tag:blogger.com,1999:blog-37148773.post4005939295147775073..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Sequenced genomes contain thousands of "unknown" genesLarry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-37148773.post-20136236148643925112009-04-22T15:15:00.000-04:002009-04-22T15:15:00.000-04:00I am analyzing cytochrome P450s from 64 sequenced ...I am analyzing cytochrome P450s from 64 sequenced fungal genomes, including correct gene assembly and naming according to a systematic nomenclature for this family. I have completed 2700+ sequences with about 1300 genes to go. Even in the Apergillus species, after looking in detail at 8 genomes, there are new CYP families in each genome. There is a core of conserved families, but there are always new ones. I don't think de novo evolution of these families is responsible. I supect there is a huge reservoir of genes that fungi are accessing by lateral gene transfer and this explains the novelty among even close species.<br />As we get more and more genomes sequenced it may be possible to see the source of these novel genes.David R. Nelsonhttp://drnelson.utmem.edu/cytochromeP450.htmlnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-48862396936405349422009-04-22T13:53:00.000-04:002009-04-22T13:53:00.000-04:00One of the interesting things is how unreported th...One of the interesting things is how unreported this is! The similarity between chimp and human is frequently given as 99%, but this is only when you are looking at shared genes. Check out Gollery, et. al., "What makes species unique?" in Genome Biology.Unknownhttps://www.blogger.com/profile/12208917410239554640noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-47839065923663407202009-04-22T13:16:00.000-04:002009-04-22T13:16:00.000-04:00Dikarya are the more derived Basidiomycetes and As...Dikarya are the more derived Basidiomycetes and Ascomycetes with a dikaryotic phase, not all fungi.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-42389784297472716422009-04-22T10:02:00.000-04:002009-04-22T10:02:00.000-04:00Look at the zebrafish genome...it's a mess!Look at the zebrafish genome...it's a mess!gillthttp://blogs-r.us/bioblog/noreply@blogger.com