tag:blogger.com,1999:blog-37148773.post339318969283717793..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Modified Bases in DNALarry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-37148773.post-44621779992105898502012-05-20T13:06:19.919-04:002012-05-20T13:06:19.919-04:00Re: Ian Vitro, there is now a way to distinguish O...Re: Ian Vitro, there is now a way to distinguish OHMeC from MeC:<br />http://www.sciencemag.org/content/336/6083/934Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-6493412281713557542010-02-12T02:23:50.367-05:002010-02-12T02:23:50.367-05:00Great post, thank you for pointing this out. There...Great post, thank you for pointing this out. There are many inaccuracies in press releases, which makes one wonder, why is there no peer review for press articles? It should take only 5-10 minutes to read a press article, and often more people read this false info than the true article. We should implement peer review for press releases!meni1noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-22972653921915178702009-04-24T13:14:00.000-04:002009-04-24T13:14:00.000-04:00You can't expect press releases to have good, or e...You can't expect press releases to have good, or even complete, scientific information. It might not be the "6th base" but it's still damned interesting.<br /><br />Among the most interesting things about the 5-hydroxymethylcytosine are that 1) it is indistinguishable from MeC using bisulfite mapping, and 2) methyl-binding proteins like MeCP2 have a different affinity for the OHMeC compared to the MeC. This could be huge in that it may account for differential activation and repression of some genes by MeCP2, and some of the ambiguity around the actual role of methylation in gene expression...Ian Vitrohttps://www.blogger.com/profile/11144502741558706531noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-29842341581123096472009-04-20T17:38:00.000-04:002009-04-20T17:38:00.000-04:00Uuhh, they forgot T4 phage, which has Hydroxymethy...Uuhh, they forgot T4 phage, which has Hydroxymethyl C, as a site for glycosylation.Franknoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-44092086381342682232009-04-20T03:35:00.000-04:002009-04-20T03:35:00.000-04:00I heard about this a few weeks ago by word of mout...I heard about this a few weeks ago by word of mouth. I had no idea about the 1972 paper though, and it seems they find it in brain tissue there too. Still, it's an interesting discoveryGeorgi Marinovhttps://www.blogger.com/profile/12226357993389417752noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-53816834842332874792009-04-19T23:40:00.000-04:002009-04-19T23:40:00.000-04:00DNA base J (-D-glucosylhydroxymethyluracil) in Try...DNA base J (-D-glucosylhydroxymethyluracil) in Trypanosomes.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-41692376352211616602009-04-19T23:06:00.000-04:002009-04-19T23:06:00.000-04:00Thanks for getting to this. I saw the story a few ...Thanks for getting to this. I saw the story a few days ago but thought there was something iffy about how overblown it was.Kele Cablenoreply@blogger.com