptationism can't explain all of evolutionary biology. To call yourself an adaptationist while knowing that slightly deleterious alleles can be fixed by random genetic drift seems somewhat unsatisfying.

John has a paper in the latest issue of Biology and Philosophy, an issue devoted to Adaptationism. It's not a very enlightening issue, from my perspective. The main problem with adaptationism isn't that it can't explain adaptation and it isn't that some just-so stories are wrong. The main problem is that adaptationists don't even consider any other alternatives to fixation by natural selection. Everything, especially everything with a visible phenotype, is automatically assumed to be adaptive and the arguments proceed from there.

One of the papers I liked was Seven Types of Adaptationism by Tim Lewens (Lewens, 2009). The seven types are:

A Empirical adaptationisms

1. Pan-selectionism–natural selection is the most significant of the evolutionary forces that act on populations.
2. Good-designism–evolutionary processes tend to result in organisms with suites of well-designed traits. Most lineages are highly evolvable.
3. Gradualism–adaptation is always the result of selection acting on gradual
variation.

B Methodological Adaptationisms

4. Weak heuristic adaptationism–those traits that are adaptations are likely to be correctly recognised as such only if we begin by assuming that all traits are adaptations.
5. Strong heuristic adaptationism–only by beginning to think of traits as adaptations can we uncover their true status, whether they are adaptations or not.

C Disciplinary Adaptationism

6. Explanatory adaptationism–an evolutionary biologist’s proper business is the study of adaptations.

D Epistemological Adaptationism

7. Epistemological optimism–investigators have access to the data that reliably discriminate between conflicting evolutionary hypotheses.

There are problems with all seven forms of adaptationism but the nice thing about Lewens' paper is that he effectively refutes #4, #5, and #7. In the case of methodological adaptationism it's just not true that the default assumption has to be adaptation. Evolutionary biology will be just as productive in the long run if drift is the default assumption and adaptation has to be proven.

In explanatory adaptationism, the assumption is that all of the interesting parts of evolution are adaptations and fixation of alleles by random genetic drift is so boring that it might as well not even be evolution. This is the stance taken by many adaptationists, like Richard Dawkins. As you might imagine, it doesn't take much effort to refute that kind of argument. One's personal opinion about what's interesting and what's not interesting should not play a role in determining how everyone else should go about studying evolution.

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Gould, S.J. and Lewontin, R.C. (1979) The Spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme. Proc. R. Soc. Lond. B 205:581-598.

Lewens, T. (2009) Seven types of adaptionism. Biol. Philos. 24:161–182. [doi: 10.1007/s10539-008-9145-7]

Monday's Molecule #138

 
This is the earliest posting of a Monday's Molecule. It should make the contest open to a whole new category of Sandwalk readers, especially those in Europe who will see it long before the readers in North America are awake.

It will also work for Asian readers and a few North and South Americans who are up very late at night. (Note to the latter group: get a life! )

The molecule is a compex of three different proteins. One of them—the yellow one—has already been featured as a Monday's Molecule last April. This time I want you to identify the purple molecule. It was first identified and characterized in the organism shown below then subsequently found in lots of other species.

The Nobel Laureate from last April shared the prize with the person who discovered today's molecule. Name that Nobel Laureate.

The first person to identify the molecule and name the Nobel Laureate wins a free lunch. Previous winners are ineligible for six weeks from the time they first won the prize.

There are only three ineligible candidates for this week's reward: Philip Johnson of the University of Toronto, Ben Morgan of the University of North Carolina at Chapel Hill and Frank Schmidt of the University of Missouri.

Frank has agreed to donate his free lunch to a deserving undergraduate. Consequently, I have an extra free lunch for a deserving undergraduate so I'm going to award an additional prize to the first undergraduate student who can accept it. Please indicate in your email message whether you are an undergraduate and whether you can make it for lunch. If you can't make it for lunch then please consider donating it to someone who can in the next round.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule(s) and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Prizes so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow.

Comments will be blocked for 24 hours. Comments are now open.

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Extreme Atheists Are Like Extreme Religious Fundamentalists

 
Joshua Rosenau blogs at Thoughts from Kansas but don't be confused by the geography. He actually lives in California and works at the National Center for Science Education (NCSE).

His most recent posting concerns an issue that is often raised when we discuss the compatibility of science and religion [see On cracks]. The issue is outlined in a quotation from Kevin Padian, who is a strong supporter of NCSE and a vocal opponent of creationism.

The two kinds people who believe that religion and evolution can not coexist are extreme atheists and extreme religious fundamentalists. Everyone else doesn't really have a problem. [A majority] of Americans believe that a belief in god is compatible with evolution.

Many atheists interpret this kind of statement as an insult and Jerry Coyne called it "an anti-atheist crack." This prompted Joshua Rosenau to respond like this.

First, note that Kevin Padian is a fairly open atheist, so if this line were "anti-atheist" it would have to be a sort of self-hating atheism. Second, how is it factually wrong? Some atheists (but not all) think science and religion are incompatible. Some religious fundamentalists also think this. There are also a bunch of people in the middle of the spectrum of belief who do not think that. Whether these represent a majority of Americans depends how you ask the question and what you do with undecided responses, but it is absolutely the case that most Americans belong to religious groups whose governing bodies have asserted the compatibility of science (including evolution) and their brand of religion.

What, then, makes Padian's factually correct statement about the beliefs of some atheists a "crack"? Is there any method at all to Coyne's outrage

Yes, Josh, there's a reason why some atheists are annoyed at remarks like that. Here's a list ....

1. Padian disagrees with those of us who argue that religion and science are almost always incompatible. By labeling his opponents as "extreme atheists" he is trying to marginalize us. That's insulting.
2. He insults us by associating us with our worst enemies (religious fundamentalists) and suggesting that we think alike.
3. He uses the argument of popularity to support his position. Imagine that he lived in a country where a majority of citizens were atheists and believed that religion was incompatible with science. Would that change his opinion? Why should non-Americans, like Richard Dawkins for example, form an opinion based on whether or not it agrees with a majority of Americans? It's a silly argument. Either religion and science are compatible or they aren't. Since when did the opinion of the average American become relevant in debates like that?

If you are truly interested in the actual debate about compatibility then those kind of statements are completely useless in advancing your position.

On the other hand, if your primary objective is accommodationism—creating a comfortable place for theistic evolutionists—then Padian's statements make a lot of sense. It's a political argument, not a philosophical one. It's called "framing" and it's the official position of NCSE.

Kevin Padian is the President of the National Center for Science Education so it's not surprising that Josh defends him and the official NCSE position. Unfortunately, that defense involves alienating many former allies who happen to disagree with NCSE on the accommodationist issue. Those of us who disagree think that NCSE should be adopting a neutral position with respect to the overall compatibility of science and religion.

NCSE should continue to opposes the more obvious examples of incompatibility as manifest by the creationist attacks on evolution but it should not be in the business of defining those other areas where science is supposed to be perfectly compatible with religious beliefs.¹

UPDATE: Jason Rosenhouse weighs in: Who Rejects Evolution?

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1. What are those areas? I wonder if Josh or Kevin has a list?

Dead Fish Thinking

 
One of the popular techniques in psychology these days is to analyze brain activity in an MRI machine. In a typical experiment, the subject will be shown various images and the machine will maps those parts of the brain that are responding.

In the latest study, a group of psychologists showed a bunch of photographs to a dead salmon and measured the brain activity. The results were announced in a poster: Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: An argument for multiple comparisons correction. Apparently, the salmon was thinking about the photos.

Here's the method ....

Subject. One mature Atlantic Salmon (Salmo salar) participated in the fMRI study. The salmon was approximately 18 inches long, weighed 3.8 lbs, and was not alive at the time of scanning.

Task. The task administered to the salmon involved completing an open-ended mentalizing task. The salmon was shown a series of photographs depicting human individuals in social situations with a specified emotional valence. The salmon was asked to determine what emotion the individual in the photo must have been experiencing.

Design. Stimuli were presented in a block design with each photo presented for 10 seconds followed by 12 seconds of rest. A total of 15 photos were displayed. Total scan time was 5.5 minutes.

Preprocessing. Image processing was completed using SPM2. Preprocessing steps for the functional imaging data included a 6-parameter rigid-body affine realignment of the fMRI timeseries, coregistration of the data to a T1-weighted anatomical image, and 8 mm full-width at half-maximum (FWHM) Gaussian smoothing.

Analysis. Voxelwise statistics on the salmon data were calculated through an ordinary least-squares estimation of the general linear model (GLM). Predictors of the hemodynamic response were modeled by a boxcar function convolved with a canonical hemodynamic response. A temporal high pass filter of 128 seconds was include to account for low frequency drift. No autocorrelation correction was applied.

Voxel Selection. Two methods were used for the correction of multiple comparisons in the fMRI results. The first method controlled the overall false discovery rate (FDR) and was based on a method defined by Benjamini and Hochberg (1995). The second method controlled the overall familywise error rate (FWER) through the use of Gaussian random field theory. This was done using algorithms originally devised by Friston et al. (1994).

The point of the study was to show that you need to be aware of false positives and make the effort to filter the data in order to remove them.

The bigger point, as far as the rest of of us are concerned, is that all aspects of science are complicated and we need to be appropriately skeptical. There's a tendency in the popular press to treat all these brain activity studies as gospel truth because they use a fancy machine.

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[Hat Tip: John Hawks]

University of Toronto Enrolment

 
There's some discussion about enrolment at the University of Toronto in the comments to University Students Aren't as Intelligent as They Used To Be.

Some people seem to be under the impression that enrolment at the University of Toronto has not increased recently. Here's the data from the 2009 Enrolment Report.


Enrolment has doubled since 1970 with most of the increase occurring in the past ten years as the echo boomers reach university age. The participation rate is also increasing. We currently have about 64,000 students (actually they're full-time equivalents (FTEs), but who's quibbling?). There are roughly 13,000 graduate students and 51,000 undergraduates.

Expansion is a good thing. I support it. However, it would be nice to have the extra resources that are required to do a good job of teaching these extra students.

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Atheists in America

A recent survey of religious beliefs in America resulted in 15% of the population saying they did not belong to any religion. This group, referred to as the "Nones," is the fastest growing segment having just about doubled over the past two decades.

What do these people actually believe? Are most of them atheists? The answers are in the following detailed report: American Nones: The Profile of the No Religion Population.

What does this group think about evolution? The results are surprising.


Among the general public, only 38% think that evolution is definitely or probably correct. This number only rises to 61% among the nones! 17% of them are certain that humans didn't evolve. What in the world are they thinking?

Well, it turns out that the "no religion" category hides a great deal of diversity. When asked about the existence of God you get the following responses ...


More than half of them believe in some sort of supernatural being and only a small percentage qualify as atheists.

An even smaller percentage will actually admit to being an atheist or an agnostic in spite of the fact that their answers to other questions identify them as atheists or agnostics. The "belonging" category refers to the answer to the question, "What is your religion, if any?" It's a way of allowing respondants to self-identify as atheists or agnostics.

As you can see from the data, almost 90% prefer to identify themselves as having no religion rather than label themselves atheists or agnostics. This group includes, of course, those people who really are religious but just don't belong to a particular religious group.

We conclude from this data that about 12% of Americans don't believe in God—or at least have serious doubts—but only 2% admit it. This number is considerably higher in other industrialized nations according to adherents.com. Atheists, agnostics, and non-believers probably represent a majority of the population in Sweden, Denmark, Norway, Japan, and the Czech Republic and they are close to a majority in Finland, France, South Korea, Estonia, and Germany.

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[Hat Tip: Razib Khan]

University Students Aren't as Intelligent as They Used To Be

 
It's a well-known fact that the average intelligence of university students has been declining over the past four or five decades. This is true in spite of the fact that the average university grades have been going up.

The decline in average intelligence is exactly what one would expect, as Razib Khan explains on his blog Gene Expression: College students are not as intelligent.¹

Surprisingly, the typical student at my university doesn't want to hear this. You'd be impressed by the number of explanations they can come up with to refute the data. Maybe we'll see some of them in the comments. Are they scientific explanations?

You might also be surprised at the reluctance to accept the fact of grade inflation. The most common explanation for grade inflation is that today's students are smarter than those of the 60s and 70s and that's why they get higher grades.

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1. This is not an argument against increasing the participation rate and expanding university enrolment. I'm in favor of that. Let's just realize that there are consequences that universities need to deal with.

The real question we need to address is gradation rate. In an ideal world, what percentage of those who enter university should graduate? Should it be 100%? 50%?

Swine Flu and "The Canadian Problem"

 
TV, radio, and newspapers in Canada are abuzz with the lastest studies on swine flu. According to "preliminary reports" your chances of getting swine flu are increased if you get/got? the regular flu shot. This is prompting Canadian public health officials to recommend holding off on the regular flu shot until after you get the swine flu shot ... which won't be available until November.

The so-called "preliminary data" doesn't make any sense as public health experts on Effect measure point out: Once more on the vaccine question.

The confusion isn't helped by ambiguous reporting such as this from Canadian Press: Study linking flu shots, swine flu raises concern abroad, prompt changes at home.

The data, referred to as "the Canadian problem" by some scientists outside this country, are reported to link getting a flu shot last year with double the risk of contracting swine flu this year.

The link, if real, is to mild disease. One person who has seen the study says it seems to suggest that those who got a seasonal flu shot were less likely to develop severe disease if they became infected than those who hadn't received the shot.

Say what?

Nobody else is reporting a connection between this year's swine flu and whether or not you got a flu shot last year. Part of the problem is that Canadian health officials might be basing decisions on a flawed study. That's unacceptable.

One of the most disturbing aspects of this situation is that the actual study may not be available for some time. According to Canadian Press ...

Drawn from a series of studies from British Columbia, Quebec and Ontario, the work is led by Dr. Danuta Skowronski of the British Columbia Centre for Disease Control and Dr. Gaston De Serres of Laval University.

They have submitted the paper to an unnamed scientific journal and are therefore constrained about what they can say about the work. Journals bar would-be authors from discussing their results before they are published.

"For me, it's very important that we respect the peer-review process as good scientists. Because the implications ... are important," Skowronski said in an interview Wednesday.

"And if there are methodologic flaws, we need to be assured that every stone was turned over to make sure what we're reporting is valid."

This is unethical behavior at many levels. First, journals have no right to block access to essential information that's needed to make public health decisions in the middle of a pandemic. That journal should be identified and forced to defend it's policy. Second, no reputable scientists should agree to such an embargo in the first place. Third, if the journal and the scientists enter into a deal to remain silent then how come we know about this study? It sounds like the authors may want to have their cake and eat it too.

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SEED Magazine

 
The last issue of SEED magazine was published in June. Since then, I've been scanning the shelves of my local convenience stores looking for the latest informative article by PZ Myers and the latest fuel for complaints about the quality of science journalism.

No luck so far. According to the SEED website ...

We are currently finishing an exciting redesign that will be on press this fall. This will also be our first issue with the new tagline.

This sounds ominous. Is the print version of SEED dead?

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Internet Connection Speed Test

 
I think I have a pretty good internet connection but many of my friends tell they have much faster connections. Here's a site that tests your upload and download speeds: Speedtest.net.

I don't know how reliable these are, but here are my results (avg. of five trials):

          DOWNLOAD:  8290 kbps
          UPLOAD:        8080 kbps

I'm pretty happy with my connection through the University of Toronto. Are there better ones out there?



There's another speed test at InterFrog.com. It gives a difference result for upload speeds.

In the first student labs we ran back in 1987 we downloaded DNA sequence files via a 28.8 kbps modem. That was 22 years ago and the connection speed has only increased about 300×. Doesn't Moore's Law say that the improvement should have been more than 1000-fold?

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Creationist Thinking about Spontaneous Generation

 
It's not surprising to discover that creationists are opposed to the idea that life began by purely natural processes. After all, that's at the heart of the dispute between creationists and scientists.

One of the rhetorical tricks used by creationists is to refer to the origin of life as "spontaneous generation." Why is this a trick? Because the term is most commonly associated with an old-fashioned view of spontaneous generation as a process that occurs regularly when new living things spring into existence. The idea was that the maggots on rotting meat arose spontaneously, for example, without the need for pre-existing life.

This notion was put to rest once-and-for-all by nineteenth century scientists; notably, Louis Pasteur. We all know that spontaneous generation of this sort doesn't happen. The creationists take advantage of this when they talk about abiogenesies—the origin of life. If they can confuse their audience by associating abiogenesis with discredited spontaneous generation, then that's a good thing, as far as they are concerned. They know what they're doing and that's what makes it despicable.

This brings me to Denyse O'Leary, Toronto's own version of IDiot. Last month she posed the following question on her blog: Is accidental origin of life a doctrine that holds back science?.

Accidental origin of life is the basic thesis of origin of life researchers. Life all just somehow sort of happened one day, billions of years ago, under the right conditions – which we may be able to recreate. But there is a constant, ongoing dispute about just what those conditions were.

Here is the problem I have always had with accidental origin of life: It amounts to spontaneous generation. However, banishing the doctrine of spontaneous generation played a key role in modern medicine’s success. If we assume that life forms (for medical purposes, we focus on pathogens) cannot start spontaneously, then they must have been introduced. Hence, we can develop procedures for a sterile operating room or lab.

If life can be spontaneously generated, why isn’t it happening now? Conditions for life today are probably as good as they have ever been, and maybe better. For over 500 million years they have obviously been good for complex life forms, and for billions of years they have been good for simple ones.

You can win a creationist book for the best response to her question.

Well, the results are in and the prize goes to StephenB. Here's part of his response. Presumably, this is the best argument the IDiots have to offer on what science is all about.

The accidental origin of life idea hurts science because it militates against the vital principle of causation, the rational and indispensible standard on which science is based. The first question any researcher asks is this: “How did it happen? or—What caused it? Yet, the concept of spontaneous generation popularizes the idea that physical events can occur without causes—that there need not be a “how”—that they can “just happen.”

Consider the following proposition: Streets don’t just “get wet.” Using the scientific and philosophical principle of causation, we understand that something had to cause the streets to get wet. So, we say that if the streets are wet, then it must be raining, or else someone turned on a fire hydrant, or we look for some other reason. But if, as Darwinists or postmodern cosmologists claim, physical events do not always need causes or necessary conditions, that is, if something really can come from nothing, then streets can indeed just get wet. With this mind set, science is severely compromised. If, indeed, something can appear spontaneously or without a cause, why cannot it happen again somewhere else in some other situation?

In keeping with that point, if one thing can “just happen,” then why cannot anything just happen? Why not everything? Under these circumstances, how could the scientist know which things were caused and which ones were not? Science would become an intellectual madhouse where the impossible is affirmed with confidence and the obvious is dismissed with disdain, which, come to think of it, is not a bad description of Darwinst epistemology. For Darwinists, and for postmodern cosmologists, a universe can pop into existence, life can come from non-life, and, yes, streets could, in principle, just “get wet.” Science cannot survive this irrational mind set indefinitely.

Are there any evolutionists out there who believe that the first living cell just "poofed" into existence without any cause or antecedents? If you believe this then please post a comment below.

If nobody admits to holding such a belief, then how do we account for the fact that the IDiots misunderstand and misrepresent science?

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Next-Generation DNA Sequencing

 
There's a real revolution under way in terms of our ability to collect sequence information. The so-called Next-generation DNA sequencing technology relies on the ability to sequence billions of single DNA molecules simultaneously.

How does it work? I was planning on writing up a blog posting to explain the technology since so many experiments rely on it. I kept putting it off but that turns out to be a good thing 'cause others have explained it much better that I ever could have. Watch this video from Helicos.

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[Hat Tip: ScienceRoll]

Nobel Laureate: Ivan Pavlov

 

The Nobel Prize in Physiology or Medicine 1904

"in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged"

Ivan Petrovich Pavlov (1849 - 1936) (Иван Петрович Павлов) won the Noble Prize in 1904 for his contribution to understanding the physiology and biochemistry of digestion. Part of his contribution was the discovery that some of the digestion enzymes needed to be activated before they could work in the stomach [Monday's Molecule #133].

Pavlov is famous for his work with dogs. Most people know of his studies on conditioned reflexes where he was able to show that the mere anticipation of food caused dogs to salivate. He is famous as one of the founders of modern psychology but the Nobel Prize was for a different study where he examined the stomach secretions of dogs by redirecting secretory ducts to the exterior where the secretions could be collected and analyzed. Pavlov was actually more of a biochemist than a psychologist!

Pavlov had a large, well-equipped lab with many workers. In that sense he was much more of a professional scientist than many of the other biological scientists of the late nineteenth century. Pasteur was another example. Many others, like Charles Darwin, worked alone and didn't seek out students.

The knowledge gained from his studies on digestion had no practical application in medicine. They simply advanced our understanding of how our bodies work. In presenting the Nobel Prize the presenter, Count K.A.H. Mörner, took pains to make this point clear and to pronounce it a good thing. Science for the sake of knowledge.

One gets the impression that the audience at the award ceremonies needed to hear that.

Here's part of the Presentation Speech that describes Pavlov's contribution.

THEME:
Nobel Laureates

In the early days opinions on the course of digestion were speculations as to what was termed as «cooking» or «grinding» in the stomach etc. So long as the digestive processes could not be observed or investigated directly in the stomach no real knowledge could be obtained. An accident turned physiological research in this field in a direction which has later become very important. In the 1820's a young man sustained a gunshot wound in the stomach and developed a gastric fistula which to some extent permitted the gastric processes to be studied. Observations were carried out on this man by the American physician W. Beaumont. This accidental path of investigation, allowing actual observation of processes taking place in the digestive tract, was later followed by many workers using animals. Technique is an important factor in such experiments and has been perfected in a masterly way by Pavlov, whose animals remain in good health, without any injury to the function of their digestive tract, permitting observation and systematic investigation over an almost unlimited period.

These methods for the study of the physiology of digestion established by Pavlov have been taken up by various physiological institutions, but above all much important work was performed in his own laboratory. From this has followed a far-reaching transformation of our knowledge in this field which has also been enriched by new fundamental facts.

The following may be mentioned as an illustration.

The digestive canal can be influenced in various ways by the nervous system. When we remember that the nervous system can induce not only the secretory processes as well as the movements of various parts of the system, but also can bring such processes to a standstill, that it controls the blood supply to these organs and that sensory nerves arise from them, we can get an idea of the complexity one encounters. The complications become still greater when it is realised that we must take into account not only nervous pathways having their origin in the brain or the spinal cord, but also the sympathetic nervous system, and that we have further to pay attention to the interdependence between the different parts of the digestive system through the nerves, so that variations in the behaviour of one may affect that in other organs.

It is in the nature of things that cognition of the scope and character of the functional interdependence of the nervous system and the digestive organs is of great importance to the knowledge of the physiology of these organs. It is also clear that one can only hope that answers to these complicated questions will advance step by step by much research. In this respect Pavlov has acquired very great merit. He has revealed new points of view and has fruitfully stimulated the solution of these problems, and through his methods has made it possible to reach conclusive analysis of them.

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The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.

[Photo Credit: Pasteur [Hulton Archive/Getty Images]

Monday's Molecule #137: Winner

 
This is poliovirus and the Nobel Laureates are John Enders, Thomas Weller, and Frederick Robbins. This week's winner is Frank Schmidt of the University of Missouri.

One of the Nobel Laureates, Frederick Robbins, is a graduate of the University of Missouri.

Frank has generously agreed to donate his free lunch to a hungry, deserving, undergraduate so there may be two winners next week.

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Today's "molecule" is actually several molecules, one of which is shown in a diagram below the electron micrograph. You have enough clues to identify this virus. As soon as you get the right answer it will lead you directly to one or more Nobel Laureates.

The first person to describe the "molecule" and name the Nobel Laureate wins a free lunch. Previous winners are ineligible for six weeks from the time they first won the prize.

There are only three ineligible candidates for this week's reward: Maria Altshuler of the University of Toronto, Philip Johnson of the University of Toronto and Ben Morgan of the University of North Carolina at Chapel Hill.

All of the recent winners are in a position to accept their prize so there haven't been any recent winners who donated the free lunch to a deserving undergraduate. Consequently, I do not have an extra free lunch for a deserving undergraduate so I'm not going to continue to award an additional prize to the first undergraduate student who can accept it. Please indicate in your email message whether you are an undergraduate and whether you can make it for lunch. If you can't make it for lunch then please consider donating it to someone who can in the next round.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule(s) and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Prizes so you might want to check the list of previous Sandwalk postings by clicking on the link in the theme box.

Correct responses will be posted tomorrow.

Comments will be blocked for 24 hours. Comments are now open.

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The Devil Among Us: America's First Witch Hunt

 
Here's a clip from the movie The Devil Among Us: America's First Witch Hunt. It's about the first witches who were executed in the colonies of New Haven and Connecticut in New England. (See: The Hanging of Goodwife Knapp in 1653.)

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