Sandwalk

                                    Strolling with a skeptical biochemist

Saturday, June 13, 2020

What's in Your Genome? Chapter 3: Repetitive DNA and Mobile Genetic Elements

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By the end of chapter 3, readers will be familiar with two main lines of evidence for junk DNA: the C-Value Paradox, and the fact that most ...
8 comments:

What's in Your Genome? Chapter 2: The Evolution of Sloppy Genomes

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I had to completely reorganize chapter 2 in order to move population genetics closer to the beginning of the book and reduce the number of w...

What's in Your Genome? Chapter 1: Introducing Genomes

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My book is progressing slowly. The main task is to reduce it to about 120,000 words and that's proving to be a lot more difficult that I...
Thursday, June 11, 2020

Dan Graur proposes a new definition of "gene"

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I've thought a lot about how to define the word "gene." It's clear that no definition will capture all the possibilities b...
13 comments:
Saturday, April 18, 2020

Three scientists discuss junk DNA

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I just found this video that was posted to YouTube on May 2019. It's produced by the University of California and it features three rese...
53 comments:
Wednesday, April 08, 2020

Alternative splicing: function vs noise

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This post is about a recent review of alternative splicing published by my colleague Ben Blencowe in the Dept. of Medical Genetics at the U...
39 comments:
Monday, April 06, 2020

The Function Wars Part VII: Function monism vs function pluralism

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This post is mostly about a recent paper published in Studies in History and Philosophy of Biol & Biomed Sci where two philosophers pre...
2 comments:
Wednesday, February 12, 2020

Happy Darwin Day! 2020

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Charles Darwin , the greatest scientist who ever lived, was born on this day in 1809 [ Darwin still spurs tributes, debates ] [ Happy Darwin...
16 comments:
Friday, February 07, 2020

The Function Wars Part VI: The problem with selected effect function

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The term "Function Wars" refers to the debate over the meaning of 'function,' especially in the context of junk DNA. 1 Th...
9 comments:
Friday, January 31, 2020

lncRNA nonsense from Los Alamos

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A group of scientists at the Los Alamos National Laboratory (Los Alamos, NM, USA) and their collaborators in Vienna (Austria) and Lethbridge...
2 comments:
Tuesday, January 14, 2020

The Three Domain Hypothesis: RIP

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The Three Domain Hypothesis died about twenty years ago but most people didn't notice. The original idea was promoted by Carl Woese an...
27 comments:
Wednesday, January 08, 2020

Are pseudogenes really pseudogenes?

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There are many junk DNA skeptics who claim that most of our genome is functional. Some of them have even questioned whether pseudogenes are ...
8 comments:
Wednesday, January 01, 2020

Remember MOOCs?

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We learned back in 2012 that Massive Open Online Courses (MOOCs) were going to transform higher education. People all over the world, especi...
10 comments:
Tuesday, December 31, 2019

Are introns mostly junk?

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There are many reasons for thinking that introns are mostly junk DNA. The size and sequence of introns in related species are not conserved...
23 comments:
Sunday, December 15, 2019

The evolution of citrate synthase

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Citrate synthase [ EC 2.3.3.1 ] is one of the key enzymes of the citric acid cycle. It catalyzes the joining of acetyl-CoA and oxaloacetate ...
4 comments:
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