Strolling with a skeptical biochemist
Monday, May 16, 2022
Wikipedia editors want to supress an article on junk DNA
I've been trying to fix the Wikipedia artilce on Noncoding DNA but it's quite a challenge because the page is controlled by editors...
Sunday, May 15, 2022
Describing non-coding DNA on the NIH (USA) National Human Genome Research Institute website
Here's a link to a short podcast on non-coding DNA narrated by Shurjo K. Sen, Program Director, Divison of Genome Sciences. This is the...
Saturday, May 14, 2022
Editing the Wikipedia article on non-coding DNA
I decided to edit the Wikipedia article on non-coding DNA by adding new sections on "Noncoding genes," "Promoters and regula...
Friday, April 15, 2022
Most lncRNAs are junk
A hard-hitting review will be published in Annual Review of Genomics and Human Genetics . It shows that the case for large numbers of functi...
Friday, April 08, 2022
The structures of centromeres
The new complete human genome sequence gives us a first-time look at the structures of human centromeres. This is my sixth post on the c...
Wednesday, April 06, 2022
Genetic variation and the complete human genome sequence
The new complete human genome sequence adds an extra 8% of DNA sequence that's a source of variation in the human population. The sequen...
Tuesday, April 05, 2022
Two different views of the history of molecular biology
How can different molecular biologists have such opposite views of the history of their field? I'm posting links to two papers wit...
Transcription activity in repeat regions of the human genome
A detailed examination of the new complete human genome reveals that 54% of it consists of various repetitive elements. Some of them are tra...
Monday, April 04, 2022
If you were a Harvard freshman you could take a course on the dark matter of the genome.
Check out this freshperson seminar course on Parts Unknown: The Dark Matter of the Genome at Harvard. It is offfered by Amanda J. Whipple ...
Sunday, April 03, 2022
Karen Miga and the telomere-to-telomere consortium
Karen Miga deserves a lot of the credit for the complete human genome sequence. Karen Miga is a professor at the University of Califo...
What do we do with two different human genome reference sequences?
It's going to be extremely difficult, perhaps impossible, to merge the new complete human genome sequence with the current standard refe...
Segmental duplications in the human genome
The new completed human genome sequence contains some previously unknown large duplicatons (segmental duplications). This is my third...
Epigenetic markers in the last 8% of the human genome sequence
The newly sequenced part of the human genome contains the same chromatin regions as the rest of the genome and they don't tell us very m...
A complete human genome sequence (2022)
The first complete human genome sequence has finally been published. This is my first post on the complete telomere-to-telomere sequence...
Friday, April 01, 2022
Illuminating dark matter in human DNA?
A few months ago, the press office of the University of California at San Diego issued a press release with a provocative title ... Illu...
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