tag:blogger.com,1999:blog-37148773.post5128526982439864586..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: The biggest mistake in the history of molecular biology (not!)Larry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-37148773.post-71074039441264544232021-10-14T13:47:11.832-04:002021-10-14T13:47:11.832-04:00Permission from who ? Dr. Josef Mengele ?Permission from who ? Dr. Josef Mengele ?steve oberskihttps://www.blogger.com/profile/14067724166134333068noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-21083660244435668622021-10-12T18:40:45.035-04:002021-10-12T18:40:45.035-04:00@unknown
Here's a good place to start:
https:...@unknown<br />Here's a good place to start:<br /><br />https://sandwalk.blogspot.com/2011/05/whats-in-your-genome.html<br /><br />Transposons and viral remnants alone would cut the genome size in half.Divalenthttps://www.blogger.com/profile/11069255366514887594noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-58776618713619498092021-10-09T22:06:06.760-04:002021-10-09T22:06:06.760-04:00This is really hard to do. However, it's been...This is really hard to do. However, it's been done with one chromosome in mice. The mice were OK.Barbarahttps://www.blogger.com/profile/14484430852843017156noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-69929278420014962182021-10-07T15:24:08.528-04:002021-10-07T15:24:08.528-04:00Yes! Forgive my eukaryocentrism.Yes! Forgive my eukaryocentrism.Brianhttps://www.blogger.com/profile/13530564543928677353noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-91821455328458718852021-10-05T18:57:58.919-04:002021-10-05T18:57:58.919-04:00@Unknown: If he gave you some sequences, what wo...@Unknown: If he gave you some sequences, what would you do with them?Fair Witnesshttps://www.blogger.com/profile/02096585841391610098noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-82155777743807958682021-10-05T03:06:42.965-04:002021-10-05T03:06:42.965-04:00Think of a hypothetical scenario:
You got the pe...Think of a hypothetical scenario: <br /><br />You got the permission as well as the expertise to knockout all "junk" sequences present in the germline cells of a human couple. What sequences present in that "90 percent junk" would you knockout with absolute certainty? <br />The newborn child should not be abnormal.Anonymoushttps://www.blogger.com/profile/03739450601869245187noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-40896071864983345762021-10-01T23:56:53.965-04:002021-10-01T23:56:53.965-04:00Not to mention Jacob and Monod who got the Nobel P...Not to mention Jacob and Monod who got the Nobel Prize in 1965 for gene control in E. coli which involved proteins binding to a site outside the coding sequence. Kind of hard to ignore or forget.Joe Felsensteinhttps://www.blogger.com/profile/00430555755335300584noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-72226504956284857002021-10-01T14:50:34.131-04:002021-10-01T14:50:34.131-04:00This amnesia is really strange. As you know, folks...This amnesia is really strange. As you know, folks were doing multi-pairwise alignments of non-coding sequences flanking coding regions as early as 1990 (limited until then by computing power) to identify conserved sequences, which turned out to indicate discrete binding sites for transcription factors, ushering in the promoter bashing age. Indeed, if anything, we tended to overestimate the functionality of conserved sequences prior to functional testing in reporter constructs back then. So, this idea that the realization of functional sequences outside of protein coding sequence is recent or controversial is ludicrous to anyone involved in the study of gene regulation in the past 30+ years.Brianhttps://www.blogger.com/profile/13530564543928677353noreply@blogger.com