tag:blogger.com,1999:blog-37148773.post8498757836535767987..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: PolyphosphateLarry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-37148773.post-30961394251980353852007-11-01T09:22:00.000-04:002007-11-01T09:22:00.000-04:00Nick, assuming that the natural formation of polyp...Nick, assuming that the natural formation of polyphosphate from inorganic phosphate was at equilibrium in the primordial soup, it follows that the Gibbs free energy change will be zero for the hydrolysis of pyrophosphate. <BR/><BR/>The only way that naturally occurring pyrophosphate could be a significant source of chemical energy would be if it's concentration was a lot higher than the equilibrium value. How do you envisage that this could happen in the warm little pond where life began? How long would that situation last if primitive life started using pyrophosphate as a source of chemical energy? Minutes? Hours? Days?Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-28774280290487643092007-10-31T20:16:00.000-04:002007-10-31T20:16:00.000-04:00This stuff is highly relevant to the origin of lif...This stuff is highly relevant to the origin of life also. Polyphosphate can be produced geologically by heating certain rocks, and provides chemical energy very similar to ATP, GTP etc.NickMhttps://www.blogger.com/profile/04765417807335152285noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-12884140348803315812007-10-31T13:48:00.000-04:002007-10-31T13:48:00.000-04:00Maybe only tangentially related to this, but there...Maybe only tangentially related to this, but there was a paper from Solomon Snyder in PNAS a little while back where he suggested that protein phosphorylation may often in fact be pyrophosphorylation, and that this is mediated by the pyrophosphorylated inositols IP7 and IP8. This seems pretty important, and surprising if it had been missed all these yearsAnonymoushttps://www.blogger.com/profile/12291507118158076247noreply@blogger.com