Sandwalk

                                    Strolling with a skeptical biochemist

Friday, January 31, 2020

lncRNA nonsense from Los Alamos

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A group of scientists at the Los Alamos National Laboratory (Los Alamos, NM, USA) and their collaborators in Vienna (Austria) and Lethbridge...
2 comments:
Tuesday, January 14, 2020

The Three Domain Hypothesis: RIP

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The Three Domain Hypothesis died about twenty years ago but most people didn't notice. The original idea was promoted by Carl Woese an...
27 comments:
Wednesday, January 08, 2020

Are pseudogenes really pseudogenes?

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There are many junk DNA skeptics who claim that most of our genome is functional. Some of them have even questioned whether pseudogenes are ...
8 comments:
Wednesday, January 01, 2020

Remember MOOCs?

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We learned back in 2012 that Massive Open Online Courses (MOOCs) were going to transform higher education. People all over the world, especi...
10 comments:
Tuesday, December 31, 2019

Are introns mostly junk?

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There are many reasons for thinking that introns are mostly junk DNA. The size and sequence of introns in related species are not conserved...
23 comments:
Sunday, December 15, 2019

The evolution of citrate synthase

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Citrate synthase [ EC 2.3.3.1 ] is one of the key enzymes of the citric acid cycle. It catalyzes the joining of acetyl-CoA and oxaloacetate ...
4 comments:
Friday, December 13, 2019

The "standard" view of junk DNA is completely wrong

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I was browsing the table of contents of the latest issue of Cell and I came across this .... For decades, the miniscule protein-coding por...
13 comments:
Monday, October 21, 2019

The evolution of de novo genes

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De novo genes are new genes that arise spontaneously from junk DNA [ De novo gene birth ]. The frequency of de novo gene creation is impo...
37 comments:
Tuesday, September 24, 2019

How many protein-coding genes in the human genome? (2)

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It's difficult to know how many protein-coding genes there are in the human genome because there are several different ways of counting ...
11 comments:
Wednesday, September 11, 2019

Gerald Fink promotes a new definition of a gene

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This is the 2019 Killian lecture at MIT, delivered in April 2019 by Gerald Fink . Fink is an eminent scientist who has done excellent work o...
9 comments:
Sunday, September 08, 2019

Contingency, selection, and the long-term evolution experiment

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I'm a big fan of Richard Lenski's long-term evolution experiment (LTEE) and of Zachary Blount's work in particular. [ Strolling ...
66 comments:
Friday, August 30, 2019

Evolution by Accident

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Evolution by Accident v1.43 ©2006 Laurence A. Moran This essay has been transferred here from an old server that has been decommissioned. ...
26 comments:
Tuesday, August 27, 2019

First complete sequence of a human chromosome

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A paper announcing the first complete sequence of a human chromosome has recently been posted on the bioRxiv server. Miga, K. H., Koren, S....
2 comments:
Sunday, August 25, 2019

How much of the human genome has been sequenced?

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It's been more than seven years since I posted information on how much of the human genome has been sequenced [ How Much of Our Genome I...
6 comments:
Thursday, August 22, 2019

Reactionary fringe meets mutation-biased adaptation.
7. Going forward

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This the last of a series of posts by Arlin Stoltzfus on the role of mutation as a dispositional factor in evolution. Arlin has established ...
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