Sandwalk

                                    Strolling with a skeptical biochemist

Thursday, June 06, 2019

My father on D-Day: 75 years ago

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Today is the 75th anniversary of D-Day—the day British, Canadian, and American troops landed on the beaches of Normandy. 1 For us baby bo...
6 comments:
Monday, April 01, 2019

The frequency of splicing errors reflects the balance between selection and drift

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Splice variants are very common in eukaryotes. We know that it's possible to detect dozens of different splice variants for each gene wi...
4 comments:
Friday, March 29, 2019

Are multiple transcription start sites functional or mistakes?

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If you look in the various databases you'll see that most human genes have multiple transcription start sites. The evidence for the exis...
42 comments:
Monday, February 04, 2019

What is the dominant view of junk DNA?

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I think that about 90% of our genome is junk and I know lots of other scientists who feel the same way. I'm pretty sure that this view i...
49 comments:
Sunday, January 27, 2019

Yeast loses its introns

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Baker’s yeast ( Saccharomyces cerevisiae ) is one of the best studied eukaryotes. Its genome is just slightly larger than the largest bacter...
28 comments:
Wednesday, January 23, 2019

What happens when twins get their DNA tested?

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The Canadian Broadcastng Company (CBC) has a TV show called Marketplace that promotes itself as an advocate of consumers' rights. It ha...
4 comments:
Sunday, January 13, 2019

Most popular Sandwalk posts of 2018

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Blogging was light last year because I was busy with other things and because the popularity of blogs is declining rapidly. The most popular...
4 comments:
Friday, December 28, 2018

On the accuracy of Ancestry.com DNA predictions

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I'm very impressed with the DNA test administered by Ancestry.com. They report that I have over 600 fourth cousins or closer but I have ...
8 comments:
Saturday, December 22, 2018

Most popular Sandwalk posts of 2017

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I was looking at some of my posts from the past few years and wondered which ones were the most popular. I had previously identified the mos...
5 comments:
Tuesday, December 18, 2018

My DNA story

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This is the latest update from Ancestry.com. Their algorithms are getting better and better. This corresponds very closely to what I know of...
2 comments:
Saturday, December 15, 2018

Alternative splicing in the nematode C. elegans

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The importance of alternative splicing is highly controversial. In the case of humans, the competing views are: (a) more than 90% of human p...
3 comments:
Saturday, December 08, 2018

The persistent myth of alternative splicing

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I'm convinced that widespread alternative splicing does not occur in humans or in any other species. It's true that the phenomenon e...
6 comments:
Wednesday, December 05, 2018

The textbook view of alternative splicing

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As most of you know, I'm interested in the problem of alternative splicing. I believe that the number of splice variants that have been ...
18 comments:
Monday, November 26, 2018

Deflated egos and the G-value paradox

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The Deflated Ego Problem refers to the fact that many scientists were very disappointed to learn we had less than 30,000 genes. Those scient...
51 comments:
Sunday, November 25, 2018

Michael Behe's third book

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I'm looking forward to Michael Behe's third book, which is due to be published in February. As most of you probably know, Michael Be...
23 comments:
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