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Wednesday, January 18, 2012

Scientists vs. Science Writers

 
Follow the discussion on Ed Yong's blog Not Exactly Rocket Science [Every scientists-versus-journalists debate ever, in one diagram].



The main problem isn't represented on the diagram. It's when good/bad journalists write articles in praise of bad science.

Monday, January 16, 2012

What Does a Secular Society Look Like?

 
Casey Luskin wonders What Would the World Look Like if the New Atheists Won the Day?. He's just read Penn Jillette's new book, God, No!: Signs You May Already Be an Atheist and Other Magical Tales, and he's "discovered" by selective quote mining that Penn would persecute Christians if the atheists ever gained power in America.

This leads Casey to speculate on what the secular world would look like if people abandoned their religion. He imagines that it won't be a nice place.
Back to the Secular Decade. If there's one thing to admire about Penn Jillette, it's that he's transparent about what he really thinks. If only more "new atheists" were so transparent, then the public might get a more realistic picture of what Faircloth's "Secular Decade" would really look like.
If Casey had been paying attention, he wouldn't have to look very far. Many European countries are well on their way to being truly secular societies. In the Netherlands, for example, only 34% of the population believes in God [Demographics of atheism]. If the New Atheists were to succeed in America then most people would abandon religion and life would go on pretty much as usual except that the society would become more rational, more understanding, and more tolerant. Creationism would become a joke, gays could marry, and women would have the right to choose. That's what's happened in the Netherlands and many other civilized countries.


Photo Credit: Amsterdam Tourism & Convention Board

The Mind of James Shapiro

I recently read Evolution: a View from the 21st Century by James Shapiro. It was a very annoying and frustrating experience. I do not recommend this book. I've already posted a rebuttal of his silly claim that the Central Dogma of Molecular Biology needs to be revised [Revisiting the Central Dogma in the 21st Century ]

The really frustrating part was trying to figure out Shapiro's agenda. He clearly has one. Is it just that he's against "conventional evolutionary theory"—whatever that is? Or, is he laying the groundwork for introducing God and intelligent design?

Shapiro denies that he's a supporter of intelligent design yet he published several papers with Richard Sternberg, one of the darlings of Intelligent Design Creationism. Furthermore, he (Shapiro) uses many of the same anti-evolution arguments used by Intelligent Design Creationists.

This prompted Bill Dembski to accuse James Shapiro of "dancing in the DMZ between Darwin and design" [Is James Shapiro a Design Theorist?].
For proponents of intelligent design, James Shapiro's constant dancing in the DMZ between Darwin and design can be frustrating. On the one hand, Shapiro is as dismissive of Darwinism as any ID proponent. On the other, he constantly gives public notice that he is not on the side of ID. And yet, methinks he protests too much.
This got a response from Shapiro that has now been posted on Evolution News & Views ["Is James Shapiro a Design Theorist?": James Shapiro Replies]. Here's what Shapiro says ...

What is wrong with "dancing in the DMZ" between intelligent design (as articulated by Michael Behe and others) and neo-Darwinism? Are these two positions the only alternatives? I doubt it. That is why my 1997 article in Boston Review on evolution debates was called "A Third Way." What Dembski calls the "DMZ" (i.e. a zone free of futile conflict) is the place where the real evolutionary science is taking place. I am proud to be there, and I see that an increasing number of people are joining me when they realize that natural genetic engineering, horizontal DNA transfer, interspecific hybridization, genome doubling and symbiogenesis provide solutions to problems recognized to be intractable under the limitations of conventional evolutionary thinking.
Clear as mud. There's one thing I know for sure: horizontal DNA transfer etc. are perfectly compatible with today's evolutionary thinking. If Shapiro is wrong about this—and he is— then maybe he's also misleading us about his belief in intelligent design creationism.

Saturday, January 14, 2012

Phytoplankton Blooms

 
This is a spectacular view of a phytoplanton bloom in the South Atlantic. It was taken by the Envisat satellite on Dec. 2, 2011 [A Southern Summer Bloom].

These phytoplankton blooms usually consist of a single species of microorganism. The fact that they can be seen from space gives you an idea of just how abundant they are. The blooms in the oceans can be due to diatoms or algae but by far the most common large blooms are due to cyanobacteria.

Prochlorococcus sp. and Synechococcus sp. have the largest population sizes of any species on the planet. About 30% of all oxygen production on the planet is due to marine phytoplankton and these two species account for a significant proportion.

A third genus of cyanobacteria, Trichodesmium, is mostly found off the coast of Australia. In addition to producing oxygen by photosynthesis, it is responsible for a considerable proportion of nitrogen fixation in the oceans.


[Hat Tip: Bad Astronomy]

Turn Off Your Irony Meters Before Reading This!!!

Back in the days of newsgroups (last century) the howlers in talk.origins developed a running joke about irony meters. They were always being fried by outrageous comments from the anti-science creationists. New, more powerful, irony meters were needed every few months.

The following post appeared on Uncommon Descent today: Is this where science fraud begins?. You are about to read an excerpt but I caution you to turn off your irony meter unless it's a Mark IX (beta) version. Even then, I'm not sure it will survive.

Denyse O'Leary quotes from an article published on Defining Ideas: The Death of Honesty by William Damon.
In July 2011, a widely-reported cheating scandal erupted in school systems in and around Atlanta, Georgia. State investigators found a pattern of “organized and systemic misconduct” dating back for over ten years. One-hundred-and-seventy-eight teachers, and the principals of half of the system’s schools, aided and abetted students who were cheating on their tests. Top administrators ignored news reports of this cheating: a New York Times story described “a culture of fear and intimidation that prevented many teachers from speaking out.”

Nor was this an isolated incident. In a feature on school testing, CBS News reported the following: “New York education officials found 21 proven cases of teacher cheating. Teachers have read off answers during a test, sent students back to correct wrong answers, photocopied secure tests for use in class, inflated scores, and peeked at questions then drilled those topics in class before the test.”

With such prominent and recent instances of cheating among students and teachers today, one would expect a concerted effort to articulate and promote the value of honesty in our schools. Yet school programs regarding academic integrity consist of little more than a patchwork of vaguely-stated prohibitions and half-hearted responses. Our schools vacillate between routine neglect and a circle-the wagons reaction if the problem boils over into a public media scandal. There is little consistency, coherence, or transparency in many school policies.
Let's think about the 178 teachers in schools around Atlanta, Georgia. It's pretty safe to assume that the vast majority of those teachers are god-fearing Christians and most of them don't accept evolution.

So, how does Denyse O'Leary explain why unethical behavior among teachers is so rampant?
The most likely reason is that the educators involved do not believe that anyone has made a free choice to cheat or that cheating is an ethical issue.

Chalk another one up to the high cost of evolutionary psychology and related trends.


Friday, January 13, 2012

Life: You Know It When You See It

 
Carl Zimmer, who blogs at The Loom, is interested in definitions of life. His latest essay highlights a definition proposed by Edward Trifonov who says that life is: "self-reproduction with variations" [Can A Scientist Define “Life”?].

It didn't take Sean Carroll (the physicist) very long to see one of the main problems with this definition; namely that Sean isn't alive! [Do I Not Live!].

It's true that we should not restrict our definition of life to things that can self-reproduce. It's also true that we should not restrict our definition to things that reproduce badly (e.g. mutation/variation). I can easily imagine living things that could reproduce perfectly—they just wouldn't evolve by any mechanism we currently recognize.

Life is like pornography [I know it when I see it]. In the words of US Supreme Court Justice Potter Stewart,
I shall not today attempt further to define the kinds of material I understand to be embraced within that shorthand description ["hard-core pornography"]; and perhaps I could never succeed in intelligibly doing so. But I know it when I see it, and the motion picture involved in this case is not that.


Wednesday, January 11, 2012

Weep for the Poor Persecuted IDiots

 
The Intelligent Design Creationists at Evolution News & Views and Uncommon Descent have been pushing the idea that acceptance of evolution is associated with moral decay and the rise of Adolph Hitler. Recently, an IDiot going by the pseudonym of "kairosfocus" posted a similar attack on his blog: Visually exposing the Anti-Christ spirit of Nazism (and correcting the New Atheist "Hitler was a Christian" smear often used in retort to exposing* the Social Darwinist history of ideas roots of Hitler's thought.

The goal, obviously, is to link the scientific fact of evolution to the evils of social Darwinism and eugenics.

Somebody posted as comment on that blog (or a related blog) saying ...
xxx, the religious wacko who owns and runs this site, blames all the world’s ills, including Hitler and the nazis, on Darwin, atheists, and material evolutionists.

To see the truth about Hitler and the nazis, see these XXXXXXX:

XXXXXX is a LYING, arrogant, bloviating, sanctimonious, ignorant, uneducated, abusive, delusional god zombie.

See this site for a lot more about XXXXX:
The comment has been removed.

Now "kairosfocus" has complained on Uncommon Descent that such "vandalism" is outrageous and misguided [FOR RECORD: What we are dealing with . . . an example of web stalking and vandalism].
Now, this vandalism of a site wholly unrelated to the matters debated at UD (and tied onwards to a hate site that exploits Google’s freedom of comment policies), was evidently in response to my having posted here at UD, matters linked to the well-known history of ideas roots of Hitler’s thought. I therefore suggest that onlookers examine the Weikart lecture and a discussion of a key clip from Mein Kampf that demonstrated the Darwinist-Haeckelian frame of thought, that beyond reasonable doubt strongly shaped Hitler’s thinking, speech and behaviour. (Those needing documentation on Hitler’s actual attitude to and intentions for the Christian Churches, can look at the recently released Nuremberg investigatory documents here. If after seeing these documents and the like, someone still insists on trying to claim Hitler was a Christian etc etc, s/he is delusional and/or willfully deceitful.)
Furthermore, the behavior of this "vandal" is exactly what "kairosfocus" expects.
As they say, a tree is known by its fruits, and draws sustenance from its roots . . .

(In addition, a note on “blaming the world’s ills.” The likes of this hate-driven commenter will not appreciate or accept that a Bible-believing Christian will hold that much of what ails our world traces to our common challenge of being finite, fallible, morally fallen and too often ill-willed. Hence, our common need for recognition of our moral plight, repentance, forgiveness and moral-spiritual transformation through the gospel. Slander-laced strawmen and scapegoats are ever so much more easy to set up and ignite through irresponsible rhetoric that then clouds, polarises and poisons the atmosphere.)

That refusal to be responsible over a moral hazard closely tied to the Darwinist, evolutionary materialist frame of thought, and that refusal to acknowledge well-established historical facts that are inconvenient to the new atheist agenda are tellingly informative.

The pattern of obsessive, self-justifying, nihilistic hate, stalking, slander, Internet vandalism and abuse is even more informative about an unfortunately significant subset of the New Atheist movement and the danger its patent extremism poses. (After this sort of web vandalism, and worse, can any reasonable person doubt why moderation is necessary to maintain a reasonable tone at UD and elsewhere?)

Ironically, the very conscience benumbed self-justifying by smearing scapegoats that this sort of behaviour demonstrates on the small scale, is what — when such attitudes attained state power — led to the utter breakdown of morality on the grand scale that over 100 million ghosts from the past century tell us never to forget.

Can any reasonable person doubt that had a commentator like the above the power to do as he wished and get away with it, he would do me and my family further harm?

It is time for the New Atheist advocates of evolutionary materialism to take a serious look at what they have been enabling by their intemperate writings and attitudes.
Every atheist blogger gets far worse comments from Christians on a regular basis. Most of us get harassing emails every single day and the authors usually identify themselves as devout Christians doing God's work. These same Christians don't hesitate to send threatening messages to our colleagues and family members in an effort to silence us. Some of the Christian kooks are so dangerous that they have been arrested by police and are currently under forcible confinement in a mental health institution.

Don't weep for the IDiots. They need to examine their own beliefs since it's the creationists who are the biggest threat on these blogs. There must be something wrong with Christianity if that's the kind of activity it promotes. It is time for the Christian opponents of science to take a serious look at what they have been enabling by their intemperate writings and attitudes.


Monday, January 09, 2012

Monday's Molecule #155

 
We're going to talk about the evolution of this molecule in my class tomorrow. It's a good examples for illustrating some basic principles of molecular evolution.

You need to identify the exact molecule, including the species. Here's a hint: ANKSKGIVWN.

Post your answer in the comments. I'll hold off releasing any comments for 24 hours. The first one with the correct answer wins. I will only post correct answers to avoid embarrassment.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your comment.)

Some past winners are from distant lands so their chances of taking up my offer of a free lunch are slim. (That's why I can afford to do this!)

In order to win you must post your correct name. Anonymous and pseudoanonymous commenters can't win the free lunch.

Winners will have to contact me by email to arrange a lunch date.

UPDATE: The winner is Dima Klenchin who was the first to identify the molecule as cytochrome c from tuna (Thunnus alalunga). The figure is from the PDB file 3CYT. This PDB file supercedes 1CYT which was reportedly from another species of tuna.

Winners
Nov. 2009: Jason Oakley, Alex Ling
Oct. 17: Bill Chaney, Roger Fan
Oct. 24: DK
Oct. 31: Joseph C. Somody
Nov. 7: Jason Oakley
Nov. 15: Thomas Ferraro, Vipulan Vigneswaran
Nov. 21: Vipulan Vigneswaran (honorary mention to Raul A. Félix de Sousa)
Nov. 28: Philip Rodger
Dec. 5: 凌嘉誠 (Alex Ling)
Dec. 12: Bill Chaney
Dec. 19: Joseph C. Somody


Saturday, January 07, 2012

Recent Advances in Intelligent Design Creationism

 
In case you missed it, 2011 was a wonderful year for the IDiots. There were many "scientific" breakthroughs supporting the existence of god an intelligent designer. Access research network provides a list of the top ten "Darwin and Design" news stories for 2011.

I'll just give you the titles. Most of you have already read these very important science papers. The rest of you can access more information at: Top Ten Darwin and Design
Science News Stories for 2011
.
  1. 50th Peer-Reviewed Pro-ID Scientific Paper Published
  2. The Design of the Butterfly Continues to Inspire and Amaze
  3. Woodpecker Drumming Inspires Shock-Absorbing System
  4. Stylus Aims to Bridge Gap Between Real World and Artificial Evolutionary Simulation
  5. Explosive Radiation of Flowering Plants Confirmed
  6. Golden Orb-Weaver Fossil Spider Provides New Evidence for Stasis
  7. Complexity in the Universe Appears Earlier Than Thought
  8. An Identity Crises for Human Ancestors
  9. DNA Repair Mechanisms Reveal a Contradiction in Evolutionary Theory
  10. The Limits to Self-Organization Identified
The nice thing about this list is that it gives us a very good view of the quality of data supporting Intelligent Design Creationism. This is the best they have.


The God helmet is used by Michael Persinger in his neuroscience "research." When you put on the helmet it makes you see God. It's just one of many illusions that supposedly reveal the presence of a supernatural being. Of course it has nothing to do with the content of this post.

The Santorum Amendment

 
Rick Santorum is a potential candidate for President of the United States. He is currently seeking the nomination of the Republican party and so far he seems to be a leading candidate in spite of his bizarre views on many issues. The process involves things called state "primaries" which seems to be a way of generating free publicity for the two sanctioned parties.

Back in 2001, Santorum was a Senator from Pennsylvania. He was a leading proponent of Intelligent Design Creationism and he proposed an amendment to a major education bill that was being considered by the United States Senate.1 The original Santorum Amendment was described by Santorum in a brief speech ...
This is an amendment that is a sense of the Senate. It is a sense of the Senate that deals with the subject of intellectual freedom with respect to the teaching of science in the classroom, in primary and secondary education. It is a sense of the Senate that does not try to dictate curriculum to anybody; quite the contrary, it says there should be freedom to discuss and air good scientific debate within the classroom. In fact, students will do better and will learn more if there is this intellectual freedom to discuss. I will read this sense of the Senate. It is simply two sentences—frankly, two rather innocuous sentences—that hopefully this Senate will embrace: "It is the sense of the Senate that—

(1) good science education should prepare students to distinguish the data or testable theories of science from philosophical or religious claims that are made in the name of science; and
(2) where biological evolution is taught, the curriculum should help students to understand why this subject generates so much continuing controversy, and should prepare the students to be informed participants in public discussions regarding the subject.

It simply says there are disagreements in scientific theories out there that are continually tested.
The original amendment was drafted by Philip Johnson in consultation with other fellows of the Discovery Institute.

This amendment did not make it into law but a similar version was included in something called a "Conference Report" where it is often cited by Intelligent Design Creationists.
The Conferees recognize that a quality science education should prepare students to distinguish the data and testable theories of science from religious or philosophical claims that are made in the name of science. Where topics are taught that may generate controversy (such as biological evolution), the curriculum should help students to understand the full range of scientific views that exist, why such topics may generate controversy, and how scientific discoveries can profoundly affect society.
Taken at face value, these statements seem to provide an excellent opportunity for science teachers to explain how religion distorts science. They would provide legal justification for teachers who want to describe how religious views conflict with science and why scientific facts, such as evolution, generate so much controversy among religious Americans.

But that's not how the amendments are interpreted by most people. Here's Rick Santorum explaining in 2009 what the amendment really meant. It's clear that many Senators, including Ted Kennedy, were duped.




1. In American legislatures, it's normal that completely irrelevant material is inserted into bills.

Should Undergraduates Study the Primary Scientific Literature?

 
The short answer to the question posed in the title is "yes" but there are many caveats. One of them is that it depends on what level you are teaching. In my opinion, the value of exposing science students to the primary scientific literature (papers) increases as students progress from first year to the year they graduate. Students in their final year of a science program will gain a lot from being exposed correctly to the scientific literature but students in introductory course will hardly benefit at all—and may, in fact, be harmed if it takes time away from learning basic principles and concepts.

It is important to teach critical thinking and it's important to focus education on basic principles and concepts. Most of the basic principles and concepts in a discipline have been developed over several decades. The work that led to those ideas is (usually) in the primary scientific literature but you can't learn the concept by just reading a few key papers. Evolution is a good example but so is our understanding of how cells generate energy from proton gradients, how enzymes work, and how the information in messenger RNA gets translated into proteins.

I find it helpful to remind myself from time to time that the vast majority of the students I teach will never be scientists and many of them aren't really interested in how to do scientific experiments. They will become average citizens in all kinds of careers that have nothing to do with the basic sciences. Our goal is to make them scientifically literate so they will understand why evolution is true, why homeopathy is bunkum, why they should vaccinate their children, and why humans are behind global climate change. I don't think we can achieve that goal by focusing on the primary scientific literature, especially in the early years of undergraduate education.

C.R.E.A.T.E. is a education project funded by the United States National Science Foundation (Grant No. 1021443). It's goal is "transform understanding of science" by using the primary scientific literature as a teaching tool. Here's how they describe their approach ...
The C.R.E.A.T.E. (Consider, Read, Elucidate the hypotheses, Analyze and interpret the data, and Think of the next Experiment) method is a new teaching approach that uses intensive analysis of primary literature to demystify and humanize research science for undergraduates. Our goal is to use the real language of science—the journal article—as an inroad to understanding “who does science, how, and why?” At the same time, we wish to help students (1) experience authentic processes of science, in particular discussion/debate about experimental data and their interpretation (including ‘grey areas’), (2) recognize the creativity and open-ended nature of research, and (3) see the diversity of people who undertake research careers (i.e. not just the genius/geeks of popular culture). As a complement to teaching based on textbooks, which tend to oversimplify the research process, C.R.E.A.T.E. teaching focuses on on authentic published work--peer reviewed journal articles—with students reading either series of papers produced sequentially from individual labs or series of papers from different labs focused on a single line of research.

By reading/analyzing a set of papers published in series from a single lab, students experience the evolution of research projects over a period of years. Using newly-developed C.R.E.A.T.E. pedagogical tools, that encourage multiple approaches to the material (concept mapping, sketching, visualization, transformation of data, creative experimental design) students gain deep understanding of the methods (and biological content/principles) that underlie each individual experiment of the paper. In class, we emphasize scientific thinking--focusing on understanding both why and how each part of the study was done, by examining the hypotheses underlying each aspect of the study, and analyzing/discussing the data represented in each figure and table. Students learn to interpret complex data, draw conclusions, debate interpretations, and re-represent data (e.g. represent tabled data in graphic form) to aid understanding. Content knowledge is reviewed as students consider the principles underlying the techniques used, as well as the overall context of the scientific question being addressed (e.g. a module focused on regeneration would likely include review multiple aspects of cell division, cell differentiation, gene expression and stem cells, drawing on information students learned in other classes and helping them to apply it in a real-world research situation). C.R.E.A.T.E. students thus learn a variety of transferable learning skills that can be applied to complex scientific reading they do in the future. Students design their own proposed followup experiments at several points in the semester, and debate each other’s proposed studies in a classroom exercise modeled on activities of bona fide scientific grant panels. Such discussions reveal the research process to be openended, with multiple branch points or possible “next directions to go;” thus much less linear and predictable than many students expect. Late in the process, students generate a short list of questions for paper authors that are sent as an email survey to each author (not simply the PI). Responses from multiple authors provide unique behind-the-scenes insight into “the people behind the papers,” humanizing the research experience and showing researchers to be complex individuals much like the students themselves.
Here's an example based on Pattern formation during regeneration in planaria.

This is an approach that views experiment as the primary focus of science whereas I tend to see science as a much broader way of knowing. The C.R.E.A.T.E. approach to undergraduate education emphasizes the doing of science rather than the understanding of the results and how they fit into a bigger picture. It probably does a good job of looking at "trees" but not so good a job when it comes to seeing the "forest."

I don't know the correct balance between teaching principles, ideas, and concepts and teaching the experimental approach taken by actual research scientists in their day-to-day activities. There's no question that lab courses are extremely important but I'm quite skeptical about bringing the study of experimental techniques into the lecture courses if it take time away from the conceptual understanding of the discipline.


[Hat Tip: Sandra Porter at Discovering Biology in a Digital World: Learn how to use scientific articles in education at the C.R.E.A.T.E. June workshop]

Chris Hogue on Complexity and Evolution

 
Chris Hogue is a Canadian biochemist/bioinformatician who works on protein folding (among other things) at the National University of Singapore. He used to be a professor in my department here at the University of Toronto. I miss him, and wish he were still here.

Chris blogs at BioImplement and he has just started a new series of posts on Complexity and Evolution. His goal is to explain how human design can inform us about evolution. The idea is to refute the arguments of Intelligent Design Creationists who treat intelligent design as something mystical that's1 beyond naturalism.

Here's how Chris explains what's coming ...
The thread connecting these examples of human design is that each one is an analogy to biological evolution, from which evolution may be better understood by laypersons. Now by posting new examples like this, I realize that they may all be stolen by the “intelligent design” (ID) creationists to argue against evolution. My view on ID follows that most clearly expressed in the 2005 court judgment from the Pennsylvania Kitzmiller v. Dover case: “The overwhelming evidence at trial established that ID is a religious view, a mere re-labeling of creationism, and not a scientific theory.” Of course a few scientists have written in defense of evolution and against ID nonsense in the classroom, the most strident of whom is Richard Dawkins. I now add my voice in support, as in his final interview with Dawkins, Christopher Hitchens lamented “It’s the shame of your colleagues that they don’t form ranks and say, ‘Listen, we’re going to defend our colleagues from these appalling and obfuscating elements.’”

So into the breach, I add my voice with some new arguments, after this small bit of throat-clearing. I will try to avoid being derivative as I come armed with my own capacity for inquiry, insight, and argument. My examples will show how ID concepts force the gerrymandering of human design history, and surround it with mystical borders to make their claims. The individual steps in human design are small, slow and absolutely require the intellectual imprinting of lessons by trial and error. Students who are led to think falsely about human design, or any complexity as having mystical origins are harmed by the diminishment of their own aspirations of creativity. We all need to understand how small steps and tools lead to human creativity and any object of complexity. I will reveal these small steps and show, where I can, the failures that led to success.
I know Chris and I can assure you that his upcoming posts will be provocative and informative.




Friday, January 06, 2012

Plant microRNAs in Your Blood?

 
Last month the science magazines and websites were all talking about a paper by Zhang et al. (2012) published in Cell Research. These workers discovered plant micoRNAs in the serum of mice and humans. The microRNAs seem to come from ingested rice. Presumably the micoRNAs are taken up in the intestine and secreted into the blood in small vesicles. The concentration of the major rice miRNAs in serum is about 10 fM or 10×10-15 moles per liter.1

The authors have shown that microRNA MI168a binds to the mRNA of low-density lipoprotein receptor adapter protein 1, inhibiting translation. This leads to the idea that ingested plant microRNAs can regulate the expression of human genes. That's the story that generated the most press [What You Eat Affects Your Genes: RNA from Rice Can Survive Digestion and Alter Gene Expression, Food We Eat Might Control Our Genes].

This is one of those findings where the explanation doesn't make a lot of sense but the data seem sound. It seems very unlikely that small plant RNAs could survive the processing and digestion of rice or any other food and even less likely that they would find their way into the bloodstream where they could play a role in regulating mammalian gene expression. I think I'll wait for confirmation.

It's a shame that none of the articles in the popular press expressed any sort of skepticism. That's one of the problems with science journalism. How do you convey the idea that all scientific results are preliminary until they have been confirmed by others?


1. That concentration is far below the concentration where effective binding can occur but the idea seems to be that the micoRNAs are contained in small vesicles that subsequently fuse with liver cells and deliver the rice microRNA to the cytoplasm where it can inhibit translation of specific mammalian RNAs. It's difficult to see how one could get an effective concentration of plant microRNA in one of these mammalian cells.

Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., Yin, Y., Wang, C., Zhang, T., Zhu, D., Zhang, D., Xu, J., Chen, Q., Ba, Y., Liu, J., Wang, Q., Chen, J., Wang, J., Wang, M., Zhang, Q., Zhang, J., Zen, K., and Zhang, CY. (2012) Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Research 22:107–126 [PubMed] [doi:10.1038/cr.2011.158]

An important correction to several of the figures in this paper has also been published.

Zhang et al. (2012) Corrigendum [doi:10.1038/cr.2011.174]


Carnival of Evolution #43

 
This month's Carnival of Evolution (43rd version) is hosted by The EEB & Flow, a blog written by a large group of people interested in evolution and ecology [Carnival of Evolution #43]. The post was written by Marc Cadotte [Cadotte Lab], a professor in the Department of Evolution & Ecology right here at the University of Toronto.
You no longer need to ponder the mysteries of life, travel the globe making observations, or running complex experiments to test hypotheses; everything you want to know about evolution today can be found by reading the monthly installments of the Carnival of Evolution!

The first installment of 2012 (or is this the last of 2011?) offers a great smattering of many different aspects of current evolutionary understanding. These 26 posts cover many of the major areas of research that define current evolutionary biology.

The next Carnival of Evolution (February) needs a host. Contact Bjørn Østman at Carnival of Evolution if you want to volunteer. Meanwhile, you can submit your articles for next month's carnival at Carnival of Evolution.


Sunday, December 25, 2011

And the Winner Is .....

 
I collected the names of all the undergraduates who got the right answer for Monday's Molecules. I put them on slips of paper and had my colleague, Alex Palazzo draw one of them from a small beaker.

Alex still has a blog on Scienceblogs called Transcription and Translation (formerly The Daily Transcript) but he hasn't blogged very much recently. He's too busy doing experiments.

What name did he draw out of the beaker?

The winner of a free autographed textbook is .....

Thursday, December 22, 2011

The Cambrian Conundrum: Fossils vs Genes

The earliest fossil examples of most animal classes and phyla appear in the fossil record at about the same time in the Cambrian (about 530 million year as ago (Ma)). This period of apparent rapid divergence is referred to as the "Cambrian Explosion."

It seemed unlikely that this disparity could have evolved in just a few million years so many scientists have been searching for fossil antecedents in the early Cambrian and Ediacaran (635-541 Ma). Many trace fossils have been found in the past few decades, indicating that the fossil animals of the Cambrian were preceded by small wormlike creatures.

The other approach has been sequence analysis. One can construct molecular phylogenies by comparing the sequences of genes in modern extant organisms. This approach has been highly successful over the past fifty years so that we now know a great deal about the relationship of the various animal phyla. The correspondence between the old morphological taxonomy and molecular evolution is the most powerful evidence we have that evolution explains the history of life [see Twin Nested Hierarchies].

The problem with sequence comparisons has always been getting accurate dates using the molecular clock. It is hard to get an accurate date when dealing with events that occurred 500 million years ago because there aren't very many calibration points. An accurate calibration point is a known time when two lineages diverge.

If there really was a rapid divergence in the Cambrian then one would expect the molecular tree to show this. But it never has. The molecular phylogeny shows that chordates diverged from invertebrates at least one hundred million years before their fossils appear in the Cambrian. Similarly other phyla and classes of animals have their origin long before the Cambrian, according to the molecular clock.

A recent paper in Science extends this comparison by calculating more a more accurate molecular phylogeny using seven housekeeping genes from 118 different species (Erwin et al. 2011). The result is shown in Figure 1 of the paper: "The origin and diversification of animals as inferred from the geologic and genetic fossil records." (Click on the figure to embiggen.)

Do the IDiots Understand Biochemistry and Molecular Biology?

 
We've been discussing whether Intelligent Design Creationists understand enough about biochemistry, molecular biology, and evolution to warrant their criticisms of these fields. The answer is clearly "no" as they demonstrate time and time again.

This time it's an anonymous posting on the premier IDC website, Evolution News & Views [Long Non-coding RNA Punches Another Hole in "Junk Genome" Myth]. The anonymous poster links to a recent paper in Genes & Development that shows a function for a particular long non-coding (lnc) RNA. The paper implies that many of these lncRNAs (up to 400) are expressed in mouse erythroid cells.

Regulatory RNA have been known and studied for at least four decades and various lncRNAs have been characterized over the past twenty years. The IDiot at Evolution News & Views seems to think that this is a new discovery proving that there's no junk in our genome. The facts are quite different.

As I pointed out in my review of The Myth of Junk DNA, the amount of the genome devoted to producing lncRNAs is about 0.1% [Junk & Jonathan: Part 6—Chapter 3]. So, not only have we known about regulatory RNAs for many years, we also know that their genes don't account for very much of the genome, I figure it can't be more than 2% even when you include all of the most optimistic estimates of regulatory RNAs [see What's in Your Genome?].

But the ignorance of the IDiots is much more profound than just being incapable of calculating percentages. The latest posting reveals the depth of their ignorance.
These findings have two important implications. First, non-coding regions of the genome were assumed to be leftover evolutionary relics that no longer play a functional role. The assumption was not due to extensive studies of non-coding regions of the genome, but rather to a commitment to what is known as the central dogma of molecular biology: DNA is transcribed into RNA and RNA is translated into amino acids to make proteins. This was considered the primary purpose of DNA. The non-coding regions were assumed to have no function, and were dismissed as the natural consequence of genetic "junk" accumulating over time. This paper is one among an accumulating corpus of papers discussing new and interesting functions of the non-coding regions of the genome. (See The Myth of Junk DNA by Jonathan Wells for a history of "junk" DNA and additional references describing the function of so-called "junk" DNA. See here for a discussion on the regulatory role of introns.)
There was never a time in the past fifty years when knowledgeable biochemists and molecular biologists thought that all non-coding DNA was nonfunctional junk. This was never an assumption of the Central Dogma of Molecular Biology which states that "... once (sequential) information has passed into protein it cannot get out again" [Basic Concepts: The Central Dogma of Molecular Biology]. There are many scientists who have misconceptions about the Central Dogma [The Central Dogma Strawman] but the IDiots go one step farther by misunderstanding the misconception!

We've known about functions in non-coding DNA since the early 1960s as anyone who has ever glanced at a textbook would know. It's hard to tell whether the IDiots are just butt-ignorant of basic science or whether they are lying. This is an especially tricky problem when the silly strawman argument is popularized by Jonathan Wells because he's supposed to know the science [Junk & Jonathan: Part 1—Getting the History Correct] [Junk & Jonathan: Part 2— What Did Biologists Really Say About Junk DNA?].

We know that most of our genome is junk because we know a great deal about genomes, genes, biochemistry, molecular biology, and evolution. We know which parts are likely to be functional and which parts are likely to be broken genes and other kinds of junk. We know this because we understand the subject, not because we are covering up our ignorance.

The IDiots are ignorant of the science and they assume that everyone else is as well. That's a very bad assumption.


Wednesday, December 21, 2011

Center for Inquiry Canada: New Associate Members

 
The Board of Directors voted on accepting new Associate Members at its December 11th meeting. I have just received a letter from the Board signed by the new (?) Chair, Richard Thain.
Dear Professor Moran,

On December 11, 2011 one of the many important items on the agenda for the Board od Directors meeting was discussion of the applications for Associate Membership.

The goal is to have a diverse group of Associate Members which reflects our membership geographically. In order to achieve this, the Board recognizes that we must update our website and post the By-Laws which explain the governance of CFI Canada. We hope to attract more applications which will then be reviewed before the next CFI Canada AGM in March 2012.

We felt it was important to approve some of the applications at the December 11th board meeting, so we reviewed and accepted the following five people:

Iain Martel, Seanna Watson, Brian Eelhart, Craig Irving and Marlowe Filippov.

The other applications were put under review and will be considered with the next wave of applicants at a future board meeting.

The Board of Directors realizes you have made and are continuing to make significant contributions to our success. We would like to sincerely thank you for your continued support and committment to helping CFI build a better Canada through reason.

Richard Thain DDS
Chair, Board of Directors
CFI Canada
My application was rejected!

I wish I knew why the Board didn't accept my application but did accept some others. Iain Martel is the Chair of CASS and Seanna Watson is the Director of the Ottawa branch of CFI so I assume that the people filling these positions are a sort of ex officio Associate Members. That makes a lot of sense especially for Iain and Seanne who have devoted so much time and effort to CFI.

Bryan Eelhart was the Financial Agent for the Green Party in the riding of Trinity-Spadina (Toronto) during the recent Ontario election. He's a member of the Board of Directors at Conscience Canada and he works for Science for Peace. Bryan has extensive expertise in website design and implementation.

Craig Irving is a freelance videographer from Toronto. He serves on the Multimedia Committee at Centre for Inquiry Canada.

Marlowe Filippov lives in Ottawa where she volunteers at the Centre for Inquiry. She's also an expert in websites. She's been helping out with membership problems and advising the National Director on other issues.

It appears that three two of the new Associate Members were chosen for their ability to help out with updating the CFI website.

There are currently three Associate Members who are CFI Advisory Fellows; Jeff Rosenthal from Toronto, Chris diCarlo from Guelph, and Ethan Clow from Vancouver. It's possible that the Board of Directors felt that only three CFI Canada Advisory Fellows should also be Associate Members, or maybe they felt that having two from the Toronto area was too much and that's why my application was rejected.

I'll try and find out more about the qualifications required for Associate Membership. It's clear that length of membership in CFI is not important since there are Associate Members who only joined CFI two years ago. I think that active volunteering on administrative tasks is an important criterion so if you are currently helping out in this area you will probably have a good chance of being appointed.

I'm a little unclear about the criterion of reflecting membership geographically. About half of all CFI Canada members are from the Toronto area but I don't think this means that half of the Associate Members will be from Toronto. I think it means that you're more likely to be chosen as an Associate Member if you are from one of the other centres that isn't already represented.

I'm not sure what the role of a CFI Canada Advisory Fellows is supposed to be. If we can't be Associate Members then who are we supposed to advise? :-)

Post a comment if your application was also rejected. That way we might be able to figure out what the Board of Directors is thinking when it comes to appointing new Associate Members. I'll let the Board know about this posting so they can comment, or at least see your comments.


A Torley Defense of Irreducible Complexity

Vincent Joseph Torley (vjtorley) has a Ph.D. in Philosophy (2007) from the University of Melbourne (Australia). He currently teaches English in Japan.

Torley hangs out at Uncommon Descent where he tries to defend Intelligent Design Creationism. He didn't like my recent posting on Irreducible Complexity [Barry Arrington Explains Irreducible Complexity] because I accused Barry Arrington of not understanding evolution. You might recall that Arrington began his defense of irreducible complexity by saying, "(1) By definition, evolution can work only in a stepwise fashion wherein each successive step is “selected for” because it has conferred a selective advantage on the organism."

This is not how evolution is defined and it's a particularly bad way to begin because the scientific understanding of many irreducibly complex systems involves the fixation of neutral or even detrimental alleles. Competency in evolution also requires an understanding of redundancy, contingency, and sloppiness.

Vincent Joseph Torley asks, "Will this do, Professor Moran?" He starts with ....
Let me state up-front that I am a philosopher, not a scientist. However, I believe in arguing rigorously, so I have attempted to state the argument from irreducible complexity in a rigorous fashion. I’d appreciate hearing from Professor Moran thinks of this argument, as a biologist.

Tuesday, December 20, 2011

These are not berries!

 

This is Juniperus communis from Botany Photograph of the Day. If you visit that website you'll learn two three things about juniper that you didn't know before: (1) juniper grows in lots of places, (2) the "berries" aren't berries, (3) gin comes from the French word for juniper.


The Mite Genome

 
The genome of the two-spotted spider mite, Tetranychus urticae has been sequenced and the results were published in Nature last month (Grbic et al. 2011).

Spider mites eat plants. They produce silk-like webs and that's why they're called "spider mites". They belong to the class Arachnida, which is the same group that contains spiders. The Arachnids are in the subphylum Chelicerata, a large group of arthropods distantly related to the insects and crustaceans. This is the first genome sequence of a chelicerate and that's why it's important.

Genome Size

The genome is only 90 Mb in size. It's the smallest arthropod genome that has been sequenced so far. Contrast this size with the human genome at 3,200 Mb or the genome of another tick, Ixodes scapularis, estimated to be 2,100 Mb. (Honeybee = 236 Mb, Drosophila = 140 Mb.) According to Ryan Gregory's animal genome size database this is the smallest known arachnid genome and the smallest known arthropod genome.

The authors estimate that there are 18,414 protein-encoding genes in the mite genome. This is about the same number of genes as most insects whose genomes have been sequenced and only slightly less than the number of genes in the human genome.

About 41% of the mite genome consists of exons (protein-encoding). Recall that less than 2% of our genome encodes proteins and in most insects the exon sequences make up less than 10% of the genome. (Honeybees and Drosophila also have smaller than average genome sizes.)

Introns

As you might imagine, the mite genome has a lot less junk DNA than other animals. This is partially reflected in the number and size of the introns. The average protein-encoding gene has less than three introns and the ones that are present are a lot smaller than the introns in species with larger genomes.

The figure on the right is a truncated version of a figure that appears in the supplemental information. It shows that the smallest introns are 40 bp and 70% of all introns are less that 150 bp in length (median = 96 bp). This is close to the smallest possible intron size allowing for slices sites and formation of a loop during splicing.

Transposons and Repetitive Sequences

Transposons (active and degenerate) make up less than 10% of the T. urticae genome and highly repetitive sequences (microsatellites) are almost absent. (The spider mite chromosomes don't have centromeres.)

Transposon sequences and highly repetitive sequences are a major component of the junk DNA found in large genomes so their absence in the mite genome is not a surprise.

Why Is the Mite Genome So Small?

The short answer is, we don't know. The long answer is much more complicated. As Michael Lynch points out (Lynch 2007 p.37), there's a balance between rates of insertion and deletion mutations. In species with small genomes the spontaneous rate of nucleotide deletion exceeds that of insertion so genome sizes shrink over time.

There may not be a selective advantage to having small or large genomes. It may just be that in some species the repair machinery tends to favor deletions while in closely related species the enzymes don't have this bias. Or maybe large genomes are slightly deleterious but the population size isn't large enough to allow natural selection to act. Some lineages may never have encountered significant bottlenecks so they've maintained a huge population size for millions of years allowing natural selection to operate on slightly deleterious mutations. This leads to smaller genomes.

Whatever the explanation, the small genome of mites shows us that most of the junk DNA present in other arthropod genomes is dispensable. That's why it's called "junk."



Grbic, M. et al. (2011) The genome of Tetranychus urticae reveals herbivorus pest adaptations. Nature 479:487-492. [doi: 10.1038/nature10640] [PubMed]

Lynch, M. (2007) "The Origins of Genome Architecture" Sinauer Associates, Inc. Publishers, Sunderland, Massachusetts, United States

Monday, December 19, 2011

Jonathan McLatchie and Junk DNA

 
THEME

Genomes & Junk DNA
Jonathan McLatchie takes on PZ Myers in a spirited attack on junk DNA [Treasure in the Genetic Goldmine: PZ Myers Fails on "Junk DNA"]. The Intelligent Design Creationists are convinced that most of our genome is functional because that's what a good designer would create. They claim that junk DNA is a myth and their "evidence" is selective quotations from the scientific literature. They ignore the big picture, as they so often due.

I discussed most of the creationist arguments in my review of The Myth of Junk DNA.

Jonathan McLatchie analyzes three argument made by PZ Myers in his presentation at Skepticon IV. In that talk PZ said that introns are junk, telomeres are junk, and transposons are junk. I have already stated that I diasgree with PZ on these points [see PZ Myers Talks About Junk DNA]. Now I want to be clear on why Jonathan McLatchie is wrong.
  1. Introns are mostly junk. I think PZ exaggerated a bit when he dismissed all introns as junk. My position is that we should treat introns as functional elements of a gene even though many (but not all) of them could probably be deleted without affecting the survival of the species. Each intron has about 50-80 bp of essential information that's required for proper splicing [Junk in Your Genome: Protein-Encoding Genes]. The rest of the intron, which can be thousand of base pairs in length, is mostly junk [Junk in Your Genome: Intron Size and Distribution]. Some introns contain essential gene regulatory regions and some contain essential genes. That does not mean that all intron sequences are functional.
  2. Telomeres are not junk. I don't think telomeres are junk [Telomeres]. They are absolutely required for proper DNA replication. PZ Myers agrees that telomeres (and centromeres) are functional DNA (28 minutes into the talk). Jonathan McLatchie claims that PZ describes telomeres as junk DNA, "Myers departs from the facts, however, when he asserts that these telomeric repetitive elements are non-functional." McLatchie is not telling the truth.
  3. Defective Transposons are Junk. PZ Myers talks about transposons as mobile genetic elements and states that transposons make up more than half of our genome. That's all junk according to PZ Myers. My position is that the small number of active transposons are functional selfish genes and the real junk is the defective transposon sequences that make up most of the genome [Transposon Insertions in the Human Genome]. Thus, I differ a bit from PZ's position. Jonathan McLatchie, like Jonathan Wells, argues that because the occasional defective transposon in the odd species has acquired a function, this means that most of the defective transposon sequences (~50% of the genome) are functional. This is nonsense.

[Image Credit: The image shows human chromosomes labelled with a telomere probe (yellow), from Christoher Counter at Duke University.]

Monday's Molecule #154

 
Today's molecule is a bit more complicated than some of the others. You have to identify the molecule (common name only) and describe (briefly) its function. Can you name the precursor?

Post your answer in the comments. I'll hold off releasing any comments for 24 hours. The first one with the correct answer wins. I will only post correct answers to avoid embarrassment. This is your last chance to enter the Christmas draw for a free textbook!

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your comment.) Every undergraduate who posts a correct answer will have their names entered in a Christmas draw. The winner gets a free autographed copy of my book! (One entry per week. If you post a correct answer every week you will have ten chances to win.)

Some past winners are from distant lands so their chances of taking up my offer of a free lunch are slim. (That's why I can afford to do this!)

In order to win you must post your correct name. Anonymous and pseudoanonymous commenters can't win the free lunch.

Winners will have to contact me by email to arrange a lunch date.

UPDATE: The molecule is thyrotropin-releasing hormone. It's derived from a long precursor protein containing multiple repeats of the tripeptide Glu-His-Pro.

The winner is Joseph C. Somody.

I'll announce the undergraduate winner of my textbook on Christmas day.

Winners
Nov. 2009: Jason Oakley, Alex Ling
Oct. 17: Bill Chaney, Roger Fan
Oct. 24: DK
Oct. 31: Joseph C. Somody
Nov. 7: Jason Oakley
Nov. 15: Thomas Ferraro, Vipulan Vigneswaran
Nov. 21: Vipulan Vigneswaran (honorary mention to Raul A. Félix de Sousa)
Nov. 28: Philip Rodger
Dec. 5: 凌嘉誠 (Alex Ling)
Dec. 12: Bill Chaney


Friday, December 16, 2011

Key Figures in Intelligent Design Creationism

 
Here's a recording of interviews with three prominent Intelligent Design Creationists ....

Guillermo Gonzalez is a Senior Fellow at the Center for Science and Culture (Discovery Institute).
Douglas Axe, director of The Biologic Institute, which is largely funded by the Discovery Institute.
David Berlinski is a Senior Fellow at the Center for Science and Culture (Discovery Institute).

This is the best they have to offer. It gives you a very good idea of what Intelligent Design Creationism is all about. It's about nothing ... there's not a single mention of what IDC stands for and not a single bit of evidence for the existence of a designer. All you hear is whining about real science (evolution) and conspiracies.

Here's a quotation from Berlinski.
Nobody else is doing what the Discovery Institute has been able to do, and that is really put an entire scientific establishment on the defensive, forced for the first time to respond to some very significant criticism...




Christopher Hitchens (1949 - 2011 )

 
Christopher Hitchens died yesterday and everyone in the atheist community is going to pay tribute in their own special way. For me, the highlight of Hitchen's career was last year's debate with Tony Blair here in Toronto (Nov. 26, 2010). The subject was "Is religion a force for good or ill?"

This is his opening statement.




Wednesday, December 14, 2011

Centre for Inquiry Canada: Update

 
The Board of Directors of CFI Canada met with a few Associate members last Sunday (Dec. 11, 2011). The purpose of the meeting was to discuss the termination of Justin Trottier as national Executive Director. Ian Bushfield has put together a brief description of the meeting at: The Continuing Story at CFI Canada.

The Board of Directors has emailed a statement to interested parties (see below). You can find out who's on the Board of Directors and who's an Associate Member at: What's Happening at Centre for Inquiry Canada?.

It's difficult to know what the Board has in mind with respect to Justin. They have not given him a paying job but they seem to be holding out hope that he might take over when the acting National Executive Director leaves in March 2012.

According to their statement, the Board is committed to adding new associate members. They say they have made decisions on some of the applications that they have already received. I have not heard from them on the status of my application.

Meanwhile, the Chair of CFI Edmonton, Brent Kelley, has resigned [Resignation as Chair of CFI Edmonton].
On Sunday, December 11, the Associate Members of CFI Canada met in Toronto. This meeting was followed shortly thereafter by a meeting of the board of directors. We, the board, believe it is important to provide you with information about these meetings and the actions and decisions that took place at these meetings.

The meeting of Associate Members was scheduled pursuant to the by-laws of our organization, that is, it was scheduled after the requisite number of Associate Members requested the meeting. The request for the meeting indicated its purpose was to consider the separation of Justin Trottier from the position of National Executive Director (NED), so that topic was discussed. Justin Trottier, who was present at the meeting, was provided a summary of the concerns of some of the directors and he was provided an opportunity to address those concerns. Some Associate Members also expressed their views, as did some of the Regional Executive Directors who audited the meeting.

We believe there was a frank and candid discussion of Justin Trottier’s tenure and the circumstances that led to his separation. We also believe this frank, candid exchange of views was of benefit to the organization.

Shortly after the Associate Members meeting, the board met. One of the issues considered was increasing the number of Associate Members. Among the decisions of the board on this issue were the following:
  • The board unanimously agreed to invite additional applications to the position of Associate Member, to ensure broader representation of the supporters of CFI Canada in this important class of membership;
  • Application forms can be obtained from the Interim NED, Michael Payton (mpayton@cficanada.ca), or from Kevin Smith, Secretary for the board;
  • Because the primary duty of the Associate Members is to elect directors at the organization’s annual meeting, applications will be reviewed carefully, and emphasis will be placed on the applicant’s prior work for and familiarity with the organization, as well as commitment to its mission;
  • The board concluded, consistent with the by-laws, that Associate Members should be a subset of the general membership and that the number of Associate Members should be kept at a manageable level;
  • The board resolved to act on applications in a timely manner so that applicants would be informed of their status prior to the March 11 annual meeting;
  • The board considered and acted on some of the applications it received prior to the December 11 meeting, and accepted applicants will be notified via email.
The board heard a report on the organization’s finances and the status of the organization from Interim NED Michael Payton. Although the organization has no cash crisis, and has sufficient assets to maintain operations in 2012, it was apparent that the organization needs to make efforts to increase donor support, and the board directed Mr. Payton to undertake fundraising. The Interim NED indicated he needed assistance in his new position to deal with the many tasks which require immediate attention.The board expressed appreciation for Mr. Payton’s willingness to step in quickly and assume the Interim NED position given the sudden departure of the prior NED. The board authorized Mr. Payton to seek volunteer assistance and stated it would consider a request to authorize
hiring of additional staff.

The board decided the branding initiative would continue, but that it would be put on hold given the current status of the organization. The organization’s first priorities are to ensure stability and reliable management, raise money, and begin to offer regular programming and services again as soon as possible.

After appropriate motions, the board resolved the following:
  • No final decision would be made on Justin Trottier’s possible reemployment in any position until the March 11 board meeting. In reaching this decision, the board carefully considered the views that had been offered concerning Mr. Trottier, both pro and con, as well as his record as NED. We also took into account the fact that we agreed to retain our current NED untill March at which time he will
    voluntarily step down.
  • The board would look favorably upon Mr. Trottier’s volunteering of his services to CFI Canada during the period prior to the March 11 board meeting.
    Lorne Trottier took no part in the voting on these motions. The motions carried 3-0, with Tom Flynn absent and Kevin Smith abstaining.
After the board meeting, the board was informed that Justin Trottier would volunteer to assist the organization. CFI Canada welcomes his willingness to volunteer, as it welcomes the willingness of all its volunteers to donate their valuable time and energy to furthering our mission.

One other item the board discussed at length was the perception that there is a lack of transparency and openness in board deliberations. To that end the board will be doing some renovations to the web site which will include, among other things, the posting of our by laws. We will also make available, the application to become an Associate Member along with the guidelines for applying. We will also have a dedicated email so CFI supporters can directly contact the board, the email directors@cficanada.ca
will be up by starting Thursday Dec 15th.

The board is committed to using its best efforts to ensuring not only the survival, but the success of CFI Canada and its important mission. We are well aware that many of the decisions we make are bound to be controversial. We cannot please everybody. At the end of the day we have to rely on our judgment. Our service as directors is not perpetual. Associate Members will be able to reelect or remove us at the March 11 meeting. In the meantime, we pledge to you that we will act in good faith, motivated by what we think is best for the organization and its missio

Thank you for your support.


Monday's Molecule #153

 
Today's1 molecule has a special significance for me since I "accidentally" purified the enzyme that catalyzes the last step in its synthesis. That was one of my first successful experiments as a graduate student (1969).

This is a complex molecule so I'm not going to insist on the IUPAC name. You can supply a common name as long as it is unambiguous (be careful!). This time it's not sufficient to just give me the name of the molecule. You also have to briefly explain what it does and where you can find it, including the "species." The functional explanation has to be a biochemical explanation.

Post your answer in the comments. I'll hold off releasing any comments for 24 hours. The first one with the correct answer wins. I will only post correct answers to avoid embarrassment.

There could be two winners. If the first correct answer isn't from an undergraduate student then I'll select a second winner from those undergraduates who post the correct answer. You will need to identify yourself as an undergraduate in order to win. (Put "undergraduate" at the bottom of your comment.) Every undergraduate who posts a correct answer will have their names entered in a Christmas draw. The winner gets a free autographed copy of my book! (One entry per week. If you post a correct answer every week you will have ten chances to win.)

After today, you have only one more chance to win an autographed book.

Some past winners are from distant lands so their chances of taking up my offer of a free lunch are slim. (That's why I can afford to do this!)

In order to win you must post your correct name. Anonymous and pseudoanonymous commenters can't win the free lunch.

Winners will have to contact me by email to arrange a lunch date.

UPDATE:The molecule is β-D-glucopyranosyl-5-hydroxymethylcytosine. This is a modified base found in T4 bacteriophage and its relatives. The modification is required to protect phage DNA from E. coli host restriction endonucleases.

The winner is Bill Chaney.

Winners
Nov. 2009: Jason Oakley, Alex Ling
Oct. 17: Bill Chaney, Roger Fan
Oct. 24: DK
Oct. 31: Joseph C. Somody
Nov. 7: Jason Oakley
Nov. 15: Thomas Ferraro, Vipulan Vigneswaran
Nov. 21: Vipulan Vigneswaran (honorary mention to Raul A. Félix de Sousa)
Nov. 28: Philip Rodger
Dec. 5: 凌嘉誠 (Alex Ling)


1. Yes, I know it's Wednesday. I was too busy on Monday to post a molecule.

Tuesday, December 13, 2011

Barry Arrington Explains Irreducible Complexity

The Intelligent Design Creationists are feeling a little bit threatened these days. Some scientists are—believe it or not—actually addressing their main arguments head-on and showing them to be vacuous.

The IDiots don't like this because they are used to posting very silly arguments from amateurs on their blogs and then complaining that scientists are only picking the low-hanging fruit and not addressing the true "experts." Truth is, all of the so-called "expert" arguments have been refuted ages ago.

Here's an example from Barry Arrington who explains the real meaning of irreducible complexity and why it supports intelligent design [Denis Alexander’s Strawman Just as Silly].
No ID theorist has ever argued that evolution is impossible because complex biochemical systems cannot self assemble “all in one go.” This is an absurd caricature of the argument from irreducible complexity (IC).

The basic logic of IC goes like this: (1) By definition, evolution can work only in a stepwise fashion wherein each successive step is “selected for” because it has conferred a selective advantage on the organism. (2) an irreducibly complex system is a system which if one part is removed all function ceases. (3) by definition, therefore, an irreducibly complex system cannot be produced in a stepwise fashion. (4) therefore evolution is not capable of producing an irreducibly complex system.

Starting with this logic the ID proponent argues that certain systems are irreducibly complex and therefore could not have been produced by evolution. The bacterial flagellum and the blood clotting cascade are classic examples of such systems.
I have frequently accused Intelligent Design Creationists of not understanding evolution. For example, one of their heroes, Phillip Johnson, clearly thinks that natural selection is a synonym for evolution in spite of the fact that other mechanisms have been known for almost a century [see This Video Should Be Shown to all Biology Students and Phillip Johnson, One of the Very Best Intelligent Design Creationists].

Jonathan McLatchie defended his hero by saying [Maligning Phil Johnson, with Lots of Rhetoric but Little Substance] ...
This is the type of condescending rhetoric that is so prevalent in anti-ID writings. Does Shallit really think that we haven't heard of processes such as genetic drift and endosymbiosis?
We look forward to hearing again from Jonathan McLatchie about how IDiots like Barry Arrington understand evolution.

Arrington's false premise (#1) isn't the only thing wrong with his argument because one can quite easily construct plausible scenarios where each step in constructing an irreducibly complex system confers a selective advantage. All you have to do is postulate that the intermediate selective advantages are not the same as the final purpose of the system.

This is all been thoroughly debated over a decade ago. It's just not true that the concept of irreducible complexity has so flummoxed evolutionary biologists that they have abandoned evolution.

Barry Arrington also takes on one of my comments from somewhere. I don't remember the context but apparently I questioned whether the definition of "information" from computer science and philosophy could be applied to the "information" in DNA sequences. The problem is that, according to Intelligent Design Creationists, if the DNA information is the same as other kinds of information then it has to be created by an agent like some god or some space alien.

They don't seem to be troubled by such an explanation because they never ask the obvious question ... where did the information in the designer come from?1

Anyway, read Barry's defense of the idea that information in a DNA sequence is the same as other kinds of information that requires a designer [Upright Biped Replies to Dr. Moran on “Information”].

[UPDATE: Apparently that last posting was written by someone called "Upright Biped" and Barry Arrington just posted it under his own name on Uncommon Descent.]

Remember that Barry Arrington is a lawyer from Colorado and one of the regular bloggers on Uncommon Descent. Most IDiots consider him an expert on Intelligent Design Creationism. In other words, this is as good as it gets.


1. It's turtles all the way down, right?