Google wishes happy birthday to ..... ?
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The Eighth Day, first published in 1979, is a gift that keeps on giving. It is not the completeness of his history, nor even the vivid prose that imparts its lasting effect. Rather, Judson had the drive and wit to probe until he understood not just who did what, and with what quirks of personality, but why they did it, and how they did it. At each stage he reveals what was at stake, what the crucial alternatives were, and how the problems were solved (or not, as the case may be). Who cares about this past, you might ask, we scientists being neither artists nor composers?Shortly after I read this obituary I was browsing Biology News Net and came across this remarkable opening statement in a press release from Stowers Institute for Medical Research in Kansas City, Missouri, USA.
Could it be that—for scientists as well as composers and artists—the past can be a source of inspiration, and that we ignore it at our peril? Consider the question of how states of gene expression are conveyed from mother to daughters as cells divide. Are instructions passed along by regulatory proteins present in the cytoplasm (so-called “cytoplasmic determinants”), or is the information somehow built into, or attached to, the DNA and transferred along with it? Experiments performed by Francois Jacob and Jacques Monod and their colleagues at the Institut Pasteur in the 1960s distinguish between the models, strikingly supporting the first of these possibilities. These experiments (including the famous “zygotic induction” and “PaJaMa” experiments—see Judson's book) were, of course, performed with bacteria.
I recently spoke with an editor of a major journal that regularly publishes sensational papers on the question as it applies to higher organisms, and learned that s/he, like many of the journal's authors, had never heard of these bacterial experiments! You realize, reading Judson's book, that the challenge is to engage the thought processes of these French scientists, ponder their approaches and results, and design experiments of comparable power and clarity to confirm or refute their conclusions in a different setting. Without that engagement, the new answers are apt to be (and in my opinion usually are) baloney.
Look up “transcription”—the copying of a gene’s DNA into RNA intermediaries—in any old molecular biology text book, and it all seems very simple: RNA polymerase II, the enzyme that catalyzes the reaction, assembles at the start site and starts motoring down the strand, cranking out the RNA ribbon used to construct proteins. But researchers now know that RNA polymerase II often stalls on DNA strands where it was once assumed to just barrel down.This is a very misleading statement. Back in 1989 I wrote an extensive section on "RNA Polymerase Pauses While Transcribing Some Sequences" in my first textbook. I described the effects of sequence and secondary structure on the rate of elongation and explained how a protein component of the the transcription complex (NusA) promotes pausing in order to enhance transcription termination. The idea that rates of elongation were NOT constant was an important part of most molecular biology textbooks.
A report from the Conaway lab at the Stowers Institute for Medical Research in the July 8, 2011, edition of the journal Cell identifies a switch that allows RNA polymerase to shift gears from neutral into drive and start transcribing. This work sheds light on a process fundamental to all plant or animal cells and suggests how transcriptional anomalies could give rise to tumors.
There is overwhelming evidence that life has evolved over thousands of millions of years. The ancestors of modern organisms, as well as whole groups that are now completely extinct, have been found in great abundance as fossils. The main processes responsible for evolutionary change, such as variation and natural selection, have been repeatedly observed and verified in natural populations and in laboratory experiments. All the features of living organisms, including those discovered in the recent advances in molecular biology, are readily explained by the principles of evolution. Any scientific theory that provides a clear mechanism, offers a broad explanation of natural phenomena, receives strong support from observation and experiment and that is never refuted by careful investigation is usually called a “fact”. The cell theory of organisms, the germ theory of infection, the gene theory of inheritance and the theory of evolution are all facts. Teaching alternative theories as though they had equivalent scientific status is a perversion of education that damages children’s ability to understand the natural world. In particular, creationism is a religious doctrine long since known to be a fallacious account of Earth history that has no scientific standing and cannot be represented as a credible alternative to evolution. Evolution is the single most important principle of modern biology and the foundation of any sound biology curriculum.I don't like this statement because: (1) it implies that the "theory of evolution" is only about variation and natural selection, (2) it confuses evolutionary theory with the facts of evolution, and (3) it confuses creationism with Young Earth Creationism.
Graham Bell
President, Canadian Society for Ecology and Evolution
Li, X., Zhu, C., Lin, Z., Wu, Y., Zhang, D., Bai, G., Song, W., Ma, J., Muehlbauer, G.J., Scanlon, M.J., Zhang, M., and Yu, J. (2011) Chromosome Size in Diploid Eukaryotic Species Centers on the Average Length with a Conserved Boundary. Mol. Biol. Evol. 28: 1901-1911. [doi: 10.1093/molbev/msr011]Here's the challenge. Read the abstract and try and guess what important scientific point the authors are making that deserves publication in a molecular evolution journal. For extra points, read the entire article and see if you can improve your guess. You'll be impressed when you read the discussion and it all becomes clear (not!)
Abstract
Understanding genome and chromosome evolution is important for understanding genetic inheritance and evolution. Universal events comprising DNA replication, transcription, repair, mobile genetic element transposition, chromosome rearrangements, mitosis, and meiosis underlie inheritance and variation of living organisms. Although the genome of a species as a whole is important, chromosomes are the basic units subjected to genetic events that coin evolution to a large extent. Now many complete genome sequences are available, we can address evolution and variation of individual chromosomes across species. For example, “How are the repeat and nonrepeat proportions of genetic codes distributed among different chromosomes in a multichromosome species?” “Is there a general rule behind the intuitive observation that chromosome lengths tend to be similar in a species, and if so, can we generalize any findings in chromosome content and size across different taxonomic groups?” Here, we show that chromosomes within a species do not show dramatic fluctuation in their content of mobile genetic elements as the proliferation of these elements increases from unicellular eukaryotes to vertebrates. Furthermore, we demonstrate that, notwithstanding the remarkable plasticity, there is an upper limit to chromosome-size variation in diploid eukaryotes with linear chromosomes. Strikingly, variation in chromosome size for 886 chromosomes in 68 eukaryotic genomes (including 22 human autosomes) can be viably captured by a single model, which predicts that the vast majority of the chromosomes in a species are expected to have a base pair length between 0.4035 and 1.8626 times the average chromosome length. This conserved boundary of chromosome-size variation, which prevails across a wide taxonomic range with few exceptions, indicates that cellular, molecular, and evolutionary mechanisms, possibly together, confine the chromosome lengths around a species-specific average chromosome length.
Field D, Amaral-Zettler L, Cochrane G, Cole JR, Dawyndt P, et al. 2011 The Genomic Standards Consortium. PLoS Biol 9(6): e1001088. doi:10.1371/journal.pbio.1001088.I'm interested in this sort of thing since back in the olden days (1993) I spent a bit of time at GenBank exploring annotation issues with a view to correcting the growing number of errors that were being propagated in online databases.
Abstract
A vast and rich body of information has grown up as a result of the world's enthusiasm for 'omics technologies. Finding ways to describe and make available this information that maximise its usefulness has become a major effort across the 'omics world. At the heart of this effort is the Genomic Standards Consortium (GSC), an open-membership organization that drives community-based standardization activities, Here we provide a short history of the GSC, provide an overview of its range of current activities, and make a call for the scientific community to join forces to improve the quality and quantity of contextual information about our public collections of genomes, metagenomes, and marker gene sequences.
The Internet has resulted in a Cambrian explosion of productivity and data sharing through the adoption of a huge stack of agreed-upon protocols (standards) that allow many devices and programs to communicate to the transformative benefit of the everyday user [26]. Enabling access to user-generated content is key to harnessing the resources of a distributed community: Flickr has over 5 billion photographs uploaded, and Wikipedia has over 3.5 million English articles as of this writing. Standards for organizing sequence data will be similarly needed as sequencing instruments themselves, especially as these instruments are more and more commoditized and owned by individuals rather than institutions.I'm sad to find this sort of content-free language creeping into scientific journals. We've been spared up to now but it looks like the 23 scientists listed as authors feel comfortable with this new style of writing.
[Image Credit: modified from Wikipedia]
[Hat Tip: Canadian Atheist]
# Theme: Medical InnovationIt's nice that Canada is celebrating science.
Canadians have long been at the frontiers of medical research and as a result have helped to save millions of lives worldwide. Notable Canadian contributions include pioneering the use of insulin to treat diabetes, DNA and genetic research, the invention of the pacemaker, and the first hospital-to-hospital robot-assisted surgery.
Researcher at a microscope
The image of a researcher using a microscope depicts Canada’s long-standing commitment to medical research.
DNA strand
Deoxyribonucleic acid (DNA) is the genetic blueprint of life. Canadian researchers have been at the forefront of mapping our human genetic makeup in this field of medical science.
ECG
This electrocardiogram provides a visual cue to Canada’s contributions to heart health, including the invention of the pacemaker by John Hopps in 1950.
Insulin
The discovery of insulin to treat diabetes was made by Canadian researchers Frederick Banting and Charles Best in 1921.
# Theme: CCGS Amundsen, Research IcebreakerMore mention of research and another language. The $50 dollar bill has words from three languages (French, English, and Inuktitut. (I think there's only two languages on American bills. )
The vastness and splendour of Canada’s northern frontier have helped to shape our cultural identity. The icebreaker plays an important role in the North, keeping Canada’s historic passages open, undertaking marine search and rescue, supporting isolated communities, and participating in international environmental research. The CCGS Amundsen helps Canada—the nation with the world’s longest stretch of Arctic coastline—to remain at the leading edge of Arctic research, providing the world’s oceanographers, geologists and ecologists with unparalleled access to the North.
CCGS Amundsen, Research Icebreaker
The Canadian Coast Guard Ship Amundsen became a research icebreaker in 2003. It is jointly operated by ArcticNet and the Canadian Coast Guard.
“Arctic” in Inuktitut
This syllabic text is taken from Inuktitut, a language of Canada’s Inuit population. It stands for “Arctic.”
Map of Canada’s northern regions
The map on the back of this note shows Canada’s northern regions in their entirety, including Inuit regions of the Arctic. This image was provided by Natural Resources Canada.