Sandwalk

                                    Strolling with a skeptical biochemist

Wednesday, January 31, 2018

Herding Hemingway's Cats by Kat Arney

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Kat Arney has written a very good book on genes and gene expression. She covers all the important controversies in a thorough and thoughtful...
13 comments:
Friday, November 17, 2017

Calculating time of divergence using genome sequences and mutation rates (humans vs other apes)

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There are several ways to report a mutation rate. You can state it as the number of mutations per base pair per year in which case a typical...
52 comments:
Wednesday, November 08, 2017

How much mitochondrial DNA in your genome?

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Most mitochondrial genes have been transferred from the ancestral mitochondrial genome to the nuclear genome over the course of 1-2 billion ...
30 comments:
Tuesday, November 07, 2017

Lateral gene transfer in eukaryotes - where's the evidence?

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Lateral gene transfer (LGT), or horizontal gene transfer (HGT), is widespread in bacteria. It leads to the creation of pangenomes for many b...
32 comments:

Contaminated genome sequences

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The authors of the original draft of the human genome sequence claimed that hundreds of genes had been acquired from bacteria by lateral gen...
Thursday, November 02, 2017

Parental age and the human mutation rate

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Theme Mutation -definition -mutation types -mutation rates -phylogeny -controversies Mutations are mostly due to errors in DNA repl...
11 comments:
Tuesday, October 31, 2017

The history of DNA sequencing

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This year marks the 40th anniversary of DNA sequencing technology (Gilbert and Maxam, 1977; Sanger et al., 1977) 1 The Sanger technique soo...
11 comments:

Escape from X chromosome inactivation

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Mammals have two sex chromosomes: X and Y. Males have one X chromosome and one Y chromosome and females have two X chromosomes. Since female...
1 comment:
Saturday, October 28, 2017

Creationists questioning pseudogenes: the GULO pseudogene

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This is the second post discussing creationist 1 papers on pseudogenes. The first post addressed a paper by Jeffrey Tomkins on the β-globin...
137 comments:
Saturday, October 14, 2017

Creationists questioning pseudogenes: the beta-globin pseudogene

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Jonathan Kane recently (Oct. 6, 2017) posted an article on The Panda's Thumb where he claimed that Young Earth Creationists often don...
67 comments:
Wednesday, October 11, 2017

Historical evolution is determined by chance events

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Modern evolutionary theory is based on the idea that alleles become fixed in a population over time. They can be fixed by natural selection ...
32 comments:
Wednesday, September 13, 2017

Sequencing human diploid genomes

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Most eukaryotes are diploid, including humans. They have two copies of each autosome. Thousands of human genomes have been sequenced but in ...
22 comments:
Monday, September 11, 2017

What's in Your Genome?: Chapter 4: Pervasive Transcription (revised)

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I'm working (slowly) on a book called What's in Your Genome?: 90% of your genome is junk! The first chapter is an introduction to g...
15 comments:
Saturday, September 09, 2017

Cold Spring Harbor tells us about the "dark matter" of the genome (Part I)

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This is a podcast from Cold Spring Harbor [ Dark Matter of the Genome, Pt. 1 (Base Pairs Episode 8) ]. The authors try to convince us that ...
43 comments:
Saturday, September 02, 2017

Winter is coming ... I want this for Xmas (or whenever)

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3 comments:
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