Sandwalk

                                    Strolling with a skeptical biochemist

Saturday, February 10, 2018

We live in the age of bacteria

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I'm sad because we now have almost a whole generation of young people who know very little about Stephen Jay Gould . (He died of cancer ...
9 comments:
Friday, February 09, 2018

Junior scientist snowflakes

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A recent letter in Nature draws attention to a serious (?) problem in modern society; namely, the persecution of junior scientists by older...
11 comments:

Are splice variants functional or noise?

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This is a post about alternative splicing. I've avoided using that term in the title because it's very misleading. Alternative splic...
6 comments:
Wednesday, February 07, 2018

The Salzburg sixty discuss a new paradigm in genetic variation

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Sixty evolutionary biologists are going to meet next July in Salzburg (Austria)to discuss "a new paradigmatic understanding of genetic ...
8 comments:
Tuesday, February 06, 2018

How many lncRNAs are functional?

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There's solid evidence that 90% of your genome is junk. Most of it is transcribed at some time but the transcripts are transient and usu...
6 comments:
Monday, February 05, 2018

ENCODE's false claims about the number of regulatory sites per gene

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Some beating of dead horses may be ethical, where here and there they display unexpected twitches that look like life. Zuckerkandl and Pau...
3 comments:
Saturday, February 03, 2018

What's in Your Genome?: Chapter 5: Regulation and Control of Gene Expression

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I'm working (slowly) on a book called What's in Your Genome?: 90% of your genome is junk! The first chapter is an introduction to g...
25 comments:
Thursday, February 01, 2018

Sex isn't as beneficial as you might think

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One of the most interesting topics in my molecular evolution class was the discussion over the importance of sex. Most students seem to thin...
37 comments:

Kevin Laland's view of "modern" evolutionary theory (again)

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Kevin Laland has just published another critique of modern evolutionary theory. This one appears in Aeon [ Evolution unleashed ]. His criti...
11 comments:
Wednesday, January 31, 2018

Herding Hemingway's Cats by Kat Arney

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Kat Arney has written a very good book on genes and gene expression. She covers all the important controversies in a thorough and thoughtful...
13 comments:
Friday, November 17, 2017

Calculating time of divergence using genome sequences and mutation rates (humans vs other apes)

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There are several ways to report a mutation rate. You can state it as the number of mutations per base pair per year in which case a typical...
52 comments:
Wednesday, November 08, 2017

How much mitochondrial DNA in your genome?

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Most mitochondrial genes have been transferred from the ancestral mitochondrial genome to the nuclear genome over the course of 1-2 billion ...
30 comments:
Tuesday, November 07, 2017

Lateral gene transfer in eukaryotes - where's the evidence?

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Lateral gene transfer (LGT), or horizontal gene transfer (HGT), is widespread in bacteria. It leads to the creation of pangenomes for many b...
32 comments:

Contaminated genome sequences

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The authors of the original draft of the human genome sequence claimed that hundreds of genes had been acquired from bacteria by lateral gen...
Thursday, November 02, 2017

Parental age and the human mutation rate

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Theme Mutation -definition -mutation types -mutation rates -phylogeny -controversies Mutations are mostly due to errors in DNA repl...
11 comments:
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