Watch the full story in this clip from Inside the Actors Studio, which, incidentally, is one of my favorite shows.
The good bit comes at four and a half minutes.
[Hat Tip: Friendly Atheist]
[Hat Tip: Friendly Atheist]
The way we work here is that the writer of the piece generally has almost no say over the headline, standfirst and other bits of "page furniture". These are the resonsibility of the copy editor and the sub-editors. The online version often has its own headline, which again is out of the control of the writer (in this case the magazine headline is "Uprooting Darwin's Tree").I, for one, am not surprised by this "revelation." I have known for some time that decisions on titles and covers are not made by authors. I've known for some time that decisions about titles and covers can be based on "sales pitch" and "hype" and that scientific accuracy can play a minor role in those decisions.
Coverlines, similarly, are written not by the writer but by senior editors with the express purpose of selling the magazine (the line between marketing and journalism blurs a little here).
As I'm a senior editor too, however, I can't and won't claim that the coverline was entirely beyond my control. Not my ultimate decision, but I was in on the discussions. We knew we were courting controversy but the feeling was that the story was solid enough to allow us to be provocative and, in any case, the statement is true.
So I feel very strong ownership of the article itself, particularly the print version (and I totally stand by the story, which is the product of weeks of hard work, extensive interviews with scientists, a stack of journal papers and much thought, despite what some bloggers are saying). I feel some ownership of the front cover "sell", though as always I'm acutely aware that it is 50% journalism, 50% sales pitch.
Perhaps the most important thing for prospective graduate students in particular to keep in mind is that admissions committees, while certainly holding great power over individuals’ futures, are in fact desperately seeking good candidates, and are willing to overlook all kinds of blemishes, indiscretions, and specific weaknesses if they feel that they’re getting a fundamentally good candidate. A single specific fact about an application is very unlikely to ruin a person’s chances (you’d be amazed at the GRE scores of some students admitted to even the top programs). Rather, the committee tries to get an overall picture of the candidate, and then to rank them relative to other candidates (also taking into account the department’s research needs at a given time). Only then are admissions decision taken.
I have certainly missed some issues and subtleties here. But the basic idea should be clear and, if my own experience is anything like typical, then it should help some of you, particularly prospective graduate students, to understand what really goes on with letters. It is quite terrifying to ask people for letters and not to know precisely what’s said in them. Hopefully it helps to know that mostly, by far, you can rely on people to do what they can for you, without being dishonest (and this is important - you can’t expect them to write that you’re one of the best students they’ve ever seen if they don’t think that is the case).
Ever since Darwin the tree has been the unifying principle for understanding the history of life on Earth. At its base is LUCA, the Last Universal Common Ancestor of all living things, and out of LUCA grows a trunk, which splits again and again to create a vast, bifurcating tree. Each branch represents a single species; branching points are where one species becomes two. Most branches eventually come to a dead end as species go extinct, but some reach right to the top - these are living species. The tree is thus a record of how every species that ever lived is related to all others right back to the origin of life.As it happens, I was at a function last night with Jan Sapp of York University (Toronto, Canada). Loyal Sandwalk readers might recall a series of articles on the Three Domain Hypothesis. The articles were based on a book edited by Jan Sapp. Sapp is a supporter, as am I, of the scheme advocated by Ford Doolittle (see below).
For much of the past 150 years, biology has largely concerned itself with filling in the details of the tree. "For a long time the holy grail was to build a tree of life," says Eric Bapteste, an evolutionary biologist at the Pierre and Marie Curie University in Paris, France. A few years ago it looked as though the grail was within reach. But today the project lies in tatters, torn to pieces by an onslaught of negative evidence. Many biologists now argue that the tree concept is obsolete and needs to be discarded. "We have no evidence at all that the tree of life is a reality," says Bapteste. That bombshell has even persuaded some that our fundamental view of biology needs to change.
"for their discoveries concerning the humoral transmittors in the nerve terminals and the mechanism for their storage, release and inactivation"
Professor Ulf von Euler has discovered that the substance noradrenaline serves as neurotransmitter at the nerve terminals of the sympathetic nervous system. He has also shown how this substance is stored in small nerve granules within the nerve fibres of this system.
Dr. Julius Axelrod's discoveries concern the mechanisms which regulate the formation of this important transmitter in the nerve cells and the mechanisms which are involved in the inactivation of noradrenaline, partly under the influence of an enzyme discovered by himself.
von Euler's and Axelrod's discoveries have not only increased our knowledge about the transmission in the sympathetic nervous system, they also form the basis for the understanding of the transmission in the central nervous system and its pharmacology. Thus in a very significant way, the laureates have presented basic data about the physical and chemical mechanisms of the synaptic transmission and thus given us basic information about how the messages are mediated between nerve cells. Their discoveries concerning these regulatory mechanisms in the nervous system are fundamental in neurophysiology and neuropharmacology and have greatly stimulated the search for remedies against nervous and mental disturbances.
The images of the Nobel Prize medals are registered trademarks of the Nobel Foundation (© The Nobel Foundation). They are used here, with permission, for educational purposes only.
Welcome to the 42nd edition of Gene Genie, the blog carnival of clinical genetics and personalised medicine.The beautiful logo was created by Ricardo at My Biotech Life.
Most of the entries in this edition fall under the broad umbrella of personalised genetics, with posts emphasising both the pros and cons of the emerging consumer genetic testing industry.
Scientists have found that the pleasure women get from making love is directly linked to the size of their partner’s bank balance.This explains why some women like being "trophy" wives.
They found that the wealthier a man is, the more frequently his partner has orgasms.
“Women’s orgasm frequency increases with the income of their partner,” said Dr Thomas Pollet, the Newcastle University psychologist behind the research.
He believes the phenomenon is an “evolutionary adaptation” that is hard-wired into women, driving them to select men on the basis of their perceived quality.
The study is certain to prove controversial, suggesting that women are inherently programmed to be gold-diggers.
However, it fits into a wider body of research known as evolutionary psychology which suggests that both men and women are genetically predisposed to ruthlessly exploit each other to achieve the best chances of survival for their genes.
The big mistake in Origin that Darwinists won’t admit is gradualism. Darwin explained that according to his theory we should expect to observe a continuum of living species each with only the slightest of variations between them. He postulated that we don’t observe this because the fittest species take over and the insensibly slight variants die off leaving species that are fully characteristic of their kind which then makes possible taxonomic classification by those characters. It’s in the full title in the latter half “The Preservation of Favored Races”.Bzzzzz!!!! Wrong!
That left Darwin with explaining the fossil record which is indisputably a record of saltation.
Physics professor William Happer GS ’64 has some tough words for scientists who believe that carbon dioxide is causing global warming.More proof, if it's needed, that Al Gore is smarter than George Bush (either one).
“This is George Orwell. This is the ‘Germans are the master race. The Jews are the scum of the earth.’ It’s that kind of propaganda,” Happer, the Cyrus Fogg Brackett Professor of Physics, said in an interview. “Carbon dioxide is not a pollutant. Every time you exhale, you exhale air that has 4 percent carbon dioxide. To say that that’s a pollutant just boggles my mind. What used to be science has turned into a cult.”
Happer served as director of the Office of Energy Research in the U.S. Department of Energy under President George H.W. Bush and was subsequently fired by Vice President Al Gore, reportedly for his refusal to support Gore’s views on climate change.
He asked last month to be added to a list of global warming dissenters in a Senate Environment and Public Works Committee report. The list includes more than 650 experts who challenge the belief that human activity is contributing to global warmingI've been watching the excitement build in Washington as the inauguration approaches. Who knew that one of the unintended consequences would be to flush out the kooks?1
Though Happer has promulgated his skepticism in the past, he requested to be named a skeptic in light of the inauguration of President-elect Barack Obama, whose administration has, as Happer notes, “stated that carbon dioxide is a pollutant” and that humans are “poisoning the atmosphere.”
1. For the record, I don't think it's helpful to call CO2 a "pollutant." That doesn't mean there isn't an optimal concentration; after all, there's also an optimal concentration of N2 (100% is too much) and O2 (more than 50% and fires become a really serious problem. I'd also like to go on record as one of those who think that human activity is an important part of global warming but it's probably not the only cause of the current trend.
The Liberals are opposed to making tax cuts the centrepiece of the budget, and new leader Michael Ignatieff signalled yesterday the party is prepared to dump the Conservative minority if the budget is inadequate.This could get interesting. I would support the Liberals if they vote against the budget because it contains significant tax cuts. Cutting taxes is typical conservative dogma so we may be headed for an election.
...
As they position themselves in advance of the budget, the Liberals argue that, while they generally favour income-tax cuts, it's the wrong approach during the recession.
"We don't want to see the Prime Minister come up with the kind of broad-based tax cuts that put Canada in a permanent, structural deficit once we recover from this (recession)," Liberal finance critic Scott Brison (Kings-Hants) told CTV yesterday as his party gathered in Ottawa for the caucus meeting.
Liberal MP John McCallum said such cuts are fiscally irresponsible at a time when the Tories have already put Ottawa's books in a deficit position and there's no way to ensure tax cuts benefit those who have lost their jobs or otherwise need help during the recession.
"There's a very good argument to be made that this is not the right time for across-the-board tax reductions," said McCallum, MP for Markham-Unionville and chair of a party advisory committee on the economy.
The lesson is that to make best use of the internet as an educational resource, its content has to be audited for reliability, and a system of classification introduced. Given that the internet is already the main resource for students, the need is urgent. I suggest that an international consortium of universities should set up panels to audit the worth of websites, endorsing those that are reliable. They should not censor, nor comment on matters of opinion - the price we pay for the internet's open democracy is the rubbish it contains. But they should authoritatively identify worthwhile sites, and warn of factual error when it occurs. Without such expert monitoring, the internet will increasingly be a problem rather than a boon, and limited in educational value.Can you imagine a panel of Professors from different universities agreeing on which websites are reliable and accurate?
The issue is not really whether a gene could go from 1 copy to 4 percent in 1200 generations by chance. That wouldn't be so terribly unlikely in Pleistocene humans -- in fact, the mean time for a mutation to go from 1 copy to 4 percent by drift in a population of effective size 10,000 individuals is not 30,000 years, but only around 20,000 years. On the other hand, mtDNA variation today suggests that South Asia experienced early and rapid population growth -- so we're not likely talking about a population of 10,000, but more like a minimum of 100,000 effective individuals through the past 30,000 years at least. It would take genetic drift at least 10 times longer to accomplish the requisite frequency change given that demographic history. Still, a single allele at a single gene locus might be exceptional.John is an expert on evolution within human populations but he seems to be basing all of his calculations on the idea that the mutation arose in a population of 100,000 individuals and that this population was the effective population (e.g. they all freely interbred). I don't think this is very likely.
But that scenario, however unlikely, is simply not the situation we have here. Here we have a deletion that must have some disadvantage, because it gives people a fatal disease. This disadvantage is apparently dominant in effect, based on the case-control study. Yet the deletion has managed to persist within the large South Asian populations of the last 10,000 years so that today it is still around 4 percent.
I would hypothesize that the disadvantages of the deletion have actually increased over time. The average lifespan increased into the Upper Paleolithic and probably later as well. Meanwhile, as the population grew, larger completed family sizes became more important to fitness. As people became more sedentary, the accumulation and inheritance of possessions and land became an important means of investing in children. The increasing importance of later survival and investment in children should have raised the fitness cost of chronic disease. That would explain a pattern of evolution in which this deletion increased in frequency early in its history, but later remained static or declined.This makes sense to me. It's consistent with John's idea that the rate of human evolution has changed substantially over the past 30,000 years but I don't see why he objects so much to a random genetic drift explanation. Why does he suggest the the authors of the paper are crazy to suggest drift as an explanation?
So, I don't suppose I can say people are crazy for thinking genetic drift could explain this deletion's current high frequency. But considering the powerful effect of weak selection over the many generations involved here, and the very large size of the South Asian population during most of that time, genetic drift seems pretty unlikely.
Dhandapany, P.S., Sadayappan, S., Xue, Y., Powell, G.T., Rani, D.S., Nallari, P., Rai, T.S., Khullar, M., Soares, P., Bahl, A., Tharkan, J.M., Vaideeswar, P., Rathinavel, A., Narasimhan, C., Ayapati, D.R., Ayub, Q., Mehdi, S.Q., Oppenheimer1, S., Richards, M.B., Price, A.L., Patterson, N., Reich, D., Singh, L., Tyler-Smith, C., and Thangaraj, K. (2009) A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nature Genetics, Published online: 18 January 2009 [doi:10.1038/ng.309]
Unit 1 if they have a teaching contract (note - teaching includes demonstrating, tutoring, and marking) and they are a full-time graduate student.What I'm mostly interested in is the graduate students in Units 1 & 3.
Unit 2 if they have a teaching contract and are not a full-time graduate student.
Unit 3 if they have a graduate assistantship or research assistantship and are a full-time graduate student.
Another group urging the union to vote yes is nearly 300 faculty members who signed their names to a letter urging CUPE to accept the current contract proposal.Why is this a problem? Well, for one thing, it's a problem because these 300 faculty members are going against the advice of their own union.
The signees of the letter are also members of the York University Faculty Association (YUFA).
YUFA president Arthur Hilliker said while he does not endorse the letter, he does not condemn it or believe it to be illegal either, according to Eric Lawee, a York humanities professor and one of the letter’s signees. YUFA maintains it wants a fair and equitable offer for CUPE.
“We, the undersigned retirees and full-time faculty members of York University, urge our colleagues in CUPE 3903 who have been on strike since November 6, 2008, to end their labour action by accepting the current contract offer of the York University administration,” the letter begins.
The letter addresses specific concerns if the strike were to drag on, including the potential loss of the summer term, which not only would hurt the school’s undergraduate students, but would affect CUPE as well, with possible job losses due to the elimination of the summer term.
“In their own interest and that of the entire university community, we urge CUPE members to end their labour action and help the university resume expeditiously the provision of its full academic programs,” the letter concludes.
Mr. Lawee said that there were two main reasons behind the letter. The first was due to “a strong sense that the strike has dragged on too long and that the rights and needs of students must now take priority over all else,” he said. “And ... that this should be an easy settlement to endorse because the offer is very fair.”
Press ReleaseThe second and third points are very important. Faculty members are often the bosses of teaching assistants and they need to be very careful to remain neutral in situations like this. Because they are in a position of authority over graduate students they should not be urging these students to vote one way or the other. You can see why this is a problem. If Professors tell their graduate student to vote for ratification when the student wants to vote the other way, then this sets up a dangerous conflict for the student. What can be gained by doing that?
These are our principles with respect to the CUPE 3903 forced ratification vote. They are motions passed unanimously at the YUFA Executive meeting of 12 January 2009:We recognize the serious problems the strike is causing for the students and for York. We also recognize that the issues of this strike need to be resolved for the future of York University.
- YUFA Executive re-affirms its support of free collective bargaining and does not endorse a ratification vote of CUPE 3903 members as forced by the Employer.
- YUFA Executive strongly urges all YUFA members to respect individual CUPE 3903 members’ rights in the forced ratification vote to vote freely and according to their conscience. We urge all YUFA members to respect CUPE members’ rights to vote freely.
- YUFA Executive, recognizing the power relations implicit in the roles of YUFA members and CUPE 3903 members, does not endorse any YUFA member attempting to influence how a CUPE 3903 member might vote in the forced ratification vote.
Professor Berland has claimed that the open letter by full-time faculty and retirees to striking members of CUPE 3903 is in direct defiance of motions passed by the faculty union's executive. The signees have never claimed to speak on behalf of, or to represent, the faculty union.Let's be clear about one thing. YUFA was offering advice to its members based on decades of experience. The advice was to keep your mouth shut because you are in a position of authority over your graduate student TAs.
Professor Berland interprets the motions of the faculty union's executive as saying that faculty are not free to express their opinions on the strike. I do not believe that that is the correct interpretation. However, if Professor Berland's interpretation were correct, then I would have to defy the faculty union.
It is not the business of a faculty union to gag its own members. One of the most important priorities of a university is to encourage free discussion and expression. That priority is not suspended during a strike, especially when the fate of more than 50,000 students hangs in the balance.
1. It may be illegal as well, but that's another thing entirely. I doubt that any Professor would be prosecuted for pressuring their graduate students unless that Professor holds a prominent administrative position where the potential for retaliation against a student is much more likely.