Monday's Molecule #68

 
This is an easy one. Your task for today is to identify the molecule shown on the right. Be as specific as possible.

In addition you have to identify the Nobel Laureate who was awarded a Nobel Prize for—among other things—working out the chemical structure of this molecule.

The first person to correctly identify the specific molecule and name the Nobel Laureate wins a free lunch at the Faculty Club. Previous winners are ineligible for one month from the time they first collected the prize. There are two ineligible candidates for this week's reward.

THEME:

Nobel Laureates
Send your guess to Sandwalk (sandwalk (at) bioinfo.med.utoronto.ca) and I'll pick the first email message that correctly identifies the molecule and names the Nobel Laureate(s). Note that I'm not going to repeat Nobel Laureates so you might want to check the list of previous Sandwalk postings.

Correct responses will be posted tomorrow along with the time that the message was received on my server. I may select multiple winners if several people get it right.

Comments will be blocked for 24 hours. Comments are now open.

UPDATE: This was much harder than I expected. The winner is Marc Perry, co-author of the textbook from which the drawing is taken. He recognized it as a strand of DNA—I assume everyone got at least that far. Marc figured out that the Nobel Laureate had to be Sir Alexander Todd. He adds,

This was an excellent quiz because it forced me to learn a relevant fact that I was previously ignorant of. I never recall learning of this individual and his work, but based on the fact that there would be no repeats on the list of Sandwalk Laureates, _and_ on my intimate use of the website for NobelPrize.org (for my course on personalities in science, HMB305--shameless plug here), I was able to use the power of a search engine and the process of elimination to inform my guess.

If you're a student at the University of Toronto take Marc's course next year. You can also take the course that we teach together: HMB210H "Popular Scientific Misconceptions."

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Prince Charles

 
Having watched six episodes of John Adams, I'm thoroughly immersed in anti-monarchy rhetoric. Usually, I defend my Queen as a viable alternative to a system of government that doesn't make a distinction between a head of state and political leader. I like the idea that the head of state is ceremonial and non-political.

However, the presumptive heir to the current monarch leaves a lot to be desired. Now he's gone and published more superstitious nonsense that clearly demonstrates his deficiency in the intelligence category¹ [Prince of Wales's guide to alternative medicine ‘inaccurate’].

The Prince of Wales is being challenged today to withdraw two guides promoting alternative medicine, by scientists who say that they make misleading and inaccurate claims about its benefits.

The documents, published by the Prince and his Foundation for Integrated Health, misrepresent scientific evidence about therapies such as homoeopathy, acupuncture and reflexology, say the authors of a new evaluation of alternative treatments.

In a letter to The Times, Edzard Ernst, Professor of Complementary Medicine at the University of Exeter, and Simon Singh, a science writer and broadcaster, call on the Prince to recall the publications, one of which was produced with a £900,000 grant from the Department of Health.

You know you're in big trouble when a Professor of Complementary Medicine thinks your documents are inaccurate!

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1. Fortunately, his sons seem to have gotten a good dose of intelligence genes from their mother. That's saying a lot.

[Hat Tip: Skepchick]

Overthrowing the Central Dogma

I believe that the Central Dogma of Molecular Biology is widely misunderstood [Basic Concepts: The Central Dogma of Molecular Biology]. It is usually interpreted to mean that information must flow exclusively from DNA to RNA to protein. But he original definition by Francis Crick was ...

... once (sequential) information has passed into protein it cannot get out again (F.H.C. Crick, 1958)

Fig. 1. Information flow and the sequence hypothesis. These diagrams of potential information flow were used by Crick (1958) to illustrate all possible transfers of information (left) and those that are permitted (right). The sequence hypothesis refers to the idea that information encoded in the sequence of nucleotides specifies the sequence of amino acids in the protein.

I think we should retain the original definition.

A biology teacher has been discussing this issue with me and he points out that the term "Central Dogma" is defined by consensus. If the vast majority of scientists define it incorrectly, then that becomes the new definition. I agree, but I'm not yet prepared to concede defeat.

My correspondent made an interesting observation. He noted that the Nobel Prize committee has awarded three Nobel Prizes for, in part, overthrowing the Central Dogma of Molecular Biology. This is very interesting. What's the value of continuing to refer the the "Central Dogma" if it has, indeed, been refuted?

Here are the three examples. The first is from a 1975 press release announcing the Nobel Prizes to Howard Temin, David Baltimore, and Renato Dulbecco [The Nobel Prize in Physiology or Medicine 1975].

Howard Temin was since the end of the 1950ies concerned with studies of tumour viruses which contain the alternative type of genetic material, i.e. RNA. He noticed that certain characteristics of tumour cells arising after infection with this type of virus suggested a possible persistence of virus genetic material in them. It was very difficult however to understand how the genetic information of viruses containing RNA could form a part of the hereditary material of the tumour cells. In order to explain this Temin postulated that the genetic information of an RNA virus capable of giving transformation could be copied into DNA, and that this DNA in a manner similar to that described for a DNA tumour virus could become integrated into the genetic material of cells. This proposal by the overall majority of scientists was considered as heresy since it was in conflict with the central dogma accepted in the field of molecular biology in those days. This dogma implied that information transfer in nature occurred only from DNA to RNA and not in the other direction.

Note that Crick's original paper (see above) allowed for information flow from RNA back to DNA so Temin's work did not overthrow the original concept of theoretical information flow. It did conflict with the incorrect version of the Central Dogma that had been promoted by Jim Watson. It was Temin's work, and the subsequent hype about the Central Dogma, that prompted Crick to publish his 1970 paper.

The second example comes from the press release for 1989 Nobel Prizes to Sydney Altman and Thomas Cech in 1989 [Ribonucleic acid (RNA) - a biomolecule of many functions].

The genetic information in the DNA strand is arranged as a long sentence of three-letter words (e.g. CAG ACT GCC), each corresponding to one of the twenty amino acids which build the proteins. This means that there is a flow of genetic information from the DNA to the proteins, which in turn provide the structural framework of living cells and give them their different functions in the organism. However, this flow of genetic information cannot occur unless the DNA code is transcribed to another code in another type of nucleic acid - RNA (ribonucleic acid). This connection between the nucleic acids (the molecules of heredity) and the proteins (the molecules of structure and function) is what has been called the central dogma of the biosciences.
The genetic information in the DNA molecules determines the composition and function of the proteins. Altman and Cech have now modified this by showing that the RNA molecules not only transmit the genetic information but can also function as biocatalyst.

The third example comes from the press release of the 2006 Nobel Prize to Andrew Fire and Craig Mello for thier work on intrefering RNA [The Nobel Prize in Physiology or Medicine 2006]. In this case, the press release does not claim that Fire and Mello overthrew the Central Dogma but it does give an incorrect version of the Central Dogma of Molecular Biology. This is ironic since, according to the Noble Prize committee, the Central Dogma had been called into question in 1975 and 1989.

The genetic code in DNA determines how proteins are built. The instructions contained in the DNA are copied to mRNA and subsequently used to synthesize proteins (Fig 1). This flow of genetic information from DNA via mRNA to protein has been termed the central dogma of molecular biology by the British Nobel Laureate Francis Crick. Proteins are involved in all processes of life, for instance as enzymes digesting our food, receptors receiving signals in the brain, and as antibodies defending us against bacteria.

It is not true that Francis Crick referred to this process of information flow as the Central Dogma.

Is any of this important? Yes, I think it is. I think there is too much sloppiness in science these days. There are too many instances where sloppy thinking is acceptable. On this particular issue you can't have it both ways. Either the Watson definition of the Central Dogma of Molecular Biology was correct, in which case it has been discredited to such an extent that it's no longer useful. Or, the original Crick version is correct, in which case the work of Temin, Altman, Cech, Fire, and Mello have nothing to do with the Central Dogma.

If a scientist is going to write about the Central Dogma of Molecular Biology then they better be damned sure that they understand it. If they are going to quote the original papers (Crick 1958, 1970) then it might be a very good idea to read them.

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Crick, F.H.C. (1958) On protein synthesis. Symp. Soc. Exp. Biol. XII:138-163

Crick, F. (1970) Central Dogma of Molecular Biology. Nature 227, 561-563. [PDF file]

Discovery Institute Praises Expelled

 
The President of the Discovery Institute, Bruce Chapman, has posted a message extolling the virtues of the movie expelled [Discovery Salutes Expelled].

The producers of Expelled have high hopes as the film opens today.

Practical questions of theater exposures and audience awareness are things that we, as a think tank, cannot assess, of course. But we are cheering the filmmakers on. First signs look positive. The over-the-top attacks of most official reviewers--offended by the film's message, not its quality--may turn out to help in some quarters. These are the exact same reviewers who commonly tell us not to object to offensive Hollywood products, but just to judge a film for its production quality. By now a large share of the population is wise to such hypocritical standards.

So, how is the film doing so far? Not so good. You can read the reviews of Expelled on the "Expelled Exposed" website created and maintained by the National Center for Science Education (NCSE). The reviewers ratings are making this one of the worst films ever.

The people at NCSE have been working hard to debunk all the false claims in Exposed and so far they're doing an excellent job.

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Evolution at the Chautauqua Institution

 
The program for Week 9 (Aug. 17-23) at the Chautauqua Institution has been posted [Week Nine: Darwin and Linnaeus: Their Impact on Our View of the Natural World].

Here's the lineup of lectures in the main amphitheater (morning) and the Hall of Philosophy (afternoon).

Monday Aug. 18

10:45 am: Kenneth Miller, prof. of biology, Brown University; author, Finding Darwin's God.

Tuesday Aug. 19

10:45 am: Beth Shapiro, asst. prof. of biology, Penn State Univ.; researcher in field of ancient DNA.
2:00 pm: Carl Zimmer, science journalist, author, Evolution: The Triumph of an Idea.

Wednesday Aug. 20

10:45 am: Edward Larson, prof. of law, Pepperdine Univ; Pulitzer Prize-winner for Summer for the Gods.
2:00 pm: Barbara J. King, prof. of anthropology, College of William & Mary; author, Evolving God

Thursday, Aug. 21

10:45 am: Spencer Wells, population geneticist; director of Genographic Project.
2:00 pm: Eugenie C. Scott, executive director, National Center for Science Education.

Friday, Aug. 22

10:45 am: Mattias Klum, National Geographic Society photographer; documentary filmmaker, The Linnaeus Expedition.
2:00 pm: Michael Ruse, professor of philosophy, Florida State University; director of program in history and philosophy of science, Bristol Univ.

Throughout the week you can further improve your mind by taking special courses. You might be interested in course #1948 on What Is Evolution. I can guarantee you a good time in the course. We will finish at 2 pm on Tuesday, Thursday, and Friday.

For entertainment there's the Philadelphia Dance Company on Monday night, the very excellent Chautauqua Symphony on Tuesday night, a Vince Gill concert on Friday night, and an evening with Bill Cosby on Saturday night.

I'm also going to be there for week 4 on The Ethical Frontiers of Science.

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An Example of Framing by Matt Nisbet

Last summer I blogged about a survey of 149 professional, prominent, evolutionary biologists [Evolutionary Biologists Flunk Religion Poll].

The great majority of the evolutionists polled (78 percent) chose A, billing themselves as pure naturalists. Only two out of 149 described themselves as full theists (F), two as more theist than naturalist (D) and three as theistic naturalists (B). Taken together, the advocacy of any degree of theism is the lowest percentage measured in any poll of biologists' beliefs so far (4.7 percent).

The study was done by Gregory W. Graffin and William B. Provine and you can read the full report in American Scientist [ Evolution, Religion and Free Will]. The study quotes the findings of Larson in 1998 where only 5.5% of biologists in the National Academy of Sciences believe in God.

An earlier study of average scientist by Larson showed that 40% believe in a god and 45% do not [NEW SURVEY: SCIENTISTS "MORE LIKELY THAN EVER" TO REJECT GOD BELIEF]. Couple these results to the fact that somewhere between 30% and 50% of the general population of Western European countries are atheists and agnostics [Atheists and Agnostics] and I think it would be fair to say that the majority of evolutionary biologists do not believe in god. The data supports the statement that, among evolutionary biologists, the consensus is lack of belief in god. This probably applies to all professional scientists.

Now, let's look at how Matt Nisbet spins the story [Francis Collins: The Angry Atheists Do Not Speak for Us]. He opens by quoting an interview with Francis Collins, a deluded scientist, who, quite predictably, says ...

I also think that those of us who are interested in seeking harmony here have to make it clear that the current crowd of seemingly angry atheists, who are using science as part of their argument that faith is irrelevant, do not speak for us. Richard Dawkins, Sam Harris and Christopher Hitchens do not necessarily represent the consensus of science; 40 percent of scientists are believers in a personal God. A lot more are rather uncomfortable about the topic but certainly would not align themselves with a strong atheistic perspective.

Collins is talking about the "angry atheists" when he claims that they don't represent the consensus. Then he spins the argument to make it look like most scientists are believers, or at least have some doubts. Of course, when Collins says they "do not speak for us" he doesn't mean members of the National Academy of Scientists or prominent evolutionary biologists. No, he's referring to the broader survey that included many other categories of scientist. Among that group, there are still more non-believers (45%) than believers (40%).

Matt Nisbet then says ...

As Collins accurately notes, the argument by Dawkins, PZ Myers, and other atheist hardliners that science undermines the validity of religion, even respect for religion, is at odds with the consensus view in the scientific community.

For example, as the recent National Academies report on evolution concludes: "The evidence for evolution can be fully compatible with religious faith. Science and religion are different ways of understanding the world. Needlessly placing them in opposition reduces the potential of each to contribute to a better future."

I don't think Nisbet is representing the consensus view in the scientific community—at least not in the scientific community of professional evolutionary biologists. In that community the overwhelming majority are non-believers in god(s). This is how framing works, is it different from lying?

Furthermore, Nisbet is picking up on a paragraph in Science, Evolution and Creationism, a recent publication of the National Academy of Sciences. That paragraph is, itself, a "frame" and a misrepresentation of the consensus view among scientists as many of us have pointed out [How the National Academy of Sciences Framed their Book on Evolution]. The polls clearly show that the vast majority of members of the National Academy of Sciences are atheists. Thus, Nisbet is putting his own spin frame on the topic and quoting more inaccurate spin framing to support his position. I guess this is how framing is supposed to work.

I don't want any part of it. It's way too close to "lying." Matt Nisbet goes on to beat up on his regular victims by saying ...

Dawkins and Myers are entitled to their opinion and as a fellow atheist I strongly support their right to voice criticism of religion. Yet at some point they need to consider the unintended consequences of their preferred brand of atheist punditry, and to recognize the pragmatism of the consensus message from the National Academies and other leading science organizations.

In their campaign, Dawkins and Myers may honestly believe that they are speaking truth to religion and that by adding their voice to the argument culture, they can raise awareness among the non-religious while potentially shifting society towards greater secularization. However, in coming decades, if the goal is to defend the teaching of evolution in schools and to maintain public trust in science and scientists, their message likely serves as a liability towards that end.

Matt, you are completely wrong about this. The "consensus message" of the National Academies and other leading science organizations is flat-out wrong. Most scientists do not believe in God and among prominent evolutionary biologists Francis Collins is part of a 5.5% minority. You may have convinced the authors of Science, Evolution and Creationism to mislead the public about the beliefs of scientists but you'll never convince the scientists themselves to go along with it.

If the goal is to maintain "public trust in science and scientists" then speaking the truth is always better than framing.

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I Prefer People Who Sign their Names to Comments and Blogs

 
Given a choice between anonymous bloggers (and commenters) and those who sign their real names, I prefer to deal with those who use their real names. In part, this is because I admire their willingness to stand behind what they say regardless of the possible consequences. I do understand that it's easy for a tenured Professor to say this but I've never hidden behind anonymity even when I was an undergraduate, a graduate student, a postdoc, or an untenured Professor.

Greg Laden discusses anonymous bloggers in Some of my best friends are pseudonymous bloggers. I pretty much agree with his position. His posting is well worth reading.

I also agree with his stance on arguing from authority. In the real world, it makes a difference if someone is someone is putting forth an argument based on years of experience in the field or not. Nobody has time to evaluate all of the facts on every issue. We have to learn who we can trust and who we can't. The connection between this and anonymous blogging is obvious.

Please do not interpret this as a blanket recommendation to trust everyone in a position of authority. Similarly, I'm well aware of the fact that non-experts often make insightful contributions to a debate. The issue is much more complex than that. We don't need to list all the exceptions to the general principle that wisdom and experience usually count for something.

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[Cartoon Credits: (top)Anonymity and Sovreignty (bottom) Cerebral Kitchen Productions]

Evolutionary Teapot

 
There's an exhibit of china and pottery inside the Legion of Honor museum in San Francisco. One of the items that caught the attention of Leslie is a funny looking teapot.

The teapot itself isn't that unusual but there's an inscription on the bottom that refers to evolution. Apparently, there was a bit of hysteria and over-reaction to Darwin's ideas in the 1880's and this teapot pokes fun at that era.

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Legion of Honor: San Francisco

 
Last Sunday we visited the Legion of Honor art museum in San Francisco. We went specifically to see the Annie Leibovitz: A Photographer’s Life, 1990–2005 exhibit but there were lots of other wonderful sights to see. The building is a 3/4 scale copy of the Palais de la Légion d’Honneur in Paris.

There are two works of art in the main courtyard. The most impressive is a casting of Rodin's Thinker, which I interpret to be an icon for rationalism and a warning to creationists. The second is clearly an impressionist view of the Flying Spaghetti Monster

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Evolution: 24 myths and misconceptions

 

If you think you understand it, you don't know nearly enough about it.

New Scientist has just published an excellent series of articles on evolution [Evolution: 24 myths and misconceptions]. These are some of the best explanations of evolution that I've ever seen in a popular magazine. Thus, it's all the more tragic that they spoil it all by putting a false picture of evolution (right) on the website.

Shared misconceptions:

Everything is an adaptation produced by natural selection

We tend to assume that all characteristics of plants and animals are adaptations that have arisen through natural selection. Many are neither adaptations nor the result of selection at all.

Natural selection is the only means of evolution

Much change is due to random genetic drift rather than positive selection. It could be called the survival of the luckiest.

Natural selection leads to ever-greater complexity

In fact, natural selection often leads to ever greater simplicity. And, in many cases, complexity may initially arise when selection is weak or absent.

Evolution produces creatures perfectly adapted to their environment

You don't have to be perfectly adapted to survive, you just have to be as well adapted as your competitors. The apparent perfection of plants and animals may be more a reflection of our poor imaginations than of reality.

Evolution always promotes the survival of species

The phrase "survival of fittest" is widely misunderstood (see 'Survival of the fittest' justifies everyone for themselves). Many wrongly assume it means that evolution always increases the chances of a species surviving.

Evolution sometimes results in individuals or populations becoming less fit and may occasionally even lead to extinction.

It doesn't matter if people do not understand evolution

At an individual level, it might not matter much. However, any modern society which bases major decisions on superstition rather than reality is heading for disaster

"Survival of the fittest" justifies "everyone for themselves"

The "fittest" can be the most loving and selfless, not the most aggressive and violent. In any case, what happens in nature does not justify people behaving in the same way

Evolution is limitlessly creative

It might seem like there is no end to nature's inventiveness but there are some features that could probably never evolve, at least on Earth.

Evolution cannot explain traits such as homosexuality

There are numerous evolutionary mechanisms that might explain homosexual behaviour, which is common in many species of animals.

Creationism provides a coherent alternative to evolution

The only thing that creationists agree on is that they don't like evolution. Even Genesis gives two contradictory accounts of creation.

Creationist myths:

Evolution must be wrong because the Bible is inerrant

This argument is undermined by the hundreds of errors and inaccuracies and contradictions found in Bible. It is anything but "inerrant".

Accepting evolution undermines morality

Actually people in more secular countries appear to behave more morally. And even if this claim was true, that would not alter the facts or justify their suppression.

Evolutionary theory leads to racism and genocide

Darwin's ideas have been invoked as justification for all sorts of policies, including some very unpleasant ones. But evolutionary theory is a descriptive science. It cannot tell us what is right and wrong.

Religion and evolution are incompatible

There are various ways in which the known facts about evolution can be reconciled with theistic religions. Some of these ways might be illogical and irrational, but they are no more illogical and irrational than other aspects of religions.

Half a wing is no use to anyone

Just as objects designed for one purpose can be used for another, so genes, structures and behaviours that evolve for one purpose become adapted to do another.

Evolutionary science is not predictive

It might not be possible to predict exactly what life will look like in a billion years but what counts are the predictions that can be made.

Evolution cannot be disproved so is not science

There are all sorts of findings and experiments that could have falsified evolution. In the century-and-a-half since Darwin published his theory, not one has.

Evolution is just so unlikely to produce complex life forms

By weeding out harmful mutations and assembling beneficial ones, natural selection acts like an "improbability drive" that can, given enough time, produce results that appear utterly impossible at first glance.

Evolution is an entirely random process

No and yes. Natural selection is a rigorous testing process that filters out what works from what doesn’t, driving organisms to evolve in particular directions. However, chance events play a big role too.

Mutations can only destroy information, not create it

Biologists are uncovering thousands of examples of how mutations lead to new traits and even new species. This claim not only flies in the face of the evidence, it is also a logical impossibility.

Darwin is the ultimate authority on evolution

Modern evolutionary theory is built on some - but not all - of Darwin's ideas, but has gone far beyond them.

The bacterial flagellum is irreducibly complex

Actually, flagella vary widely from one species to another, and some of the components can perform useful functions by themselves. They are anything but irreducibly complex.

Yet more creationist misconceptions

Evolution is just a theory: Yes it is, like Einstein's theory of special relativity. By theory, scientists mean an explanation backed by evidence. What creationists mean is that evolution is just a hypothesis, unsupported by evidence - which it is not. Evolution is a fact as well a theory.

Evolution violates the second law of thermodynamics

The second law of thermodynamics states that entropy, a measure of randomness, cannot decrease in a closed system. Our planet is not a closed system.

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Tangled Bank #103

 
The latest issue of Tangled Bank is #103. It's hosted at rENNISance woman on the Nature network [The 103rd edition of the Tangled Bank].

Hello from Vancouver! I blog about current genetics, genomics, virology and evolution research. I'll also include posts about grant writing and any other ideas that take my fancy. Don't be shy - leave a comment and start a conversation!

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If you want to submit an article to Tangled Bank send an email message to host@tangledbank.net. Be sure to include the words "Tangled Bank" in the subject line. Remember that this carnival only accepts one submission per week from each blogger. For some of you that's going to be a serious problem. You have to pick your best article on biology.

We Beat the Scientologists!

 
The good news is that atheists are no longer in last place! The bad news is that we have a long way to go to catch up with the Methodists.

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[Hat Tip: Framing Science]

Gene Genie #29

 
The 29th edition of Gene Genie has been posted at My Biotech Life [Gene Genie: the better late than never personal genomics special edition].

It’s a couple of days off schedule but Gene Genie has arrived. I’d like to thank Berci for the opportunity once again. That said, here goes the juicy genetic content.

The beautiful logo was created by Ricardo at My Biotech Life.

The purpose of this carnival is to highlight the genetics of one particular species, Homo sapiens.

Here are all the previous editions .....

1. Scienceroll
2. Sciencesque
3. Genetics and Health
4. Sandwalk
5. Neurophilosophy
6. Scienceroll
7. Gene Sherpa
8. Eye on DNA
9. DNA Direct Talk
10. Genomicron
11. Med Journal Watch
12. My Biotech Life
13. The Genetic Genealogist
14. MicrobiologyBytes
15. Cancer Genetics
16. Neurophilosophy
17. The Gene Sherpa
18. Eye on DNA
19. Scienceroll
20. Bitesize Bio
21. BabyLab
22. Sandwalk
23. Scienceroll
24. biomarker-driven mental health 2.0
25. The Gene Sherpa
26. Sciencebase
27. DNA Direct Talk
28. Greg Laden’s Blog
29. My Biotech Life

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EXPELLED: The Movie

 
This is a slick trailer for the movie Expelled: No Intelligence Allowed (irony alert!). Unfortunately, the contents of the movie won't measure up to the pre-release hype. Check out EXPELLED EXPOSED for a detailed rebuttal of the claims made in the movie.

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A Slight Error

 

John Wilkins posted a brief note about a German school kid who "corrected" NASA's calculation of the probability of an asteroid hitting the Earth.

You need to read the comments to fully appreciate the irony of the title Oops, a slight error never killed anyone. (Sorry, John, I couldn't resist.)

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[Photo Credit: AAPPL]