tag:blogger.com,1999:blog-37148773.post2513732463086249597..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Stop the Press!!! Scientists Discover the 7th and 8th Bases of DNA!Larry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-37148773.post-31244740710936045072011-07-25T05:14:13.340-04:002011-07-25T05:14:13.340-04:00anonymous asks,
Any idea when your text will be p...anonymous asks,<br /><br /><i>Any idea when your text will be published?</i><br /><br />It goes to the printer on Friday. We should have copies by September 1st.<br /><br>Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-57943380290934593402011-07-24T22:45:29.507-04:002011-07-24T22:45:29.507-04:00Even supposedly knowledgeable researchers are comp...<i>Even supposedly knowledgeable researchers are completely ignorant of fundamental work done years ago in bacteria and phage. </i><br /><br />This complaint sounds a little like getting all upset that people are so busy being impressed with lasers that they forgot all that pioneering work does years ago with flashlights. *tease*Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-52910564782493814182011-07-24T22:37:33.954-04:002011-07-24T22:37:33.954-04:00Any idea when your text will be published?Any idea when your text will be published?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-1370100784967574882011-07-23T19:35:59.559-04:002011-07-23T19:35:59.559-04:00Thanks getzal,
I fixed it.Thanks getzal,<br /><br />I fixed it.<br /><br>Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-32629482050823352782011-07-23T14:35:56.632-04:002011-07-23T14:35:56.632-04:00Dr. Moran,
In the figure, O4 in 5-hydroxymethylur...Dr. Moran,<br /><br />In the figure, O4 in 5-hydroxymethyluracil needs a double bond. Just wanted to point that out in case the error is present in the figure from your textbook as well.qetzalnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-48011857862897776002011-07-23T05:42:34.649-04:002011-07-23T05:42:34.649-04:00anonymous says,
the cool thing about the new base...anonymous says,<br /><br /><i>the cool thing about the new bases is that they are actually found in mammals, unlike most of the other ones.</i><br /><br />Hmmm ... I thought it was pretty cool when the other 25 modified bases were found in variety of different species. Why is it more cool that some are found in mammalian genomes?<br /><br />And does this myopic view justify implying that the new bases are only the 7th and 8th bases that have been found? This is one of the problems with science these days. Even supposedly knowledgeable researchers are completely ignorant of fundamental work done years ago in bacteria and phage. <br /><br>Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-56054178042422171622011-07-23T04:35:14.047-04:002011-07-23T04:35:14.047-04:00the cool thing about the new bases is that they ar...the cool thing about the new bases is that they are actually found in mammals, unlike most of the other ones. The fuzz about the discovery of formylcytosine is quite interesting, as it has already been published by a european group a month ago - but nobody seemed to care ...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-61465469860558645972011-07-23T00:11:56.017-04:002011-07-23T00:11:56.017-04:00Oh, dear, if that's how number of bases get mu...Oh, dear, if that's how number of bases get multiplied, think of how many different amino acid residues in proteins are out there!DKnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-66478465787937942062011-07-22T16:34:28.722-04:002011-07-22T16:34:28.722-04:00There is even a 5-hmC detection kit for sale.
It&...There is even a 5-hmC detection kit for sale.<br /><br />It's been shown to inhibit binding of methyl-CpG-binding domain proteins, reversing some of the effects of DNA methylation on expression. <br /><br />If this is the case, then it's another layer of epigenetic control, and all our bisulfite sequencing will have to be reconsidered.gilltnoreply@blogger.com