Sandwalk

The development of protein structure prediction programs began fifty years ago and culminated in the remarkable success of AlphaFold , devel...

Genomics is a powerful tool that allows you to collect massive amounts of data that can point the way to new understanding. But it can also ...

Johnathan Wells died recently. He was a well-known Intelligent Design Creationist and that's why Evolution News (sic) is eulogizing hi...

I just learned that John Mattick gave a seminar this morning at the Department of Cell & Systems Biology at the University of Toronto. U...

This is a Reuters report about misinformation spread by the United States military in order to discredit China's Sinovac vaccine. It was...

Should universities remove online courses that contain incorrect or misleading information? There are lots of scientific controversies...

With age comes wisdom, but sometimes age comes alone. Oscar Wilde Like many baby boomers, I sometimes forget people's names and other ...

Most of the genes in eukaryotes contain introns that are removed by splicing during processing of the primary transcript. In some cases the ...

This chapter describes gene families in the human genome. I explain how new genes are born by gene duplication and how they die by deletion ...

ENCODE has mostly abandoned it's definition of function based on biochemical activity and replaced it with "candidate" functio...

The most important issue in alternative splicing, in my opinion, is whether splice variants are due to splicing errors (= junk RNA) or wheth...

The important issue is whether alternative splicing is ubiquitous or rare. What are the evolutionary implications? I believe that al...

It's going to be extremely difficult, perhaps impossible, to merge the new complete human genome sequence with the current standard refe...

You can't get much more anti-science than a book about Adam and Eve. Nevertheless, Stephen Schaffner —a computational biologist at the B...

An interesting paper on COVID-19 infections in the USA during 2020 was recently published in Nature . The take-home lessons are: abou...

I just received an invitation to a meeting ... On behalf of the international organizing committee, we would like to invite you to a conf...

This post is about a recent review of alternative splicing published by my colleague Ben Blencowe in the Dept. of Medical Genetics at the U...

Splice variants are very common in eukaryotes. We know that it's possible to detect dozens of different splice variants for each gene wi...

The importance of alternative splicing is highly controversial. In the case of humans, the competing views are: (a) more than 90% of human p...

As most of you know, I'm interested in the problem of alternative splicing. I believe that the number of splice variants that have been ...