Should Cloning Humans Be Legal?

 
In the July 21 issue of New Scientist, Hugh McLachlan thinks that we should legalize cloning of humans [Let's legalise cloning].

But why are we so against the idea of cloned human babies? As a bioethicist specialising in reproductive issues, I believe it has more to do with an irrational fear of cloning than any logical reason. All the arguments in favour of a ban describe risks that we accept quite easily and naturally in other areas of reproduction.

One argument against human cloning is the idea that it is morally wrong or undesirable to create replicas of people. But although a clone has the same gene set as the adult from which it was cloned, environmental factors will ensure that the resulting individual is not an identical copy, either psychologically or physically. What's more, we accept genetically identical people in the form of twins. If anything, clones would be less alike than twins because they would be different ages and be brought up in different contexts. Objecting to cloning on these grounds makes no sense.

I agree with McLachlan. Aside from the safety issue, there doesn't seem to be any good reason to forbid the cloning of humans.

This is a topic that's frequently discussed in "ethics" classes. I've never really understood what "ethics" actually means—but I'm working on it. The cloning of humans isn't an ethical issue for me personally because there isn't a conflict between two versions of what I think I ought to do. However, maybe it's an ethical issue for society as a whole because there are some people who think that it is unethical to clone people. Is that right? What's unethical about it?

Do we define "ethical" issues in terms of conflict between different groups? If so, is there a way of distinguishing between issues where the two sides are almost equally represented and those where one side has an overwhelming majority? For example, is the cloning of humans still an ethical issue in a society where 99% of the population is opposed? Does it cease to be an ethical issue if 99% are persuaded to accept human cloning?

Amazing Grace

 
Last night we saw a screening of the film Amazing Grace in a small cozy theater. At the end of the movie there was a fascinating talk by one of the producers Ken Wales. We learned a lot about how the film was made.

The film follows the efforts of William Wilberforce to abolish slavery in the British Empire at the end of the eighteenth century. Wilberforce and his close friend William Pitt the Younger, who became Prime Minister in 1783, finally succeeded in eliminating slavery by 1807.

There's mention of the fact that Wilberforce was a Christian and some of his allies were preachers but this isn't an important theme. The movie makes it clear that Pitt, who was a prime mover in social change, did not share Wilberforce's beliefs. During the discussion afterward it was clear that the religious motivation was important to some people.

The title of the movie comes from the song Amazing Grace whose words were composed by John Newton, an ex-slave trader who converted to Christianity. Newton, who has a significant part in the movie, influenced Wilberforce and served as his mentor.

One interesting scene depicts a debate in the House of Commons in 1778. The newly elected Wilberforce is advocating the withdrawal of British forces from America, thus abandoning the attempt to put down the rebellion. Wilberforce is attacked and challenged to distinguish between appeasement and surrender. "It's merely a question of timing," he says.

This scene, and many others, reveal that Great Britain was a functioning democracy at the time of the American Revolution. It contrasts markedly with the general impression of Americans who tend to think that this sort of representative democracy was invented by them in 1776.

William Wilberforce's third son was Samuel Wilberforce ("Soapy Sam") who became the Bishop of Oxford and debated evolution with Thomas Huxley in 1860.

Tangled Bank #86

 

The 86th issue of the Tangled Bank has been posted on Fish Feet [Tangled Bank #86].

Peter Lawrence on What's Wrong with Science

 
Peter Lawrence is a Professor at the University of Cambridge in Cambridge, UK. He has worked on various aspects of fruit fly development for almost 40 years. Readers may know him as one of the authors of Wolpert's Principles of Development or as the author of The Making of a Fly.

Peter is a very smart guy. He thinks a lot about the "big picture" and not just the minutiae of day-to-day work in a competitive environment. That's why his article in this month's issue of Current Biology is worth reading. Lawrence writes about what's wrong with modern science [The Mismeasure of Science].

For most scientists, there won't be any revelations in the article but it's put together well and covers all the bases. The main point is that today's scientists have to worry far too much about "productivity" in order to get funded. The system is geared towards artificial measurements of research success that may, or may not, reward creativity and innovation.

Modern science, particularly biomedicine, is being damaged by attempts to measure the quantity and quality of research. Scientists are ranked according to these measures, a ranking that impacts on funding of grants, competition for posts and promotion. The measures seemed, at first rather harmless, but, like cuckoos in a nest, they have grown into monsters that threaten science itself. Already, they have produced an “audit society” [2] in which scientists aim, and indeed are forced, to put meeting the measures above trying to understand nature and disease.

The journals are evaluated according to impact factors, and scientists and departments assessed according to the impact factors of the journals they publish in. Consequently, over the last twenty years a scientist's primary aim has been downgraded from doing science to producing papers and contriving to get them into the “best” journals they can [3]. Now there is a new trend: the idea is to rank scientists by the numbers of citations their papers receive. Consequently, I predict that citation-fishing and citation-bartering will become major pursuits.

You need to read the full article to get all the details.

So, what can we do about it? It's an old complaint, one that's been openly discussed even since I first met Peter Lawrence back in the mid-1970's. If a bunch of (relatively) smart scientists can't figure out how to fix the problem then maybe it's unfixable.

Here's where I think Lawrence drops the ball. He proposes the same tired old "remedies" that we've never adopted in the past in spite of the fact that we all pay lip service to their benefits. He wants us all to pay attention to "quality" and "originality" over quantity. He wants us to be more careful about putting authors names on a paper. He wants a code of ethics for scientists. He wants to reform the peer review process in the leading journals. None of this is going to happen as long as money is tight and the granting agencies have to come up with defensible policies for turning down 75% of grant applications.

The short term solution is to put more money into the grant system and to stop hiring more scientists. The long term solution is to look for better ways of funding. I like the idea of giving large block grants to departments and letting the researchers divide it up as they see fit. This would have worked well in any department I've been in but I hear horror stories about other departments.

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[Photo Credit: The photograph of Peter Lawrence is from his website at the University of Cambridge (Peter A. Lawrence]

Lawrence, P.A. (2007) The mismeasurement of science. Current Biology 17:R583-R585.

Half-Truths in Sicko?

 
Jim Giles reviewed Michael Moore's Sicko in the July 14th issue of New Scientist [Review: Sicko, directed by Michael Moore]. Like many reviews, this one conceded that Moore has a point about the shape of health care in the USA but was reluctant to admit that other countries are doing better. One paragraph mentioned "half-truths."

For the most part, Moore makes his case by absenting himself from the screen and allowing those who have been let down by the system to do the talking. Then he travels to the UK and France and finds that what conservatives in the US damn as "socialised medicine" actually works well. He does the same in Cuba, ferrying ill Americans to the island where they receive excellent healthcare at almost no cost. The result is a moving, funny and shocking film. It is a powerful call for change, despite its half-truths.

In last week's issue of New Scientist, a letter writer challenged Giles to produce his "half-truths," pointing out that the Sicko website documents every claim in the movie.

Here's how Jim Giles responded ...

The most obvious half-truths were the slanted depictions of the healthcare systems in the UK, France, and Cuba. The British NHS can be great, but waiting lists are often long and access to certain drugs can depend on where a patient lives. France's system is indeed highly rated, but Moore did not mention the very high taxes there. Cuba's public health is far above what would be expected for a country with limited resources and suffering the consequences of the US trade embargo, but it also restricts access to certain drugs and technologies.

Some of these sound very much like half-truths to me. Yes, waiting lists for non-lifethreatening procedures are often longer in countries with socialized medicine. That is, they are longer than the wait for similar procedures in a fully private system where people can afford to pay for it. On the other hand, the waiting time in the UK is a lot shorter than it is for Americans who can't afford decent health insurance, isn't it?

Access to certain drugs is restricted in all socialized medicine systems. For example, the system won't pay for drugs that don't work and haven't been approved. This is bad news for quacks who generally do much better under a private system. Socialized medicine often won't pay for expensive drugs if a cheaper alternative is available. Is this what Giles meant?

It's true that taxes are higher in countries that provide universal access to medical treatments. This isn't a half-truth in Sicko. As I recall, it's one of the main points. The US system is more expensive in spite of the fact that it's run by the private sector.

Gene Genie #13

 




Gene Genie #13 has been posted on The Genetic Geneologist [Gene Genie #13: Into the Future].

The Hominid Bush

 
Brian Switek of Laelaps has posted a wonderful essay on Homo sapiens: The Evolution of What We Think About Who We Are. Read it.

In a just world, the IDiots like Jonathan Wells would read what Brian, and others, have to say and stop spreading lies about what scientists think.

[Photo Credit: The photograph of Hamlet is from The Young Shakespeare Workshop]

Jim Watson on the Discovery of the Double Helix

 
THEME

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Deoxyribonucleic acid (DNA)
This is a nice addition to my earlier postings on the story of DNA [The Story of DNA (Part 1)][The Story of DNA (Part 2)]. This story (below) is straight from the horse's mouth.



[Hat Tip:Shalini].

University of Toronto Professor in Space

 
That's astronaut Dave Williams on the right. He's a University of Toronto adjunct professor of surgery. According the the University of Toronto press release,Williams was a Professor here in emergency medicine until he was selected for the astronaut training program in 1992 [U of T professor to walk in space].

Chautauqua Institution

 
Today we're off to the Chautauqua Institution for an entire week of learning and fun. I'm really looking forward to hearing Judy Collins on Tuesday.

This week's program is Music: Heart, Soul and Dollar. Last year it was Global Climate Change with Al Gore.

Next year we'll be attending the week on Darwin and Linnaeus: Their Impact on Our View of the Natural World. In 2009 it's a full week on Darwin again as we celebrate the 150th anniversary of something important. I'm hoping to offer courses on evolution next year and in 2009 so book now. :-)

Chautauqua is one of my favorite places in the USA. If you've never been there, you are missing some of the best that America has to offer. See the Wikipedia entry [Chautauqua Institution] for a brief description.

This is a great opportunity to mingle with people of various faiths and to attend discussions and debates about the intersection between faith and society. But it's not all about religion—there's a significant percentage of the guests who are non-religious and we don't have to hide it.

Misanthropic Principle

 
In the June 30th issue of New Scientist Paul Davies discussed the anthropic principle [The flexi-laws of physics]. He says,

If the universe came with any old rag-bag of laws, life would almost certainly be ruled out. Indeed, changing the existing laws by even a scintilla could have lethal consequences. For example, if protons were 0.1 per cent heavier than neutrons, rather than the other way about, all the protons coughed out of the big bang would soon have decayed into neutrons. Without protons and their crucial electric charge, atoms could not exist and chemistry would be impossible.

Physicists and cosmologists know many such examples of uncanny bio-friendly "coincidences" and fortuitous fine-tuned properties in the laws of physics. Like Baby Bear's porridge in the story of Goldilocks, our universe seems "just right" for life. It looks, to use astronomer Fred Hoyle's dramatic description, as if "a super-intellect has been monkeying with physics". So what is going on?

As far as we know, life exists on one small planet orbiting an insignificant star in an unremarkable galaxy off in one small corner of the known universe. This reminds me of a famous Mark Twain quotation [Mark Twain and the Eiffel Tower].

I really like the letter from Nathaniel Hellerstein that appeared in the July 21st issue of New Scientist.

If Paul Davies says that the universe is bio-friendly, then I say he hasn't taken a good look at it (30 June, p 30). The universe is bio-tolerant, maybe, or better yet bio-indifferent. Looking at the night sky, I do not see a cosmos optimised for producing life. It appears to be optimised for producing vacuum.

Even if the universe somehow "needs" life, it evidently doesn't need very much of it. Perhaps, from the cosmic point of view, life is a necessary evil, to be tolerated and limited.

I call this the misanthropic principle - it certainly fits the facts better than the anthropic principle does.

Cody on the Sandwalk

 


Here's a picture of Cody from 90% True on the Sandwalk.

Ethidium Bromide Is a Dangerous Chemical

 
Friday's Urban Legend: PROBABLY FALSE

Monday's Molecule #35 from last month was ethidium. The salt, ethidium bromide, is used as a dye to stain DNA [Ethidium Bromide Binds to DNA].

Most of us have heard that ethidium is a potent mutagen so you need to be very careful when using it in the lab. Wear gloves at all times and dispose of any excess ethidium solutions in the proper containers.

According to Rosie Redfield, a microbiologist at the University of British Columbia (Canada), this may have been an overreaction to the presumed dangers of ethidium bromide [Heresy about Ethidium Bromide].

THEME

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Deoxyrobonucleic Acid (DNA)Apparently ethidium is regularly used as a drug to treat African Sleeping Sickness and it shows no significant ill effects when used at doses that are 1000 times what we use in a typical laboratory.

Creationist Delusions about Transitional Fossils and Information

 
As expected, the IDiots are gloating over the widespread media misrepresentation of human evolution based on a recent Nature paper [The Ileret Skulls: My Two Cents] [Man Bites Dog].

Over on Uncommon Descent, one of our favorite IDiots has jumped on the bandwagon [Paleoanthropologists bungle again…]. The sycophants that are allowed to post comments on that blog have raised the old issue about the presumed lack of transitional fossils. As usual, they demonstrate their lack of understanding of evolution although, in this case, they have lots of company in the media and even among some scientists.

One person has posted this video of Richard Dawkins being interviewed by Creationists. The sycophants are delighted because it supposedly shows Dawkins being stumped by the demand that he give an example of the increase in genetic information in the genome. They ignore the second part of the video where he explains why we don't see the kinds of transitional fossils that the Creationists demand.



Look at the first part of the video. This is a very famous incident and Dawkins has written about it several times, most notably in a lengthy article on Australian Skeptics [The Information Challenge]. The article also appears in A Devil's Chaplain. Here's how Dawkins describes the incident.

In September 1997, I allowed an Australian film crew into my house in Oxford without realising that their purpose was creationist propaganda. In the course of a suspiciously amateurish interview, they issued a truculent challenge to me to "give an example of a genetic mutation or an evolutionary process which can be seen to increase the information in the genome." It is the kind of question only a creationist would ask in that way, and it was at this point I tumbled to the fact that I had been duped into granting an interview to creationists - a thing I normally don't do, for good reasons. In my anger I refused to discuss the question further, and told them to stop the camera. However, I eventually withdrew my peremptory termination of the interview as a whole. This was solely because they pleaded with me that they had come all the way from Australia specifically in order to interview me. Even if this was a considerable exaggeration, it seemed, on reflection, ungenerous to tear up the legal release form and throw them out. I therefore relented.

My generosity was rewarded in a fashion that anyone familiar with fundamentalist tactics might have predicted. When I eventually saw the film a year later, I found that it had been edited to give the false impression that I was incapable of answering the question about information content. In fairness, this may not have been quite as intentionally deceitful as it sounds. You have to understand that these people really believe that their question cannot be answered! Pathetic as it sounds, their entire journey from Australia seems to have been a quest to film an evolutionist failing to answer it.

With hindsight - given that I had been suckered into admitting them into my house in the first place - it might have been wiser simply to answer the question. But I like to be understood whenever I open my mouth - I have a horror of blinding people with science - and this was not a question that could be answered in a soundbite. First you first have to explain the technical meaning of "information". Then the relevance to evolution, too, is complicated - not really difficult but it takes time. Rather than engage now in further recriminations and disputes about exactly what happened at the time of the interview (for, to be fair, I should say that the Australian producer's memory of events seems to differ from mine), I shall try to redress the matter now in constructive fashion by answering the original question, the "Information Challenge", at adequate length - the sort of length you can achieve in a proper article.

Now that I've provided the link, I'm certain all the IDiots over on Uncommon Descent will read the Dawkins article and learn how new information gets into the genome. That should be the end of this little episode, right?

Dawkins on the Sandwalk

 
Somebody else has walked the walk [90% True]. They took a picture of Dawkins' book but if they have pictures of themselves on the Sandwalk I'd be happy to post them.

T. Ryan Gregory on the Sandwalk

John Wilkins on the Sandwalk

Walk the Sandwalk

[Hat Tip: PZ Myers]