John Horgan has upped the ante with his Ten Worst Science Books. I haven't read most of the ones on his list but I certainly agree with Consilience. I disagree with The Tipping Point 'cause it's not a science book and I disagree with Rock of Ages 'cause when you read it carefully you see that Gould has a valid point.
PZ Meiers adds Darwin's Black Box by Michael Behe and The Language of God by Francis Collins. I'm not sure if the Collins book qualifies as science. It's in the superstition section of my local bookstore.
John Lynch over at Stranger Fruit has an even more interesting suggestion for John Horgan's list of worst science books. Lynch would add The End of Science by John Horgan. Ouch!
I have three suggestions. The one everyone is forgetting is Icons of Evolution by Jonathan Wells. This one's a no-brainer.
One of my personal favorites is Sudden Origins: Fossils, Genes, and the Emergence of Species by Jeffrey H. Schwartz. This is a really, really, bad science book.
Another book that gets my vote is Darwin's Dangerous Idea by Daniel Dennett.