1. It's past my bedtime.
Q: Why do pseudogenes and most of the transposon-related sequences look so much like broken genes?
A: They may look like broken genes but they probably have some function.
Q: Why is the DNA sequence in most of our DNA not conserved?
A: It's not conserved because it's a reservoir for evolution. In addition, it probably contains genes for small RNAs and, as we all know, those predicted small RNA genes are not conserved.
Q: Why can we delete large segments of mammalian DNA with no observable effect?
A: There is an effect. We just haven't found it yet.
Q: Why is there so much variations in repetitive DNA within a species? Some people have segments that are ten times longer than segments found in other people. Are all of the nucleotides in the longer segments functional?
A: There are some examples of differences in repeats that do make a difference. Therefore, it is wrong to conclude that most of the variation has no effect. Furthermore, the discovery of copy number variation is a new phenomenon and it may turn out the have profound effects.
This belief that there’s hidden function to be found, treasures to unearth if you will, is the difference between those advocating these parts of DNA as “junk” and me. In my opinion, It’s not the details of what is junk and what isn’t, ..- and how much, that bothers me…..This is nonsense but I already covered that complaint in my previous posting.
It’s the attitude. To dismiss something as junk is contrary to my idea of science being driven out of curiosity and the need to explore. Curiosity may kill a cat every now and then, but I’ll take that risk and continue to praise the scientist who recognize possibilities in the junk rather than dismissing it.
Gene duplications have occurred from time to time throughout the genomes. It is by these, and similar means, that genome size can increase in evolution. But remember the distinction between the total capacity of the whole genome, and the capacity of the proportion that is actually used. Recall that not all the globin genes are actually used. Some of them, like theta in the alpha cluster of globin genes, are pseudogenes, recognizably kin to functional genes in the same genomes, but never actually translated into the action language of protein. Genomes are littered with with nonfunctional pseudogenes, faulty duplicates of functional genes that do nothing, while their functional cousins (the word doesn't even need scare quotes) get on with their business in a different part of the same genome. And there's lots more DNA that doesn't even deserve the name pseudogene. It, too, is derived by duplication, but not duplication of functional genes. It consists of multiple copies of junk, "tandem repeats," and other nonsense that may be useful for forensic detectives but which doesn't seem to be useful in the body itself.
Richard Dawkins in "The "Information Challenge",
The Skeptic magazine, 1998
1. The Extended Phenotype p. 157
In 1991 there were 30 young people beginning graduate school in the Molecular Biophysics and Biochemistry Progam at Yale University. Where are they now? How many have tenure at a university? The answer might surprise you. Read about the fate of these students in this week's issue of Science [And Then There Was One]. [Hat Tip: Chance and Necsssity]
Institutions may wish to implement more formal vetting mechanisms, however, such as periodic review by institutional moderators or peer review by official committees of blog-literate individuals, established scientists, and bloggers. Institutions might use one of a variety of mechanisms to confer a visible token of this review—such as a “blog badge”—in order to both reward quality bloggers and help readers identify trusted blogs. A blog badge is simply a small picture or icon that is prominently featured on the blog and represents an award or achievement. Such badges are usually given as awards (such as the “Weblog Awards” or the “MedBlog Awards”), and are awarded to particular outstanding blogs in a variety of categories, such as “Best Group Blog,” “Most Informative,” and “Best Translation of Published Research.” Traditional blogging awards are conferred by a committee who invites submissions until a deadline, reviews them, and then posts the winners on their Web site. The winners can then download the badge to post on their blog. Institutions might find it useful, and bloggers might find it motivating, if institutional blog badges were conferred for particularly insightful posts or as a token for passing their test or review periods. Accumulating these badges would be a public and official way for the institution to reward and validate the blogger, while conferring authority to the blog by letting readers know it has met the criterion for institutional peer review.I think this may be missing the point of blogs. Their value is based on the fact that there's no "institutional" control or monitoring. There is no peer review. This is the internet and it's free-wheeling and opinionated. I don't know of an "institution" that can officially attach its name to those kind of blogs—although they must tolerate them in the name of academic freedom. (Besides, if we use science press releases as our criterion for judging institutional accuracy, then institutional blog badges aren't going to be worth very much.)
[Hat Tip: John Dennehy]
I bet almost all of you think it's Arthropoda since there are so many insects and especially beetles, which God was very fond of.11. This is a reference to a famous quip by J.B.S. Haldane. When asked to name the most important thing he has learned about God from studying biology he reportedy said, "I'm not sure, but He seems to be inordinately fond of beetles."
[Photo Credit: Iowa State University Plant Disease]
An equinox in astronomy is the moment in time (not a whole day) when the centre of the Sun can be observed to be directly above the Earth's equator, occurring around March 20 and September 23 each year.
More technically, at an equinox, the Sun is at one of two opposite points on the celestial sphere where the celestial equator (i.e., declination 0) and ecliptic intersect. These points of intersection are called equinoctial points—the vernal point and the autumnal point. By extension, the term equinox may be used to denote an equinoctial point.
[Image Credit: eSky]
Turner was an English artist who did most of his work in the first half of the nineteenth century. I'm a fan of most of Turner's paintings but I particularly like the seascapes that show Napoleonic era battleships.
Yesterday was 111th anniversary of an editorial published in The New York Sun. The author was Francis Pharcellus Church. See the article on Wikipedia for the complete history of Yes, Virginia, there is a Santa Claus.Virginia,
Your little friends are wrong. They have been affected by the skepticism of a skeptical age. They do not believe except they see. They think that nothing can be which is not comprehensible by their little minds. All minds, Virginia, whether they be men’s or children’s, are little. In this great universe of ours, man is a mere insect, an ant, in his intellect as compared with the boundless world about him, as measured by the intelligence capable of grasping the whole of truth and knowledge. Yes, Virginia, there is a Santa Claus. He exists as certainly as love and generosity and devotion exist, and you know that they abound and give to your life its highest beauty and joy. Alas! how dreary would be the world if there were no Santa Claus! It would be as dreary as if there were no Virginias. There would be no childlike faith then, no poetry, no romance to make tolerable this existence. We should have no enjoyment, except in sense and sight. The eternal light with which childhood fills the world would be extinguished. Not believe in Santa Claus! You might as well not believe in fairies. You might get your papa to hire men to watch in all the chimneys on Christmas eve to catch Santa Claus, but even if you did not see Santa Claus coming down, what would that prove? Nobody sees Santa Claus, but that is no sign that there is no Santa Claus. The most real things in the world are those that neither children nor men can see. Did you ever see fairies dancing on the lawn? Of course not, but that’s no proof that they are not there. Nobody can conceive or imagine all the wonders there are unseen and unseeable in the world. You tear apart the baby’s rattle and see what makes the noise inside, but there is a veil covering the unseen world which not the strongest man, nor even the united strength of all the strongest men that ever lived could tear apart. Only faith, poetry, love, romance, can push aside that curtain and view and picture the supernal beauty and glory beyond. Is it all real? Ah, Virginia, in all this world there is nothing else real and abiding. No Santa Claus! Thank God! he lives and lives forever. A thousand years from now, Virginia, nay 10 times 10,000 years from now, he will continue to make glad the heart of childhood.
Alvin Plantinga defines "fideism" as "the exclusive or basic reliance upon faith alone, accompanied by a consequent disparagement of reason and utilized especially in the pursuit of philosophical or religious truth." The fideist therefore "urges reliance on faith rather than reason, in matters philosophical and religious," and therefore may go on to disparage the claims of reason.[3] The fideist seeks truth, above all: and affirms that reason cannot achieve certain kinds of truth, which must instead be accepted only by faith.[4] Plantinga's definition might be revised to say that what the fideist objects to is not so much "reason" per se — it seems excessive to call Blaise Pascal anti-rational — but evidentialism: the notion that no belief should be held unless it is supported by evidence.I wonder if this belief is widespread? I always thought that Christians wanted their religious beliefs to be rational and certainly the Intelligent Design Creationists are among those who think that God's existence has been demonstrated.
The fideist notes that religions that are founded on revelation call their faithful to believe in a transcendent deity even if believers cannot fully understand the object of their faith. Some fideists also contend that human rational faculties are themselves untrustworthy, because the entire human nature has been corrupted by sin, and as such the conclusions reached by human reason are therefore untrustworthy: the truths affirmed by divine revelation must be believed even if they find no support in human reason. Fideism, of a sort which has been called naive fideism, is frequently found in response to anti-religious arguments; the fideist resolves to hold to what has been revealed as true in his faith, in the face of contrary lines of reasoning.
Specifically, fideism teaches that rational or scientific arguments for the existence of God are fallacious and irrelevant, and have nothing to do with the truth of Christian theology.
[Hat Tip: Friendly Atheist]
The West Wing was one of my favorite TV shows during its time. Maureen Dowd thinks so too 'cause she asked its creator, Aaron Sorkin, to imagine what President Jed Bartlet might say to Barack Obama if given the chance. Her op-ed piece was published in yesterday's New York Times [Seeking a President Who Gives Goose Bumps? So’s Obama].OBAMA The problem is we can’t appear angry. Bush called us the angry left. Did you see anyone in Denver who was angry?Whoa! That doesn't sound like bipartisanship to me!
BARTLET Well ... let me think. ...We went to war against the wrong country, Osama bin Laden just celebrated his seventh anniversary of not being caught either dead or alive, my family’s less safe than it was eight years ago, we’ve lost trillions of dollars, millions of jobs, thousands of lives and we lost an entire city due to bad weather. So, you know ... I’m a little angry.
OBAMA What would you do?
BARTLET GET ANGRIER! Call them liars, because that’s what they are. Sarah Palin didn’t say “thanks but no thanks” to the Bridge to Nowhere. She just said “Thanks.” You were raised by a single mother on food stamps — where does a guy with eight houses who was legacied into Annapolis get off calling you an elitist? And by the way, if you do nothing else, take that word back. Elite is a good word, it means well above average. I’d ask them what their problem is with excellence. While you’re at it, I want the word “patriot” back. McCain can say that the transcendent issue of our time is the spread of Islamic fanaticism or he can choose a running mate who doesn’t know the Bush doctrine from the Monroe Doctrine, but he can’t do both at the same time and call it patriotic. They have to lie — the truth isn’t their friend right now. Get angry. Mock them mercilessly; they’ve earned it. McCain decried agents of intolerance, then chose a running mate who had to ask if she was allowed to ban books from a public library. It’s not bad enough she thinks the planet Earth was created in six days 6,000 years ago complete with a man, a woman and a talking snake, she wants schools to teach the rest of our kids to deny geology, anthropology, archaeology and common sense too? It’s not bad enough she’s forcing her own daughter into a loveless marriage to a teenage hood, she wants the rest of us to guide our daughters in that direction too? It’s not enough that a woman shouldn’t have the right to choose, it should be the law of the land that she has to carry and deliver her rapist’s baby too? I don’t know whether or not Governor Palin has the tenacity of a pit bull, but I know for sure she’s got the qualifications of one. And you’re worried about seeming angry? You could eat their lunch, make them cry and tell their mamas about it and God himself would call it restrained. There are times when you are simply required to be impolite. There are times when condescension is called for!
OBAMA Good to get that off your chest?Gee, I almost forgot about the lapel pins. It's how you demonstrate that you've sold out to the framers.
BARTLET Am I keeping you from something?
OBAMA Well, it’s not as if I didn’t know all of that and it took you like 20 minutes to say.
BARTLET I know, I have a problem, but admitting it is the first step.
OBAMA What’s the second step?
BARTLET I don’t care.
OBAMA So what about hope? Chuck it for outrage and put-downs?
BARTLET No. You’re elite, you can do both. Four weeks ago you had the best week of your campaign, followed — granted, inexplicably — by the worst week of your campaign. And you’re still in a statistical dead heat. You’re a 47-year-old black man with a foreign-sounding name who went to Harvard and thinks devotion to your country and lapel pins aren’t the same thing and you’re in a statistical tie with a war hero and a Cinemax heroine. To these aged eyes, Senator, that’s what progress looks like. You guys got four debates. Get out of my house and go back to work.
1. And, in Canada, Stéphane Dion really is a whole lot smarter than Stephan Harper or Jack Layton?
[Big Hat Tip to Chance and Necsssity]
The congresscritter in question being Sherwood Boehlert, who represented New York's 24th Congressional district (1983-2007), and chaired the House Science Committee (2001-2007). Boehlert offers this advice in a video called "Speaking for Science: Bringing Your Message to Policymakers," available for download from the American Chemical Society website.*As you might guess, the effective way to talk to a politician about science is to be brief and to the point and avoid all that sciency stuff that only confuses everyone. You need to stop trying to explain science to the staff member and concentrate on what's in it for the politician.
The video presents two scenarios in which a group of scientists meets with their Congressional representative (who happens to be a member of the House Science Committee, played by Boehlert). As you might guess, the idea is to contrast the effective meeting with the disastrous one.
A press release from Cold Spring Harbor Laboratory promotes the work of Michael Zhang and Adrian Krainer who work with splicing factors. In a typical attempt to hype the significance of the work, the press release claims that each human gene has many different variants produced by alternative splicing [CSHL team traces extensive networks regulating alternative RNA splicing]. Biologists involved in the Human Genome Project were frankly astonished to discover that everything that makes us human is the product of a set of only 23,000 or so genes.1 That number in itself, though several times smaller than prior estimates, is not shocking; it is the relative size of other genomes that surprised scientists.This is one version of what I call The Deflated Ego Problem. The "problem" is that some people are really, really, upset about the fact that humans may only have a few thousand genes more than a fruit fly.
The common fruit fly that hovers over your ripening bananas, for instance, possesses some 14,000 genes. It's perfectly obvious that human beings are vastly more complex, biologically, than a fly. Molecular biologists have demonstrated in recent years that it is not the number of genes that is the key to complexity but rather the number and diversity of gene products that a given set of genes can instruct cells to manufacture.
Rather than a single gene ordering the production of a single kind of protein, as scientists used to assume, it turns out that individual genes can in some cases give rise to dozens or even thousands of different proteins, thanks to a phenomenon called alternative splicing.
Some people were surprised and embarrassed by the "low" number of genes in the human genome but others were pretty happy that their estimates were close to the mark [Facts and Myths Concerning the Historical Estimates of the Number of Genes in the Human Genome].
