tag:blogger.com,1999:blog-37148773.post1190698507593167795..comments2024-03-27T14:50:47.345-04:00Comments on <center>Sandwalk</center>: Monday's Molecule #170Larry Moranhttp://www.blogger.com/profile/05756598746605455848noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-37148773.post-69774034193915968922012-05-15T11:23:25.429-04:002012-05-15T11:23:25.429-04:00I'm not sure why there are already comments vi...<i>I'm not sure why there are already comments visible?</i><br /><br />Because I turned off comment moderation but forgot that it would have this effect. I'll try and figure out something for next week.Larry Moranhttps://www.blogger.com/profile/05756598746605455848noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-44900340476279909892012-05-14T23:08:59.212-04:002012-05-14T23:08:59.212-04:00The molecule is hidroxitetrahydrobiopterin (BH4). ...The molecule is hidroxitetrahydrobiopterin (BH4). BH4 is synthesized from guanosin triphospate through 3 enzymatic reactions guanosin triphospate cichohidrolase, 6 piruvoil tetrahydrobiopterin synthase and sepiapterine reductase. Phenylalanine hydroxylase catalyses the hydroxylation of phenylalanine which is converted on tyrosine, this product is the electrons donor for BH4 which at same time gets oxidized and transformed in dihydrobiopterina (BH2). Then BH2 is reduced again to BH4 and this reaction is catalyzed for dihydrobiopterin reductase. The symptom of patients who can't make this enzyme is hyperphenylalaninemia.<br />Obert Marin Sanchez<br />UndergraduateAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-37148773.post-57935258477579204002012-05-14T19:08:13.292-04:002012-05-14T19:08:13.292-04:00I'm not sure why there are already comments vi...I'm not sure why there are already comments visible? Anyway, I think the molecule is 4a-carbinolamine. The most important enzyme that uses this molecule as a substrate in the normal direction of flux is 4a-carbinolamine dehydratase. The dominant symptom of patients who can't make this enzyme is hyperphenylalaninemia (high blood levels of phenylalanine), accompanied by high levels of 7-biopterin.Jason Oakleyhttps://www.blogger.com/profile/14414529190965164341noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-62842401204228689662012-05-14T18:19:24.036-04:002012-05-14T18:19:24.036-04:00Sorry for the comment spam, but the molecule poste...Sorry for the comment spam, but the molecule posted here seems to actually be the PRODUCT of this reaction, not tetrahydrobiopterin. I don't know what it's called.Sean Ridouthttps://www.blogger.com/profile/17920913146530127438noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-68531852305580734372012-05-14T18:18:09.073-04:002012-05-14T18:18:09.073-04:00This comment has been removed by the author.Sean Ridouthttps://www.blogger.com/profile/17920913146530127438noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-30018554719238337512012-05-14T18:16:10.418-04:002012-05-14T18:16:10.418-04:00Also, I believe it's tetrahydrobiopterin. Dihy...Also, I believe it's tetrahydrobiopterin. Dihydrobiopterin reductase converts dihydrobiopterin to this molecule, I believe, and the enzyme which takes this molecule as its subtrate and is defective in PKU is phenylalanine hydroxylase.Sean Ridouthttps://www.blogger.com/profile/17920913146530127438noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-67855660802862641672012-05-14T18:13:52.218-04:002012-05-14T18:13:52.218-04:00While phenylketone in the urine is certainly the d...While phenylketone in the urine is certainly the diagnostic symptom, I would hardly call it "dominant" over such things as brain damage, etc. :PSean Ridouthttps://www.blogger.com/profile/17920913146530127438noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-27028682504630768792012-05-14T17:53:34.571-04:002012-05-14T17:53:34.571-04:00the molecule is dihydrobiopterin.
the enzyme that ...the molecule is dihydrobiopterin.<br />the enzyme that uses it is Dihydrobiopterin reductase.<br />deficiency causes a secondary form of phenylketonuria and the dominant symptom of that disease is phenylketone in urine.Karan Hingoranihttps://www.blogger.com/profile/08511481934805318551noreply@blogger.comtag:blogger.com,1999:blog-37148773.post-72764786927788661422012-05-14T17:51:45.281-04:002012-05-14T17:51:45.281-04:00This comment has been removed by the author.Karan Hingoranihttps://www.blogger.com/profile/08511481934805318551noreply@blogger.com