tag:blogger.com,1999:blog-37148773.post4881615566480873193..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Monday's Molecule #167Larry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-37148773.post-84651706835590044902012-04-24T03:04:05.298-04:002012-04-24T03:04:05.298-04:00This molecule is tetrodotoxin. Its importance as a...This molecule is tetrodotoxin. Its importance as a neurotoxin involves blocking actin potential via interfering with voltage gated sodium channels. One of its natural sources is from pufferfish. <br /><br />UofT UndergraduateDmitri Tchigvintsevnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-88184630761210999102012-04-23T22:13:26.914-04:002012-04-23T22:13:26.914-04:00Tetrodotoxin (TTX), is a potent neurotoxin with no...Tetrodotoxin (TTX), is a potent neurotoxin with no known antidote. There have been successful tests of a possible antidote in mice, but further tests must be carried out to determine efficacy in humans. Tetrodotoxin blocks action potentials in nerves by binding to the voltage-gated, fast sodium channels in nerve cell membranes, essentially preventing any affected nerve cells from firing by blocking the channels used in the process.<br />Its mechanism of action, selective blocking of the sodium channel, was shown definitively in 1964 by Toshio Narahashi and John W. Moore at Duke University, using Moore's sucrose gap voltage clamp technique.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-62730933450361401572012-04-23T21:34:56.935-04:002012-04-23T21:34:56.935-04:00Tetrodotoxin. Neurotoxic component of fugu (puffe...Tetrodotoxin. Neurotoxic component of fugu (pufferfish), and alleged ingredient of zombie powder.Nostranoodlehttps://www.blogger.com/profile/04808159695811673848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-72080480445365870572012-04-23T21:18:50.809-04:002012-04-23T21:18:50.809-04:00Tetrodotoxin, frequently abbreviated as TTX, is a ...Tetrodotoxin, frequently abbreviated as TTX, is a potent neurotoxin with no known antidote. There have been successful tests of a possible antidote in mice, but further tests must be carried out to determine efficacy in humans. Tetrodotoxin blocks action potentials in nerves by binding to the voltage-gated, fast sodium channels in nerve cell membranes,.chemicalscumhttps://www.blogger.com/profile/00456611765432242326noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-18098808730689415102012-04-23T19:27:51.914-04:002012-04-23T19:27:51.914-04:00tetrodotoxintetrodotoxinFirsthttps://www.blogger.com/profile/05301983060982959781noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-10560624477495522212012-04-23T17:27:27.925-04:002012-04-23T17:27:27.925-04:00Molecule # 167 is tetrodoxin or TTX or (4R,4aR,5R,...Molecule # 167 is tetrodoxin or TTX or (4R,4aR,5R,6S,7S,8S,8aR,10S,12S)-2-azaniumylidene-4,6,8,12-tetrahydroxy-6-(hydroximethyl)-2,3,4,4a,5,6,7,8-octahydro-1H-8a,10-methano-5,7-(epoxymethanooxy)quinazolin-10-olic acid, a deadly neurotoxin that blocks sodium channels in nerve cell membranes. The Pacific Ocean inspires you to have dinner in a good Japanese restaurant, where delicious 'fugu' is served.Raul A. FĂ©lix de Sousanoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-87633791703996659042012-04-23T14:53:40.068-04:002012-04-23T14:53:40.068-04:00Tetrodotoxin, a potent neurotoxin. The most common...Tetrodotoxin, a potent neurotoxin. The most common source is pufferfish, but it is found in a number of other species as well. It is believed to be produced by the bacterium <i>Vibrio alginolyticus</i>, not by the fish itself.<br />Tetrodotoxin is important for a couple of reasons:<br />1) If you eat improperly prepared pufferfish, it could kill you. That's fairly important.<br />2) Tetrodotoxin specifically blocks sodium channels, and therefore it has been a valuable tool for neuroscience.Bayesian Bouffant, FCDnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-43633151112359289042012-04-23T13:40:48.069-04:002012-04-23T13:40:48.069-04:00This molecule is tetrodotoxin, the potent neurotox...This molecule is tetrodotoxin, the potent neurotoxin with no known antidote found in a number of fish in the Pacific Ocean, namely the pufferfish, the porcupinefish, the ocean sunfish, and the triggerfish. I am an undergraduate.Deena Allamnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-28080306247352487422012-04-23T11:50:03.469-04:002012-04-23T11:50:03.469-04:00Looks like tetrodotoxin, the toxin in pufferfish. ...Looks like tetrodotoxin, the toxin in pufferfish. Important because it's sort of toxic. Well, a lot. If one aims to eat pufferfish, I would find the most experienced chef possible, regardless of the expense...<br /><br />If I'm not mistaken, it is a Na-channel blocker, and is probably made by prokaryotic symbiotes.Sean Ridouthttps://www.blogger.com/profile/17920913146530127438noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-10657637913358861562012-04-23T11:38:08.909-04:002012-04-23T11:38:08.909-04:00As I used it on a couple of occasions, I know it r...As I used it on a couple of occasions, I know it right away. Tetrodotoxin, pufferfish toxin, an inhibitor of the voltage-gated Na channel.Dima Klenchinnoreply@blogger.com