tag:blogger.com,1999:blog-37148773.post6534048733496808869..comments2024-03-19T00:24:23.577-04:00Comments on <center>Sandwalk</center>: Nobel Laureate: Günter BlobelLarry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-37148773.post-50500309376365599422007-09-26T21:20:00.000-04:002007-09-26T21:20:00.000-04:00I remember going to a talk Blobel gave in the mid-...I remember going to a talk Blobel gave in the mid-1990s, at MIT (before his Nobel, but everyone knew he was going to get one), where in passing he made the comment that (because signal receptors were themselves directed to the right place by signals, and so if one got mistargeted then there would be a cascade of mistargeting that would quickly destroy the cell) traffic signals were probably more important to the cell than transcriptional integrity. Phil Sharp, in the front row, just a couple years past his own Nobel, leaped to his feet, raised his fists, and challenged Blobel to take it outside ...Anonymousnoreply@blogger.com