tag:blogger.com,1999:blog-37148773.post8098521893311933894..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Junk in your Genome: LINEsLarry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-37148773.post-50070430159411225582007-10-09T12:37:00.000-04:002007-10-09T12:37:00.000-04:00LINEs also have regulatory elements that can alter...LINEs also have <A HREF="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11991712&ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" REL="nofollow">regulatory elements</A> that can alter the ways in which our genes are expressed. (my own research bias rears its ugly head again...)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-21166208946543182952007-10-09T06:01:00.000-04:002007-10-09T06:01:00.000-04:00Don't forget that pseudogenes and endogenous retro...Don't forget that pseudogenes and endogenous retroviral sequences can only enter via the germ line. Theres a lot of interesting data coming out now concerning piwi RNAs - germline specific small functional RNAs that may work in repressing the expression of the repetitive elements.Sigmundhttps://www.blogger.com/profile/00262375488263086844noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-77659733149315877762007-10-08T11:35:00.000-04:002007-10-08T11:35:00.000-04:00Yes it has always been fascinating to me to think ...Yes it has always been fascinating to me to think that Alu RNA has retained the ability to bind SRP. I am looking forward to reading your posts on the topic.CedricFhttps://www.blogger.com/profile/16249369973743375041noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-63314765875091731032007-10-08T08:23:00.000-04:002007-10-08T08:23:00.000-04:00I've been heading for a posting about Alus ever si...I've been heading for a posting about Alus ever since I named signal recognition particle as Monday's Molecule. Please be patient. There are several articles in the works.Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-14517953232217184852007-10-08T01:32:00.000-04:002007-10-08T01:32:00.000-04:00Nice summary Larry. The LINE1 machinery is also kn...Nice summary Larry. The LINE1 machinery is also known to be responsible for the propagation of over 1 million copies of Alu elements, which account for another 10% of our genome. Alu is the most abundant family of transposable elements in the human genome and its spread is ongoing (although at a much reduced rate than it used to in the distant past). It has been estimated that there is a new Alu insertion for every 100 human births. <BR/><BR/>What's conceptually interesting is that Alu is a parasite's parasite, which has been even more successful at propagating than LINE1 itself. It shows that the genome is a dynamic ecosystem, with many fascinating creatures.CedricFhttps://www.blogger.com/profile/16249369973743375041noreply@blogger.com