tag:blogger.com,1999:blog-37148773.post7499614780880099633..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Structure and expression of the SARS-CoV-2 (coronavirus) genomeLarry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-37148773.post-39353338453169680312020-08-05T05:45:38.480-04:002020-08-05T05:45:38.480-04:00According to nextstrain.org the most divergent SAR...According to nextstrain.org the most divergent SARS-CoV-2 strain found from Senegal contains 24 mutations https://nextstrain.org/ncov/global?m=div.Jouni Väliahohttps://www.blogger.com/profile/04364559756030503669noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-2992620594691287672020-07-13T21:03:13.698-04:002020-07-13T21:03:13.698-04:00There is an interesting post about the sequence an...There is an interesting post about the sequence and structure of Covid19 written by Carl Zimmer in the New York Times.<br /><br />https://www.nytimes.com/interactive/2020/04/03/science/coronavirus-genome-bad-news-wrapped-in-protein.htmlRoberto Munguiahttps://www.blogger.com/profile/13771873119862163084noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-47023319147262619282020-07-13T17:22:18.182-04:002020-07-13T17:22:18.182-04:00From my Facebook post ...
"SARS-CoV-2 is evo...From my Facebook post ...<br /><br />"SARS-CoV-2 is evolving at a normal rate from the initial isolate first identified and sequenced in China. Tung Phan at the University of Pittsburg (USA) has compared the sequences of 86 strains from all over the world and he has identified a total of 93 mutations including three deletions (see figure below). Forty-two of these mutations are missense mutations located in the ORF1ab polyprotein gene, the spike surface glycoprotein gene, the matrix protein gene, and the nucleocapsid proetin gene. No mutations in the envelope protein genes were found.<br /><br />Phan, T. (2020). "Genetic diversity and evolution of SARS-CoV-2." Infection, genetics and evolution 81: 104260. [doi: j.meegid.2020.104260]"<br />Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-45434815580861640552020-07-12T12:05:54.751-04:002020-07-12T12:05:54.751-04:00Though you state that the Coronavirus currently re...Though you state that the Coronavirus currently responsible for this pandemic seems to have a low mutation rate, I still wonder how different have the most divergent strains of the current Coronavirus pandemic become so far? <br />In absolute numbers, how many mutations separate them from their common ancestor as it was back in December-January, at this point?Mikkel Rumraket Rasmussenhttps://www.blogger.com/profile/07670550711237457368noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-23857668723426793342020-07-12T10:42:49.515-04:002020-07-12T10:42:49.515-04:00Yes, nucleotides is better. I thought I had made a...Yes, nucleotides is better. I thought I had made all the corrections but I clearly missed a lot. Fixed now.Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-18756439002422255412020-07-12T06:28:27.218-04:002020-07-12T06:28:27.218-04:00Sorry, the autocorrection turned bp into be. Sorry, the autocorrection turned bp into be. SPARChttps://www.blogger.com/profile/09563722742249547887noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-11152295195240466372020-07-12T06:26:03.148-04:002020-07-12T06:26:03.148-04:00Wouldn‘t it be more appropriate to use nt rather t...Wouldn‘t it be more appropriate to use nt rather than be?SPARChttps://www.blogger.com/profile/09563722742249547887noreply@blogger.com