Sandwalk

                                    Strolling with a skeptical biochemist

Wednesday, June 29, 2022

The Function Wars Part XII: Revising history and defending ENCODE

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I'm very disappointed in scientists and philosophers who try to defend ENCODE's behavior on the grounds that they were using a legit...
3 comments:
Tuesday, June 28, 2022

The Function Wars Part XI: Stefan Linquist responds to my critique

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Stefan Linquist is a philosopher at the University of Guelph (Guelph, Ontario, Canada). He recently published a paper on function that I di...
3 comments:
Thursday, June 23, 2022

The Function Wars Part X: "Spam DNA"?

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The authors of a recent paper think we need a new term "spam DNA" to describe some features of the human genome. Fagundes, N.J....
16 comments:
Wednesday, June 22, 2022

The Function Wars Part IX: Stefan Linquist on Causal Role vs Selected Effect

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How much of the human genome is functional? This a problem that will be solved by biochemists not epistemologists. What is junk DNA? Wha...
1 comment:
Tuesday, June 14, 2022

Distrust simplicity (and turn off your irony meters)

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I just stumbled upon an opinion piece published in EMBO Reports on May 22, 2022. The author is Frank Gannon who is identified as the forme...
12 comments:
Monday, June 13, 2022

Manolis Kellis dismisses junk DNA

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Manolis Kellis is a professor of computer science at the Massachusetts Institute of Technology (MIT). Sandwalk readers will remember him a...
8 comments:
Monday, June 06, 2022

My father on D-day

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Today is the 78th anniversary of D-Day—the day British, Canadian, and American troops landed on the beaches of Normandy in World War II. 1 ...
6 comments:
Monday, May 16, 2022

Wikipedia editors want to supress an article on junk DNA

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I've been trying to fix the Wikipedia artilce on Noncoding DNA but it's quite a challenge because the page is controlled by editors...
8 comments:
Sunday, May 15, 2022

Describing non-coding DNA on the NIH (USA) National Human Genome Research Institute website

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Here's a link to a short podcast on non-coding DNA narrated by Shurjo K. Sen, Program Director, Divison of Genome Sciences. This is the...
Saturday, May 14, 2022

Editing the Wikipedia article on non-coding DNA

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I decided to edit the Wikipedia article on non-coding DNA by adding new sections on "Noncoding genes," "Promoters and regula...
21 comments:
Friday, April 15, 2022

Most lncRNAs are junk

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A hard-hitting review will be published in Annual Review of Genomics and Human Genetics . It shows that the case for large numbers of functi...
4 comments:
Friday, April 08, 2022

The structures of centromeres

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The new complete human genome sequence gives us a first-time look at the structures of human centromeres. This is my sixth post on the c...
2 comments:
Wednesday, April 06, 2022

Genetic variation and the complete human genome sequence

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The new complete human genome sequence adds an extra 8% of DNA sequence that's a source of variation in the human population. The sequen...
Tuesday, April 05, 2022

Two different views of the history of molecular biology

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How can different molecular biologists have such opposite views of the history of their field? I'm posting links to two papers wit...
22 comments:

Transcription activity in repeat regions of the human genome

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A detailed examination of the new complete human genome reveals that 54% of it consists of various repetitive elements. Some of them are tra...
1 comment:
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