tag:blogger.com,1999:blog-37148773.post1295070862063236251..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Junk in Your Genome: SINESLarry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-37148773.post-54988937628582099822013-07-12T10:08:42.202-04:002013-07-12T10:08:42.202-04:00What are you skeptical about?What are you skeptical about?Paul Korirhttps://www.blogger.com/profile/12799349282968238631noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-87840814233897900772008-03-14T06:15:00.000-04:002008-03-14T06:15:00.000-04:00Intelligent Designer asks,What determines whether ...Intelligent Designer asks,<BR/><BR/><I>What determines whether one SINE is a decendent of another?</I><BR/><BR/>Their sequence similarity. Each member of the SINE family has a slightly different sequence because they have evolved from a very ancient common ancestor.<BR/><BR/><I>How can we tell which SINES are recent descendents as opposed to old descendents?</I><BR/><BR/>Again, it's because of their sequence. Once you have identified the particular family of SINES then there will still be variation withinthat family. If two SINES are identical then you know that one of them has recently arisen by transposition. If you are looking at the human genome then the recent one will be the one that's not found at that site in the chimpanzee genome.) <BR/><BR/><I>How is the chronological history of these SINES determined?</I><BR/><BR/>By comparing the locations of various SINES to the known history of the lineage. We know, for example, a great deal about the historical evolution of the primate lineage so it's quite easy to work out the history of SINE movement.Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-25830072076943183132008-03-13T16:01:00.000-04:002008-03-13T16:01:00.000-04:00I hope you don't mind me bothering you with a few ...I hope you don't mind me bothering you with a few more questions.<BR/><BR/>What determines whether one SINE is a decendent of another?<BR/><BR/>How can we tell which SINES are recent descendents as opposed to old descendents?<BR/><BR/>How is the chronological history of these SINES determined?Randy Stimpsonhttps://www.blogger.com/profile/09626444950916244368noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-60038782144990300562008-03-13T11:27:00.000-04:002008-03-13T11:27:00.000-04:00Intelligent Designer asks,What determines if a SIN...Intelligent Designer asks,<BR/><BR/><I>What determines if a SINE is defective?</I><BR/><BR/>The easiest was to tell is when you see that essential elements have been deleted or mutated. For example, if the RNA polymerase binding site is disrupted then the SINE can't be transcribed.<BR/><BR/>Historically, you can look to see whether a particular SINE sequence has transposed (moved) to another location. Active SINES will have lots of recent descendants whereas inactive ones will not.<BR/><BR/>Most SINES are inactive by these criteria. They are randomly accumulating mutations at the rate expected for non-essential junk DNA.Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-91463898177192232662008-03-13T01:58:00.000-04:002008-03-13T01:58:00.000-04:00What determines if a SINE is defective?What determines if a SINE is defective?Randy Stimpsonhttps://www.blogger.com/profile/09626444950916244368noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-71118101917419062012008-02-08T08:56:00.000-05:002008-02-08T08:56:00.000-05:00Thanks. I'm delighted that at least one person rea...Thanks. I'm delighted that at least one person read the article!Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-10427443216205270502008-02-08T02:51:00.000-05:002008-02-08T02:51:00.000-05:00"SINEs that are decective."Evidently there was a s..."SINEs that are decective."<BR/><BR/>Evidently there was a single nucleotide polymorphism in the word "defective", leaving it "decective".Anonymousnoreply@blogger.com