Sandwalk

                                    Strolling with a skeptical biochemist

Tuesday, November 17, 2020

Using modified nucleotides to make mRNA vaccines

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The key features of the mRNA vaccines are the use of modified nucleotides in their synthesis and the use of lipid nanoparticles to deliver t...
1 comment:
Sunday, November 15, 2020

Why is the Central Dogma so hard to understand?

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The Central Dogma of molecular biology states ... ... once (sequential) information has passed into protein it cannot get out again (F....
8 comments:
Wednesday, November 11, 2020

On the misrepresentation of facts about lncRNAs

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I've been complaining for years about how opponents of junk DNA misrepresent and distort the scientific literature. The same complaints ...
11 comments:
Wednesday, October 07, 2020

Undergraduate education in biology: no vision, no change

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I was looking at the Vision and Change document the other day and it made me realize that very little has changed in undergraduate educatio...
51 comments:
Saturday, October 03, 2020

On the importance of random genetic drift in modern evolutionary theory

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The latest issue of New Scientist has a number of articles on evolution. All of them are focused on extending and improving the current the...
3 comments:
Wednesday, September 30, 2020

New Scientist doesn't understand modern evolutionary theory

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New Scientist has devoted much of their September 26th issue to evolution, but not in a good way. Their emphasis is on 13 ways that we must...
6 comments:
Tuesday, September 22, 2020

The Function Wars Part VIII: Selected effect function and de novo genes

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Discussions about the meaning of the word "function" have been going on for many decades, especially among philosphers who love th...
1 comment:
Friday, August 07, 2020

Alan McHughen defends his views on junk DNA

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Alan McHughen is the author of a recently published book titled DNA Demystified . I took issue with his stance on junk DNA [ More misconcept...
104 comments:
Thursday, August 06, 2020

More misconceptions about junk DNA - what are we doing wrong?

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I'm actively following the views of most science writers on junk DNA to see if they are keeping up on the latest results. The latest boo...
9 comments:
Saturday, August 01, 2020

ENCODE 3: A lesson in obfuscation and opaqueness

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The Encyclopedia of DNA Elements (ENCODE) is a large-scale, and very expensive, attempt to map all of the functional elements in the human g...
4 comments:
Saturday, July 11, 2020

The coronavirus life cycle

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The coronavirus life cycle is depicted in a figure from Fung and Liu (2019). See below for a brief description. The virus particle attaches...
9 comments:
Thursday, July 09, 2020

Structure and expression of the SARS-CoV-2 (coronavirus) genome

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Coronaviruses are RNA viruses, which means that their genome is RNA, not DNA. All of the coronaviruses have similar genomes but I'm sur...
7 comments:
Wednesday, July 08, 2020

Where did your chicken come from?

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Scientists have sequenced the genomes of modern domesticated chickens and compared them to the genomes of various wild pheasants in southern...
2 comments:
Monday, July 06, 2020

A storm of cytokines

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Cytokines are a diverse groups of small signal proteins that act like hormones to turn on genes in blood cells and cells of the immune syste...
13 comments:
Saturday, June 13, 2020

What's in Your Genome? Chapter 3: Repetitive DNA and Mobile Genetic Elements

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By the end of chapter 3, readers will be familiar with two main lines of evidence for junk DNA: the C-Value Paradox, and the fact that most ...
8 comments:
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