tag:blogger.com,1999:blog-37148773.post3996792184185234607..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Horace Judson (1931 - 2011)Larry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger21125tag:blogger.com,1999:blog-37148773.post-57278970931991511332013-06-12T08:18:39.020-04:002013-06-12T08:18:39.020-04:00Some more gems in the shape of eulogies to Horace ...Some more gems in the shape of eulogies to Horace Judson - I append some quotes from both superb commentaries:<br />http://www.lastwordonnothing.com/2011/06/22/remembering-horace-judson-2/<br />including this observation of note attributed to Judson :<br /><br />"Terry and I were in Horace’s workshops together. All I can add to Terry’s elegant, intelligent essay here is Horace’s rule for a good sentence: it has an arrow running through it, it’s ordered beginning to end, every word is in the right place. Try that for even a paragraph and you’ll break a sweat."<br /><br />This tribute also includes useful insights into the ingredients of powerful prose...<br />http://genotopia.scienceblog.com/22/horace-judson-a-eulogy/<br /><br />see the appended Comments to this euology, especially the story about training under live fire in telephonic interviews.<br /><br />And then there is Judson's pithy take on the place of popular science writing:<br /><br />"Writing about music is not the same as composing it or performing it—and in just that trivial way writing about science, talking about science, explaining science, is not science. But is the pleasure taken in science by the non-scientist therefore illegitimate? Listening to music with an instructed ear and the aid of a score is certainly a musical activity—and in just that self-evident way, along a continuum from dummy to savant there is a point p at which reading about science with an instructed mind and with reference to original research becomes a scientific activity."<br /> "...It’s a coda by the pioneer himself, and it remains a worthy meditation for anyone in our line of work<br />..."<br />“I like a florid line,” Horace once told me....Fine and witty rage, master of language, mordant stylist—yes, also Horace."<br />he was distinctly Huxleyian - not least in his attention to dress and indeed all matters of style. He was indeed, “the last living Edwardian."<br /><br /> And another tribute:<br />"Whereas too many academics are selfish, aspergeric and nasty behind their smiling and convivial personas, Horace was the other way around...."<br />http://www.museion.ku.dk/2011/05/horace-judson-pioneer-historian-of-molecular-biology-dies-at-80/<br />fcotterillhttps://www.blogger.com/profile/05196132511592879273noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-86849408733880174472013-06-12T08:11:07.400-04:002013-06-12T08:11:07.400-04:00An e-book edition, or pdf, of the Eighth Day of Cr...An e-book edition, or pdf, of the Eighth Day of Creation (ideally the updated 1996 edition) does not appear to exist, a deplorable gap in knowledge availability that needs to change....<br /><br />So To quote and endorse this plea:<br /><br />"Although I really agree with Larry Moran’s concluding sentence “The solution to this problem is to make all students read The Eighth Day of Creation” I think that the chances are remote without good modern publishers helping the process along. Do something useful today, go to the Amazon webpage of Eighth Day of Creation and click on the link (usually just under the picture) to request a Kindle version from the publisher."<br /><br />http://www.amazon.co.uk/gp/product/0879694785/ref=kinw_rke_rti_1<br /><br />http://www.davelunt.net/evophylo/2011/07/the-eighth-day-of-creation-and-the-weight-of-knowledge/<br /><br /><br />fcotterillhttps://www.blogger.com/profile/05196132511592879273noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-24865788236014966032013-06-11T08:56:41.433-04:002013-06-11T08:56:41.433-04:00Horace Judson's masterpiece remains in a class...Horace Judson's masterpiece remains in a class of its own, no matter its vintage. Four of Judson's essays are well worth the read - even though they appear poorly known. They can be downloaded here:<br />https://sites.google.com/site/fpdcotterill/philosophy-of-science/papers-and-books-of-note?pli=1fcotterillhttps://www.blogger.com/profile/05196132511592879273noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-55235114443595148762011-07-21T15:41:36.006-04:002011-07-21T15:41:36.006-04:00I'll obviously need to add ECOC to my list; my...I'll obviously need to add ECOC to my list; my go-to book for similar reasons has long been PATOOMB (Phage and the Origins of Molecular Biology).Guy Plunkett IIIhttp://www.genome.wisc.edu/information/gplunkett.htmlnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-17746419492249769622011-07-20T12:07:11.759-04:002011-07-20T12:07:11.759-04:00Negative Entropy said...
"Gasp! Are you me?&...Negative Entropy said...<br /><br />"Gasp! Are you me?"<br /><br />Hmmm...I see you post at 4pm when I'm usually at work so unless there is some sort of Tyler Durden thing going on I doubt it.<br /><br />I have to admit I've never read EDOC though its been on my LONGLIST for years. I'm sure Judson does a great job of 'humanizing' the story as most good science writers do but I would think to really understand the nuts and bolt of the experiments ( which is what you'd want for a college course), you'd have to go to the primary literatureAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-91239249684132401892011-07-20T11:53:49.626-04:002011-07-20T11:53:49.626-04:00Is the 1996 edition a great improvement on the 197...Is the 1996 edition a great improvement on the 1979 edition? I ask only because I can get the 1979 edition for about $5 whereas the 1996 edition is $30. Does the 96 version add decent detail on the intervening years or is it only a new preface and end chapter as many updates seem to be?Paul Southworthhttps://www.blogger.com/profile/15391618344599368502noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-86228062645061592762011-07-20T09:48:43.643-04:002011-07-20T09:48:43.643-04:00But students are being taught to think for themsel...But students are being taught to think for themselves. Right?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-77414853995183926252011-07-19T19:46:26.246-04:002011-07-19T19:46:26.246-04:00I am at a small liberal arts college. On my campu...I am at a small liberal arts college. On my campus, biology gets the "molecular biology" content. The course is all about the latest papers without critically thinking about what it means. Biochemistry is taught in the Chemistry department. Before I got there, polymerases were only taught in any depth by the Biology department. I now go into detail on structure/function & kinetics but regulation I still have to leave the molecular biology course. I am also the only one that discusses molecular evolution. At first the students dislike it but come around when they realize it really helps to understand biological macromolecules and the pathways we are covering. <br /><br />Wish I could get the biology department to do the same. Still haven't won them over on the sequence hypothesis distinction from the central dogma.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-73301345444763872422011-07-19T16:14:10.258-04:002011-07-19T16:14:10.258-04:00Anonymous said...
I'm shocked to hear that the...Anonymous said...<br /><i>I'm shocked to hear that these things are no longer taught. It seems to me the primary reason for teaching them isnt even the history, its the logic and elegance of the experiments which should inspire future generations. So much in mol bio seems to be massive data collection without a shred of creativity...but then again I'm old (48)</i><br /><br />Gasp! Are you me? You stole both the lines I use when defending my insistence that students read this book, and my age! Is this the twilight zone? The Matrix? Is there a spoon?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-65450685490708397942011-07-19T15:37:58.935-04:002011-07-19T15:37:58.935-04:00"The Eighth Day of Creation" is one of m..."The Eighth Day of Creation" is one of my favorite books, both because Horace Freeland Judson was a brilliant author, and because I had some direct experience with the subject of the book, first as an undergraduate biology student from 1962 to 1966 and later as a graduate student working at first on gene regulation in bacteriophage lambda.<br /><br /> I have read the book twice and for many years recommended it to students in my lectures on "gene technology", saying that it should be considered as the preface to the stuff I would tell them about. I'm not sure that any of them actually read it, but if they were ever to look again at the course notes I distributed, there would be a page with a picture of the book cover and in large print at the top, "Read this book!"<br /><br />Finally, the talent for good scientific writing has been passed down to another generation in the Judson family-- see the texts by H.F.'s daughter Olivia Judson.<br /><br />NedNednoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-61220880940569636032011-07-19T11:12:06.184-04:002011-07-19T11:12:06.184-04:00I'm shocked to hear that these things are no l...I'm shocked to hear that these things are no longer taught. It seems to me the primary reason for teaching them isnt even the history, its the logic and elegance of the experiments which should inspire future generations. So much in mol bio seems to be massive data collection without a shred of creativity...but then again I'm old (48)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-75015958243475200762011-07-18T22:08:45.533-04:002011-07-18T22:08:45.533-04:00What this means is that we are graduating students...<i>What this means is that we are graduating students who are completely unaware of the fundamental principles of biochemistry that apply to all species.</i><br /><br />Well... principles of biochemistry that were hoped to apply to all species, especially to medically relevant species like humans. I wouldn't begrudge the people that actually validate these "universal principles" their moment in the sun for finally establishing human biology relevance.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-38116880862954567672011-07-18T16:45:28.750-04:002011-07-18T16:45:28.750-04:00I use this book in my courses. I agree, it should ...I use this book in my courses. I agree, it should be required material for any self-respecting molecular biologist (and derivatives).Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-32180126830660667552011-07-18T13:50:54.864-04:002011-07-18T13:50:54.864-04:00It's even worse in my field. Most synthetic bi...It's even worse in my field. Most synthetic biologists I know come from an engineering background, so not only are they ignorant of most of the older research in biology, they're proud of it.Devinhttps://www.blogger.com/profile/12511286189866238296noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-43129599874599968842011-07-18T08:44:11.821-04:002011-07-18T08:44:11.821-04:00I think the problem with leaving out the history i...I think the problem with leaving out the history is not terribly unique to biochemistry, though I certainly noticed eventually. I don't think it is even really a problem about knowing stuff. The bigger impact is that without the history, as Larry pointed out science is largely reduced to technological puzzle solving. History and biography are important for conveying all of those other parts about being a scientist to the next generation, at least as much as getting the concepts right.JGBnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-25609643512479577492011-07-18T07:56:53.344-04:002011-07-18T07:56:53.344-04:00@Mark Pallen,
It's even worse than you imagin...@Mark Pallen,<br /><br />It's even worse than you imagine. These "eukaryotic cell biology" courses are almost always about mammalian cells and, maybe, yeast cells. Plants and protists also have cells!<br /><br />Many introductory biochemistry courses are taught from the perspective of fuel metabolism and relevance to medicine. What this means is that we are graduating students who are completely unaware of the fundamental principles of biochemistry that apply to all species. <br /><br />We've talked about this problem before. For example, when transcription is taught properly, based on all the fundamental concepts discovered in bacteria, students will appreciate how RNA polymerase binds to DNA. They will understand non-specific binding and why spurious transcription is an expected property.<br /><br />If they are not taught properly they may grow up to become scientists who are completely ignorant of these fundamental concepts. These researchers may discover that most of the mammalian genome is transcribed at one time or another. Because they haven't been taught proper molecular biology, they may jump to a ridiculous conclusion. They may interpret this to mean that most of the genome has a function.<br /><br />Whose fault is this? It's OUR fault (university professors)! Unfortunately, I can't even convince my colleagues that there's a problem so there's little chance that we can fix it.<br /><br>Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-66962314551023978902011-07-18T04:56:31.696-04:002011-07-18T04:56:31.696-04:00And why is "cell biology" in courses and...And why is "cell biology" in courses and departments and textbooks always eukaryotic cell biology. Bacteria have cells too!!Mark Pallenhttps://www.blogger.com/profile/06911675151032525386noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-5031683274675738172011-07-18T02:04:08.609-04:002011-07-18T02:04:08.609-04:00Encode keeps ignoring the history (http://www.plo...Encode keeps ignoring the history (http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000625) as well and is denying new data contradicting their conclusions. Their critics respond: http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001102Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-37798580885064749492011-07-18T00:45:09.170-04:002011-07-18T00:45:09.170-04:00That's right, we are now firmly into an era wh...That's right, we are now firmly into an era where professors who lecture don't know the history themselves. <br /><br />Almost ten years ago I discovered, to my dismay, that a graduate student in the lab didn't know what Hershey–Chase experiment was (nor, for that matter, Meselson-Stahl). Turns out, it wasn't part of his biochemistry. Since then, I ask the same question of most other students. 100% failure so far. N is probably around 7.<br /><br />Not knowing names is not really a problem. Problem is, most students/postdocs don't have an appreciation of how smart and inventive some of their predecessors were. The prevailing feeling seems to be "things were too easy and crude back then with their phages and E.coli". Not co-incidentally, this attitude is coupled with the approach to science as a series of tasks to be accomplished. I've come to hate the word "protocol" because most of the time it is part of the "I need a project and a series of protocols to apply to it; then, if I do it faithfully and carefully, my scientific task will be successfully accomplished".DKnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-55074737385949520352011-07-18T00:40:00.077-04:002011-07-18T00:40:00.077-04:00I would love to read Eighth Day of Creation but it...I would love to read Eighth Day of Creation but it costs $30, new and used. Why is it still so high?Kelehttps://www.blogger.com/profile/13873654583309967875noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-891699566453283952011-07-17T22:45:51.121-04:002011-07-17T22:45:51.121-04:00"TFIIS may play a role in pausing and transcr..."TFIIS may play a role in pausing and transcription termination that is similar to the role of NusA in bacteria." <br /><br />"...identifies a switch that allows RNA polymerase to shift gears from neutral into drive and start transcribing."<br /><br />It looks like your earlier idea was confirmed by the later study that actually identified the "switch" involved.Anonymousnoreply@blogger.com